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1. 发明申请

US20080292685A1 Transdermal Patch Containing Isosorbide Dinitrate and Bisoprolol 有权
标题翻译：含有硝酸异山梨酯和比索洛尔的透皮贴剂
公开(公告)号：US20080292685A1
公开(公告)日：2008-11-27
申请号：US12096545
申请日：2005-12-09
申请人： Shuming Wang , Li Wang , Xiaoling Fan , Huiyong Xue , Shuang Zhang , Enhong Zhang , Xuying Zhong , Yucheng Lu , Chun Li , Li Song
发明人： Shuming Wang , Li Wang , Xiaoling Fan , Huiyong Xue , Shuang Zhang , Enhong Zhang , Xuying Zhong , Yucheng Lu , Chun Li , Li Song
IPC分类号： A61K9/70 , A61K31/343 , A61P9/00
CPC分类号： A61K9/7061 , A61K31/138 , A61K31/724
摘要： This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol.
摘要翻译：本发明涉及层复合物形式的透皮贴剂，其包含背衬层，包含药理活性成分和药学上可接受的佐剂的药物储库层，以及覆盖药物储库层的释放衬垫，其特征在于药物作为药理活性成分，含有硝酸异山梨酯和比索洛尔，比例为1:3〜3:1。动物试验表明，所述贴片可以降低心电图T波的升高，血清中心肌酶水平的升高，以及通过在动物中连接冠状动脉引起的心肌梗塞范围的延长。结果表明，所述贴片在治疗心血管疾病方面具有相当大的协同效应，对心脏上的几种不良事件具有良好的预防和治疗作用。此外，动物试验表明，根据本发明的贴剂具有比仅含有硝酸异山梨酯和比洛维罗之一的贴剂的施用更好的减压效果，并且不会使应用容易引起的心律失常恶化该补丁仅含有硝酸异山梨酯或比索洛尔。

2. 发明授权

US08071125B2 Transdermal patch containing isosorbide dinitrate and bisoprolol 有权
标题翻译：透皮贴剂含有硝酸异山梨酯和比索洛尔
公开(公告)号：US08071125B2
公开(公告)日：2011-12-06
申请号：US12096545
申请日：2005-12-09
申请人： Shuming Wang , Li Wang , Xiaoling Fan , Huiyong Xue , Shuang Zhang , Enhong Zhang , Xuying Zhong , Yucheng Lu , Chun Li , Li Song
发明人： Shuming Wang , Li Wang , Xiaoling Fan , Huiyong Xue , Shuang Zhang , Enhong Zhang , Xuying Zhong , Yucheng Lu , Chun Li , Li Song
IPC分类号： A61F13/00
CPC分类号： A61K9/7061 , A61K31/138 , A61K31/724
摘要： This invention relates to a transdermal patch in the form of a layer complex, comprising a backing layer, a drug-reservoir layer comprising pharmacologically active ingredients and pharmaceutically acceptable adjuvants, and a release liner covering the drug-reservoir layer, characterized in that the drug-reservoir layer comprises isosorbide dinitrate and Bisoprolol at a ratio of 1:3 to 3:1 by weight, as the pharmacologically active ingredients. Animal tests show that said patch can reduce the elevation of T wave of cardiogram, the increase of the level of myocardial enzyme in blood serum, and the extension of the range of myocardial infarction caused by ligating the coronary artery in animals. Results show that said patch exhibits a considerable synergistic effect in the treatment of cardiovascular diseases and has good preventive and therapeutic effects on several adverse events on heart. In addition, the animal tests show that the patch according to the invention has a better pressure-reducing effect than the application of the patch containing only one of isosorbide dinitrate and Bisoprolol, and does not worsen the arrhythmia that is easily caused by the application of the patch containing only isosorbide dinitrate or Bisoprolol.
摘要翻译：本发明涉及层复合物形式的透皮贴剂，其包含背衬层，包含药理活性成分和药学上可接受的佐剂的药物储库层，以及覆盖药物储库层的释放衬垫，其特征在于药物作为药理活性成分，含有硝酸异山梨酯和比索洛尔，比例为1:3〜3:1。动物试验表明，所述贴片可以降低心电图T波的升高，血清中心肌酶水平的升高，以及通过在动物中连接冠状动脉引起的心肌梗塞范围的延长。结果表明，所述贴片在治疗心血管疾病方面具有相当大的协同效应，对心脏上的几种不良事件具有良好的预防和治疗作用。此外，动物试验表明，根据本发明的贴剂具有比仅含有硝酸异山梨酯和比洛维罗之一的贴剂的施用更好的减压效果，并且不会使应用容易引起的心律失常恶化该补丁仅含有硝酸异山梨酯或比索洛尔。

3. 发明授权

US09265752B2 Transdermal patch containing Rotigotine 有权
标题翻译：含有罗替高汀的透皮贴剂
公开(公告)号：US09265752B2
公开(公告)日：2016-02-23
申请号：US12667915
申请日：2008-07-03
申请人： Shuming Wang , Huiyong Xue , Li Wang , Enhong Zhang , Hongjun Lian , Xiaoyan Shi , Guohua Chi , Yucheng Lu , Xiquan Liu , Li Song , Xuying Zhong , Hongguang Du
发明人： Shuming Wang , Huiyong Xue , Li Wang , Enhong Zhang , Hongjun Lian , Xiaoyan Shi , Guohua Chi , Yucheng Lu , Xiquan Liu , Li Song , Xuying Zhong , Hongguang Du
IPC分类号： A61K9/70 , A61K31/381 , A61P25/16
CPC分类号： A61K9/7023 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/381
摘要： A Rotigotine-containing composition having a matrix mixture system formed from a polyvinylpyrrolidone and a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive. The polyvinylpyrrolidone may be present in an amount of about 1-10% by weight in matrix mixture system. The acrylic pressure-sensitive adhesive may be present in an amount of about 1-25% by weight in the matrix mixture system. The silicone pressure-sensitive adhesive may be present in an amount of about 65-98% by weight in the matrix mixture system. The composition further includes 1-40% of Rotigotine on the basis of the total weight of the composition. The composition provides improved properties in the solubility, release and initial penetration level of Rotigotine. Also disclosed is a transdermal patch that includes the Rotigotine-containing composition, as well as methods of manufacturing and using the Rotigotine-containing composition.
摘要翻译：一种含有罗替那定的组合物，其具有由聚乙烯吡咯烷酮形成的基质混合物体系和丙烯酸类压敏粘合剂与硅氧烷压敏粘合剂的组合。聚乙烯吡咯烷酮的存在量可以在基质混合体系中约1-10％（重量）。丙烯酸类压敏粘合剂可以在基质混合物体系中以约1-25重量％的量存在。在基质混合物体系中，硅氧烷压敏粘合剂可以以约65-98重量％的量存在。该组合物还包括基于组合物总重量的1-40％的罗替戈汀。该组合物提供了罗替戈汀的溶解度，释放和初始渗透水平的改善的性质。还公开了包括含有罗替多汀的组合物的透皮贴剂，以及制造和使用含有罗替尼汀的组合物的方法。

4. 发明申请

US20110027345A1 COMPOSITION CONTAINING ROTIGOTINE AND USE THEREOF AND TRANSDERMAL PATCH CONTAINING THE COMPOSITION 有权
标题翻译：含有ROTIGOTINE的组合物及其用途及含有组合物的透皮贴剂
公开(公告)号：US20110027345A1
公开(公告)日：2011-02-03
申请号：US12667915
申请日：2008-07-03
申请人： Shuming Wang , Huiyong Xue , Li Wang , Enhong Zhang , Hongjun Lian , Xiaoyan Shi , Guohua Chi , Yucheng Lu , Xiquan Liu , Li Song , Xuying Zhong , Hongguang Du
发明人： Shuming Wang , Huiyong Xue , Li Wang , Enhong Zhang , Hongjun Lian , Xiaoyan Shi , Guohua Chi , Yucheng Lu , Xiquan Liu , Li Song , Xuying Zhong , Hongguang Du
IPC分类号： A61K31/381 , A61K9/00 , A61K9/70 , A61P25/16
CPC分类号： A61K9/7023 , A61K9/7053 , A61K9/7061 , A61K9/7069 , A61K31/381
摘要： The present invention relates to a composition containing Rotigotine and the use thereof in the manufacture of a Rotigotine-containing transdermal patch, wherein said composition is based on a matrix mixture system formed from a combination of an acrylic pressure-sensitive adhesive with a silicone pressure-sensitive adhesive, and polyvinylpyrrolidone which are present in a particular weight ratio, wherein (1) the acrylic pressure-sensitive adhesive is present in an amount of about 1-25% by weight in the matrix mixture system, (2) the silicone pressure-sensitive adhesive is present in an amount of about 65-98% by weight in the matrix mixture system, and (3) the polyvinylpyrrolidone is present in an amount of about 1-10% by weight in the matrix mixture system, and comprises 1-40% of Rotigotine on the basis of the total weight of the composition. The present invention further relates to an improved transdermal patch containing Rotigotine comprising said composition. Said patch has improved properties in the solubility, release and initial penetration level of Rotigotine.
摘要翻译：本发明涉及含有罗替高汀的组合物及其在制造含罗替尼汀的透皮贴剂中的用途，其中所述组合物是基于由丙烯酸压敏粘合剂与硅氧烷压敏粘合剂组合形成的基质混合物体系，敏感性粘合剂和聚乙烯吡咯烷酮，其特征在于：（1）所述丙烯酸类压敏粘合剂在所述基质混合物体系中以约1-25％（重量）的量存在，（2）在基质混合体系中，敏感粘合剂的存在量为约65-98重量％，（3）在基质混合体系中，聚乙烯吡咯烷酮的存在量为约1-10重量％，并且包含1- 基于组合物总重量的罗替高汀为40％。本发明还涉及包含所述组合物的含有罗替高汀的改良透皮贴剂。所述贴剂具有改善的罗替戈汀的溶解度，释放和初始渗透水平的性质。

5. 发明申请

US20130006956A1 Computer Processing Method and System for Searching 审中-公开
标题翻译：计算机处理方法和搜索系统
公开(公告)号：US20130006956A1
公开(公告)日：2013-01-03
申请号：US13602872
申请日：2012-09-04
申请人： Shao Chun Li , Li Wang
发明人： Shao Chun Li , Li Wang
IPC分类号： G06F17/30
CPC分类号： G06F16/9535
摘要： The present invention provides a computer processing method and a system thereof for searching. The computer processing method includes: receiving a first keyword; performing search using the first keyword to obtain a first search result; receiving user evaluation of the first search result; in response to the evaluation being unsatisfactory, searching for associated keywords from a keyword data source based on the first keyword; recommending associated keywords to the user according to matching degrees of the associated keywords and the first keyword; and in response to that the user selects an associated keyword from the recommended associated keywords, performing search based on the associated keyword selected by the user. The related specific implementation of the present application will help a user to find an input keyword more effectively during a search so as to enable him/her get more satisfactory search result.
摘要翻译：本发明提供一种用于搜索的计算机处理方法及其系统。计算机处理方法包括：接收第一关键字; 使用所述第一关键字执行搜索以获得第一搜索结果; 接收对第一搜索结果的用户评价; 响应于评估不满意，基于第一关键字从关键字数据源搜索关联关键字; 根据关联关键词和第一个关键字的匹配程度向用户推荐关联关键词; 并且响应于该用户从推荐的关联关键字中选择相关联的关键字，基于用户选择的关联关键字进行搜索。本申请的相关具体实现将帮助用户在搜索期间更有效地找到输入关键字，以使他/她获得更令人满意的搜索结果。

6. 发明申请

US20120271843A1 Computer Processing Method and System for Searching 审中-公开
标题翻译：计算机处理方法和搜索系统
公开(公告)号：US20120271843A1
公开(公告)日：2012-10-25
申请号：US13449429
申请日：2012-04-18
申请人： Shao Chun Li , Li Wang
发明人： Shao Chun Li , Li Wang
IPC分类号： G06F17/30
CPC分类号： G06F16/9535
摘要： The present invention provides a computer processing method and a system thereof for searching. The computer processing method includes: receiving a first keyword; performing search using the first keyword to obtain a first search result; receiving user evaluation of the first search result; in response to the evaluation being unsatisfactory, searching for associated keywords from a keyword data source based on the first keyword; recommending associated keywords to the user according to matching degrees of the associated keywords and the first keyword; and in response to that the user selects an associated keyword from the recommended associated keywords, performing search based on the associated keyword selected by the user. The related specific implementation of the present application will help a user to find an input keyword more effectively during a search so as to enable him/her get more satisfactory search result.
摘要翻译：本发明提供一种用于搜索的计算机处理方法及其系统。计算机处理方法包括：接收第一关键字; 使用所述第一关键字执行搜索以获得第一搜索结果; 接收对第一搜索结果的用户评价; 响应于评估不满意，基于第一关键字从关键字数据源搜索关联关键字; 根据关联关键词和第一个关键字的匹配程度向用户推荐关联关键词; 并且响应于该用户从推荐的关联关键字中选择相关联的关键字，基于用户选择的关联关键字进行搜索。本申请的相关具体实现将帮助用户在搜索期间更有效地找到输入关键字，以使他/她获得更令人满意的搜索结果。

7. 发明申请

US20090048893A1 System and Method of Role-based Calendaring 审中-公开
标题翻译：基于角色的日历的系统和方法
公开(公告)号：US20090048893A1
公开(公告)日：2009-02-19
申请号：US12120423
申请日：2008-05-14
申请人： Li Wang , Hai Bo Yu , Feng Li Wang , John Turek
发明人： Li Wang , Hai Bo Yu , Feng Li Wang , John Turek
IPC分类号： G06Q10/00
CPC分类号： G06Q10/109 , G06Q10/1093
摘要： A method for calendaring an activity based on roles, including the steps of acquiring a request for calendaring the activity for a plurality of roles invited to attend the activity; acquiring data on existing activities which have been calendared for all the specific individuals in the plurality of roles invited to attend the activity; and determining the time interval for holding the activity based on the data on existing activities which have been calendared for all the specific individuals in the plurality of roles invited to attend the activity and the request for calendaring the activity.
摘要翻译：一种用于基于角色对活动进行日程安排的方法，包括获取对被邀请参加该活动的多个角色的活动的日历请求的步骤; 获取被邀请参加活动的多个角色中针对所有具体个人进行的已登录活动的数据; 以及基于被邀请参加活动的多个角色中的所有特定个人已经被日历的已有活动的数据以及对活动进行日程安排的请求，确定保持活动的时间间隔。

8. 外观设计

USD965519S1 Wireless charging stand 有权
公开(公告)号：USD965519S1
公开(公告)日：2022-10-04
申请号：US29791203
申请日：2022-01-05
申请人： Li Wang
设计人： Li Wang

9. 发明申请

US20220155691A1 METHOD AND APPARATUS FOR PRINTING A PERIODIC PATTERN WITH A VARYING DUTY CYCLE 有权
公开(公告)号：US20220155691A1
公开(公告)日：2022-05-19
申请号：US17598409
申请日：2020-03-27
申请人： Francis Clube , Andreas Amrein , Maxime Lebugle , Harun Solak , Li Wang
发明人： Francis Clube , Andreas Amrein , Maxime Lebugle , Harun Solak , Li Wang
IPC分类号： G03F7/20 , G03F1/70 , G02B5/18
摘要： A method for forming a surface-relief grating with a desired spatial variation of duty cycle in a layer of photoresist includes: providing a first mask bearing a high-resolution grating of linear features, arranging the first mask at a first distance from a substrate, providing a second mask bearing a variable-transmission grating of opaque and transparent linear features that has a designed spatial variation of duty cycle, arranging the second mask at a distance before the first mask such that the linear features of the variable-transmission grating are orthogonal to the linear features of the high-resolution grating, illuminating the second mask while varying the first distance according to displacement Talbot lithography and also displacing the second mask at an angle to its linear features such that there is substantially no component of modulation with the period of the variable-transmission grating in the energy density distribution that exposes the photoresist.

10. 外观设计

USD845197S1 Clutch pressure plate cover 有权
公开(公告)号：USD845197S1
公开(公告)日：2019-04-09
申请号：US29622169
申请日：2017-10-14
申请人： Li Wang
设计人： Li Wang

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