专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09242929B2 Compounds as diacylglycerol acyltransferase inhibitors 有权
公开(公告)号：US09242929B2
公开(公告)日：2016-01-26
申请号：US14118913
申请日：2012-05-18
申请人： Siegfried Benjamin Christensen, IV , Rowena Christensen , Donghui Qin , Hemant Joshi , Raghuram S. Tangirala
发明人： Siegfried Benjamin Christensen, IV , Donghui Qin , Hemant Joshi , Raghuram S. Tangirala
IPC分类号： C07C275/42 , C07D217/26 , C07D239/42 , C07D213/75 , C07D241/20 , C07D237/20 , A61K31/17 , A61K31/4418 , A61K31/444 , A61K31/472 , A61K31/4965
CPC分类号： C07C275/42 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D213/75 , C07D217/24 , C07D217/26 , C07D237/20 , C07D239/42 , C07D241/20
摘要： This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.

2. 发明授权

US08859536B2 Compounds as diacylglycerol acyltransferase inhibitors 有权
标题翻译：化合物作为二酰基甘油酰基转移酶抑制剂
公开(公告)号：US08859536B2
公开(公告)日：2014-10-14
申请号：US14118976
申请日：2012-05-18
申请人： Donghui Qin , Mui Cheung , Hemant Joshi , Raghuram Tangirala , Sridhar Reddy Bethi
发明人： Donghui Qin , Mui Cheung , Hemant Joshi , Raghuram Tangirala , Sridhar Reddy Bethi
IPC分类号： C07D498/04 , A61K31/519 , C07D519/00
CPC分类号： C07D519/00 , C07D498/04
摘要： This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.
摘要翻译：本发明涉及作为酰基辅酶A：二酰基甘油酰基转移酶1（DGAT-1）的抑制剂的新化合物，含有它们的药物组合物，其制备方法及其在治疗中用于预防或治疗与DGAT有关的疾病 -1功能障碍或DGAT-1活性的调节可能具有治疗益处，包括但不限于肥胖症，肥胖相关疾病，高甘油三酯血症，高脂蛋白血症，乳糜微粒血症，血脂异常，非酒精性脂肪性肝炎，糖尿病，胰岛素抵抗，代谢综合征，丙型肝炎病毒感染和痤疮或其他皮肤疾病。

3. 发明申请

US20140080809A1 Novel Compounds as Diacylglycerol Acyltransferase Inhibitors 有权
标题翻译：新型化合物作为二酰基甘油酰基转移酶抑制剂
公开(公告)号：US20140080809A1
公开(公告)日：2014-03-20
申请号：US14118976
申请日：2012-05-18
申请人： Donghui Qin , Mui Cheung , Hemant Joshi , Raghuram Tangirala , Sridhar Reddy Bethi
发明人： Donghui Qin , Mui Cheung , Hemant Joshi , Raghuram Tangirala , Sridhar Reddy Bethi
IPC分类号： C07D498/04
CPC分类号： C07D519/00 , C07D498/04
摘要： This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders.
摘要翻译：本发明涉及作为酰基辅酶A：二酰基甘油酰基转移酶1（DGAT-1）的抑制剂的新化合物，含有它们的药物组合物，其制备方法及其在治疗中用于预防或治疗与DGAT有关的疾病 -1功能障碍或DGAT-1活性的调节可能具有治疗益处，包括但不限于肥胖症，肥胖症相关疾病，高甘油三酯血症，高脂蛋白血症，乳糜微粒血症，血脂异常，非酒精性脂肪性肝炎，糖尿病，胰岛素抵抗，代谢综合征，丙型肝炎病毒感染和痤疮或其他皮肤疾病。

4. 发明授权

US08592591B2 Fused bicyclic imidazoles 失效
标题翻译：稠合双环咪唑
公开(公告)号：US08592591B2
公开(公告)日：2013-11-26
申请号：US12191706
申请日：2008-08-14
申请人： Swen Hölder , Armin Zülch , Thomas Bär , Thomas Maier , Astrid Zimmermann , Thomas Beckers , Volker Gekeler , Hemant Joshi , Yogesh Munot , Umesh Bhise , Sunil Chavan , Sachin Shivatare , Sarvesh Patel , Vikas Gore
发明人： Swen Hölder , Armin Zülch , Thomas Bär , Thomas Maier , Astrid Zimmermann , Thomas Beckers , Volker Gekeler , Hemant Joshi , Yogesh Munot , Umesh Bhise , Sunil Chavan , Sachin Shivatare , Sarvesh Patel , Vikas Gore
IPC分类号： C07D401/04 , C07D401/14 , A61K31/4188 , A61K31/4465 , A61P35/00
CPC分类号： A61K31/454 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K45/06 , C07D401/10 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译：式（I）化合物其互变异构体或立体异构体或其盐，其中环B和与其稠合的咪唑，R4，R6和R7具有在说明书和权利要求书中给出的含义，是有效的抑制剂 Pi3K / Akt途径。

5. 发明申请

US20050273745A1 Determining feasibility of IC edits 有权
标题翻译：确定IC编辑的可行性
公开(公告)号：US20050273745A1
公开(公告)日：2005-12-08
申请号：US10861294
申请日：2004-06-04
申请人： John Bach , Rand Carawan , Hemant Joshi , David Thomas
发明人： John Bach , Rand Carawan , Hemant Joshi , David Thomas
IPC分类号： G06F9/45 , G06F9/455 , G06F17/50
CPC分类号： G06F17/5081
摘要： A computer method of analyzing an integrated circuit (“IC”) masked design data, comprising grouping into a cluster areas of layers preceding a target metal layer that are suitable for milling, deleting portions of the target metal layer that do not meet minimum tool spacing requirements to produce a modified metal layer, deleting portions of the modified metal layer that do not meet minimum design rule width requirements to produce a final metal layer, and comparing the final metal layer and the cluster to identify common areas.
摘要翻译：一种分析集成电路（“IC”）掩蔽设计数据的计算机方法，包括将适合于铣削的目标金属层之前的层分组成组合，删除目标金属层的不符合最小刀具间距的部分要求生产改性金属层，删除不符合最小设计规则宽度要求的部分修饰金属层以产生最终金属层，以及比较最终金属层和簇以识别公共区域。

6. 发明授权

US08440830B2 Tetrahydro-fused pyridines as histone deacetylase inhibitors 失效
标题翻译：四氢稠合吡啶作为组蛋白脱乙酰酶抑制剂
公开(公告)号：US08440830B2
公开(公告)日：2013-05-14
申请号：US12678806
申请日：2008-09-19
申请人： Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
发明人： Thomas Maier , Thomas Beckers , Thomas Baer , Matthias Vennemann , Volker Gekeler , Astrid Zimmermann , Petra Gimmnich , Kamlesh Padiya , Hemant Joshi , Uday Joshi , Mahindra Makhija , Dipak Harel
IPC分类号： C07D471/04 , A61K31/4355 , A61K31/4365 , A61K31/4353 , A61K31/437
CPC分类号： C07D513/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The compounds of formula (I), wherein ring D and ring E together form a fused ring system selected from formula (II), (III), (IV), (V), (VI), (VII), and the salts of these compounds are novel, effective inhibitors of histone deacetylases.
摘要翻译：式（I）化合物，其中环D和环E一起形成选自式（II），（III），（IV），（V），（VI），（VII）的这些化合物是组蛋白脱乙酰酶的新颖有效的抑制剂。

7. 发明申请

US20060241078A1 Pharmaceutical compositions comprising a contraceptive agent in solution and a teratogen 审中-公开
标题翻译：包含溶液中的避孕剂和致畸物的药物组合物
公开(公告)号：US20060241078A1
公开(公告)日：2006-10-26
申请号：US11376147
申请日：2006-03-16
申请人： Salah Ahmed , Sivakumar Vaithiyalingam , Hemant Joshi
发明人： Salah Ahmed , Sivakumar Vaithiyalingam , Hemant Joshi
IPC分类号： A61K31/7072 , A61K31/56 , A61K31/57 , A61K31/525 , A61K31/454 , A61K31/203
CPC分类号： A61K31/56 , A61K31/203 , A61K31/454 , A61K31/525 , A61K31/57 , A61K31/7072 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising an estrogen and a progestin in solution, and a teratogen suspended in the estrogen and progestin solution. The present invention also relates to methods of making and using the pharmaceutical compositions described herein.
摘要翻译：本发明涉及药物组合物，其包含溶液中的雌激素和孕激素，以及悬浮于雌激素和孕激素溶液中的致死因子。本发明还涉及制备和使用本文所述药物组合物的方法。

8. 发明申请

US20090156604A1 FUSED BICYCLIC IMIDAZOLES 失效
标题翻译：熔化的双环咪唑
公开(公告)号：US20090156604A1
公开(公告)日：2009-06-18
申请号：US12191706
申请日：2008-08-14
申请人： Swen HOLDER , Armin Zulch , Thomas Bar , Thomas Maier , Astrid Zimmermann , Thomas Beckers , Volker Gekeler , Hemant Joshi , Yogesh Munot , Umesh Bhise , Sunil Chavan , Sachin Shivatare , Sarvesh Patel , Vikas Gore
发明人： Swen HOLDER , Armin Zulch , Thomas Bar , Thomas Maier , Astrid Zimmermann , Thomas Beckers , Volker Gekeler , Hemant Joshi , Yogesh Munot , Umesh Bhise , Sunil Chavan , Sachin Shivatare , Sarvesh Patel , Vikas Gore
IPC分类号： A61K31/53 , C07D487/02 , A61K31/519 , A61K31/497 , A61K31/4545 , A61K31/5025 , A61P35/00 , A61K31/4985 , C07D401/14 , C07D471/02 , A61K31/437
CPC分类号： A61K31/454 , A61K31/4545 , A61K31/5025 , A61K31/519 , A61K45/06 , C07D401/10 , C07D417/04 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04
摘要： Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the imidazole to which it is fused, R4, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译：式（I）化合物其互变异构体或立体异构体或其盐，其中环B和与其稠合的咪唑，R4，R6和R7具有在说明书和权利要求书中给出的含义，是有效的抑制剂 Pi3K / Akt途径。

9. 发明申请

US20090137607A1 FUSED BICYCLIC PYRIMIDINES 有权
标题翻译：熔融双相PYRIMIDINES
公开(公告)号：US20090137607A1
公开(公告)日：2009-05-28
申请号：US12191703
申请日：2008-08-14
申请人： Swen Holder , Matthias Vennemann , Gerrit Beneke , Armin Zulch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
发明人： Swen Holder , Matthias Vennemann , Gerrit Beneke , Armin Zulch , Volker Gekeler , Thomas Beckers , Astrid Zimmermann , Hemant Joshi
IPC分类号： A61K31/497 , C07D487/02 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
摘要： Compounds of formula (I) a tautomer or stereoisomer thereof, or a salt thereof, wherein ring B and the pyrimidine to which it is fused, R4, R5, R6 and R7 have the meanings as given in the description and the claims, are effective inhibitors of the Pi3K/Akt pathway.
摘要翻译：式（I）化合物其互变异构体或立体异构体或其盐，其中环B和其稠合的嘧啶，R4，R5，R6和R7具有在说明书和权利要求书中给出的含义，是有效的 Pi3K / Akt途径的抑制剂。

10. 发明授权

US06941530B2 Method of cross-mapping integrated circuit design formats 有权
标题翻译：交叉映射集成电路设计格式的方法
公开(公告)号：US06941530B2
公开(公告)日：2005-09-06
申请号：US10395476
申请日：2003-03-24
申请人： Hemant Joshi , David A. Thomas , John Bach , Rand B. Carawan
发明人： Hemant Joshi , David A. Thomas , John Bach , Rand B. Carawan
IPC分类号： G01R31/317 , G06F17/50
CPC分类号： G01R31/31707 , G01R31/31718 , G06F17/5081
摘要： A method of cross-mapping integrated circuit (“IC”) elements nets in a IC and/or directing a probe to points on an IC to achieve minimal interference from adjacent structures is disclosed. The method of provides a more streamlined approach than referencing points from a physical layout representation of the IC to the actual IC being tested. The improved correlation between the actual packaged IC and the layout of the IC is accomplished using artificial locator cells. Preferably, the artificial locator cells are generated from mathematical operations of the extracted version of the layout, and they further provide coordinate information for where minimal interference from adjacent structures may be accomplished. Artificial locator cells may be generated from a layout representing a hierarchical representation or alternately each element that is instantiated from a reference library may already have artificial locator cells included.
摘要翻译：公开了一种将集成电路（“IC”）元件网络交叉映射到IC中和/或将探针引导到IC上的点以实现来自相邻结构的最小干扰的方法。该方法提供了一种比从IC的物理布局表示到正在测试的实际IC的点的更简化的方法。实际封装IC和IC布局之间的改善相关性是使用人工定位器单元完成的。优选地，人造定位器单元是从所提取的布局版本的数学运算产生的，并且它们还提供了可以实现来自相邻结构的最小干扰的坐标信息。可以从表示层次表示的布局生成人工定位单元，或者替代地，从参考库中实例化的每个元素可能已经包括人造定位单元。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式