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1. 发明申请

US20120071646A1 PROCESS FOR PRODUCING NUCLEOSIDE 有权
标题翻译：生产核苷的方法
公开(公告)号：US20120071646A1
公开(公告)日：2012-03-22
申请号：US13260096
申请日：2010-03-30
申请人： Tadashi Umemoto , Yoji Hayase , Shumpei Murata , Kenichi Miyata
发明人： Tadashi Umemoto , Yoji Hayase , Shumpei Murata , Kenichi Miyata
IPC分类号： C07H23/00 , C07H19/173
CPC分类号： C07H23/00 , C07H19/06 , C07H19/16
摘要： There is a demand for a convenient production method of an NC type purine nucleoside.The present invention relates to a method of producing a purine nucleoside represented the formula (I′) or a salt thereof, which comprising reacting a pyrimidine nucleoside represented by the formula (I) or a salt thereof with a purine nucleobase represented by the formula B′H in the presence of a Lewis acid.
摘要翻译：需要一种方便的NC型嘌呤核苷的生产方法。本发明涉及一种制备式（I'）的嘌呤核苷或其盐的方法，该方法包括使由式（I）表示的嘧啶核苷或其盐与由式B表示的嘌呤核碱基反应在路易斯酸存在下的H。

2. 发明授权

US08653254B2 Process for producing nucleoside 有权
标题翻译：生产核苷的方法
公开(公告)号：US08653254B2
公开(公告)日：2014-02-18
申请号：US13260096
申请日：2010-03-30
申请人： Tadashi Umemoto , Yoji Hayase , Shumpei Murata , Kenichi Miyata
发明人： Tadashi Umemoto , Yoji Hayase , Shumpei Murata , Kenichi Miyata
IPC分类号： C07H21/00
CPC分类号： C07H23/00 , C07H19/06 , C07H19/16
摘要： There is a demand for a convenient production method of an NC type purine nucleoside.The present invention relates to a method of producing a purine nucleoside represented the formula (I′) or a salt thereof, which comprising reacting a pyrimidine nucleoside represented by the formula (I) or a salt thereof with a purine nucleobase represented by the formula B′H in the presence of a Lewis acid.
摘要翻译：需要一种方便的NC型嘌呤核苷的生产方法。本发明涉及一种制备式（I'）的嘌呤核苷或其盐的方法，该方法包括使由式（I）表示的嘧啶核苷或其盐与由式B表示的嘌呤核碱基反应在路易斯酸存在下的H。

3. 发明申请

US20120108800A1 METHOD FOR SYNTHESIZING NUCLEIC ACID 审中-公开
标题翻译：合成核酸的方法
公开(公告)号：US20120108800A1
公开(公告)日：2012-05-03
申请号：US13379485
申请日：2010-06-22
申请人： Shumpei Murata , Tadashi Umemoto , Kenichi Miyata , Yoji Hayase
发明人： Shumpei Murata , Tadashi Umemoto , Kenichi Miyata , Yoji Hayase
IPC分类号： C07H19/16 , C07H17/04 , C07H1/00 , C07H19/20
CPC分类号： C07H9/04 , C07H19/16 , Y02P20/55
摘要： Provided is a new production method for the synthesis of an NC type nucleoside efficiently and conveniently in a high yield without unnecessary protecting group conversion steps. It relates to a step of producing a compound represented by the formula (II): or a salt thereof, by inverting a compound represented by the formula (I): and a method of producing a compound represented by the formula (III): or a salt thereof (wherein each symbol is as defined in the specification), which includes the step.
摘要翻译：提供了一种用于以高产率有效且方便地合成NC型核苷的新方法，而无需不需要的保护基转化步骤。本发明涉及通过使由式（I）表示的化合物反转而制备由式（II）表示的化合物或其盐：和由式（III）表示的化合物的制备方法：或其盐（其中每个符号如说明书中所定义），其包括该步骤。

4. 发明授权

US06001850A Thienopyridine derivatives, their production and use 失效
标题翻译：噻吩并吡啶衍生物，其生产和使用
公开(公告)号：US06001850A
公开(公告)日：1999-12-14
申请号：US894318
申请日：1997-08-14
申请人： Shuichi Furuya , Hirokazu Matsumoto , Yoji Hayase , Nobuhiro Suzuki , Takashi Imada
发明人： Shuichi Furuya , Hirokazu Matsumoto , Yoji Hayase , Nobuhiro Suzuki , Takashi Imada
IPC分类号： C07D495/04 , A61K31/435
CPC分类号： C07D495/04
摘要： The present thienopyridine derivatives and composition having gonadotropin-releasing hormone antagonistic activity are useful as prophylactic or therapeutic agents for the prevention or treatment of several hormone dependent diseases, for example, a sex hormone dependent cancer (e.g. prostatic cancer, cancer of uterine cervix, breast cancer, pituitary adenoma), benign prostatic hypertrophy, myoma of the uterus, endometriosis, precocious puberty, amenorrhea, premenstrual syndrome, polycystic ovary syndrome and acne vulgaris; is effective as a fertility controlling agent in both sexes (e.g. a pregnancy controlling agent and a menstrual cycle controlling agent); is useful as a contraceptive of male or female, as an ovulation-inducing agent of female; is useful as an infertility treating agent by using a rebound effect owing to a stoppage of administration thereof; is useful as modulating estrous cycles in animals in the field of animal husbandry, as an agent for improving the quality of edible meat or promoting the growth of animals; is useful as an agent of spawning promotion in fish.
摘要翻译： PCT No.PCT / JP97 / 01434 371日期1997年8月14日 102（e）日期1997年8月14日PCT 1997年4月24日PCT PCT。出版物WO97 / 41126 日期1997年11月6日目前具有促性腺激素释放激素拮抗活性的噻吩并吡啶衍生物和组合物可用作预防或治疗若干激素依赖性疾病的预防或治疗剂，例如性激素依赖性癌症（例如前列腺癌，癌症子宫颈癌，乳腺癌，垂体腺瘤），良性前列腺肥大，子宫肌瘤，子宫内膜异位症，早熟性青春期，闭经，经前期综合征，多囊卵巢综合征和寻常型痤疮; 作为两性生育调节剂（例如妊娠控制剂和月经周期控制剂）是有效的; 作为女性的排卵诱导剂作为男性或女性的避孕药具是有用的; 作为不孕症治疗剂，由于其施用停止而使用反弹效应是有用的; 可用作调整动物饲养领域的发情周期，作为提高食用肉质量或促进动物生长的药剂; 作为鱼类产卵促销的代理人是有用的。

5. 发明申请

US20100130737A1 Regulating Agent of GPR34 Receptor Function 审中-公开
标题翻译： GPR34受体功能调节剂
公开(公告)号：US20100130737A1
公开(公告)日：2010-05-27
申请号：US11884447
申请日：2006-02-17
申请人： Fumio Itoh , Eiji Kimura , Yumi Imai , Masaaki Mori , Yoshio Aramaki , Yasuhisa Kohara , Tsukasa Sugo , Yoji Hayase , Hiromi Kobayashi , Kazuhiro Ogi
发明人： Fumio Itoh , Eiji Kimura , Yumi Imai , Masaaki Mori , Yoshio Aramaki , Yasuhisa Kohara , Tsukasa Sugo , Yoji Hayase , Hiromi Kobayashi , Kazuhiro Ogi
IPC分类号： C07D295/12 , C07D307/78 , C07D333/52 , C07D471/04 , C07D487/04 , C07C229/50 , C07D207/02 , C07D233/00 , C07D277/70 , C07D241/04 , C07D307/02 , C07D333/22 , C07D263/30 , C07D235/04 , C07D213/46 , C07D211/06 , C07D257/04 , C07D335/06 , C07D215/00
CPC分类号： C07D487/04 , A61K31/195 , A61K31/198 , A61K31/343 , A61K31/381 , A61K31/437 , C07C233/51 , C07C233/52 , C07C235/36 , C07C237/04 , C07C237/20 , C07C237/22 , C07C237/24 , C07C271/22 , C07C275/30 , C07C311/08 , C07C311/13 , C07C317/44 , C07C323/60 , C07C2602/08 , C07D209/42 , C07D211/34 , C07D213/56 , C07D215/54 , C07D235/24 , C07D257/04 , C07D261/08 , C07D277/24 , C07D277/74 , C07D307/52 , C07D307/85 , C07D333/16 , C07D333/70 , C07D335/06 , C07D405/10 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D471/04
摘要： The present invention provides a GPR receptor function regulator comprising the compound represented by the formula: [wherein ring A is an optionally substituted isocyclic or heterocyclic ring, P is a bond or spacer, ring D is an optionally substituted monocyclic aromatic ring which may be condensed with a 5- to 7-membered ring, V is a bond or the group represented by the formula —CR14═CR15— or —N═CR16— (wherein R14, R15 and R16 each represents a hydrogen atom or optionally substituted hydrocarbon group), Q is a bond or spacer, and W is a carboxyl or a group biologically equivalent to a carboxyl] or its salt or a prodrug thereof.
摘要翻译：本发明提供一种GPR受体功能调节剂，其包含由下式表示的化合物：其中环A为任选取代的环或杂环，P为键或间隔基，环D为任选取代的可以缩合的单环芳环具有5-至7-元环，V是键或由式-CR14 = CR15-或-N = CR16-表示的基团（其中R14，R15和R16各自表示氢原子或任选取代的烃基） Q是键或间隔基，W是羧基或与羧基生物等同的基团或其前体药物。

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