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    • 1. 发明授权
    • Bile acid derivatives and production thereof
    • 胆汁酸衍生物及其生产
    • US4793948A
    • 1988-12-27
    • US7663
    • 1987-01-28
    • Shunsou HatonoAkira YazakiSusumu Yoshida
    • Shunsou HatonoAkira YazakiSusumu Yoshida
    • A61K31/575C07J41/00C07J1/00
    • A61K47/48123C07J41/0055C07J41/0061
    • A bile acid derivative having carcinostatic activity represented by the following formula (1): ##STR1## wherein each of R.sub.1 and R.sub.2 is a hydrogen atom or a hydroxyl group, R.sub.3 is a hydroxyl group, benzyloxyl group or --NH--CH.sub.2n R.sub.5 (wherein R.sub.5 is a carboxyl group or sulfonyl group, and n represents the integer of 1 or 2), X is a halogen atom, R.sub.4 is a hydrogen atom or XCH.sub.2 CH.sub.2 --,.chi. is an .alpha.-bond, and .chi. is an .alpha.- or .beta.-bond is produced by the steps (a) and (b), the steps (a), (b) and (c), or the steps (a), (b), (c) and (d) described below:(a) causing an active carbonation reagent to react with a bile acid derivative wherein the carboxyl group is esterified;(b) causing an aminoalkylhalide to react with the active carbonated product obtained;(c) subjecting the bile acid derivative obtained in the above steps (a) and (b) to hydrolysis; and(d) causing the above hydrolyzate to react with an aminoalkyl derivative in the presence of a condensing agent.
    • 具有由下式(1)表示的具有制癌活性的胆汁酸衍生物:其中R1和R2各自为氢原子或羟基,R3为羟基,苄氧基或-NH-CH2nR5 (其中R5是羧基或磺酰基,n表示1或2的整数),X是卤素原子,R4是氢原子或XCH2CH2-,chi是α键,chi是α - 或(b),步骤(a),(b)和(c),或步骤(a),(b),(c)和(d) (a)使活性碳酸化试剂与其中羧基被酯化的胆汁酸衍生物反应; (b)使氨基烷基卤化物与得到的活性碳酸化产物反应; (c)将上述步骤(a)和(b)中获得的胆汁酸衍生物进行水解; 和(d)使上述水解产物在缩合剂存在下与氨基烷基衍生物反应。
    • 2. 发明授权
    • Antifungal agents
    • 抗真菌剂
    • US4876281A
    • 1989-10-24
    • US93001
    • 1987-09-04
    • Susumu YoshidaShizutoshi NakagawaTsuyoshi UshiroguchiHiromichi MatsuuraAkira Yazaki
    • Susumu YoshidaShizutoshi NakagawaTsuyoshi UshiroguchiHiromichi MatsuuraAkira Yazaki
    • A61K31/10A61K31/22A61P17/00A61P31/04A61P31/10
    • A61K31/22A61K31/10
    • An antifungal agent comprising as an effective component a polysulfide compound represented by formulaR.sub.1 --S(O).sub.p --R.sub.2 (A)whereinR.sub.1 is CH.sub.3 --, CH.sub.2 .dbd.CHCH.sub.2 -- or C.sub.2 H.sub.5 OCO(CH.sub.2).sub.3 --,p is an integer 1 or 2, andR.sub.2 is --S--CH.sub.2 CH.dbd.CH.sub.2 or --CH.sub.2 CH(H) CH(H)--S.sub.q --S(O).sub.r --R.sub.3 in which--CH.sub.2 CH(H) CH(H)-- is --CH.sub.2 CH.sub.2 CH.sub.2 -- or--CH.sub.2 CH.dbd.CH--,q is an integer 0 or 1, r is integer from 0 to 2, and R.sub.3 is selected from the group consisting of alkyl having 1 to 6 carbon atoms, benzyl, --CH.sub.2 CH.dbd.CH.sub.2, --CH.sub.2 CH.dbd.CHCH.sub.3, --(CH.sub.2).sub.3 COOC.sub.2 H.sub.5, and --CH.dbd.CHCH.sub.2 --S--(CH.sub.2).sub.3 COOC.sub.2 H.sub.5,with the proviso that p is 2 when R.sub.1 is CH.sub.2 .dbd.CHCH.sub.2 --, R.sub.2 is --CH.sub.2 CH(H) CH(H)--S.sub.q --S(O).sub.r --R.sub.3, --CH.sub.2 CH(H) CH(H)-- is --CH.sub.2 CH.dbd.CH--, q is 1, r is 0 and R.sub.3 is --CH.sub.2 CH.dbd.CH.sub.2.
    • 包含作为有效成分的由式R 1 -S(O)p -R 2(A)表示的多硫化合物作为有效成分的抗真菌剂,其中R 1为CH 3 - ,CH 2 = CHCH 2 - 或C 2 H 5 OCO(CH 2)3 - ,p为整数1或 2,并且R 2是-S-CH 2 CH = CH 2或-CH 2 CH(H)CH(H)-Sq-S(O)r -R 3,其中-CH 2 CH(H)CH(H) - 是-CH 2 CH 2 CH 2 - 或-CH 2 CH = CH-,q为整数0或1,r为0至2的整数,并且R 3选自具有1至6个碳原子的烷基,苄基,-CH 2 CH = CH 2,-CH 2 CH = CHCH 3, - (CH 2)3 COOC 2 H 5和-CH = CHCH 2 -S-(CH 2)3 COOC 2 H 5,条件是当R 1为CH 2 = CHCH 2 - 时,p为2,R 2为-CH 2 CH(H)CH(H)-Sq-S )r-R3,-CH2CH(H)CH(H) - 为-CH2CH = CH-,q为1,r为0,R3为-CH2CH = CH2。
    • 6. 发明授权
    • Magnetic sensor formed of magnetoresistance effect elements
    • 磁传感器由磁阻效应元件形成
    • US07589528B2
    • 2009-09-15
    • US11682841
    • 2007-03-06
    • Hideki SatoToshiyuki OohashiYukio WakuiSusumu YoshidaKokichi Aiso
    • Hideki SatoToshiyuki OohashiYukio WakuiSusumu YoshidaKokichi Aiso
    • G01R33/02
    • B82Y25/00B82Y40/00G01R33/09G01R33/093H01F41/302Y10T29/49002Y10T29/49037Y10T428/32
    • On a single chip are formed a plurality of magnetoresistance effect elements provided with pinned layers having fixed magnetization axes in the directions that cross each other. On a substrate 10 are formed magnetic layers that will become two magnetic tunnel effect elements 11, 21 as magnetoresistance effect elements. Magnetic-field-applying magnetic layers made of NiCo are formed to sandwich the magnetic layers in plan view. A magnetic field is applied to the magnetic-field-applying magnetic layers. The magnetic field is removed after the magnetic-field-applying magnetic layers are magnetized in the direction shown by arrow A. As a result of this, by the residual magnetization of the magnetic-field-applying magnetic layers, magnetic fields in the directions shown by arrows B are applied to the magnetic layers that will become magnetic tunnel effect elements 11, 21, whereby the magnetization of the pinned layers of the magnetic layers that will become magnetic tunnel effect elements 11, 21 is pinned in the directions shown by arrows B.
    • 在单个芯片上形成有多个磁阻效应元件,该元件具有在彼此交叉的方向上具有固定的磁化轴的固定层。 在基板10上形成作为磁阻效应元件的两个磁隧道效应元件11,21的磁性层。 形成由NiCo制成的磁场施加磁性层,以在平面图中夹着磁性层。 对磁场施加磁性层施加磁场。 在磁场施加磁性层沿着箭头A所示的方向被磁化之后,去除磁场。结果,通过磁场施加磁性层的剩余磁化,所示方向上的磁场 通过箭头B施加到将成为磁隧道效应元件11,21的磁性层,由此将成为磁隧道效应元件11,21的磁性层的被钉扎层的磁化被固定在箭头B所示的方向上 。