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1. 发明申请

US20110318771A1 DEUTERIUM ISOBARIC TAG REAGENTS FOR QUANTITATIVE ANALYSIS 有权
标题翻译：用于定量分析的DEUTERIUM ISOBARIC标签试剂
公开(公告)号：US20110318771A1
公开(公告)日：2011-12-29
申请号：US13255849
申请日：2010-03-10
申请人： Shuwei Li , Dexing Zeng
发明人： Shuwei Li , Dexing Zeng
IPC分类号： C12Q1/30 , C07C237/04 , G01N33/00 , C07D207/46
CPC分类号： G01N33/6848 , G01N2458/15 , Y10T436/24
摘要： Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more 2H in each reagent. Generally, the reagents are described by the formula: reporter group—balancer group—reactive group, wherein the reporter group and the balancer group are linked by an MS/MS scissionable bond. Each of the reporter group and balancer groups independently contain 0 to 9 heavy isotope atoms selected from 13C, 15N and 2H and the total number of 2H atoms in each reagent is 1 to 6. The mass of the reporter group is from 114-123 Daltons. Exemplary deuterium isobaric tag reagents include Di-ART, DiART-t-I, DiART-t-Br and DiART-t-M. Also provided are compositions containing more than one deuterium isobaric tag reagent and methods for making and using deuterium isobaric tag reagents.
摘要翻译：提供氘同位素标签试剂用于定量生物分子，其中试剂含有重的同位素原子，包括每种试剂中的一个或多个2H。通常，试剂由下式描述：报告基团 - 平衡基团 - 反应性基团，其中报告基团和平衡基团通过MS / MS可分离键连接。每个报告基团和平衡基团独立地含有选自13C，15N和2H中的0至9个重质同位素原子，每种试剂中的2H原子总数为1至6.报告基团的质量为114-123道尔顿。示例性氘同位素标签试剂包括Di-ART，DiART-t-1，DiART-t-Br和DiART-t-M。还提供含有多于一种氘同位素标签试剂的组合物和制备和使用氘同位素标记试剂的方法。

2. 发明授权

US08486712B2 Deuterium isobaric tag reagents for quantitative analysis 有权
标题翻译：氘同位素标签试剂进行定量分析
公开(公告)号：US08486712B2
公开(公告)日：2013-07-16
申请号：US13255849
申请日：2010-03-10
申请人： Shuwei Li , Dexing Zeng
发明人： Shuwei Li , Dexing Zeng
IPC分类号： G01N33/68 , C07D207/46
CPC分类号： G01N33/6848 , G01N2458/15 , Y10T436/24
摘要： Deuterium isobaric tag reagents are provided for the quantitation of biomolecules, where the reagents contain heavy isotope atoms, including one or more 2H in each reagent. Generally, the reagents are described by the formula: reporter group—balancer group—reactive group, wherein the reporter group and the balancer group are linked by an MS/MS scissionable bond. Each of the reporter group and balancer groups independently contain 0 to 9 heavy isotope atoms selected from 13C, 15N and 2H and the total number of 2H atoms in each reagent is 1 to 6. The mass of the reporter group is from 114-123 Daltons. Exemplary deuterium isobaric tag reagents include Di-ART, DiART-t-I, DiART-t-Br and DiART-t-M. Also provided are compositions containing more than one deuterium isobaric tag reagent and methods for making and using deuterium isobaric tag reagents.
摘要翻译：提供氘同位素标签试剂用于定量生物分子，其中试剂含有重的同位素原子，包括每种试剂中的一个或多个2H。通常，试剂由下式描述：报告基团 - 平衡基团 - 反应性基团，其中报告基团和平衡基团通过MS / MS可分离键连接。每个报告基团和平衡基团独立地含有选自13C，15N和2H中的0至9个重质同位素原子，每种试剂中的2H原子总数为1至6.报告基团的质量为114-123道尔顿。示例性氘同位素标签试剂包括Di-ART，DiART-t-1，DiART-t-Br和DiART-t-M。还提供含有多于一种氘同位素标签试剂的组合物和制备和使用氘同位素标记试剂的方法。

3. 发明申请

US20130225791A1 MICROREACTOR AND METHOD FOR PREPARING A RADIOLABELED COMPLEX OR A BIOMOLECULE CONJUGATE 有权
公开(公告)号：US20130225791A1
公开(公告)日：2013-08-29
申请号：US13818569
申请日：2011-08-25
申请人： David E. Reichert , Paul J.A. Kenis , Tobias D. Wheeler , Amit V. Desai , Dexing Zeng , Birce C. Önal
发明人： David E. Reichert , Paul J.A. Kenis , Tobias D. Wheeler , Amit V. Desai , Dexing Zeng , Birce C. Önal
IPC分类号： C07K1/13 , C07K1/107 , C07B59/00 , B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00833 , B01J2219/0086 , B01J2219/00862 , B01J2219/00889 , C07B59/00 , C07B59/008 , C07K1/1077 , C07K1/13
摘要： A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.

4. 发明授权

US08980185B2 Microreactor and method for preparing a radiolabeled complex or a biomolecule conjugate 有权
标题翻译：用于制备放射性标记的复合物或生物分子缀合物的微反应器和方法
公开(公告)号：US08980185B2
公开(公告)日：2015-03-17
申请号：US13818569
申请日：2011-08-25
申请人： David E. Reichert , Paul J. A. Kenis , Tobias D. Wheeler , Amit V. Desai , Dexing Zeng , Birce C. Önal
发明人： David E. Reichert , Paul J. A. Kenis , Tobias D. Wheeler , Amit V. Desai , Dexing Zeng , Birce C. Önal
IPC分类号： G21C1/00 , C07K1/13 , C07B59/00 , B01J19/00 , C07K1/107
CPC分类号： B01J19/0093 , B01J2219/00833 , B01J2219/0086 , B01J2219/00862 , B01J2219/00889 , C07B59/00 , C07B59/008 , C07K1/1077 , C07K1/13
摘要： A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.
摘要翻译：用于制备放射性标记的复合物或生物分子缀合物的微反应器包括用于流体流动的微通道，其中微通道包括包含一个或多个被动混合元件的混合部分和用于孵育混合流体的储存器。储存器与微通道流体连通并且设置在混合部分的下游。制备放射性标记的复合物的方法包括使包含金属放射性核素的放射性金属溶液流过微通道的下游混合部分，其中下游混合部分包括一个或多个被动混合元件，并使包含双功能螯合剂的配体溶液流过下游混合部分。配体溶液和放射性金属溶液在下游混合部分被动混合，以引发金属放射性核素和双功能螯合剂之间的螯合反应。完成螯合反应以形成放射性标记的复合物。

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