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1. 发明授权

US08512559B2 Device, method, and system for separation and detection of biomolecules and cells 有权
标题翻译：用于分离和检测生物分子和细胞的装置，方法和系统
公开(公告)号：US08512559B2
公开(公告)日：2013-08-20
申请号：US11281891
申请日：2005-11-18
申请人： Shriram Ramanathan , Chang-Min Park
发明人： Shriram Ramanathan , Chang-Min Park
IPC分类号： G01N33/553 , C02F1/48
CPC分类号： G01N33/553 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C02F2209/36 , G01N33/54326 , G01N33/5438 , G01N33/569
摘要： Embodiments of the invention relate to device, method, and system for separation and/or detection of biological cells and biomolecules using micro-channels, magnetic interactions, and magnetic tunnel junctions. The micro-channels can be integrated into a microfluidic device that may be part of an integrated circuit. Magnetic interactions used for the separation are created, in part, by magnetic stripes associated with the micro-channels. Detection of biological cells and biomolecules is effectuated by a magnetic tunnel junction sensor that comprises two ferromagnetic layers separated by a thin insulating layer. The magnetic tunnel junction sensor can be integrated into a silicon based device, such a microfluidic device, an integrated circuit, or a microarray to achieve rapid and specific separation and/or detection of biomolecules and cells.
摘要翻译：本发明的实施方案涉及使用微通道，磁相互作用和磁性隧道结分离和/或检测生物细胞和生物分子的装置，方法和系统。微通道可以集成到可以是集成电路的一部分的微流体装置中。用于分离的磁相互作用部分地由与微通道相关联的磁条产生。生物细胞和生物分子的检测由磁隧道结传感器实现，磁传感器包括由薄绝缘层分隔的两个铁磁层。磁性隧道结传感器可以集成到基于硅的装置，如微流体装置，集成电路或微阵列中，以实现生物分子和细胞的快速和特异性分离和/或检测。

2. 发明授权

US07800371B2 Portable NMR device and method for making and using the same 有权
标题翻译：便携式NMR装置及其制造和使用方法
公开(公告)号：US07800371B2
公开(公告)日：2010-09-21
申请号：US11851291
申请日：2007-09-06
申请人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
发明人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
IPC分类号： G01V3/00
CPC分类号： G01N24/08 , B82Y30/00 , G01R33/302
摘要： An embodiment of the invention relates to a portable or handheld device for performing NMR analysis. The device comprises a console and a strip which can be placed into the console through a slot or other means. The strip comprises a sample holding place and a microcoil for generating an excitation magnetic field across a sample in the sample holding space. A permanent magnet is provided either by the console or the strip and generates a static magnetic field which, together with the excitation magnetic field, creates NMR within the sample. Other embodiments of the invention also encompass method of performing NMR analysis using the portable device and method of making such devices.
摘要翻译：本发明的实施例涉及用于执行NMR分析的便携式或手持式装置。该装置包括控制台和条，其可以通过槽或其他方式放置到控制台中。条带包括用于在样品保持空间中的样品上产生激发磁场的样品保持位置和微线圈。永久磁铁由控制台或条带提供，并产生一个静磁场，与磁场一起在样品内产生NMR。本发明的其他实施方案还包括使用便携式装置进行NMR分析的方法和制造这种装置的方法。

3. 发明申请

US20070296413A1 PORTABLE NMR DEVICE AND METHOD FOR MAKING AND USING THE SAME 有权
标题翻译：便携式NMR装置及其制造和使用方法
公开(公告)号：US20070296413A1
公开(公告)日：2007-12-27
申请号：US11851291
申请日：2007-09-06
申请人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
发明人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
IPC分类号： G01R33/44
CPC分类号： G01N24/08 , B82Y30/00 , G01R33/302
摘要： An embodiment of the invention relates to a portable or handheld device for performing NMR analysis. The device comprises a console and a strip which can be placed into the console through a slot or other means. The strip comprises a sample holding place and a microcoil for generating an excitation magnetic field across a sample in the sample holding space. A permanent magnet is provided either by the console or the strip and generates a static magnetic field which, together with the excitation magnetic field, creates NMR within the sample. Other embodiments of the invention also encompass method of performing NMR analysis using the portable device and method of making such devices.
摘要翻译：本发明的实施例涉及用于执行NMR分析的便携式或手持式装置。该装置包括控制台和条，其可以通过槽或其他方式放置到控制台中。条带包括用于在样品保持空间中的样品上产生激发磁场的样品保持位置和微线圈。永久磁铁由控制台或条带提供，并产生一个静磁场，与磁场一起在样品内产生NMR。本发明的其他实施方案还包括使用便携式装置进行NMR分析的方法和制造这种装置的方法。

4. 发明申请

US20070221961A1 Forming a hybrid device 有权
标题翻译：形成混合设备
公开(公告)号：US20070221961A1
公开(公告)日：2007-09-27
申请号：US11389860
申请日：2006-03-27
申请人： Chang-Min Park , Shriram Ramanathan
发明人： Chang-Min Park , Shriram Ramanathan
IPC分类号： H01L29/768
CPC分类号： G11C11/15 , H01L25/16 , H01L27/222 , H01L2224/48091 , H01L2924/00014
摘要： In one embodiment, the present invention includes a hybrid device having a first die including a semiconductor device and a second die coupled to the first die, where the second die includes a magnetic structure. The first die may be a semiconductor substrate, while the second die may be a magnetic substrate, and the first die may be stacked on the second die, in one embodiment. Other embodiments are described and claimed.
摘要翻译：在一个实施例中，本发明包括具有包括半导体器件的第一管芯和耦合到第一管芯的第二管芯的混合器件，其中第二管芯包括磁结构。在一个实施例中，第一管芯可以是半导体衬底，而第二管芯可以是磁性衬底，并且第一管芯可以堆叠在第二管芯上。描述和要求保护其他实施例。

5. 发明授权

US07345479B2 Portable NMR device and method for making and using the same 有权
标题翻译：便携式NMR装置及其制造和使用方法
公开(公告)号：US07345479B2
公开(公告)日：2008-03-18
申请号：US11319773
申请日：2005-12-29
申请人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
发明人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
IPC分类号： G01V3/00
CPC分类号： G01N24/08 , B82Y30/00 , G01R33/302
摘要： An embodiment of the invention relates to a portable or handheld device for performing NMR analysis. The device comprises a console and a strip which can be placed into the console through a slot or other means. The strip comprises a sample holding place and a microcoil for generating an excitation magnetic field across a sample in the sample holding space. A permanent magnet is provided either by the console or the strip and generates a static magnetic field which, together with the excitation field, creates NMR within the sample. Other embodiments of the invention also encompass method of performing NMR analysis using the portable device and method of making such devices.
摘要翻译：本发明的实施例涉及用于执行NMR分析的便携式或手持式装置。该装置包括控制台和条，其可以通过槽或其他方式放置到控制台中。条带包括用于在样品保持空间中的样品上产生激发磁场的样品保持位置和微线圈。永久磁铁由控制台或条带提供，并产生静磁场，与磁场一起在样品内产生NMR。本发明的其他实施方案还包括使用便携式装置进行NMR分析的方法和制造这种装置的方法。

6. 发明授权

US07319323B2 Device and method using magnetic pattern on disk 有权
标题翻译：在磁盘上使用磁性图案的设备和方法
公开(公告)号：US07319323B2
公开(公告)日：2008-01-15
申请号：US11394160
申请日：2006-03-31
申请人： Chang-Min Park , Shriram Ramanathan , Kenneth Cadien
发明人： Chang-Min Park , Shriram Ramanathan , Kenneth Cadien
IPC分类号： G01V3/00
CPC分类号： G01N24/08 , G01N24/10 , G01R33/3806 , G01R33/3808 , G01R33/383
摘要： An embodiment of the invention relates to a device for performing NMR or ESR analysis. The device comprises a detection unit, a magnet, and a disk having a magnetic pattern. The detection unit comprises a sample holding space for holding a sample and a microcoil for detecting NMR or ESR signals generated within the sample. The magnet generates a static magnetic field within the sample. The disk and magnetic pattern, when rotating, generate an excitation magnetic field, which, together with the static magnetic field, creates an NMR or ESR within the sample. Other embodiments of the invention encompass methods for performing NMR or ESR analysis using the device and methods of making such devices.
摘要翻译：本发明的一个实施方案涉及用于进行NMR或ESR分析的装置。该装置包括检测单元，磁体和具有磁性图案的盘。检测单元包括用于保持样品的样品保持空间和用于检测在样品内产生的NMR或ESR信号的微线圈。磁体在样品内产生静态磁场。盘和磁图在旋转时产生激励磁场，其与静磁场一起在样品内产生NMR或ESR。本发明的其它实施方案包括使用该装置进行NMR或ESR分析的方法和制备这种装置的方法。

7. 发明申请

US20070167723A1 Optical magnetometer array and method for making and using the same 审中-公开
标题翻译：光学磁力计阵列及其制造和使用方法
公开(公告)号：US20070167723A1
公开(公告)日：2007-07-19
申请号：US11319792
申请日：2005-12-29
申请人： Chang-Min Park , Shriram Ramanathan
发明人： Chang-Min Park , Shriram Ramanathan
IPC分类号： G01R33/02 , A61B5/05
CPC分类号： G01R33/032 , B82Y30/00 , G01R33/0322 , G01R33/24
摘要： An embodiment of the invention relates to a device comprising an array of optical magnetometers. The magnetometers comprise se a light source, a container having a chamber filled with an atomic vapor, and a photo detector capable of detecting optical properties of the atomic vapor. The substrate and the array of the magnetometers are designed such that the magnetometers are able to detect weak magnetic fields. Also, the magnetometers are capable of detecting distinct portions of a magnetic field, such as a non-uniform magnetic field, using a single or a plurality of the magnetometers in the array simultaneously. Other embodiment of the invention include methods of making a device that comprises an array of magnetometers and methods of detecting a magnetic field using the device. The device and method can be used in medical diagnostics, such as detecting biomagnetic activities of the human's heart and brain.
摘要翻译：本发明的实施例涉及一种包括光学磁力计阵列的装置。磁力计包括光源，具有填充有原子蒸气的室的容器和能够检测原子蒸气的光学性质的光电检测器。磁性计的基板和阵列被设计成使得磁力计能够检测弱磁场。此外，磁力计能够同时使用阵列中的单个或多个磁力计来检测磁场的不同部分，例如不均匀的磁场。本发明的其他实施例包括制造包括磁力计阵列的装置的方法和使用该装置检测磁场的方法。该装置和方法可用于医学诊断，例如检测人类心脏和脑的生物磁性活动。

8. 发明申请

US20070152670A1 Portable NMR device and method for making and using the same 有权
标题翻译：便携式NMR装置及其制造和使用方法
公开(公告)号：US20070152670A1
公开(公告)日：2007-07-05
申请号：US11319773
申请日：2005-12-29
申请人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
发明人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
IPC分类号： G01V3/00
CPC分类号： G01N24/08 , B82Y30/00 , G01R33/302
摘要： An embodiment of the invention relates to a portable or handheld device for performing NMR analysis. The device comprises a console and a strip which can be placed into the console through a slot or other means. The strip comprises a sample holding place and a microcoil for generating an excitation magnetic field across a sample in the sample holding space. A permanent magnet is provided either by the console or the strip and generates a static magnetic field which, together with the excitation field, creates NMR within the sample. Other embodiments of the invention also encompass method of performing NMR analysis using the portable device and method of making such devices.
摘要翻译：本发明的实施例涉及用于执行NMR分析的便携式或手持式装置。该装置包括控制台和条，其可以通过槽或其他方式放置到控制台中。条带包括用于在样品保持空间中的样品上产生激发磁场的样品保持位置和微线圈。永久磁铁由控制台或条带提供，并产生静磁场，与磁场一起在样品内产生NMR。本发明的其他实施方案还包括使用便携式装置进行NMR分析的方法和制造这种装置的方法。

9. 发明申请

US20070152669A1 INTEGRATED ON-CHIP NMR AND ESR DEVICE AND METHOD FOR MAKING AND USING THE SAME 有权
标题翻译：集成的片上NMR和ESR装置及其制造和使用方法
公开(公告)号：US20070152669A1
公开(公告)日：2007-07-05
申请号：US11319755
申请日：2005-12-29
申请人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
发明人： Chang-Min Park , Shriram Ramanathan , Patrick Morrow , Kenneth Cadien
IPC分类号： G01V3/00
CPC分类号： G01R33/302 , B82Y30/00 , G01N24/08 , G01N24/10
摘要： An embodiment of the invention relates to an integrated on-chip NMR or ESR device for performing chemical analysis and medical diagnostics. Specifically, the device contains, on a single substrate, a sample holding space, a magnet for generating a static magnetic field across the sample holding space and a microcoil for generating an excitation magnetic field across sample holding space. The magnetic fields are able to create NMR or ESR within a sample in the sample holding space and collect and/or process the signals from the NMR or ESR. The substrate may comprise an array of microcoils and sample holding spaces for performing multiple NMR or ESR analysis, such as multiple DNA analysis. Other embodiments of the invention relate methods for fabrication such devices and methods for performing NMR or ESR analysis using such devices.
摘要翻译：本发明的实施例涉及用于进行化学分析和医学诊断的集成的片上NMR或ESR装置。具体地，该装置在单个基板上包含样品保持空间，用于在样品保持空间上产生静态磁场的磁体和用于在样品保持空间上产生激励磁场的微线圈。磁场能够在样品保持空间中的样品内产生NMR或ESR，并收集和/或处理来自NMR或ESR的信号。底物可以包括用于进行多个NMR或ESR分析的微量线圈和样品保持空间的阵列，例如多重DNA分析。本发明的其它实施例涉及制造这种装置的方法和使用这种装置进行NMR或ESR分析的方法。

10. 发明申请

US20070114180A1 Device, method, and system for separation and detection of biomolecules and cells 有权
标题翻译：用于分离和检测生物分子和细胞的装置，方法和系统
公开(公告)号：US20070114180A1
公开(公告)日：2007-05-24
申请号：US11281891
申请日：2005-11-18
申请人： Shriram Ramanathan , Chang-Min Park
发明人： Shriram Ramanathan , Chang-Min Park
IPC分类号： C02F1/48
CPC分类号： G01N33/553 , B82Y15/00 , B82Y25/00 , B82Y30/00 , C02F2209/36 , G01N33/54326 , G01N33/5438 , G01N33/569
摘要： Embodiments of the invention relate to device, method, and system for separation and/or detection of biological cells and biomolecules using micro-channels, magnetic interactions, and magnetic tunnel junctions. The micro-channels can be integrated into a microfluidic device that may be part of an integrated circuit. Magnetic interactions used for the separation are created, in part, by magnetic stripes associated with the micro-channels. Detection of biological cells and biomolecules is effectuated by a magnetic tunnel junction sensor that comprises two ferromagnetic layers separated by a thin insulating layer. The magnetic tunnel junction sensor can be integrated into a silicon based device, such a microfluidic device, an integrated circuit, or a microarray to achieve rapid and specific separation and/or detection of biomolecules and cells.
摘要翻译：本发明的实施方案涉及使用微通道，磁相互作用和磁性隧道结分离和/或检测生物细胞和生物分子的装置，方法和系统。微通道可以集成到可以是集成电路的一部分的微流体装置中。用于分离的磁相互作用部分地由与微通道相关联的磁条产生。生物细胞和生物分子的检测由磁隧道结传感器实现，磁传感器包括由薄绝缘层分隔的两个铁磁层。磁性隧道结传感器可以集成到基于硅的装置，如微流体装置，集成电路或微阵列中，以实现生物分子和细胞的快速和特异性分离和/或检测。

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