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    • 3. 发明授权
    • Methods for producing L-aspartic acid
    • 生产L-天冬氨酸的方法
    • US06821760B1
    • 2004-11-23
    • US09408142
    • 1999-09-29
    • Masaharu MukouyamaShinzo YasudaSatomi Komatsuzaki
    • Masaharu MukouyamaShinzo YasudaSatomi Komatsuzaki
    • C12P1320
    • C12P13/20
    • This invention relates to a method for producing L-aspartic acid comprising treating an ammonium fumarate solution with aspartase to generate an ammonium L-aspartate solution; adding fumaric acid to the solution; and then crystallizing L-aspartic acid from the solution, wherein fumaric acid is added to the ammonium L-aspartate solution after the solution has been heated to 50 to 130° C. in an amount 0.4 to 0.8 times the total amount of fumarate and the L-aspartate contained therein in terms of mole, and the resultant mixture is once turned into a homogeneous solution by applying thereto a shearing force, and then L-aspartic acid is deposited therefrom, or wherein the solution is cooled at a rate of 0.1-5° C./min from the temperature at which fumaric acid is added thereto to the temperature at which crystallized L-aspartic acid is separated therefrom, to thereby deposit L-aspartic acid.
    • 本发明涉及L-天冬氨酸的制造方法,其特征在于,包括用天冬氨酸酶处理富马酸铵溶液,生成L-天冬氨酸铵溶液; 向溶液中加入富马酸; 然后从溶液中结晶L-天冬氨酸,其中在将溶液加热至50至130℃之后,将富马酸加入到L-天冬氨酸铵溶液中,其量为富马酸盐总量的0.4至0.8倍, L-天冬氨酸以摩尔计含有,通过施加剪切力将所得混合物一次变成均匀溶液,然后从其中沉积L-天冬氨酸,或其中溶液以0.1- 从其中加入富马酸的温度至结晶的L-天冬氨酸与其分离的温度为5℃/ min,从而沉积L-天冬氨酸。