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1. 发明授权

US06299912B1 Preparation for administration to animals and feeding method thereof 失效
标题翻译：给予动物的制剂及其饲养方法
公开(公告)号：US06299912B1
公开(公告)日：2001-10-09
申请号：US09556460
申请日：2000-04-24
申请人： Shinobu Ito , Kuniaki Shimbo , Eiji Ogata
发明人： Shinobu Ito , Kuniaki Shimbo , Eiji Ogata
IPC分类号： A23K100
CPC分类号： A23K50/80 , A23K20/174 , A23K20/189 , A23K50/00 , A23K50/10 , A23K50/40 , A23K50/75 , Y10S426/805 , Y10S426/807
摘要： A preparation for administration to animals, comprising a sparingly soluble L-ascorbic acid-2-phosphoric ester salt having a solubility in water of 10 wt % or less, the solubility being a value obtained by placing 100 g of purified water in a 200 ml-volume beaker, stirring the water while keeping the temperature at 20° C., adding 0.1 g of the L-ascorbic acid-2-phosphoric ester salt every 5 minutes by taking care not to cause gelation, and 30 minutes after the addition of L-ascorbic acid-2-phosphoric ester salt when the undissolved L-ascorbic acid-2-phosphoric ester salt is observed visually in the aqueous solution, determining the amount in weight percentage of L-ascorbic acid-2-phosphoric ester salt added based on water, and a method for feeding animals, using the preparation.
摘要翻译：一种用于给予动物的制剂，其包含在水中的溶解度为10重量％以下的微溶L-抗坏血酸-2-磷酸酯盐，其溶解度为将100g纯化水放入200ml 在保持温度为20℃的同时搅拌水，每5分钟加入0.1g L-抗坏血酸-2-磷酸酯盐，注意不引起凝胶化，加入后30分钟在水溶液中观察未溶解的L-抗坏血酸-2-磷酸酯盐时，测定L-抗坏血酸-2-磷酸酯盐的重量百分比量在水上，以及饲养动物的方法。

2. 发明授权

US06635253B2 Composition for enhancing immunological effects 失效
标题翻译：用于增强免疫学效果的组合物
公开(公告)号：US06635253B2
公开(公告)日：2003-10-21
申请号：US09794161
申请日：2001-02-28
申请人： Shinobu Ito , Eiji Ogata
发明人： Shinobu Ito , Eiji Ogata
IPC分类号： A61K3938
CPC分类号： A61K47/24 , A61K9/0019 , A61K31/375 , A61K31/665 , A61K39/39 , A61K45/06 , A61K47/22 , A61K2039/55511
摘要： An object of the present invention is to provide a composition for enhancing the immunological effects of a vaccine for viruses, bacteria and/or infectious disease pathogens, containing a stable activity-type provitamin; a method for enhancing the immunological effects of a vaccine for viruses, bacteria and/or infectious disease pathogens by administering the composition; and a method of employing the composition. A composition for enhancing the immunological effects of a vaccine for viruses, bacteria and/or infectious disease pathogens, contains L-ascorbic acid-2-phosphate and/or &agr;-tocopheryl phosphate as a stable activity antioxidant provitamin.
摘要翻译：本发明的目的是提供一种用于增强含有稳定的活性型前病毒的病毒，细菌和/或感染性疾病病原体的疫苗的免疫效果的组合物; 通过施用组合物来增强疫苗对病毒，细菌和/或感染性疾病病原体的免疫效果的方法; 和采用该组合物的方法。用于增强疫苗对病毒，细菌和/或感染性疾病病原体的免疫效果的组合物含有L-抗坏血酸-2-磷酸和/或α-生育酚磷酸酯作为稳定活性的抗氧化剂前维生素。

3. 发明授权

US6127409A Ascorbic acid derivative and vitamin C preparation containing the same 失效
标题翻译：抗坏血酸衍生物和含有相同的维生素C制剂
公开(公告)号：US6127409A
公开(公告)日：2000-10-03
申请号：US70012
申请日：1998-04-30
申请人： Masahiro Suzuki , Toshi Tsuzuki , Shinobu Ito , Eiji Ogata
发明人： Masahiro Suzuki , Toshi Tsuzuki , Shinobu Ito , Eiji Ogata
IPC分类号： A61K8/67 , A61Q19/00 , C07F9/655 , A01N43/08 , C07D307/02
CPC分类号： C07F9/65515 , A61K8/676 , A61Q19/00 , A61K2800/52
摘要： A novel ascorbic acid derivative having both sufficiently improved stability and liposolubility, and facilitated cellular uptake. Also disclosed is a process for producing the derivative and a composition capable of effectively providing the action of vitamin C, for use in medical preparations, agricultural chemicals, animal drugs, foods, feeds or cosmetic preparations. The ascorbic acid derivative is a compound represented by the following formula (1) or a salt thereof: ##STR1## wherein R represents an acyl group having eleven or more carbon atoms and n is 0, 1 or 2.
摘要翻译：具有足够改善的稳定性和脂溶性的新型抗坏血酸衍生物，促进细胞摄取。还公开了一种生产该衍生物的方法和能够有效提供维生素C作用的组合物，用于医疗制剂，农药，动物药物，食品，饲料或化妆品制剂。抗坏血酸衍生物是由下式（1）表示的化合物或其盐：其中R表示具有11个或更多个碳原子且n为0,1或2的酰基。

4. 发明授权

US5869525A Ascorbic acid drugs for intracerebral administration 失效
标题翻译：抗坏血酸药物用于脑内给药
公开(公告)号：US5869525A
公开(公告)日：1999-02-09
申请号：US647767
申请日：1996-05-15
申请人： Shinobu Ito , Eiji Ogata , Nobuhiko Miwa
发明人： Shinobu Ito , Eiji Ogata , Nobuhiko Miwa
IPC分类号： A61K31/375 , A61K31/34 , A61K31/70 , A61K31/715
CPC分类号： A61K31/375
摘要： An L-ascorbic acid drug for intracerebral administration comprising one or more stable activity L-ascorbic acid compounds and one or more blood brainbarrier deobstruents. Also disclosed is a method for increasing intracerebral concentration of L-ascorbic acid in a human being comprising administering by injection an L-ascorbic acid drug comprising one or more stable activity L-ascorbic acid compounds. Additionally disclosed is a method for increasing intracerebral concentration of L-ascorbic acid in a human being comprising administering by injection an L-ascorbic acid drug comprising one or more stable activity L-ascorbic acid compounds and one or more blood brainbarrier deobstruents. Also disclosed is a method for treating diseases or disorders that result from intracerebral bloodstream inhibition or intracerebral bloodstream lowering comprising administering by injection to a person in need of such treatment, a dosage effective amount of an L-ascorbic acid drug comprising one or more stable activity L-ascorbic acid compounds. Additionally disclosed is a method for treating diseases or disorders that result from intracerebral bloodstream inhibition or intracerebral bloodstream lowering comprising administering by injection to a person in need of such treatment, a dosage effective amount of an L-ascorbic acid drug comprising one or more stable activity L-ascorbic acid compounds and one or more blood brainbarrier deobstruents.
摘要翻译：一种用于脑内给药的L-抗坏血酸药物，其包含一种或多种稳定的活性L-抗坏血酸化合物和一种或多种血液脑阻滞剂。还公开了增加人体中L-抗坏血酸的脑内浓度的方法，包括通过注射施用包含一种或多种稳定活性L-抗坏血酸化合物的L-抗坏血酸药物。另外公开了一种增加人抗坏血酸的脑内浓度的方法，包括通过注射施用包含一种或多种稳定的活性L-抗坏血酸化合物和一种或多种血脑屏障去除剂的L-抗坏血酸药物。还公开了一种用于治疗由脑内血流抑制或脑内血流降低引起的疾病或病症的方法，其包括通过注射给予需要这种治疗的人，剂量有效量的包含一种或多种稳定活性的L-抗坏血酸药物 L-抗坏血酸化合物。另外公开了一种治疗由脑内血流抑制或脑内血流降低引起的疾病或病症的方法，其包括通过注射给予需要这种治疗的人，剂量有效量的包含一种或多种稳定活性的L-抗坏血酸药物 L-抗坏血酸化合物和一种或多种血脑屏障阻断剂。

5. 发明申请

US20060100178A1 Dermal agent 审中-公开
标题翻译：皮肤试剂
公开(公告)号：US20060100178A1
公开(公告)日：2006-05-11
申请号：US11304577
申请日：2005-12-16
申请人： Eiko Masatsuji , Toshi Tsuzuki , Shinobu Ito , Eiji Ogata
发明人： Eiko Masatsuji , Toshi Tsuzuki , Shinobu Ito , Eiji Ogata
IPC分类号： A61K31/665
CPC分类号： A61K8/27 , A61K8/671 , A61K8/676 , A61K31/315 , A61K31/375 , A61K31/555 , A61K33/30 , A61K45/06 , A61K2800/75 , A61Q19/00 , A61K2300/00
摘要： A dermal agent for preventing or treating acne, comprising an ascorbic acid derivative which liberates in vivo ascorbic acid, and a zinc salt or comprising a zinc salt of the ascorbic acid-2-phosphate, and a composition comprising tretinoin and an ascorbic acid derivative or a salt thereof, relieving in the irritation of tretinoin by using the dermal agent and tretinoin in combination.
摘要翻译：一种用于预防或治疗痤疮的真皮剂，其包含在体内抗坏血酸中释放的抗坏血酸衍生物，以及锌盐或包含抗坏血酸-2-磷酸锌的锌盐，以及包含维甲酸和抗坏血酸衍生物的组合物，或其盐，通过组合使用真皮剂和维甲酸来缓解维A酸的刺激。

6. 发明授权

US5965750A High- purity tocopherol phosphates, process for the preparation thereof, methods for analysis thereof, and cosmetics 失效
公开(公告)号：US5965750A
公开(公告)日：1999-10-12
申请号：US849052
申请日：1997-05-29
申请人： Yutaka Oonishi , Tsutomu Nozawa , Takami Ooe , Keisuke Mano , Naoaki Misu , Yohei Kurata , Shinobu Ito , Eiji Ogata
发明人： Yutaka Oonishi , Tsutomu Nozawa , Takami Ooe , Keisuke Mano , Naoaki Misu , Yohei Kurata , Shinobu Ito , Eiji Ogata
IPC分类号： A61K8/02 , A61K8/67 , A61Q1/02 , A61Q1/04 , A61Q5/02 , A61Q7/00 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C07F9/655 , G01N30/02 , G01N30/88 , G01N33/82 , C07F9/06
CPC分类号： G01N33/82 , A61K8/0212 , A61K8/678 , A61Q19/00 , C07F9/65522 , A61Q1/02 , A61Q1/04 , A61Q11/00 , A61Q19/10 , A61Q5/02 , A61Q7/00 , G01N2030/884 , G01N30/02 , Y10S514/846
摘要： Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.

7. 发明授权

US5937790A Anti-stress agent for animals and a method of reducing stress in animals 失效
标题翻译：动物用抗压剂和减轻动物压力的方法
公开(公告)号：US5937790A
公开(公告)日：1999-08-17
申请号：US993714
申请日：1997-12-18
申请人： Shinobu Ito , Eiji Ogata , Masahiro Yamada
发明人： Shinobu Ito , Eiji Ogata , Masahiro Yamada
IPC分类号： A61K31/70 , A01K29/00 , A23K1/165 , A23K1/17
CPC分类号： A61K31/70
摘要： An anti-stress agent for animals for reducing the growth inhibition or mortality of animals and a method of reducing stress using a feed composition having blended therein the anti-stress agent. The anti-stress agent for animals comprises one or more substances selected from L-ascorbic acid-2-phosphoric acid, a salt thereof and an L-ascorbic acid-2-glucoside, as an active ingredient, for inhibiting the increase of blood plasma lactate dehydrogenase (LDH), malate dehydrogenase (MDH) and aspartate aminotransferase (AspAT) and for inhibiting the increase of stress proteins in blood, which occur when animals are placed under stress. Also disclosed is a feed composition comprising the anti-stress agent, and a method of reducing the stress of animals by supplying the same as feed.
摘要翻译：用于降低动物的生长抑制或死亡率的动物的抗应激剂和使用其中混合有抗应激剂的饲料组合物来降低应激的方法。用于动物的抗应激剂包含选自L-抗坏血酸-2-磷酸，其盐和L-抗坏血酸-2-葡萄糖苷作为活性成分的一种或多种物质，用于抑制血浆中的增加乳酸脱氢酶（LDH），苹果酸脱氢酶（MDH）和天冬氨酸氨基转移酶（AspAT），并用于抑制动物在压力下发生的血液中应激蛋白的增加。还公开了包含抗应激剂的饲料组合物，以及通过将饲料作为饲料供应来减少动物的压力的方法。

8. 发明授权

US06437002B1 Agent for preventing and treating skin diseases 失效
标题翻译：预防和治疗皮肤病的药剂
公开(公告)号：US06437002B1
公开(公告)日：2002-08-20
申请号：US09418317
申请日：1999-10-14
申请人： Shinobu Ito , Eiji Ogata , Hiroshi Ikeno
发明人： Shinobu Ito , Eiji Ogata , Hiroshi Ikeno
IPC分类号： A61K3100
CPC分类号： C07F9/65515 , A61K8/11 , A61K8/14 , A61K8/676 , A61K9/127 , A61K31/7048 , A61K2800/412 , A61K2800/522 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07D307/62
摘要： The present invention relates to an agent for preventing and treating skin diseases comprising as an active ingredient an ascorbic acid derivative which is a compound represented by the following formula (1) or a salt thereof and which per se exhibits no anti-oxidation activity but is capable of transforming in vivo into a compound having an anti-oxidation activity; wherein R1 represents a group capable of bonding to the carbon at the 2-position of the ascorbic acid skeleton through an ether or ester bond and transformable in vivo into a hydroxyl group, and R2 to R4 may be the same or different and each represents a hydroxyl group or a group derived therefrom.
摘要翻译：本发明涉及一种用于预防和治疗皮肤疾病的药剂，其包含作为活性成分的作为下式（1）表示的化合物的抗坏血酸衍生物或其盐，本身不具有抗氧化活性，能够在体内转化成具有抗氧化活性的化合物;其中R1表示能够通过醚或酯键与抗坏血酸骨架的2-位上的碳键合并在体内可转化为羟基的基团，R 2〜R 4可以相同或不同，表示羟基或由其衍生的基团。

9. 发明授权

US06420419B1 L-ascorbic acid 2-phosphate zinc salt and process for manufacturing the same 失效
标题翻译： L-抗坏血酸2-磷酸锌盐及其制造方法
公开(公告)号：US06420419B1
公开(公告)日：2002-07-16
申请号：US09095895
申请日：1998-06-11
申请人： Masahiro Suzuki , Toshi Tsuzuki , Shinobu Ito , Eiji Ogata
发明人： Masahiro Suzuki , Toshi Tsuzuki , Shinobu Ito , Eiji Ogata
IPC分类号： A61K31341
CPC分类号： A61K31/665 , C07D307/62
摘要： L-Ascorbic acid 2-phosphate zinc salt and a salt hydrate thereof having excellent solubility and exhibiting good stability even under weakly acidic conditions. Also disclosed is a process of manufacturing L-ascorbic acid 2-phosphate zinc salt by displacing a cation of a salt of an L-ascorbic acid 2-phosphate other than a zinc salt with a zinc cation. Further disclosed is a composition containing L-ascorbic acid 2-phosphate zinc salt or a salt hydrate thereof as an active ingredient.
摘要翻译： L-抗坏血酸2-磷酸锌盐及其盐水合物，即使在弱酸性条件下也具有优异的溶解性和良好的稳定性。还公开了通过用锌阳离子置换除了锌盐之外的L-抗坏血酸2-磷酸盐的阳离子来制造L-抗坏血酸2-磷酸锌盐的方法。进一步公开了含有L-抗坏血酸2-磷酸锌盐或其盐水合物作为活性成分的组合物。

10. 发明授权

US6046181A Highly purified tocopheryl phosphate, process for producing the same, analytical method therefor and cosmetic 有权
标题翻译：高纯度生育磷酸酯，其生产方法，分析方法和化妆品
公开(公告)号：US6046181A
公开(公告)日：2000-04-04
申请号：US342228
申请日：1999-06-29
申请人： Yutaka Oonishi , Tsutomu Nozawa , Takami Ooe , Keisuke Mano , Naoaki Misu , Yohei Kurata , Shinobu Ito , Eiji Ogata
发明人： Yutaka Oonishi , Tsutomu Nozawa , Takami Ooe , Keisuke Mano , Naoaki Misu , Yohei Kurata , Shinobu Ito , Eiji Ogata
IPC分类号： A61K8/02 , A61K8/67 , A61Q1/02 , A61Q1/04 , A61Q5/02 , A61Q7/00 , A61Q11/00 , A61Q19/00 , A61Q19/10 , C07F9/655 , G01N30/02 , G01N30/88 , G01N33/82 , A61K7/035 , A61K7/00 , A61K7/02 , A61K7/021 , A61K7/027
CPC分类号： G01N33/82 , A61K8/0212 , A61K8/678 , A61Q19/00 , C07F9/65522 , A61Q1/02 , A61Q1/04 , A61Q11/00 , A61Q19/10 , A61Q5/02 , A61Q7/00 , G01N2030/884 , G01N30/02 , Y10S514/846
摘要： Disclosed herein are a highly purified tocopheryl phosphate and/or a salt thereof (tocopheryl phosphates) wherein a P,P'-bistocopheryl hypophosphate and/or a salt thereof (P,P'-bistocopheryl diphoshates) is contained in a proportion of not higher than 3% by weight; a process for producing a highly purified tocopheryl phosphate and/or a salt thereof, which comprises the steps of reacting a tocopherol with an oxyphosphorus trihalide followed by treating with an acid or basic aqueous solution to thereby form tocopheryl phosphates (i) in which P,P'-bistocopheryl diphoshates (ii) formed as by-products are contained, hydrolyzing the P,P'-bistocopheryl diphoshates (ii) under acid condition, and, optionally, rendering the hydrolyzate neutral or basic under basic condition; and a method of analyzing tocopheryl phosphates, comprising analyzing a sample containing components (i) and (ii) with the use of a high-performance liquid chromatograph column packed with a gel of a polymethacrylate having, bonded thereto, long-chain alkyl groups. None or only an extremely minute amount of P,P'-bistocopheryl diphoshates are contained in the highly purified tocopheryl phosphates, so that the highly purified tocopheryl phosphates exhibit antioxidant and blood circulation promoting effects, have excellent water solubility, are powdery so that the handling thereof is extremely easy, are free from cutaneous irritation and allergenecity and ensure dermal safety. Therefore, the highly purified tocopheryl phosphates are useful as cosmetic ingredients. The amounts of components (i) and (ii) can be simply measured with high accuracy by the above method.
摘要翻译：本文公开了高纯度的生育磷酸酯和/或其盐（生育磷酸酯），其中P，P'-二生育酚低磷酸盐和/或其盐（P，P'-二生育基二磷酸酯）的含量不高于超过3％重量; 一种生产高纯度生育磷酸酯和/或其盐的方法，其包括使生育酚与三卤氧磷反应，然后用酸或碱性水溶液处理，从而形成生育磷酸酯（i），其中P，含有作为副产物形成的P'-二生育基二磷酸酯（ⅱ），在酸性条件下水解P，P'-二生育基二磷酸酯（ⅱ），任选地在碱性条件下使水解产物中性或碱性。以及分析生育磷酸酯的方法，包括使用填充有与其键合的聚甲基丙烯酸酯的凝胶的高效液相色谱柱分析含有成分（i）和（ii）的样品的长链烷基。高纯度的生育磷酸酯中没有或仅有非常少量的P，P'-二生育基二磷酸酯，因此高纯度的生育磷酸酯表现出抗氧化和促进血液循环的作用，具有优异的水溶性，是粉末状的，它非常容易，没有皮肤刺激和过敏原，并确保皮肤安全。因此，高纯度的生育磷酸酯可用作化妆品成分。组分（i）和（ii）的量可以通过上述方法以高精度简单地测量。

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