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1. 发明申请

US20150045550A1 Method For Dehydrating Hydrous Low-Substituted Hydroxypropyl Cellulose and Method for Producing Low-Substituted Hydroxypropyl Cellulose By Using Same 有权
标题翻译：脱水低取代羟丙基纤维素的方法及使用相同方法生产低取代羟丙基纤维素
公开(公告)号：US20150045550A1
公开(公告)日：2015-02-12
申请号：US14454964
申请日：2014-08-08
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Junichi Matsubara , Atsuhiko Yonemochi , Mitsuo Narita
IPC分类号： C08B11/20
CPC分类号： C08B11/20 , C08B11/08
摘要： Reduction of the energy burden in a step of drying hydrous low-substituted hydroxypropyl cellulose (L-HPC), reduction of water content of a cake obtained by dehydration, and others are targeted. More specifically, provided is a method for dehydrating hydrous L-HPC with a compression type dehydrator by feeding the hydrous L-HPC to a screw conveyer connected to the inlet of the dehydrator, including steps of: starting the operation of the conveyer to fill the conveyer and the dehydrator with the hydrous L-HPC, starting the operation of the filled dehydrator, and feeding the hydrous L-HPC to the conveyer, while discharging dehydrated L-HPC from an outlet of the dehydrator, wherein a feed rate of feeding the hydrous L-HPC to the conveyer is equal to a discharge rate of discharging the dehydrated L-HPC in terms of net weight of cellulose ether, and a method for producing L-HPC by using the above method.
摘要翻译：干燥含水低取代羟丙基纤维素（L-HPC）的步骤中的能量负荷的降低，脱水得到的滤饼的水分含量的降低等。更具体地，提供了一种通过将水合L-HPC进料到连接到脱水机的入口的螺旋输送机上的压缩型脱水机来脱水含水L-HPC的方法，包括以下步骤：开始输送机的操作以填充输送机和脱水器与水合L-HPC开始，开始填充脱水器的操作，并且将水合L-HPC输送到输送机，同时从脱水器的出口排放脱水的L-HPC，其中进料速率对于输送机的含水L-HPC等于脱水的L-HPC以纤维素醚的净重排出的排出量，以及使用上述方法生产L-HPC的方法。

2. 发明授权

US11753483B2 Hydroxypropyl methyl cellulose acetate succinate and method for producing the same 有权
公开(公告)号：US11753483B2
公开(公告)日：2023-09-12
申请号：US17083615
申请日：2020-10-29
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Taishi Kitaguchi , Junichi Matsubara , Mitsuhiro Yoshida
IPC分类号： C08B3/16 , B01F7/00 , B01F27/1122 , B01F27/1125 , B01F27/1145
CPC分类号： C08B3/16 , B01F27/1122 , B01F27/1125 , B01F27/1145
摘要： There is provided a method for producing hydroxypropyl methyl cellulose acetate succinate (HPMCAS), including an esterification step of reacting hydroxypropyl methyl cellulose with an acetylating agent and a succinoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCAS; a precipitation step of precipitating the HPMCAS by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCAS; and a washing and recovery step of washing the HPMCAS in the suspension and recovering the washed HPMCAS. Further, there is provided HPMCAS having yellowness at 20° C. of 15.0 or less, as determined in a 2% by mass solution of the HPMCAS in a mixed solvent of dichloromethane, methanol and water in a mass ratio of 44:44:10.

3. 发明申请

US20210130497A1 HYDROXYPROPYL METHYL CELLULOSE ACETATE SUCCINATE AND METHOD FOR PRODUCING THE SAME 有权
公开(公告)号：US20210130497A1
公开(公告)日：2021-05-06
申请号：US17083615
申请日：2020-10-29
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Taishi Kitaguchi , Junichi Matsubara , Mitsuhiro Yoshida
IPC分类号： C08B3/16 , B01F7/00
摘要： There is provided a method for producing hydroxypropyl methyl cellulose acetate succinate (HPMCAS), including an esterification step of reacting hydroxypropyl methyl cellulose with an acetylating agent and a succinoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCAS; a precipitation step of precipitating the HPMCAS by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCAS; and a washing and recovery step of washing the HPMCAS in the suspension and recovering the washed HPMCAS. Further, there is provided HPMCAS having yellowness at 20° C. of 15.0 or less, as determined in a 2% by mass solution of the HPMCAS in a mixed solvent of dichloromethane, methanol and water in a mass ratio of 44:44:10.

4. 发明授权

US10961323B2 Hypromellose phthalate and method for producing hypromellose phthalate 有权
公开(公告)号：US10961323B2
公开(公告)日：2021-03-30
申请号：US15683032
申请日：2017-08-22
申请人： SHIN-ETSU CHEMICAL CO., LTD.
发明人： Mitsuhiro Yoshida , Junichi Matsubara
IPC分类号： C08B3/12 , C08B13/00
摘要： Provided is a method for producing HPMCP capable of reducing the average particle size of HPMCP particles to an intended range without a pulverization step. Specifically provided is a method for producing hypromellose phthalate, comprising an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose phthalate, a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose phthalate, thereby obtaining a hypromellose phthalate suspension, a liquid removal step of removing a liquid from the hypromellose phthalate suspension with a centrifugal decanter to obtain liquid-removed hypromellose phthalate, and a drying step of drying the liquid-removed hypromellose phthalate.

5. 发明授权

US10888525B2 Hypromellose acetate succinate and method for producing the same 有权
公开(公告)号：US10888525B2
公开(公告)日：2021-01-12
申请号：US15797876
申请日：2017-10-30
申请人： SHIN-ETSU CHEMICAL CO., LTD.
发明人： Junichi Matsubara , Naosuke Maruyama , Mitsuhiro Yoshida
IPC分类号： C08B3/16 , A61K9/28 , A61K47/38 , C08B13/00 , A61K31/525
摘要： There are provided HPMCAS (hypromellose acetate succinate) having such a property that a solution of the HPMCAS in a solvent has a controlled viscosity; and a method for producing the HPMCAS. More specifically, provided are HPMCAS having such property that a solution of 10 parts by weight of the HPMCAS in 100 parts by weight of a mixed solvent having a weight ratio of methylene chloride to methanol of 1:1 has a viscosity at 20° C. of 135 mPa·s or less; and a method for producing the HPMCAS including an esterification step of adding acetic anhydride and succinic anhydride to a solution of hypromellose in glacial acetic acid in the presence of sodium acetate to obtain a reaction product mixture, wherein the succinic anhydride is added intermittently, and a precipitation step of mixing the reaction product mixture with water to precipitate the HPMCAS.

6. 发明授权

US11873351B2 Hydroxypropyl methyl cellulose phthalate and method for producing the same 有权
公开(公告)号：US11873351B2
公开(公告)日：2024-01-16
申请号：US17083617
申请日：2020-10-29
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Taishi Kitaguchi , Junichi Matsubara , Mitsuhiro Yoshida
IPC分类号： C08B3/16 , C08B13/00
CPC分类号： C08B3/16
摘要： There is provided a method for producing hydroxypropyl methyl cellulose phthalate (HPMCP), including an esterification step of reacting hydroxypropyl methyl cellulose with a carboxybenzoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCP; a precipitation step of precipitating the HPMCP by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCP; and a washing and recovery step of washing the HPMCP in the suspension and recovering the washed HPMCP. Further, there is provided HPMCP having yellowness at 20° C. of 10.0 or less, as determined in a 10% by mass solution of the HPMCP in acetone.

7. 发明授权

US10934369B2 Hypromellose phthalate and method for producing the same 有权
公开(公告)号：US10934369B2
公开(公告)日：2021-03-02
申请号：US16407871
申请日：2019-05-09
申请人： SHIN-ETSU CHEMICAL CO., LTD.
发明人： Junichi Matsubara , Mitsuhiro Yoshida
IPC分类号： C08B13/00
摘要： There is provided a method for producing hypromellose phthalate (HPMCP) which exhibits an excellent solubility when dissolved in a solvent, while suppressing formation of undissolved matter. More specifically, there is provided a method for producing HPMCP, including an esterification step of esterifying hypromellose dissolved in glacial acetic acid with phthalic anhydride in the presence of sodium acetate at a temperature of from 75 to 100° C. to obtain a reaction product solution; a cooling step of cooling the reaction product solution to 70° C. or lower; and a precipitation step of mixing the cooled reaction product solution with water of from 0 to 40° C. to obtain a suspension of precipitated HPMCP.

8. 发明授权

US10604588B2 Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation 有权
公开(公告)号：US10604588B2
公开(公告)日：2020-03-31
申请号：US15471224
申请日：2017-03-28
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Junichi Matsubara , Naosuke Maruyama , Mitsuhiro Yoshida , Kazuki Kikuchi
IPC分类号： C08B13/00 , A61K9/28 , A61K31/525 , A61K9/50 , A61K47/38
摘要： Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.

9. 发明授权

US10934367B2 Hypromellose acetate succinate and method for producing hypromellose acetate succinate 有权
公开(公告)号：US10934367B2
公开(公告)日：2021-03-02
申请号：US15683222
申请日：2017-08-22
申请人： SHIN-ETSU CHEMICAL CO., LTD.
发明人： Mitsuhiro Yoshida , Junichi Matsubara , Kazuki Kikuchi
IPC分类号： C08B3/06 , C08B13/00 , A61K47/38 , B04B1/20
摘要： Provided is a method for producing HPMCAS capable of reducing the average particle size of HPMCAS particles to an intended range without a pulverization step. Specifically provided is a method for producing hypromellose acetate succinate, comprising an esterification step of reacting hypromellose with an esterification agent in the presence of a catalyst to obtain a reaction solution containing crude hypromellose acetate succinate, a precipitation step of mixing the reaction solution with water to precipitate the crude hypromellose acetate succinate, thereby obtaining a hypromellose acetate succinate suspension, a liquid removal step of removing a liquid from the hypromellose acetate succinate suspension with a centrifugal decanter to obtain liquid-removed hypromellose acetate succinate, and a drying step of drying the liquid-removed hypromellose acetate succinate.

10. 发明授权

US10836836B2 Hypromellose acetate succinate powder excellent in dissolved state and production method thereof, and production methods for composition for solid dispersion, coating composition, drug-containing particle, and solid preparation 有权
公开(公告)号：US10836836B2
公开(公告)日：2020-11-17
申请号：US16789598
申请日：2020-02-13
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Junichi Matsubara , Naosuke Maruyama , Mitsuhiro Yoshida , Kazuki Kikuchi
IPC分类号： C08B13/00 , A61K31/525 , A61K9/50 , A61K9/28 , A61K47/38
CPC分类号： C08B13/00 , A61K9/2866 , A61K9/5042 , A61K9/5089 , A61K31/525 , A61K47/38
摘要： Provided are HPMCAS powder having high solubility when dissolved in a solvent and being capable of suppressing generation of undissolved materials; and a method for producing the powder. More specifically, provided is hypromellose acetate succinate powder having an average ratio of L to D of from 2.0 to 3.0, wherein L and D mean maximum and minimum diameters of each particle, respectively. Also provided is a method for producing a hypromellose acetate succinate, comprising the steps of: dissolving hypromellose powder in a solvent, esterifying the dissolved hypromellose with succinic anhydride and acetic anhydride in the presence of a catalyst to obtain a reaction mixture, and mixing the reaction mixture with water to precipitate hypromellose acetate succinate, wherein the reaction mixture just before being mixed with the water has a viscosity of from 100 to 200 Pa·s.

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