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1. 发明授权

US07323546B2 Apoptosis-inducing polypeptides 有权
标题翻译：细胞凋亡诱导多肽
公开(公告)号：US07323546B2
公开(公告)日：2008-01-29
申请号：US10863637
申请日：2004-06-08
申请人： Shu-Mei Liang , Jei-Ming Peng , Chi-Ming Liang
发明人： Shu-Mei Liang , Jei-Ming Peng , Chi-Ming Liang
IPC分类号： C07K14/00 , A61K39/00
CPC分类号： C07K14/005 , A61K31/7088 , A61K38/162 , A61K39/00 , A61K39/12 , A61K39/135 , A61K2039/523 , C07K1/1136 , C12N2770/32122 , C12N2770/32133
摘要： An isolated water-soluble VP1 polypeptide of foot-and-mouth disease virus and a nucleic acid encoding the polypeptide. Also disclosed are a pharmaceutical composition containing the polypeptide or nucleic acid and related methods of inducing apoptosis and treating an apoptosis-related disorder.
摘要翻译：口蹄疫病毒的分离的水溶性VP1多肽和编码该多肽的核酸。还公开了含有多肽或核酸的药物组合物和诱导凋亡和治疗凋亡相关病症的相关方法。

2. 发明授权

US08357652B2 Anti-tumor fibrillar human serum albumin methods and compositions 有权
标题翻译：抗肿瘤原纤维人血清白蛋白的方法和组成
公开(公告)号：US08357652B2
公开(公告)日：2013-01-22
申请号：US12623162
申请日：2009-11-20
申请人： Shu-Mei Liang , Chi-Ming Liang
发明人： Shu-Mei Liang , Chi-Ming Liang
IPC分类号： A61K35/12 , A61K38/00
CPC分类号： A61K38/385 , A61K38/162 , A61K38/38 , A61K45/06 , A61K47/643 , A61N5/10 , C07K14/765 , C12N7/00 , C12N2770/32133
摘要： Fibrillar human serum albumin was shown to be effective in the treatment of various types of cancers. Methods and compositions are disclosed for using fibrillar human serum albumin as a medicament to treat subjects having cancer.
摘要翻译：纤维素人血清白蛋白显示有效治疗各种类型的癌症。公开了使用原纤维人血清白蛋白作为治疗患有癌症的受试者的药物的方法和组合物。

3. 发明授权

US07700730B2 Apoptosis-inducing polypeptides 有权
标题翻译：细胞凋亡诱导多肽
公开(公告)号：US07700730B2
公开(公告)日：2010-04-20
申请号：US11949125
申请日：2007-12-03
申请人： Shu-Mei Liang , Jei-Ming Peng , Chi-Ming Liang
发明人： Shu-Mei Liang , Jei-Ming Peng , Chi-Ming Liang
IPC分类号： C07K14/00
CPC分类号： C07K14/005 , A61K31/7088 , A61K38/162 , A61K39/00 , A61K39/12 , A61K39/135 , A61K2039/523 , C07K1/1136 , C12N2770/32122 , C12N2770/32133
摘要： An isolated water-soluble VP1 polypeptide of foot-and-mouth disease virus and a nucleic acid encoding the polypeptide. Also disclosed are a pharmaceutical composition containing the polypeptide or nucleic acid and related methods of inducing apoptosis and treating an apoptosis-related disorder.
摘要翻译：口蹄疫病毒的分离的水溶性VP1多肽和编码该多肽的核酸。还公开了含有多肽或核酸的药物组合物和诱导凋亡和治疗凋亡相关病症的相关方法。

4. 发明申请

US20120316117A1 PROCESS TO PRODUCE FIBRILLAR PROTEINS AND METHOD OF TREATMENT USING FIBRILLAR PROTEINS 有权
标题翻译：生产纤维蛋白的方法和使用纤维蛋白的治疗方法
公开(公告)号：US20120316117A1
公开(公告)日：2012-12-13
申请号：US13572652
申请日：2012-08-12
申请人： Shu-Mei Liang , Chun-Yung Huang , Chi-Ming Liang
发明人： Shu-Mei Liang , Chun-Yung Huang , Chi-Ming Liang
IPC分类号： A61K38/38 , A61P35/00
CPC分类号： A61K31/7088 , A61K38/162 , A61K38/38 , A61K38/39 , A61K39/39 , A61K2039/55516
摘要： A method for inhibiting survival of cancer cells in a subject is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of fibrillar albumin. The preparation of the fibrillar albumin comprises: (i) forming a solution comprising an isolated and/or purified globular albumin; (ii) adding a detergent to the solution containing the isolated and/or purified globular albumin, wherein the detergent is one selected from the group consisting of sodium dodecyl sulfate (SDS) and n-tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; (iii) applying the solution to a molecular sizing column with a pore size that permits separation of a protein with a molecular weight of at least about 70 kDa so as to promote column-induced formation of the fibrillar albumin from the isolated and/or purified globular albumin; and (iv) eluting the fibrillar albumin from the column, wherein the eluted albumin has a fibrillar structure.
摘要翻译：公开了抑制受试者中癌细胞存活的方法。该方法包括向有需要的受试者施用治疗有效量的原纤维白蛋白。纤维状白蛋白的制备包括：（i）形成包含分离和/或纯化的球状白蛋白的溶液; （ii）向含有分离和/或纯化的球状白蛋白的溶液中加入洗涤剂，其中洗涤剂选自十二烷基硫酸钠（SDS）和正十四烷基-N，N-二甲基-3-氨基 -1-丙磺酸盐; （iii）将溶液施加到具有允许分离至少约70kDa的分子量的蛋白质的孔径的分子筛分柱，以便促进来自分离和/或纯化的柱状诱导的纤维状白蛋白的形成球状白蛋白和（iv）从柱中洗脱纤维状白蛋白，其中洗脱的白蛋白具有纤维状结构。

5. 发明授权

US08268974B2 Process to produce fibrillar proteins 有权
标题翻译：生产纤维蛋白的方法
公开(公告)号：US08268974B2
公开(公告)日：2012-09-18
申请号：US12082634
申请日：2008-04-11
申请人： Shu-Mei Liang , Chun-Yung Huang , Yen-Po Chen , Chi-Ming Liang
发明人： Shu-Mei Liang , Chun-Yung Huang , Yen-Po Chen , Chi-Ming Liang
IPC分类号： A61K38/00 , A61K45/00 , C07K1/00 , C07K14/00
CPC分类号： A61K31/7088 , A61K38/162 , A61K38/38 , A61K38/39 , A61K39/39 , A61K2039/55516
摘要： A method for changing a globular protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a detergent to the solution containing the globular protein, applying the solution to a molecular sizing column with a pore size of at least 70 kDa and eluting with a solution containing detergent. A method for changing an unfolded protein structure into a fibrillar protein structure. The method comprising the steps of providing a globular protein, forming a solution containing the globular protein, adding a urea to the solution to unfold the globular protein, applying the solution to a molecular sizing column and eluting with a solution containing detergent. A method for treating cancer comprising the steps of providing a protein, changing the protein into a fibrillar structure, and administering a therapeutically effective amount of the fibrillar structure protein to a patient in need thereof. A method for producing a vaccine adjuvant or antigen adjuvant comprising the steps of providing a protein, and changing the protein into a fibrillar structure.
摘要翻译：一种将球状蛋白结构变为纤维状蛋白结构的方法。该方法包括以下步骤：提供球状蛋白质，形成含有球状蛋白质的溶液，向含有球状蛋白质的溶液中加入洗涤剂，将溶液施加到孔径至少为70kDa的分子筛分柱上，并用含有洗涤剂的溶液。将展开的蛋白质结构改变成纤维蛋白结构的方法。该方法包括以下步骤：提供球状蛋白质，形成含有球状蛋白质的溶液，向溶液中加入尿素以展开球状蛋白质，将溶液施加到分子筛分柱上并用含有洗涤剂的溶液洗脱。一种治疗癌症的方法，包括提供蛋白质，将蛋白质改变成纤维结构，以及向有需要的患者施用治疗有效量的纤维结构蛋白的步骤。一种用于生产疫苗佐剂或抗原佐剂的方法，包括提供蛋白质并将蛋白质变成纤维结构的步骤。

6. 发明申请

US20080188410A1 APOPTOSIS-INDUCING POLYPEPTIDES 有权
标题翻译：病毒诱导多糖
公开(公告)号：US20080188410A1
公开(公告)日：2008-08-07
申请号：US11947935
申请日：2007-11-30
申请人： Shu-Mei Liang , Jei-ming Peng , Chi-Ming Liang
发明人： Shu-Mei Liang , Jei-ming Peng , Chi-Ming Liang
IPC分类号： A61K38/16 , C07K14/09 , A61P31/14
CPC分类号： C07K14/005 , A61K31/7088 , A61K38/162 , A61K39/00 , A61K39/12 , A61K39/135 , A61K2039/523 , C07K1/1136 , C12N2770/32122 , C12N2770/32133
摘要： An isolated water-soluble VP1 polypeptide of foot-and-mouth disease virus and a nucleic acid encoding the polypeptide. Also disclosed are a pharmaceutical composition containing the polypeptide or nucleic acid and related methods of inducing apoptosis and treating an apoptosis-related disorder.
摘要翻译：口蹄疫病毒的分离的水溶性VP1多肽和编码该多肽的核酸。还公开了含有多肽或核酸的药物组合物和诱导凋亡和治疗凋亡相关病症的相关方法。

7. 发明申请

US20050058654A1 Apoptosis-inducing polypeptides 有权
标题翻译：细胞凋亡诱导多肽
公开(公告)号：US20050058654A1
公开(公告)日：2005-03-17
申请号：US10863637
申请日：2004-06-08
申请人： Shu-Mei Liang , Jei-Ming Peng , Chi-Ming Liang
发明人： Shu-Mei Liang , Jei-Ming Peng , Chi-Ming Liang
IPC分类号： A61K38/00 , A61K38/16 , A61K39/00 , A61K39/12 , A61K39/135 , C07K1/113 , C07K14/005 , C07K14/09
CPC分类号： C07K14/005 , A61K31/7088 , A61K38/162 , A61K39/00 , A61K39/12 , A61K39/135 , A61K2039/523 , C07K1/1136 , C12N2770/32122 , C12N2770/32133
摘要： An isolated water-soluble VP1 polypeptide of foot-and-mouth disease virus and a nucleic acid encoding the polypeptide. Also disclosed are a pharmaceutical composition containing the polypeptide or nucleic acid and related methods of inducing apoptosis and treating an apoptosis-related disorder.
摘要翻译：口蹄疫病毒的分离的水溶性VP1多肽和编码该多肽的核酸。还公开了含有多肽或核酸的药物组合物和诱导凋亡和治疗凋亡相关病症的相关方法。

8. 发明授权

US08685923B2 Fibrillar albumin for use in inhibiting cancer growth 有权
标题翻译：用于抑制癌症生长的纤维白蛋白
公开(公告)号：US08685923B2
公开(公告)日：2014-04-01
申请号：US13572652
申请日：2012-08-12
申请人： Shu-Mei Liang , Chun-Yung Huang , Chi-Ming Liang
发明人： Shu-Mei Liang , Chun-Yung Huang , Chi-Ming Liang
IPC分类号： A61K38/38 , C07K14/76 , C07K1/16
CPC分类号： A61K31/7088 , A61K38/162 , A61K38/38 , A61K38/39 , A61K39/39 , A61K2039/55516
摘要： A method for inhibiting survival of cancer cells in a subject is disclosed. The method comprises administering to a subject in need thereof a therapeutically effective amount of fibrillar albumin. The preparation of the fibrillar albumin comprises: (i) forming a solution comprising an isolated and/or purified globular albumin; (ii) adding a detergent to the solution containing the isolated and/or purified globular albumin, wherein the detergent is one selected from the group consisting of sodium dodecyl sulfate (SDS) and n-tetradecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate; (iii) applying the solution to a molecular sizing column with a pore size that permits separation of a protein with a molecular weight of at least about 70 kDa so as to promote column-induced formation of the fibrillar albumin from the isolated and/or purified globular albumin; and (iv) eluting the fibrillar albumin from the column, wherein the eluted albumin has a fibrillar structure.
摘要翻译：公开了抑制受试者中癌细胞存活的方法。该方法包括向有需要的受试者施用治疗有效量的原纤维白蛋白。纤维状白蛋白的制备包括：（i）形成包含分离和/或纯化的球状白蛋白的溶液; （ii）向含有分离和/或纯化的球状白蛋白的溶液中加入洗涤剂，其中洗涤剂选自十二烷基硫酸钠（SDS）和正十四烷基-N，N-二甲基-3-氨基 -1-丙磺酸盐; （iii）将溶液施加到具有允许分离至少约70kDa的分子量的蛋白质的孔径的分子筛分柱，以便促进来自分离和/或纯化的柱状诱导的纤维状白蛋白的形成球状白蛋白和（iv）从柱中洗脱纤维状白蛋白，其中洗脱的白蛋白具有纤维状结构。

9. 发明申请

US20120309682A1 SUPPRESSION OF CANCER METASTASIS 审中-公开
标题翻译：抑制癌症分期
公开(公告)号：US20120309682A1
公开(公告)日：2012-12-06
申请号：US13510753
申请日：2010-11-19
申请人： Shu-Mei Liang , Ching-Feng Chiu , Shao-Wen Hung , Jei-Ming Peng , Chi-Ming Liang
发明人： Shu-Mei Liang , Ching-Feng Chiu , Shao-Wen Hung , Jei-Ming Peng , Chi-Ming Liang
IPC分类号： A61K38/38 , A61P35/04 , A61K38/16
摘要： Methods are provided for suppressing cancer metastasis. Cancer metastasis is the most common cause of treatment failure and death in cancer patients. Tumor cell invasion and/or migration can be significantly inhibited after fibrillar proteins (rVP1, F-HSA, and F-BSA) treatment in vitro. In addition, rVP1 can significantly suppress murine and human breast cancer metastasis and human prostate and ovarian cancer metastasis in vivo while F-HSA can significantly suppress murine breast cancer metastasis. Compositions of fibrillar proteins as anti-cancer metastasis therapeutics and methods of use thereof are provided herein.
摘要翻译：提供抑制癌症转移的方法。癌症转移是癌症患者治疗失败和死亡的最常见原因。在纤维状蛋白（rVP1，F-HSA和F-BSA）体外处理后，可以显着抑制肿瘤细胞侵袭和/或迁移。另外，rVP1可以显着抑制鼠体内人乳腺癌转移和人前列腺癌和卵巢癌转移，而F-HSA可显着抑制鼠乳腺癌转移。本文提供了作为抗癌转移治疗剂的原纤维蛋白的组合物及其使用方法。

10. 发明授权

US07488800B2 Apoptosis-inducing polypeptides 有权
标题翻译：细胞凋亡诱导多肽
公开(公告)号：US07488800B2
公开(公告)日：2009-02-10
申请号：US11947935
申请日：2007-11-30
申请人： Shu-Mei Liang , Jei-Ming Peng , Chi-Ming Liang
发明人： Shu-Mei Liang , Jei-Ming Peng , Chi-Ming Liang
IPC分类号： C07K14/00
CPC分类号： C07K14/005 , A61K31/7088 , A61K38/162 , A61K39/00 , A61K39/12 , A61K39/135 , A61K2039/523 , C07K1/1136 , C12N2770/32122 , C12N2770/32133
摘要： An isolated water-soluble VP1 polypeptide of foot-and-mouth disease virus and a nucleic acid encoding the polypeptide. Also disclosed are a pharmaceutical composition containing the polypeptide or nucleic acid and related methods of inducing apoptosis and treating an apoptosis-related disorder.
摘要翻译：口蹄疫病毒的分离的水溶性VP1多肽和编码该多肽的核酸。还公开了含有多肽或核酸的药物组合物和诱导凋亡和治疗凋亡相关病症的相关方法。

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