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1. 发明申请

US20120093708A1 DEVICE AND METHOD FOR EXTRACTING AND SEPARATING SODIUM AND POTASSIUM 审中-公开
标题翻译：用于提取和分离钠和钾的装置和方法
公开(公告)号：US20120093708A1
公开(公告)日：2012-04-19
申请号：US13378389
申请日：2010-07-22
申请人： Shuji Hamano , Tsunehira Yamamoto , Satoshi Okumura , Katsuya Sasaki
发明人： Shuji Hamano , Tsunehira Yamamoto , Satoshi Okumura , Katsuya Sasaki
IPC分类号： C01D7/00 , B01J19/00
CPC分类号： C01D7/00 , C01D3/04 , C01D3/14 , C01D3/16 , C01D7/24 , C01D7/26
摘要： Provided is an extracting and separating device which includes: an ash reactor 12 for preparing a solution having a temperature of about 60° C. by using incineration ash containing sodium, potassium, and chlorine; a cooling crystallizer 16 for reducing the temperature of the solution to 30° C. to produce and separate potassium chloride; an absorption tower 11 for reacting the solution with carbon dioxide-containing gas to produce and separate sodium hydrogen carbonate; and a circulation path 13 for returning to the ash reactor 12 a liquid obtained after the production and separation of the potassium chloride in the cooling crystallizer 16 and the sodium hydrogen carbonate in the absorption tower 11.
摘要翻译：提供了一种提取分离装置，其包括：灰烬反应器12，用于通过使用含有钠，钾和氯的焚烧灰制备温度为约60℃的溶液; 冷却结晶器16，用于将溶液的温度降低至30℃以产生和分离氯化钾; 用于使溶液与含二氧化碳的气体反应以产生和分离碳酸氢钠的吸收塔11; 以及循环路径13，用于在冷却结晶器16中生产和分离氯化钾之后获得的液体和吸收塔11中的碳酸氢钠返回到灰尘反应器12。

2. 发明申请

US20110256114A1 T-CELL RECEPTOR AND NUCLEIC ACID ENCODING THE RECEPTOR 有权
标题翻译： T细胞受体和核酸编码受体
公开(公告)号：US20110256114A1
公开(公告)日：2011-10-20
申请号：US13167414
申请日：2011-06-23
申请人： Hiroshi SHIKU , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
发明人： Hiroshi SHIKU , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
IPC分类号： A61K35/14 , A61P35/00 , C12N5/10 , A61K48/00 , C07K14/725 , C12N1/00
CPC分类号： C07K14/705 , A61K35/12 , A61K38/00 , C07K14/7051 , C12N5/0636 , C12N2501/515 , C12N2510/00
摘要： A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.
摘要翻译：一种多肽，其包含由序列表的SEQ ID NO：5所示的氨基酸序列组成的多肽或由序列中一至数个氨基酸残基的缺失，添加，插入或取代的氨基酸序列组成的多肽，能够构成HLA-A24限制性MAGE-A4143-151特异性T细胞受体的多肽以及由序列表的SEQ ID NO：2所示的氨基酸序列组成的多肽。

3. 发明授权

US08383401B2 T-cell receptor and nucleic acid encoding the receptor 有权
公开(公告)号：US08383401B2
公开(公告)日：2013-02-26
申请号：US13167414
申请日：2011-06-23
申请人： Hiroshi Shiku , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
发明人： Hiroshi Shiku , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
IPC分类号： C07H21/02 , C12N15/00 , C12N5/00 , C12N5/02 , C12N5/071
CPC分类号： C07K14/705 , A61K35/12 , A61K38/00 , C07K14/7051 , C12N5/0636 , C12N2501/515 , C12N2510/00
摘要： A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.

4. 发明申请

US20090068209A1 Cytotoxic Lymphocyte 有权
标题翻译：细胞毒性淋巴细胞
公开(公告)号：US20090068209A1
公开(公告)日：2009-03-12
申请号：US12113822
申请日：2008-05-01
申请人： Hiroshi SHIKU , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
发明人： Hiroshi SHIKU , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
IPC分类号： A61K39/00 , C12N5/08 , C07K2/00 , A61P35/00 , A61K45/00
CPC分类号： C12N5/0636 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156
摘要： The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte.
摘要翻译：本发明涉及具有诱导识别抗原的T淋巴细胞的活性的T淋巴细胞和使用T淋巴细胞的技术。

5. 发明授权

US08168191B2 Cytotoxic T lymphocyte 有权
标题翻译：细胞毒T淋巴细胞
公开(公告)号：US08168191B2
公开(公告)日：2012-05-01
申请号：US12113822
申请日：2008-05-01
申请人： Hiroshi Shiku , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
发明人： Hiroshi Shiku , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
IPC分类号： A61K39/00 , C07K7/06
CPC分类号： C12N5/0636 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156
摘要： The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte.
摘要翻译：本发明涉及具有诱导T淋巴细胞识别抗原的活性的T淋巴细胞和使用T淋巴细胞的技术。

6. 发明授权

US08003770B2 T-cell receptor and nucleic acid encoding the receptor 有权
标题翻译： T细胞受体和编码受体的核酸
公开(公告)号：US08003770B2
公开(公告)日：2011-08-23
申请号：US11991964
申请日：2006-09-07
申请人： Hiroshi Shiku , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
发明人： Hiroshi Shiku , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
IPC分类号： C07H21/02 , C12N15/00
CPC分类号： C07K14/705 , A61K35/12 , A61K38/00 , C07K14/7051 , C12N5/0636 , C12N2501/515 , C12N2510/00
摘要： A polypeptide comprising a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 5 of Sequence Listing or a polypeptide consisting of an amino acid sequence having deletion, addition, insertion or substitution of one to several amino acid residues in the sequence, the polypeptide being capable of constituting an HLA-A24-restricted, MAGE-A4143-151-specific T cell receptor together with a polypeptide consisting of an amino acid sequence shown in SEQ ID NO: 2 of Sequence Listing.
摘要翻译：一种多肽，其包含由序列表的SEQ ID NO：5所示的氨基酸序列组成的多肽或由序列中一至数个氨基酸残基的缺失，添加，插入或取代的氨基酸序列组成的多肽，能够构成HLA-A24限制性MAGE-A4143-151特异性T细胞受体的多肽以及由序列表的SEQ ID NO：2所示的氨基酸序列组成的多肽。

7. 发明授权

US09096632B2 Modulator of activity of adenylate cyclase 有权
标题翻译：腺苷酸环化酶的活性调节剂
公开(公告)号：US09096632B2
公开(公告)日：2015-08-04
申请号：US13880346
申请日：2011-10-20
申请人： Yoshihiro Ishikawa , Satoshi Okumura , Yujiro Hoshino , Seiichi Inoue
发明人： Yoshihiro Ishikawa , Satoshi Okumura , Yujiro Hoshino , Seiichi Inoue
IPC分类号： A01N43/04 , A61K31/70 , C07H19/06 , A61K31/7064 , A61K31/7056 , A61K31/706 , A61K31/7052 , A61K31/7042 , A61K31/7076 , C07H19/19 , A23L1/30
CPC分类号： C07H19/06 , A23L33/10 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7076 , C07H19/19
摘要： The present invention provides a novel compound capable of inhibiting cardiac adenylyl cyclase.The present invention relates to a compound represented by the following formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof: where R1, R2 and R3 each independently represent a hydrogen atom or an acyl group having an acidic or basic substituent, provided that all of R1, R2 and R3 are not simultaneously a hydrogen atom. The present invention also provides a modulator of adenylyl cyclase activity, a pharmaceutical composition and a food composition, all of which comprise the above-described compound or a pharmaceutically acceptable salt, ester or solvate thereof.
摘要翻译：本发明提供能够抑制心脏腺苷酸环化酶的新化合物。本发明涉及由下式（I）表示的化合物或其药学上可接受的盐，酯或溶剂合物：其中R1，R2和R3各自独立地表示氢原子或具有酸性或碱性取代基的酰基， R1，R2和R3的全部不同时为氢原子。本发明还提供腺苷酸环化酶活性的调节剂，药物组合物和食品组合物，它们都包含上述化合物或其药学上可接受的盐，酯或溶剂合物。

8. 发明申请

US20130261073A1 MODULATOR OF ACTIVITY OF ADENYLATE CYCLASE 有权
标题翻译： ADENYLATE CYCLASE活性调节剂
公开(公告)号：US20130261073A1
公开(公告)日：2013-10-03
申请号：US13880346
申请日：2011-10-20
申请人： Yoshihiro Ishikawa , Satoshi Okumura , Yujiro Hoshino , Seiichi Inoue
发明人： Yoshihiro Ishikawa , Satoshi Okumura , Yujiro Hoshino , Seiichi Inoue
IPC分类号： C07H19/06
CPC分类号： C07H19/06 , A23L33/10 , A61K31/7042 , A61K31/7052 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7076 , C07H19/19
摘要： The present invention provides a novel compound capable of inhibiting cardiac adenylyl cyclase.The present invention relates to a compound represented by the following formula (I) or a pharmaceutically acceptable salt, ester or solvate thereof: where R1, R2 and R3 each independently represent a hydrogen atom or an acyl group having an acidic or basic substituent, provided that all of R1, R2 and R3 are not simultaneously a hydrogen atom.The present invention also provides a modulator of adenylyl cyclase activity, a pharmaceutical composition and a food composition, all of which comprise the above-described compound or a pharmaceutically acceptable salt, ester or solvate thereof.
摘要翻译：本发明提供能够抑制心脏腺苷酸环化酶的新化合物。本发明涉及由下式（I）表示的化合物或其药学上可接受的盐，酯或溶剂合物：其中R1，R2和R3各自独立地表示氢原子或具有酸性或碱性取代基的酰基， R1，R2和R3的全部不同时为氢原子。本发明还提供腺苷酸环化酶活性的调节剂，药物组合物和食品组合物，它们都包含上述化合物或其药学上可接受的盐，酯或溶剂合物。

9. 发明授权

US07119900B2 Pollen sensor and method 失效
标题翻译：花粉传感器和方法
公开(公告)号：US07119900B2
公开(公告)日：2006-10-10
申请号：US10678194
申请日：2003-10-02
申请人： Satoshi Okumura , Toyohiro Usui , Toshiaki Iwai
发明人： Satoshi Okumura , Toyohiro Usui , Toshiaki Iwai
IPC分类号： G01J4/00
CPC分类号： G01N21/21 , G01N15/0211 , G01N2015/0046
摘要： A pollen sensor and method for detecting pollen which discriminates pollen particles floating in air from other particles on a real time basis. The pollen sensor includes an illumination position for generating a light beam, a first receiver for measuring the intensity (I) or (Ip) of a light beam scattered by floating particles in a detection zone, a second receiver for measuring the intensity (Is) of a polarized light beam in a direction perpendicular to light illuminated by the light beam and means for measuring the degree of polarization of the particles for distinguishing pollen particles from other particles.
摘要翻译：一种用于检测花粉的花粉传感器和方法，其实时地鉴别浮在空气中的花粉颗粒与其他颗粒。花粉传感器包括用于产生光束的照明位置，用于测量由检测区域中的浮动粒子散射的光束的强度（I）或（Ip）的第一接收器，用于测量强度（Is）的第二接收器，的偏振光束在垂直于由光束照射的光的方向上的偏振光束，以及用于测量用于区分花粉粒子与其他粒子的粒子的偏振度的装置。

10. 发明授权

US09243227B2 Cytotoxic T lymphocyte 有权
公开(公告)号：US09243227B2
公开(公告)日：2016-01-26
申请号：US13431542
申请日：2012-03-27
申请人： Hiroshi Shiku , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
发明人： Hiroshi Shiku , Atsunori Hiasa , Satoshi Okumura , Hiroaki Naota , Yoshihiro Miyahara
IPC分类号： C12N5/00 , C12N5/0783 , A61K39/00 , A61K48/00
CPC分类号： C12N5/0636 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/5154 , A61K2039/5156
摘要： The present invention relates to a T lymphocyte having an activity to induce a T lymphocyte recognizing an antigen and a technique to use the T lymphocyte.

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