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1. 发明授权

US10696707B2 Polyene macrolide derivative 有权
公开(公告)号：US10696707B2
公开(公告)日：2020-06-30
申请号：US16235262
申请日：2018-12-28
申请人： Shionogi & Co., Ltd.
发明人： Keisuke Miyazaki , Kenji Takaya , Takafumi Ohara , Hideki Sugimoto , Manabu Fujitani , Yuki Ogata , Naoyuki Suzuki
IPC分类号： C07H17/08 , C07H1/00 , C07H23/00
摘要： The present invention is the following Amphotericin B derivative: wherein each symbol is defined in description. The compound of the present invention has 16th position (X) is urea structure, cyclic structure, hydroxyalkyl or substituted monoalkylcarbamoyl. The compound of the present invention has antifungal activity.

2. 发明授权

US09499533B2 Aromatic 5-membered heterocyclic derivative having TRPV4-Inhibiting activity 有权
标题翻译：具有TRPV4抑制活性的芳香族5元杂环衍生物
公开(公告)号：US09499533B2
公开(公告)日：2016-11-22
申请号：US14387387
申请日：2013-03-26
申请人： Shionogi & Co., Ltd.
发明人： Akira Yukimasa , Naotake Kobayashi , Kenji Takaya , Yoshio Hato
IPC分类号： C07D417/04 , C07D417/12 , C07D417/14 , C07D401/04 , C07D401/14 , C07D277/44 , C07D277/46 , C07D277/48 , C07D277/56
CPC分类号： C07D417/14 , C07D277/44 , C07D277/46 , C07D277/48 , C07D277/56 , C07D401/04 , C07D401/14 , C07D417/04 , C07D417/12
摘要： The present invention is related to a compound represented by formula (I) wherein R1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, or the like; X is —N(R3)—, —O—, or —S—; Y is ═C(R4)—, or ═N—; Z is —N(R7)—, —O—, or —S—; R2 is substituted or unsubstituted alkyloxy, or the like, or a group represented by the following formula: —(CR2aR2b)n—R2c, wherein R2a is each independently a hydrogen atom, halogen, or the like; R2b is each independently a hydrogen atom, halogen, or the like; R2a and R2b which are attached to the same carbon atom may be taken together to form oxo, a substituted or unsubstituted non-aromatic carbocycle, or the like; two of R2a which are attached to the adjacent carbon atoms and/or two of R2b which are attached to the adjacent carbon atoms may be taken together to form a bond; R2c is substituted or unsubstituted aromatic carbocyclyl, or the like; n is an integer from 1 to 3; R3 and R7 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; R4 and R5 are each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like; R6 is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.

3. 发明申请

US20150065485A1 SUBSTITUTED POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE 有权
标题翻译：取代的多环碳酰胺衍生物
公开(公告)号：US20150065485A1
公开(公告)日：2015-03-05
申请号：US14536079
申请日：2014-11-07
申请人： Shionogi & Co., Ltd.
发明人： Toshiyuki Akiyama , Kenji Takaya , Makoto Kawai , Yoshiyuki Taoda , Minako Mikamiyama , Kenji Morimoto , Chika Kageyama , Kenji Tomita , Hidenori Mikamiyama , Naoyuki Suzuki
IPC分类号： C07D471/04 , C07D498/14 , C07D471/14
CPC分类号： C07D471/04 , A61K31/53 , C07D471/14 , C07D487/14 , C07D487/20 , C07D498/14
摘要： This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted 3-hydroxy-4-pyridone derivatives having cap-dependent endonuclease inhibitory activity.
摘要翻译：本发明提供具有抗病毒活性的化合物，特别是抑制流感病毒的活性，更优选提供具有cap依赖性内切核酸酶抑制活性的取代的3-羟基-4-吡啶酮衍生物。

4. 发明授权

US10246478B2 Polyene macrolide derivative 有权
公开(公告)号：US10246478B2
公开(公告)日：2019-04-02
申请号：US15315646
申请日：2015-06-12
申请人： Shionogi & Co., Ltd.
发明人： Keisuke Miyazaki , Kenji Takaya , Takafumi Ohara , Hideki Sugimoto , Manabu Fujitani , Yuki Ogata , Naoyuki Suzuki
IPC分类号： C07H17/08 , C07H23/00 , C07H1/00
摘要： The present invention is the following Amphotericin B derivative: wherein each symbol is defined in description. The compound of the present invention has 16th position (X) is urea structure, cyclic structure, hydroxyalkyl or substituted monoalkylcarbamoyl. The compound of the present invention has antifungal activity.

5. 发明申请

US20160368921A1 SUBSTITUTED POLYCYCLIC CARBAMOLYPYRIDONE DERIVATIVE 有权
标题翻译：取代的多环碳酰胺吡啶衍生物
公开(公告)号：US20160368921A1
公开(公告)日：2016-12-22
申请号：US15252791
申请日：2016-08-31
申请人： Shionogi & Co., Ltd.
发明人： Toshiyuki AKIYAMA , Kenji Takaya , Makoto Kawai , Yoshiyuki Taoda , Minako Mikamiyama , Kenji Morimoto , Kenji Tomita , Hidenori Mikamiyama , Naoyuki Suzuki
IPC分类号： C07D471/04 , C07D498/14 , C07D471/14
CPC分类号： C07D471/04 , A61K31/53 , C07D471/14 , C07D487/14 , C07D487/20 , C07D498/14
摘要： This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted 3-hydroxy-4-pyridone derivatives having cap-dependent endonuclease inhibitory activity.
摘要翻译：本发明提供具有抗病毒活性的化合物，特别是抑制流感病毒的活性，更优选提供具有cap依赖性内切核酸酶抑制活性的取代的3-羟基-4-吡啶酮衍生物。

6. 发明申请

US20150038483A1 AROMATIC 5-MEMBERED HETEROCYCLIC DERIVATIVE HAVING TRPV4-INHIBITING ACTIVITY 有权
标题翻译：具有TRPV4抑制活性的芳香五聚体杂环衍生物
公开(公告)号：US20150038483A1
公开(公告)日：2015-02-05
申请号：US14387387
申请日：2013-03-26
申请人： Shionogi & Co., Ltd.
发明人： Akira Yukimasa , Naotake Kobayashi , Kenji Takaya , Yoshio Hato
IPC分类号： C07D417/14 , C07D417/04
CPC分类号： C07D417/14 , C07D277/44 , C07D277/46 , C07D277/48 , C07D277/56 , C07D401/04 , C07D401/14 , C07D417/04 , C07D417/12
摘要： The present invention is related to a compound represented by formula (I) wherein R1 is a hydrogen atom, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, or the like; X is —N(R3)—, —O—, or —S—; Y is ═C(R4)—, or ═N—; Z is —N(R7)—, —O—, or —S—; R2 is substituted or unsubstituted alkyloxy, or the like, or a group represented by the following formula: —(CR2aR2b)n—R2c, wherein R2a is each independently a hydrogen atom, halogen, or the like; R2b is each independently a hydrogen atom, halogen, or the like; R2a and R2b which are attached to the same carbon atom may be taken together to form oxo, a substituted or unsubstituted non-aromatic carbocycle, or the like; two of R2a which are attached to the adjacent carbon atoms and/or two of R2b which are attached to the adjacent carbon atoms may be taken together to form a bond; R2c is substituted or unsubstituted aromatic carbocyclyl, or the like; n is an integer from 1 to 3; R3 and R7 are each independently a hydrogen atom, substituted or unsubstituted alkyl, or the like; R4 and R5 are each independently a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like; R6 is a hydrogen atom, halogen, substituted or unsubstituted alkyl, or the like, or a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising thereof.
摘要翻译：本发明涉及式（I）表示的化合物，其中R 1为氢原子，取代或未取代的烷基，取代或未取代的芳族碳环基等; X是-N（R 3） - ， - O-或-S-; Y为≡C（R4） - 或=N-; Z是-N（R 7） - ， - O-或-S-; R2是取代或未取代的烷氧基等，或由下式表示的基团： - （CR2aR2b）n-R2c，其中R2a各自独立地为氢原子，卤素等; R2b各自独立地为氢原子，卤素等; 连接到相同碳原子上的R 2a和R 2b可以一起形成氧代，取代或未取代的非芳族碳环等; 与相邻碳原子连接的R2a中的两个和/或与相邻碳原子连接的R2b中的两个可以一起形成键; R2c是取代或未取代的芳族碳环基等; n为1〜3的整数， R 3和R 7各自独立地为氢原子，取代或未取代的烷基等; R 4和R 5各自独立地为氢原子，卤素，取代或未取代的烷基等; R6是氢原子，卤素，取代或未取代的烷基等，或其药学上可接受的盐，或其药物组合物。

7. 发明授权

US09815835B2 Substituted polycyclic carbamolypyridone derivative 有权
公开(公告)号：US09815835B2
公开(公告)日：2017-11-14
申请号：US15252791
申请日：2016-08-31
申请人： Shionogi & Co., Ltd.
发明人： Toshiyuki Akiyama , Kenji Takaya , Makoto Kawai , Yoshiyuki Taoda , Minako Mikamiyama , Kenji Morimoto , Kenji Tomita , Hidenori Mikamiyama , Naoyuki Suzuki
IPC分类号： C07D487/14 , C07D487/20 , A61K31/53 , A61P31/16 , C07D471/04 , C07D471/14 , C07D498/14
CPC分类号： C07D471/04 , A61K31/53 , C07D471/14 , C07D487/14 , C07D487/20 , C07D498/14
摘要： This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted 3-hydroxy-4-pyridone derivatives having cap-dependent endonuclease inhibitory activity.

8. 发明授权

US09469638B2 Substituted polycyclic carbamoylpyridone derivative 有权
公开(公告)号：US09469638B2
公开(公告)日：2016-10-18
申请号：US14536079
申请日：2014-11-07
申请人： Shionogi & Co., Ltd.
发明人： Toshiyuki Akiyama , Kenji Takaya , Makoto Kawai , Yoshiyuki Taoda , Minako Mikamiyama , Kenji Morimoto , Kenji Tomita , Hidenori Mikamiyama , Naoyuki Suzuki
IPC分类号： C07D487/04 , A61K31/53 , A61P31/16 , C07D471/04 , C07D471/14 , C07D498/14
CPC分类号： C07D471/04 , A61K31/53 , C07D471/14 , C07D487/14 , C07D487/20 , C07D498/14
摘要： This invention provides compounds having antiviral activities especially inhibiting activity for influenza virus, more preferably provides substituted 3-hydroxy-4-pyridone derivatives having cap-dependent endonuclease inhibitory activity.

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