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1. 发明申请

US20060177387A1 Compositions comprising bone marrow cells, demineralized bone matrix and various site-reactive polymers for use in the induction of bone and cartilage formation 审中-公开
标题翻译：包含骨髓细胞，去矿物质骨基质和用于诱导骨和软骨形成的各种位点反应性聚合物的组合物
公开(公告)号：US20060177387A1
公开(公告)日：2006-08-10
申请号：US10526597
申请日：2003-09-04
申请人： Shimon Slavin , Olga Gurevitch , Basan Kurkalli , Daniel Cohn , Aleiandro Sosnik
发明人： Shimon Slavin , Olga Gurevitch , Basan Kurkalli , Daniel Cohn , Aleiandro Sosnik
IPC分类号： A61K35/32
CPC分类号： A61L27/3645 , A61K35/28 , A61K35/32 , A61K38/1875 , A61L27/227 , A61L27/26 , A61L27/3608 , A61L27/3821 , A61L27/3834 , A61L27/3843 , A61K2300/00
摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) or demineralized tooth matrix (DTM), together with a site-responsive polymer, optionally further comprising bone morphogenetic proteins (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint or a cranio-facial-maxillary bone, alveolar bone of maxilla and mandibula, spine, pelvis or long bones, or for construction or reconstruction of any extra skeletal bone, including for mechanical or biological support of artificial implants to the joint or of the joint or to the bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure. A kit is provided for performing transplantation of the composition into a joint, maxillary or mandibular alveolar bone or any bony structure of a mammal, including support of artificial implants.
摘要翻译：包含骨髓细胞（BMC）和脱矿质骨基质（DBM）或脱矿质牙质基质（DTM）的组合物与位点反应性聚合物一起，任选地还包含骨形态发生蛋白（BMP）和/或其它活性剂，特别是用于将间充质祖细胞移植到关节或颅面上颌骨，上颌骨和下颌骨，脊柱，骨盆或长骨的牙槽骨中，或用于构建或重建任何额外的骨骼骨，包括用于机械或生物将人造植入物支撑到关节或关节或骨骼，用于恢复和/或增强新型透明软骨和软骨下骨结构的形成。提供了用于将组合物移植到关节，上颌骨或下颌骨牙槽骨或哺乳动物的任何骨结构（包括人造植入物的支撑）中的试剂盒。

2. 发明申请

US20070264240A1 Compositions comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the induction of bone and cartilage formation 审中-公开
标题翻译：包含骨髓细胞以及脱矿质和/或矿化骨基质的组合物及其在诱导骨和软骨形成中的用途
公开(公告)号：US20070264240A1
公开(公告)日：2007-11-15
申请号：US11825894
申请日：2007-07-09
申请人： Shimon Slavin , Olga Gurevitch , Basan Kurkalli , Tatyana Prigozhina
发明人： Shimon Slavin , Olga Gurevitch , Basan Kurkalli , Tatyana Prigozhina
IPC分类号： C12N5/06 , A61K39/00 , A61P19/02
CPC分类号： A61K35/32 , A61K35/28 , A61K38/1875 , A61K2300/00
摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM) and optionally comprising bone morphogenetic protein/s (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint and/or a cranio-facial maxillary bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure. The composition of the invention and method of treatment employing the same may be used for the treatment of hereditary or acquired bone disorders, hereditary or acquired cartilage disorders, malignant bone or cartilage disorders, metabolic bone diseases, bone infections, conditions involving bone or cartilage deformities and Paget's disease. The composition and method may further be used for the correction of complex fractures, bone replacement and formation of new bone in plastic or sexual surgery, for support of implants of joints, cranio-facial-maxillary bones, or other musculoskeletal implants, including artificial implants. The method of the invention may further be used for treating damaged joints or degenerative arthropathy associated with malformation and/or dysfunction of cartilage and/or subchondral bone. A kit is provided for performing transplantation into a joint or a cranio-facial-maxillary bone of a mammal of the composition of the invention.
摘要翻译：包含骨髓细胞（BMC）和去矿化骨基质（DBM）和/或矿化骨基质（MBM）和任选地包含骨形态发生蛋白（BMP）和/或其他活性剂的组合物，特别是用于移植间质祖细胞进入关节和/或头颅上颌骨，用于恢复和/或增强新型透明软骨和软骨下骨结构的形成。本发明的组合物及其使用方法可用于治疗遗传性或获得性骨病，遗传性或获得性软骨疾病，恶性骨或软骨疾病，代谢性骨病，骨感染，涉及骨或软骨畸形的病症和佩吉特病。组合物和方法还可用于矫正复合骨折，骨替代和塑性或性手术中新骨形成，以支持关节植入物，颅面上颌骨或其他肌骨骼植入物，包括人造植入物。本发明的方法还可用于治疗与软骨和/或软骨下骨的畸形和/或功能障碍相关的损伤关节或退行性关节病。提供用于进行移植到本发明组合物的哺乳动物的关节或头颅面上颌骨中的试剂盒。

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