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1. 发明授权

US4726947A Bacterial cell extract, process for preparing same, antitumor preparation containing same, and adjuvant preparation containing same 失效
标题翻译：细菌细胞提取物，其制备方法，含有其的抗肿瘤制剂和含有它的佐剂制剂
公开(公告)号：US4726947A
公开(公告)日：1988-02-23
申请号：US271647
申请日：1981-06-08
申请人： Shizuo Shimada , Tadashi Sudo , Hitoshi Inoue , Yoshio Furutani , Yoshikazu Fujisawa
发明人： Shizuo Shimada , Tadashi Sudo , Hitoshi Inoue , Yoshio Furutani , Yoshikazu Fujisawa
IPC分类号： A61K39/04 , A61K35/74 , A61K38/00 , A61K39/39 , A61P35/00 , A61P37/04 , C12P1/04 , A61K39/02 , A61K35/78
CPC分类号： A61K39/39 , A61K35/74 , A61K2039/55594
摘要： Cells of a microorganism, such as Mycobacterium tuberculosis, belonging to the genus Mycobacterium are disrupted in distilled water or a suitable buffer solution, and then centrifuged or filtrated to remove the cell wall residue. To the aqueous cell-free extract is added a polyvalent metal salt or an antibiotic, such as streptomycin sulfate, which acts as a flocculant to form a precipitate. The precipitate consists essentially of sugar, protein, lipid, and nucleic acid. Owing to its high antitumor and adjuvant activities as well as its slight side effects, it can be used as antitumor and adjuvant preparations.
摘要翻译：属于分枝杆菌属的结核分枝杆菌等微生物的细胞在蒸馏水或合适的缓冲溶液中破碎，然后离心或过滤除去细胞壁残留物。向无水细胞提取物中加入多价金属盐或抗生素，如硫酸链霉素，其作为絮凝剂形成沉淀物。沉淀物基本上由糖，蛋白质，脂质和核酸组成。由于其抗肿瘤和佐剂活性高，并具有轻微的副作用，可用作抗肿瘤和辅助制剂。

2. 发明授权

US4515785A Neem bark extracts 失效
标题翻译：楝树皮提取物
公开(公告)号：US4515785A
公开(公告)日：1985-05-07
申请号：US531591
申请日：1983-09-13
申请人： Masaki Shimizu , Tadashi Sudo , Takeo Nomura
发明人： Masaki Shimizu , Tadashi Sudo , Takeo Nomura
IPC分类号： A61K36/00 , A61K36/58 , F16J15/18 , A61K35/78
CPC分类号： A61K36/58
摘要： Neem bark extracts produced by pre-treating the bark of neem with an organic solvent having a dielectric constant of 10 or lower, for example, benzene or ethyl acetate and subjecting the residue obtained by the pre-treatment to extraction with a hydrophilic organic solvent having a dielectric constant from 15 to 35, for example, methanol or ethanol and recovering the neem bark extracts from the hydrophilic organic extraction solvent.
摘要翻译：通过用介电常数为10以下的有机溶剂例如苯或乙酸乙酯预处理楝树皮产生的楝树皮提取物，并将经预处理得到的残余物用亲水性有机溶剂萃取，所述亲水性有机溶剂具有介电常数为15至35，例如甲醇或乙醇，并从亲水性有机萃取溶剂回收楝树皮提取物。

3. 发明授权

US5114712A Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for protecting Pseudomonas aeruginosa infection 失效
标题翻译：作为保护铜绿假单胞菌感染的药剂的铜绿假单胞菌的共同抗原（PSC-A）
公开(公告)号：US5114712A
公开(公告)日：1992-05-19
申请号：US586337
申请日：1990-09-17
申请人： Tamotsu Fukuda , Shiro Shigeta , Hiroaki Okuya , Yasuyuki Kuroiwa , Tadashi Sudo
发明人： Tamotsu Fukuda , Shiro Shigeta , Hiroaki Okuya , Yasuyuki Kuroiwa , Tadashi Sudo
IPC分类号： A61K38/00 , A61K39/00 , C07K14/21 , C07K16/12
CPC分类号： C07K14/21 , C07K16/1214 , A61K38/00 , A61K39/00 , Y10S530/825
摘要： PSC-A is a new serological common antigen to Pseudomonas aeruginosa having very low toxicity, and highly effective for protecting infection by any of the serotypes of Pseudomonas aeruginosa. PSC-A can be used as the active component in a pharmaceutical agent for protecting Pseudomonas aeruginosa infection.
摘要翻译： PSC-A是铜绿假单胞菌的新型血清学常见抗原，毒性非常低，对于保护铜绿假单胞菌血清型的感染非常有效。 PSC-A可用作用于保护铜绿假单胞菌感染的药剂中的活性成分。

4. 发明授权

US4702910A Common antigen (PSC-A) to Pseudomonas aeruginosa which acts as an agent for pretecting Pseudomonas aeruginosa infection 失效
标题翻译：作为预防铜绿假单胞菌感染的药剂的普通抗原（PSC-A）与铜绿假单胞菌
公开(公告)号：US4702910A
公开(公告)日：1987-10-27
申请号：US797796
申请日：1985-11-14
申请人： Tamotsu Fukuda , Shiro Shigeta , Hiroaki Okuya , Yasuyuki Kuroiwa , Tadashi Sudo
发明人： Tamotsu Fukuda , Shiro Shigeta , Hiroaki Okuya , Yasuyuki Kuroiwa , Tadashi Sudo
IPC分类号： G01N33/569 , A61K38/00 , A61K39/00 , A61K39/104 , A61K39/395 , C07K14/005 , C07K14/195 , C07K14/21 , C07K14/41 , C07K16/00 , C07K16/12 , C07K19/00 , C12N15/00 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/385 , C12R1/91 , G01N33/577 , C07K15/04
CPC分类号： C07K16/1214 , C07K14/21 , A61K38/00 , A61K39/00 , Y10S530/825
摘要： PSC-A is a new serological common antigen to Pseudomonas aeruginosa having very low toxicity, and highly effective for protecting infection by any of the serotypes of Pseudomonas aeruginosa. PSC-A can be used as the active component in a pharmaceutical agent for protecting Pseudonomas aeruginosa infection.
摘要翻译： PSC-A是铜绿假单胞菌的新型血清学常见抗原，毒性非常低，对于保护铜绿假单胞菌血清型的感染非常有效。 PSC-A可用作用于保护铜绿假单胞菌感染的药剂中的活性成分。

5. 发明授权

US5443957A Anti-asialo-GM1 monoclonal antibodies and method of use 失效
标题翻译：抗唾液酸GM1单克隆抗体及其使用方法
公开(公告)号：US5443957A
公开(公告)日：1995-08-22
申请号：US225075
申请日：1994-04-08
申请人： Shizio Shimada , Tadashi Sudo , Daiji Iwata
发明人： Shizio Shimada , Tadashi Sudo , Daiji Iwata
IPC分类号： G01N33/574 , C07K14/005 , C07K14/195 , C07K16/00 , C07K16/18 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/577 , G01N33/53 , C07K16/28 , C12N5/20
CPC分类号： C07K16/18
摘要： A monoclonal antibody which reacts with glycolipid asialo GM1 but not with any of glycolipids GM1 and GM2 can be produced by hybridoma cells obtained by fusing antibody-producing cells of a mammal immunized with the glycolipid asialo GM1 with myeloma cells.
摘要翻译：与糖脂脱唾液酸GM1反应但不与任何糖脂GM1和GM2反应的单克隆抗体可以通过将由糖脂脱ial GM1免疫的抗体产生细胞与骨髓瘤细胞融合获得的杂交瘤细胞产生。

6. 发明授权

US4537774A Hot-water extracts of neem bark 失效
标题翻译：楝树皮热水提取物
公开(公告)号：US4537774A
公开(公告)日：1985-08-27
申请号：US541479
申请日：1983-10-13
申请人： Masaki Shimizu , Tadashi Sudo , Takeo Nomura
发明人： Masaki Shimizu , Tadashi Sudo , Takeo Nomura
IPC分类号： A61K36/00 , A61K36/58 , A61K35/78
CPC分类号： A61K36/58
摘要： Hot-water extracts of the neem bark produced by treating the bark of neem with water at a temperature from 0.degree. to 40.degree. C. and subjecting the residue from said pre-extraction treatment to extraction treatment with hot water. Purification of the extract thus produced by means of alcohol precipitation or dialysis gives products of a higher purity. Moreover, treatments prior to the pre-extraction treatment with water at 0.degree.-40.degree. C. with a non-polar organic solvent having a dielectric constant of 10 or lower and a polar organic solvent having a dielectric constant from 15 to 35 yields neem extracts of a further higher purity. The hot-water extracts of the neem bark according to the present invention possess activity against mouse L-5178Y cells and transplanted sarcoma 180 tumors.
摘要翻译：通过在0℃至40℃的温度下用水处理楝树皮产生的楝树皮的热水提取物，并将来自所述预萃取处理的残余物用热水进行提取处理。通过醇沉淀或透析纯化由此产生的提取物，产生更高纯度的产物。此外，在用0至-40℃的水用介电常数为10或更低的非极性有机溶剂和介电常数为15至35的极性有机溶剂进行预萃取处理之前的处理产生neem 提取物具有更高的纯度。根据本发明的楝树皮的热水提取物具有针对小鼠L-5178Y细胞和移植肉瘤180肿瘤的活性。

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