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1. 发明授权

US07018613B2 Preparations for evaluating eliminative ability of stomach 失效
公开(公告)号：US07018613B2
公开(公告)日：2006-03-28
申请号：US10275072
申请日：2001-04-25
申请人： Shinsuke Nakagawa , Keigo Yamada , Masateru Miyake , Makoto Inada , Nobuhiro Ikei , Atsunari Noda , Hideji Nonomura
发明人： Shinsuke Nakagawa , Keigo Yamada , Masateru Miyake , Makoto Inada , Nobuhiro Ikei , Atsunari Noda , Hideji Nonomura
IPC分类号： A61K51/00
CPC分类号： A61K51/1206 , A61K51/12
摘要： Preparations whereby reduction or acceleration of the gastric emptying rate can be noninvasively evaluated: and a method of evaluating the gastric emptying rate by using these preparations. Thus, reduction or acceleration of the gastric emptying rate can be safely and conveniently examined. Namely, theses preparations are useful in objectively diagnosing the gastric motor function, as well as in evaluating and judging the drug effect or therapeutic effect of a drug concerning the gastric motor function on individual patients.

2. 发明申请

US20060153771A1 Preparations for measuring gastric emptying ability 审中-公开
标题翻译：测量胃排空能力的准备
公开(公告)号：US20060153771A1
公开(公告)日：2006-07-13
申请号：US11290701
申请日：2005-12-01
申请人： Shinsuke Nakagawa , Keigo Yamada , Masateru Miyake , Makoto Inada , Nobuhiro Ikei , Atsunari Noda , Hideji Nonomura
发明人： Shinsuke Nakagawa , Keigo Yamada , Masateru Miyake , Makoto Inada , Nobuhiro Ikei , Atsunari Noda , Hideji Nonomura
IPC分类号： A61K49/00
CPC分类号： A61K51/1206 , A61K51/12
摘要： Preparations whereby reduction or acceleration of the gastric emptying rate can be noninvasively evaluated: and a method of evaluating the gastric emptying rate by using these preparations. Thus, reduction or acceleration of the gastric emptying rate can be safely and conveniently examined. Namely, theses preparations are useful in objectively diagnosing the gastric motor function, as well as in evaluating and judging the drug effect or therapeutic effect of a drug concerning the gastric motor function on individual patients.
摘要翻译：可以非侵入性地评价胃排空速度的降低或加速的制剂，以及使用这些制剂评价胃排空率的方法。因此，可以安全且方便地检查胃排空速度的减少或加速。即，这些制剂可用于客观地诊断胃运动功能，以及评估和判断药物对单个患者胃运动功能的影响或治疗效果。

3. 发明授权

US07368277B2 Method for assay of antibodies and antibody assay device 有权
标题翻译：抗体测定方法和抗体测定装置
公开(公告)号：US07368277B2
公开(公告)日：2008-05-06
申请号：US10386562
申请日：2003-03-13
申请人： Tetsuya Tachikawa , Atsunari Noda , Kiyonori Katsuragi
发明人： Tetsuya Tachikawa , Atsunari Noda , Kiyonori Katsuragi
IPC分类号： A63B69/18
CPC分类号： G01N33/6857 , G01N33/5306 , G01N33/54393 , G01N33/558 , G01N33/56916 , G01N2333/245 , Y10S435/849 , Y10S435/948 , Y10S435/96 , Y10S435/962 , Y10S436/824
摘要： The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the invention provides an antibody immunoassay method in which the antigen-antibody reaction between a target antibody in a sample and an assay antigen is conducted in the presence of an E. coli component and an antibody assay method which comprises using a reagent having a specific affinity for the Fc region of an antibody IgG as the antibody assay reagent. The invention further provides an antibody assay device comprising a solid-phase support having at least (a) a first region to which a sample is applied and (b) a second region where the antibody in the sample is reacted as disposed in such an arrangement that the sample is wicked from the first region to the second region and a labeling means for detection of the result of the reaction in the second region, characterized in that the (b) second region is provided with (i) a test site in which a ligand for capturing the target antibody to be assayed is immobilized and (ii) a control site in which a ligand for capturing an arbitrary antibody occurring in the sample is immobilized.
摘要翻译：本发明涉及可以高精度，便利和特异性地测定针对体液中感染源的抗体的技术。更具体地，本发明提供一种抗体免疫测定方法，其中样品中的靶抗体与测定抗原之间的抗原 - 抗体反应在大肠杆菌成分和抗体测定方法的存在下进行，所述方法包括使用具有对抗体IgG的Fc区的特异亲和力作为抗体测定试剂。本发明进一步提供一种抗体测定装置，其包含至少具有（a）施加样品的第一区域的固相载体和（b）第二区域，其中样品中的抗体以这种布置方式设置样品从第一区域恶化到第二区域，以及用于检测第二区域中的反应结果的标记装置，其特征在于，（b）第二区域设置有（i）测试位置，其中固定用于捕获要测定的靶抗体的配体，（ii）固定用于捕获样品中发生的任意抗体的配体的对照位点。

4. 发明授权

US07201891B1 Pharmaceutical preparation for the diagnosis of helicobacter pylori infection 有权
标题翻译：用于诊断幽门螺杆菌感染的药物制剂
公开(公告)号：US07201891B1
公开(公告)日：2007-04-10
申请号：US09650749
申请日：2000-08-30
申请人： Kyoko Tsuchiya , Akio Okamura , Junichi Kawasaki , Shinichiro Uno , Atsunari Noda , Satoshi Nishiwaki
发明人： Kyoko Tsuchiya , Akio Okamura , Junichi Kawasaki , Shinichiro Uno , Atsunari Noda , Satoshi Nishiwaki
IPC分类号： A61B5/055
CPC分类号： G01N33/56922
摘要： A coated preparation for the detection of a H. pylori infection according to a urea breath test protocol which comprises a core composition containing at least an isotope C-labeled urea, an excipient and a lubricant in defined proportions and covered with 0.1˜10 weight % of a coating agent based on 100 weight % of the core composition. With this preparation, the influence of the urease-producing bacteria resident in organs other than the stomach, such as the mouth and throat, is excluded to enable a diagnosis of H. pylori infection without the risk for a false-positive test and with reasonable rapidity.
摘要翻译：一种用于根据尿素呼吸测试方案检测幽门螺杆菌感染的包衣制剂，其包含含有至少同位素C标记的尿素，赋形剂和润滑剂的核心组合物，其含有一定比例的并且覆盖有0.1〜10重量％的基于100重量％的芯组合物的涂布剂。在这种制剂中，除了胃和胃部以外的器官中，例如口腔和咽喉部分的尿素酶生产细菌的影响被排除，以便能够诊断幽门螺杆菌感染而没有假阳性试验的风险，并且具有合理的速度快

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