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1. 发明申请

US20090012096A1 PHARMACEUTICAL COMPOSITION FOR REDUCING THE AREA OF MYOCARDIAL INFARCTION AND ITS USE 有权
标题翻译：用于减少心肌梗塞面积的药物组合物及其使用
公开(公告)号：US20090012096A1
公开(公告)日：2009-01-08
申请号：US12128568
申请日：2008-05-28
申请人： Shuhua Gu , Changlin Mei , Dingfeng Su , Juan Du , Rong Fan
发明人： Shuhua Gu , Changlin Mei , Dingfeng Su , Juan Du , Rong Fan
IPC分类号： A61K31/495 , A61P9/10
CPC分类号： A61K9/0019 , A61K9/0056 , A61K9/0095 , A61K9/02 , A61K9/1623 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/495
摘要： This invention relates to a pharmaceutical composition for preventing and curing myocardium ischemia and reducing area of myocardial infarction, its pharmaceutical preparation and applications. The composition includes (a) levocarnitine or its derivatives, and (b) trimetazidine or its medicative salts. The quantity of levocarnitine or its derivatives, and trimetazidine or its medicative salts in the composition is effective amount for treating myocardial ischemia and reducing the area of myocardial infarction.
摘要翻译：本发明涉及一种用于预防和治愈心肌缺血并减少心肌梗死面积的药物组合物及其药物制备和应用。组合物包括（a）左卡尼汀或其衍生物，和（b）曲美他嗪或其药用盐。组合物中左卡尼汀或其衍生物和曲美他嗪或其药用盐的量是治疗心肌缺血并减少心肌梗死面积的有效量。

2. 发明授权

US08513245B2 Pharmaceutical composition for reducing the area of myocardial infarction and its use 有权
标题翻译：用于减少心肌梗塞面积的药物组合物及其用途
公开(公告)号：US08513245B2
公开(公告)日：2013-08-20
申请号：US12128568
申请日：2008-05-28
申请人： Shuhua Gu , Changlin Mei , Dingfeng Su , Juan Du , Rong Fan
发明人： Shuhua Gu , Changlin Mei , Dingfeng Su , Juan Du , Rong Fan
IPC分类号： A01N43/58 , A61K31/50 , A61K31/497
CPC分类号： A61K9/0019 , A61K9/0056 , A61K9/0095 , A61K9/02 , A61K9/1623 , A61K9/1635 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K31/495
摘要： This invention relates to a pharmaceutical composition for preventing and curing myocardium ischemia and reducing area of myocardial infarction, its pharmaceutical preparation and applications. The composition includes (a) levocarnitine or its derivatives, and (b) trimetazidine or its medicative salts. The quantity of levocarnitine or its derivatives, and trimetazidine or its medicative salts in the composition is effective amount for treating myocardial ischemia and reducing the area of myocardial infarction.
摘要翻译：本发明涉及一种用于预防和治愈心肌缺血并减少心肌梗死面积的药物组合物及其药物制备和应用。组合物包括（a）左卡尼汀或其衍生物，和（b）曲美他嗪或其药用盐。组合物中左卡尼汀或其衍生物和曲美他嗪或其药用盐的量是治疗心肌缺血并减少心肌梗死面积的有效量。

3. 发明授权

US09205071B2 Arsenic compounds, their preparation methods and uses thereof 有权
标题翻译：砷化合物，其制备方法和用途
公开(公告)号：US09205071B2
公开(公告)日：2015-12-08
申请号：US13318047
申请日：2010-04-16
申请人： Shuhua Gu , Xuecheng Wang
发明人： Shuhua Gu , Xuecheng Wang
IPC分类号： A61K31/285 , C07C229/22
CPC分类号： A61K31/285 , C07C229/22
摘要： Arsenic compounds of general formula (I), their preparation methods, the pharmaceutical compositions containing the compounds, and their uses in the manufacture of medicaments for treating cancer, particularly leukemia, are disclosed.
摘要翻译：公开了通式（I）的砷化合物，其制备方法，含有该化合物的药物组合物及其在制备用于治疗癌症的药物，特别是白血病中的用途。

4. 发明授权

US09096493B2 Preparation method of high-purity L-carnitine 有权
标题翻译：高纯度左旋肉碱的制备方法
公开(公告)号：US09096493B2
公开(公告)日：2015-08-04
申请号：US13121392
申请日：2009-10-09
申请人： Shuhua Gu , Xuecheng Wang , Qingyi Li
发明人： Shuhua Gu , Xuecheng Wang , Qingyi Li
IPC分类号： C07C229/22
CPC分类号： C07C229/22 , C07B2200/07
摘要： The present invention relate to a preparation method of high-purity L-carnitine which belongs to an important technique of quality control in different steps of chiral medicine production. The method comprises the following steps of: monitoring the content of the L-isomer impurity in chiral material S-epichlorohydrin by gas chromatography and chiral column and controlling the content of the L-isomer impurity in chiral raw material in the definite range; monitoring and controlling the specific optical rotation of the chiral intermediate L-3-chloro-2-hydroxy-N,N,N-trimethyl-propanaminium in the definite ranges using a polarimeter; monitoring the content of the R-isomer in the intermediate L-3-cyano-2-hydroxy-N,N,N-trimethyl-propanaminium using derivation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC and controlling the content of the isomer in the intermediate in the definite range; and measuring the final product L-carnitine using derivation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC. This method gives the high-purity L-carnitine in which the content of L-isomer may be more than 97% and that of R-isomer less than 2%.
摘要翻译：本发明涉及高纯度L-肉碱的制备方法，属于手性药物生产不同步骤中质量控制的重要技术。该方法包括以下步骤：通过气相色谱和手性柱监测手性物质S-表氯醇中L-异构体杂质的含量，控制手性原料中L-异构体杂质的含量在一定范围内; 使用偏光计监测和控制手性中间体L-3-氯-2-羟基-N，N，N-三甲基 - 丙胺在一定范围内的比旋光度; 使用衍生剂（+）α-甲基-6-甲氧基-2-萘甲酰氯通过HPLC监测中间体L-3-氰基-2-羟基-N，N，N-三甲基 - 丙胺中R-异构体的含量并控制中间体中异构体的含量在一定范围内; 并使用衍生剂（+）α-甲基-6-甲氧基-2-萘甲酰氯通过HPLC测定最终产物L-肉毒碱。该方法给出L-异构体含量高于97％，R-异构体含量低于2％的高纯度左旋肉碱。

5. 发明申请

US20120039995A1 ARSENIC COMPOUNDS, THEIR PREPARATION METHODS AND USES THEREOF 有权
标题翻译： ARSENIC化合物，其制备方法及其用途
公开(公告)号：US20120039995A1
公开(公告)日：2012-02-16
申请号：US13318047
申请日：2010-04-16
申请人： Shuhua Gu , Xuecheng Wang
发明人： Shuhua Gu , Xuecheng Wang
IPC分类号： A61K9/127 , A61K31/285 , A61K9/14 , A61P35/00 , A61P35/02 , C07C227/16 , C07C229/22 , A61K39/395 , B82Y5/00
CPC分类号： A61K31/285 , C07C229/22
摘要： Arsenic compounds of general formula (I), their preparation methods, the pharmaceutical compositions containing the compounds, and their uses in the manufacture of medicaments for treating cancer, particularly leukemia, are disclosed.
摘要翻译：公开了通式（I）的砷化合物，其制备方法，含有该化合物的药物组合物及其在制备用于治疗癌症的药物，特别是白血病中的用途。

6. 发明授权

US08709819B2 Preparation and its use of derivatization reagent for detecting L-carnitine or D-carnitine 有权
标题翻译：制备及其用于检测L-肉毒碱或D-肉碱的衍生化试剂
公开(公告)号：US08709819B2
公开(公告)日：2014-04-29
申请号：US13121388
申请日：2009-10-09
申请人： Shuhua Gu , Qingyi Li , Xuecheng Wang
发明人： Shuhua Gu , Qingyi Li , Xuecheng Wang
IPC分类号： G01N30/02
CPC分类号： G01N33/92 , C07B2200/07 , C07C59/64 , C07C59/66 , G01N33/58 , G01N33/82
摘要： A preparation method and its use of derivatization reagent for detecting L-carnitine or D-carnitine are provided. The present reagent is stable. It can be used for detecting L-carnitine or D-carnitine accurately and sensitively. That is to say, the reagent is applied to detecting the amount of synthesized or natural L-carnitine and the amount of mixing D-carnitine. The compound reagent is used for determining the chiral isomers of chemicals, biological reagents, health care reagents, cosmetic, body fluids and various foods, which contain L-carnitine or/and D-carnitine, and optical isomers of other chiral amino acids.
摘要翻译：提供了一种制备方法及其用于检测L-肉碱或D-肉毒碱的衍生试剂的用途。本试剂稳定。它可以准确，灵敏地检测左旋肉碱或D-肉毒碱。也就是说，试剂用于检测合成的或天然的L-肉毒碱的量和D-肉毒碱的混合量。化合物试剂用于测定含有左旋肉碱或/或D-肉毒碱的化学物质，生物试剂，保健剂，化妆品，体液和各种食品的手性异构体，以及其他手性氨基酸的光学异构体。

7. 发明申请

US20080249168A1 Pharmaceutical composition for gout 有权
标题翻译：用于痛风的药物组合物
公开(公告)号：US20080249168A1
公开(公告)日：2008-10-09
申请号：US11879882
申请日：2007-07-18
申请人： Shuhua Gu
发明人： Shuhua Gu
IPC分类号： A61K31/221 , A61P25/00
CPC分类号： A61K31/205 , A61K31/221
摘要： A composition for hyperuricemia disease or a related disorder, use thereof and method of using thereof are provided.
摘要翻译：提供高尿酸血症疾病或相关病症的组合物，其用途及其使用方法。

8. 发明申请

US20110281293A1 PREPARATION AND ITS USE OF DERIVATIZATION REAGENT FOR DETECTING L-CARNITINE OR D-CARNITINE 有权
标题翻译：衍生物试剂用于检测L-卡尼丁或D-卡尼汀的制备及其用途
公开(公告)号：US20110281293A1
公开(公告)日：2011-11-17
申请号：US13121388
申请日：2009-10-09
申请人： Shuhua Gu , Qingyi Li , Xuecheng Wang
发明人： Shuhua Gu , Qingyi Li , Xuecheng Wang
IPC分类号： G01N30/02 , C12Q1/02 , C07C47/198 , G01N33/50
CPC分类号： G01N33/92 , C07B2200/07 , C07C59/64 , C07C59/66 , G01N33/58 , G01N33/82
摘要： A preparation method and its use of derivatisation reagent for detecting L-carnitine or D-carnitine are provided. The present reagent is stable. It can be used for detecting L-carnitine or D-carnitine accurately and sensitively. That is to say, the reagent is applied to detecting the amount of synthesized or natural L-carnitine and the amount of mixing D-carnitine. The compound reagent is used for determining the chiral isomers of chemicals, biological reagents, health care reagents, cosmetic, body fluids and various foods, which contain L-carnitine or/and D-carnitine, and optical isomers of other chiral amino acids.
摘要翻译：提供了一种制备方法及其用于检测L-肉碱或D-肉毒碱的衍生试剂的用途。本试剂稳定。它可以准确，灵敏地检测左旋肉碱或D-肉毒碱。也就是说，试剂用于检测合成的或天然的L-肉毒碱的量和D-肉毒碱的混合量。化合物试剂用于测定含有左旋肉碱或/或D-肉毒碱的化学物质，生物试剂，保健剂，化妆品，体液和各种食品的手性异构体，以及其他手性氨基酸的光学异构体。

9. 发明申请

US20110263897A1 PREPARATION METHOD OF HIGH-PURITY L-CARNITINE 有权
标题翻译：高效L-CARNITIN的制备方法
公开(公告)号：US20110263897A1
公开(公告)日：2011-10-27
申请号：US13121392
申请日：2009-10-09
申请人： Shuhua Gu , Xuecheng Wang , Qingyi Li
发明人： Shuhua Gu , Xuecheng Wang , Qingyi Li
IPC分类号： C07C227/12
CPC分类号： C07C229/22 , C07B2200/07
摘要： The present invention relate to a preparation method of high-purity L-carnitine which belongs to an important technique of quality control in different steps of chiral medicine production. The method comprises the following steps of: monitoring the content of the L-isomer impurity in chiral material S-epichlorohydrin by gas chromatography and chiral column and controlling the content of the L-isomer impurity in chiral raw material in the definite range; monitoring and controlling the specific optical rotation of the chiral intermediate L-3-chloro-2-hydroxy-N,N,N-trimethyl-propanaminium in the definite ranges using a polarimeter; monitoring the content of the R-isomer in the intermediate L-3-cyano-2-hydroxy-N,N,N-trimethyl-propanaminium using derivation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC and controlling the content of the isomer in the intermediate in the definite range; and measuring the final product L-carnitine using derviation agent (+)α-methyl-6-methoxy-2-naphthaleneaceyl chloride by HPLC. This method gives the high-purity L-carnitine in which the content of L-isomer may be more than 97% and that of R-isomerless than 2%.
摘要翻译：本发明涉及高纯度L-肉碱的制备方法，属于手性药物生产不同步骤中质量控制的重要技术。该方法包括以下步骤：通过气相色谱和手性柱监测手性物质S-表氯醇中L-异构体杂质的含量，控制手性原料中L-异构体杂质含量在一定范围内; 使用偏光计监测和控制手性中间体L-3-氯-2-羟基-N，N，N-三甲基 - 丙胺在一定范围内的比旋光度; 使用衍生剂（+）α-甲基-6-甲氧基-2-萘甲酰氯通过HPLC监测中间体L-3-氰基-2-羟基-N，N，N-三甲基 - 丙胺中R-异构体的含量并控制中间体中异构体的含量在一定范围内; 并用高效液相色谱法测定最终产物L-肉碱，使用脱甲剂（+）α-甲基-6-甲氧基-2-萘甲酰氯。该方法得到L-异构体的含量高于97％的高纯度左旋肉碱，R异构体的含量高于2％。

10. 发明授权

US07834056B2 Pharmaceutical composition for gout 有权
标题翻译：用于痛风的药物组合物
公开(公告)号：US07834056B2
公开(公告)日：2010-11-16
申请号：US11879882
申请日：2007-07-18
申请人： Shuhua Gu
发明人： Shuhua Gu
IPC分类号： A01N37/02 , A01N37/12 , A01N37/44 , A01N37/30 , A61K31/22 , A61K31/205
CPC分类号： A61K31/205 , A61K31/221
摘要： A composition for hyperuricemia disease or a related disorder, use thereof and method of using thereof are provided.
摘要翻译：提供高尿酸血症疾病或相关病症的组合物，其用途及其使用方法。

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