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1. 发明授权

US07842701B2 Pyrazoloquinolone derivative and use thereof 失效
标题翻译：吡唑并喹啉衍生物及其用途
公开(公告)号：US07842701B2
公开(公告)日：2010-11-30
申请号：US10589443
申请日：2005-02-18
申请人： Shoji Fukumoto , Takeshi Yamamoto , Masanori Okaniwa , Toshimasa Tanaka
发明人： Shoji Fukumoto , Takeshi Yamamoto , Masanori Okaniwa , Toshimasa Tanaka
IPC分类号： A61K31/437 , C07D471/06
CPC分类号： C07D471/04
摘要： The present invention provides a pyarzoloquinolone derivative having kinase inhibitory activity. The derivative is represented by the formula: wherein R1 is an aryl group which may be substituted, or an aromatic heterocyclic group which may be substituted; R2 is a hydrogen atom, an amino group which may be substituted, a hydroxy group which may be substituted, or a thiol group which may be substituted; R3, R4, R5 and R6, which may be identical or different, are each (1) a hydrogen atom, (2) a nitro group, (3) a cyano group, (4) a halogen atom, (5) a hydrocarbon group which may be substituted, (6) an amino group which may be substituted, (7) a hydroxy group which may be substituted, or (8) a thiol group which may be substituted; and R3 and R4, R4 and R5, and R5 and R6 may respectively form a ring together with the adjacent carbon atom, or salt thereof.
摘要翻译：本发明提供具有激酶抑制活性的pyarzoloquinolone衍生物。该衍生物由下式表示：其中R1是可被取代的芳基或可被取代的芳族杂环基; R2是氢原子，可被取代的氨基，可被取代的羟基，或可以被取代的硫醇基; R 3，R 4，R 5和R 6可以相同或不同，分别为（1）氢原子，（2）硝基，（3）氰基，（4）卤素原子，（5）可以被取代的基团，（6）可以被取代的氨基，（7）可被取代的羟基，或（8）可以被取代的硫醇基; 并且R 3和R 4，R 4和R 5以及R 5和R 6可以与相邻的碳原子或其盐一起分别形成环。

2. 发明申请

US20070281963A1 Pyrazoloquinolone Derivative And Use Thereof 失效
标题翻译：吡唑并喹啉衍生物及其用途
公开(公告)号：US20070281963A1
公开(公告)日：2007-12-06
申请号：US10589443
申请日：2005-02-18
申请人： Shojl Fukumoto , Takeshi Yamamoto , Masanori Okaniwa , Toshimasa Tanaka
发明人： Shojl Fukumoto , Takeshi Yamamoto , Masanori Okaniwa , Toshimasa Tanaka
IPC分类号： A61K31/435 , A61P35/00 , C07D471/00
CPC分类号： C07D471/04
摘要： The present invention provides a pyarzoloquinolone derivative having kinase inhibitory activity. The derivative is represented by the formula: wherein R1 is an aryl group which may be substituted, or an aromatic heterocyclic group which may be substituted; R2 is a hydrogen atom, an amino group which may be substituted, a hydroxy group which may be substituted, or a thiol group which may be substituted; R3, R4, R5 and R6, which may be identical or different, are each (1) a hydrogen atom, (2) a nitro group, (3) a cyano group, (4) a halogen atom, (5) a hydrocarbon group which may be substituted, (6) an amino group which may be substituted, (7) a hydroxy group which may be substituted, or (8) a thiol group which may be substituted; and R3 and R4, R4 and R5, and R5 and R6 may respectively form a ring together with the adjacent carbon atom, or salt thereof.
摘要翻译：本发明提供具有激酶抑制活性的pyarzoloquinolone衍生物。该衍生物由下式表示：其中R 1为可被取代的芳基，或可被取代的芳族杂环基; R 2是氢原子，可以被取代的氨基，可被取代的羟基或可以被取代的硫醇基; R 3，R 4，R 5，R 6和R 6可以相同或不同，各自为（ 1）氢原子，（2）硝基，（3）氰基，（4）卤素原子，（5）可被取代的烃基，（6）可以被取代的氨基， 7）可被取代的羟基，或（8）可被取代的硫醇基; 和R 3和R 4，R 4和R 5和R 5和/或 >和R 6可以与相邻的碳原子或其盐一起分别形成环。

3. 发明授权

US08697874B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08697874B2
公开(公告)日：2014-04-15
申请号：US13132253
申请日：2009-11-30
申请人： Masanori Okaniwa
发明人： Masanori Okaniwa
IPC分类号： C07D513/04 , A61K31/4365
CPC分类号： C07D513/04
摘要： A compound represented by formula (I) or a salt thereof, which has a potent Raf inhibitory activity. In formula (I), R1 represents an optionally substituted C1-6 alkyl, etc.; X represents —O— or —NR2— (wherein R2 represents a hydrogen atom or a C1-6 alkyl); Y represents a group represented by formula 2 (2i or 2ii) (wherein ring A represents an optionally substituted benzene ring; Z represents a group represented by (1) —NR3CO—W1—, (2) —NR3CO—W1—O—, (3) —NR3CO—W1—O—W2—, (4) —NR3CO—W1—S—, (5) —NR3CO—W1—NR4—, (6) —NR3COO—, (7) —NR3COO—W1—, (8) —NR3CO—CO—, or (9) —NR3CONR4— (wherein R3 and R4 each represents a hydrogen atom, etc., and W1 and W2 each represents an optionally substituted C1-6 alkylene, etc.); and R5 represents an optionally substituted five- or six-membered ring group.
摘要翻译：由式（I）表示的化合物或其盐具有强的Raf抑制活性。在式（I）中，R 1表示任选取代的C 1-6烷基等; X表示-O-或-NR2-（其中R2表示氢原子或C1-6烷基）; Y表示由式2（2i或2ii）表示的基团（其中环A表示任选取代的苯环; Z表示由（1）-NR 3 CO-W 1表示的基团，（2）-NR 3 CO-W1-O-，（3）-NR3CO-W1-O-W2-，（4）-NR3CO-W1-S-，（5）-NR3CO-W1-NR4-，（6）-NR3COO-，（7）-NR3COO-W1- ，（8）-NR 3 CO-CO-或（9）-NR 3 CONR 4 - （其中R 3和R 4各自表示氢原子等，并且W 1和W 2各自表示任选取代的C 1-6亚烷基等）;和 R5表示任选取代的五元或六元环基团。

4. 发明授权

US08324395B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08324395B2
公开(公告)日：2012-12-04
申请号：US12674801
申请日：2008-08-22
申请人： Masaaki Hirose , Masanori Okaniwa , Takashi Imada
发明人： Masaaki Hirose , Masanori Okaniwa , Takashi Imada
IPC分类号： A61K31/428 , C07D277/82
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D417/12
摘要： Provided is a heterocyclic compound showing strong Raf inhibitory activity. A compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：提供显示出强的Raf抑制活性的杂环化合物。由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

5. 发明申请

US20110172245A1 HETEROCYCLIC COMPOUND AND USE THEREOF 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US20110172245A1
公开(公告)日：2011-07-14
申请号：US12674801
申请日：2008-08-22
申请人： Masaaki Hirose , Masanori Okaniwa , Takashi Imada
发明人： Masaaki Hirose , Masanori Okaniwa , Takashi Imada
IPC分类号： A61K31/496 , C07D235/32 , A61K31/4184 , C07D263/58 , A61K31/423 , C07D277/82 , A61K31/428 , C07D417/12 , A61P35/00
CPC分类号： C07D235/30 , C07D263/58 , C07D277/82 , C07D417/12
摘要： Provided is a heterocyclic compound showing strong Raf inhibitory activity. A compound represented by the formula wherein each symbol is as defined in the specification, or a salt thereof.
摘要翻译：提供显示出强的Raf抑制活性的杂环化合物。由下式表示的化合物，其中每个符号如说明书中所定义，或其盐。

6. 发明授权

US08497274B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08497274B2
公开(公告)日：2013-07-30
申请号：US13347302
申请日：2012-01-10
申请人： Masanori Okaniwa , Terufumi Takagi , Masaaki Hirose
发明人： Masanori Okaniwa , Terufumi Takagi , Masaaki Hirose
IPC分类号： C07D277/82 , C07D417/00
CPC分类号： C07D277/82 , C07D417/12
摘要： Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity.A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：提供显示出强的Raf抑制活性的稠合杂环衍生物。由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。

7. 发明授权

US08143258B2 Benzothiazole compounds useful for Raf inhibition 有权
标题翻译：可用于Raf抑制的苯并噻唑化合物
公开(公告)号：US08143258B2
公开(公告)日：2012-03-27
申请号：US12628697
申请日：2009-12-01
申请人： Masanori Okaniwa , Terufumi Takagi , Masaaki Hirose
发明人： Masanori Okaniwa , Terufumi Takagi , Masaaki Hirose
IPC分类号： C07D277/82 , C07D417/00
CPC分类号： C07D277/82 , C07D417/12
摘要： Provided is a fused heterocycle derivative showing a strong Raf inhibitory activity.A compound represented by the formula wherein each symbol is as defined in the present specification, or a salt thereof.
摘要翻译：提供显示出强的Raf抑制活性的稠合杂环衍生物。由下式表示的化合物，其中每个符号如本说明书中所定义，或其盐。

8. 发明申请

US20110237620A1 HETEROCYCLIC COMPOUND AND USE THEREOF 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US20110237620A1
公开(公告)日：2011-09-29
申请号：US13132253
申请日：2009-11-30
申请人： Masanori Okaniwa
发明人： Masanori Okaniwa
IPC分类号： A61K31/437 , C07D513/04 , A61K31/444 , A61K31/4545 , A61P35/00
CPC分类号： C07D513/04
摘要： A compound represented by formula (I) or a salt thereof, which has a potent Raf inhibitory activity. In formula (I), R1 represents an optionally substituted C1-6 alkyl, etc.; X represents —O— or —NR2— (wherein R2 represents a hydrogen atom or a C1-6 alkyl); Y represents a group represented by formula 2 (2ii or 2ii) (wherein ring A represents an optionally substituted benzene ring; Z represents a group represented by (1) —NR3CO—W1—, (2) —NR3CO—W1—O—, (3) —NR3CO—W1—O—W2—, (4) —NR3CO—W1—S—, (5) —NR3CO—W1—NR4—, (6) —NR3COO—, (7) —NR3COO—W1—, (8) —NR3CO—CO—, or (9) —NR3CONR4— (wherein R3 and R4 each represents a hydrogen atom, etc., and W1 and W2 each represents an optionally substituted C1-6 alkylene, etc.); and R5 represents an optionally substituted five- or six-membered ring group.
摘要翻译：由式（I）表示的化合物或其盐具有强的Raf抑制活性。在式（I）中，R 1表示任选取代的C 1-6烷基等; X表示-O-或-NR2-（其中R2表示氢原子或C1-6烷基）; Y表示由式2（2ii或2ii）表示的基团（其中环A表示任选取代的苯环; Z表示由（1）-NR 3 CO-W 1表示的基团，（2）-NR 3 CO-W1-O-，（3）-NR3CO-W1-O-W2-，（4）-NR3CO-W1-S-，（5）-NR3CO-W1-NR4-，（6）-NR3COO-，（7）-NR3COO-W1- ，（8）-NR 3 CO-CO-或（9）-NR 3 CONR 4 - （其中R 3和R 4各自表示氢原子等，并且W 1和W 2各自表示任选取代的C 1-6亚烷基等）;和 R5表示任选取代的五元或六元环基团。

9. 发明申请

US20100249119A1 HETEROCYCLIC COMPOUND AND USE THEREOF 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US20100249119A1
公开(公告)日：2010-09-30
申请号：US12675663
申请日：2008-08-28
申请人： Masaaki Hirose , Masanori Okaniwa , Yoko Hayashi , Terufumi Takagi
发明人： Masaaki Hirose , Masanori Okaniwa , Yoko Hayashi , Terufumi Takagi
IPC分类号： A61K31/496 , C07D513/04 , A61K31/437 , A61K31/5377 , A61K31/541 , A61K31/519 , A61P35/00
CPC分类号： C07D471/04 , C07D513/04
摘要： The present invention provides a heterocyclic compound having a strong Raf inhibitory activity, which is represented by the following formula wherein each substituent is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有强Raf抑制活性的杂环化合物，其由下式表示，其中各取代基如本说明书中所定义，或其盐。

10. 发明授权

US08344135B2 Heterocyclic compound and use thereof 有权
标题翻译：杂环化合物及其用途
公开(公告)号：US08344135B2
公开(公告)日：2013-01-01
申请号：US12675663
申请日：2008-08-28
申请人： Masaaki Hirose , Masanori Okaniwa , Yoko Hayashi , Terufumi Takagi
发明人： Masaaki Hirose , Masanori Okaniwa , Yoko Hayashi , Terufumi Takagi
IPC分类号： C07D345/00
CPC分类号： C07D471/04 , C07D513/04
摘要： The present invention provides a heterocyclic compound having a strong Raf inhibitory activity, which is represented by the following formula wherein each substituent is as defined in the present specification, or a salt thereof.
摘要翻译：本发明提供具有强Raf抑制活性的杂环化合物，其由下式表示，其中各取代基如本说明书中所定义，或其盐。

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