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1. 发明授权

US06224568B1 Dual-chamber type injector and connector used therefor 失效
标题翻译：双室型注射器和连接器用于此
公开(公告)号：US06224568B1
公开(公告)日：2001-05-01
申请号：US09083201
申请日：1998-05-22
申请人： Shuji Morimoto , Kazuhiro Okochi , Kotaro Wakamatsu , Nobuyoshi Tanaka
发明人： Shuji Morimoto , Kazuhiro Okochi , Kotaro Wakamatsu , Nobuyoshi Tanaka
IPC分类号： A61M3700
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2031 , A61J1/2041 , A61J1/2051 , A61J1/2055 , A61J1/2072 , A61J1/2089 , A61M5/3202 , Y10S604/905
摘要： A needle connecting portion of a syringe which includes a drug accommodating chamber accommodating a first component is arranged opposite to a takeout port of a hermetically closed container which includes a container chamber accommodating a second component. The syringe is connected to the container through a connector so as to be movable in mutual proximity and adapted to be separable from the connector. There is provided a communication passage capable of communicating the drug accommodating chamber with the container chamber. The communication passage is cut off by a closure member arranged between both of the chambers. The syringe and the container chamber are moved in proximity to each other, thereby displacing the closure member so as to open the communication passage. An injector of the present invention is compact in shape but can surely retain sterility while being stored and surely mix both of the components accommodated therein through a simple operation just before administration. Further, it can prevent the sharpness of an injection needle from being damaged at the time of a mixing operation and easily remove a syringe after the mixing operation.
摘要翻译：注射器的针连接部分包括容纳第一部件的药物容纳室，与包含容纳第二部件的容器室的气密密闭容器的取出口相对。注射器通过连接器连接到容器，以便相互接近地可移动并且适于与连接器分离。提供了能够将药物容纳室与容器室连通的连通通道。连通通道由布置在两个室之间的封闭构件切断。注射器和容器室彼此靠近地移动，从而使闭合件移位以打开连通通道。本发明的注射器的形状紧凑，但是在储存时可以确实地保持不育，并且通过在施用前的简单操作可靠地将容纳在其中的组分混合。此外，它可以防止注射针的清洁度在混合操作时被损坏，并且在混合操作之后容易地移除注射器。

2. 发明申请

US20100136122A1 Oral Preparation Comprising Pioglitazone 有权
标题翻译：包含吡格列酮的口服制剂
公开(公告)号：US20100136122A1
公开(公告)日：2010-06-03
申请号：US12227572
申请日：2007-05-22
申请人： Kazuhiro Okochi , Hiroyoshi Koyama , Arisa Maeda
发明人： Kazuhiro Okochi , Hiroyoshi Koyama , Arisa Maeda
IPC分类号： A61K31/4439 , A61K9/50 , A61P3/10 , A61P3/06 , A61P25/00 , A61P13/12 , A61P27/12 , A61P9/00 , A61P19/08 , A61P31/00 , A61P3/04 , A61P19/10 , A61P25/16 , A61P25/28 , C22B26/10
CPC分类号： A61K9/0095 , A61K9/0056 , A61K9/2009 , A61K9/2077 , A61K31/4439
摘要： The present invention provides an oral preparation sufficiently masking the bitter taste of pioglitazone and a salt thereof. The present invention provides an oral preparation containing pioglitazone or a salt thereof and alkali metal chloride.
摘要翻译：本发明提供足以掩蔽吡格列酮及其盐的苦味的口服制剂。本发明提供含有吡格列酮或其盐和碱金属氯化物的口服制剂。

3. 发明申请

US20050226928A1 Novel pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative 有权
标题翻译：含有双胍和噻唑烷二酮衍生物的新型药物制剂
公开(公告)号：US20050226928A1
公开(公告)日：2005-10-13
申请号：US11093742
申请日：2005-03-30
申请人： Unchalee Lodin , Jack Cardinal , Avinash Nangia , Kazuhiro Okochi
发明人： Unchalee Lodin , Jack Cardinal , Avinash Nangia , Kazuhiro Okochi
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/26 , A61K9/28 , A61K31/155 , A61K31/425 , A61K31/426 , A61K45/06
CPC分类号： A61K9/209 , A61K9/0004 , A61K9/2866 , A61K31/155 , A61K31/425 , A61K31/426 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is herein disclosed and described.
摘要翻译：本文公开和描述了包含与包含噻唑烷二酮衍生物的第二组分组合的抗高血糖药物的控释组分的药物剂型。

4. 发明申请

US20100034891A1 TASTE-MASKING SOLID PREPARATION OF PIOGLITAZONE 失效
标题翻译：测定PIOGLITAZONE的固体制剂
公开(公告)号：US20100034891A1
公开(公告)日：2010-02-11
申请号：US12298418
申请日：2007-04-26
申请人： Kazuhiro Okochi , Arisa Maeda
发明人： Kazuhiro Okochi , Arisa Maeda
IPC分类号： A61K9/14 , A61K31/4439
CPC分类号： A61K9/2081 , A61K9/1635 , A61K9/1676 , A61K9/5026 , A61K9/5078 , A61K31/4439
摘要： A solid preparation sufficiently masking the unpleasant taste of pioglitazone or a salt thereof; a solid preparation sufficiently masking the unpleasant taste of pioglitazone or a salt thereof and having superior properties of superior disintegration property in the oral cavity, appropriate preparation strength, long-term preservation stability and the like is provided. The present invention provides a solid preparation comprising particles comprising (i) core particles comprising an excipient, and (ii) pioglitazone or a salt thereof and an acid-soluble polymer both coating the core particles.
摘要翻译：固体制剂充分掩盖了吡格列酮或其盐的令人不快的味道; 提供足以掩盖吡格列酮或其盐的不愉快味道的固体制剂，并且具有优异的口腔崩解性质，适当的制备强度，长期保存稳定性等。本发明提供一种包含颗粒的固体制剂，其包含（i）包含赋形剂的核心颗粒，和（ii）吡格列酮或其盐和均可涂覆核心颗粒的酸溶性聚合物。

5. 发明授权

US09060941B2 Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative 有权
标题翻译：含有双胍和噻唑烷二酮衍生物的药物制剂
公开(公告)号：US09060941B2
公开(公告)日：2015-06-23
申请号：US11093742
申请日：2005-03-30
申请人： Unchalee Lodin , Jack Cardinal , Avinash Nangia , Kazuhiro Okochi
发明人： Unchalee Lodin , Jack Cardinal , Avinash Nangia , Kazuhiro Okochi
IPC分类号： A61K9/20 , A61K31/425 , A61K31/426 , A61K31/155 , A61K45/06 , A61K9/24 , A61K9/00 , A61K9/28
CPC分类号： A61K9/209 , A61K9/0004 , A61K9/2866 , A61K31/155 , A61K31/425 , A61K31/426 , A61K45/06 , A61K2300/00
摘要： A pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative is herein disclosed and described.
摘要翻译：本文公开和描述了包含与包含噻唑烷二酮衍生物的第二组分组合的抗高血糖药物的控释组分的药物剂型。

6. 发明授权

US08632808B2 Taste-masking solid preparation of pioglitazone 失效
标题翻译：吡格列酮的口味掩蔽固体制剂
公开(公告)号：US08632808B2
公开(公告)日：2014-01-21
申请号：US12298418
申请日：2007-04-26
申请人： Kazuhiro Okochi , Arisa Maeda
发明人： Kazuhiro Okochi , Arisa Maeda
IPC分类号： A61K9/32 , A61K9/14 , A61K31/425
CPC分类号： A61K9/2081 , A61K9/1635 , A61K9/1676 , A61K9/5026 , A61K9/5078 , A61K31/4439
摘要： A solid preparation sufficiently masking the unpleasant taste of pioglitazone or a salt thereof; a solid preparation sufficiently masking the unpleasant taste of pioglitazone or a salt thereof and having superior properties of superior disintegration property in the oral cavity, appropriate preparation strength, long-term preservation stability and the like is provided. The present invention provides a solid preparation comprising particles comprising (i) core particles comprising an excipient, and (ii) pioglitazone or a salt thereof and an acid-soluble polymer both coating the core particles.
摘要翻译：固体制剂充分掩盖了吡格列酮或其盐的令人不快的味道; 提供足以掩盖吡格列酮或其盐的不愉快味道的固体制剂，并且具有优异的口腔崩解性质，适当的制备强度，长期保存稳定性等。本发明提供一种包含颗粒的固体制剂，其包含（i）包含赋形剂的核心颗粒，和（ii）吡格列酮或其盐和均可涂覆核心颗粒的酸溶性聚合物。

7. 发明授权

US08865217B2 Oral preparation comprising pioglitazone 有权
标题翻译：包含吡格列酮的口服制剂
公开(公告)号：US08865217B2
公开(公告)日：2014-10-21
申请号：US12227572
申请日：2007-05-22
申请人： Kazuhiro Okochi , Hiroyoshi Koyama , Arisa Maeda
发明人： Kazuhiro Okochi , Hiroyoshi Koyama , Arisa Maeda
IPC分类号： A61K9/14 , A61K31/4439 , A61K9/20 , A61K9/00
CPC分类号： A61K9/0095 , A61K9/0056 , A61K9/2009 , A61K9/2077 , A61K31/4439
摘要： The present invention provides an oral preparation sufficiently masking the bitter taste of pioglitazone and a salt thereof. The present invention provides an oral preparation containing pioglitazone or a salt thereof and alkali metal chloride.
摘要翻译：本发明提供足以掩蔽吡格列酮及其盐的苦味的口服制剂。本发明提供含有吡格列酮或其盐和碱金属氯化物的口服制剂。

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