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1. 发明授权

US08314094B2 Benzoxazinone derivative 有权
标题翻译：苯并恶嗪酮衍生物
公开(公告)号：US08314094B2
公开(公告)日：2012-11-20
申请号：US12678785
申请日：2008-10-02
申请人： Shiho Ishikawa , Takashi Mizutani , Tsuyoshi Nagase , Nagaaki Sato , Hidekazu Takahashi
发明人： Shiho Ishikawa , Takashi Mizutani , Tsuyoshi Nagase , Nagaaki Sato , Hidekazu Takahashi
IPC分类号： A61K31/536 , A61K31/5365 , C07D265/14 , C07D413/02 , C07D498/04
CPC分类号： C07D239/80 , C07D265/18 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04
摘要： [PROBLEMS]To provide a compound useful as an agent for the treatment of circulatory diseases, nervous system diseases, metabolic diseases, reproductive system diseases, and digestive tract diseases.[MEANS FOR SOLVING PROBLEMS]The compound, which is for use as an active ingredient, is represented by the formula (I): [wherein R1 represents optionally halogenated C1-6 alkyl, etc.; R2 represents, e.g., a group represented by the formula (II-1) or (II-4) (wherein W represents C1-6 alkylene, etc. and R represents C1-6 alkyl, etc.); R3 represents hydrogen, C1-6 alkyl, etc.; X represents —O—, —NH—, etc.; and Y1, Y2, Y3, and Y4 each independently represents —CH—, —N—, etc.].
摘要翻译： [问题]提供可用作治疗循环系统疾病，神经系统疾病，代谢疾病，生殖系统疾病和消化道疾病的药剂的化合物。用于解决问题的方法用作活性成分的化合物由式（I）表示：其中R 1表示任选卤代的C 1-6烷基等; R2表示例如由式（II-1）或（II-4）表示的基团（其中W表示C1-6亚烷基等，R表示C1-6烷基等）; R3代表氢，C1-6烷基等; X表示-O-，-NH-等; Y1，Y2，Y3和Y4各自独立地表示-CH-，-N-等〕。

2. 发明申请

US20100210636A1 BENZOXAZINONE DERIVATIVE 有权
标题翻译：苯并咪唑衍生物
公开(公告)号：US20100210636A1
公开(公告)日：2010-08-19
申请号：US12678785
申请日：2008-10-02
申请人： Shiho Ishikawa , Takashi Mizutani , Tsuyoshi Nagase , Nagaaki Sato , Hidekazu Takahashi
发明人： Shiho Ishikawa , Takashi Mizutani , Tsuyoshi Nagase , Nagaaki Sato , Hidekazu Takahashi
IPC分类号： A61K31/536 , C07D265/14 , C07D413/02 , C07D498/04 , A61K31/5365 , A61P3/00 , A61P3/06 , A61P1/16 , A61P3/04 , A61P3/10 , A61P35/00
CPC分类号： C07D239/80 , C07D265/18 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D498/04
摘要： [PROBLEMS]To provide a compound useful as an agent for the treatment of circulatory diseases, nervous system diseases, metabolic diseases, reproductive system diseases, and digestive tract diseases.[MEANS FOR SOLVING PROBLEMS]The compound, which is for use as an active ingredient, is represented by the formula (I): [wherein R1 represents optionally halogenated C1-6 alkyl, etc.; R2 represents, e.g., a group represented by the formula (II-1) or (II-4) (wherein W represents C1-6 alkylene, etc. and R represents C1-6 alkyl, etc.); R3 represents hydrogen, C1-6 alkyl, etc.; X represents —O—, —NH—, etc.; and Y1, Y2, Y3, and Y4 each independently represents —CH—, —N—, etc.].
摘要翻译： [问题]提供可用作治疗循环系统疾病，神经系统疾病，代谢疾病，生殖系统疾病和消化道疾病的药剂的化合物。用于解决问题的方法用作活性成分的化合物由式（I）表示：其中R 1表示任选卤代的C 1-6烷基等; R2表示例如由式（II-1）或（II-4）表示的基团（其中W表示C1-6亚烷基等，R表示C1-6烷基等）; R3代表氢，C1-6烷基等; X表示-O-，-NH-等; Y1，Y2，Y3和Y4各自独立地表示-CH-，-N-等〕。

3. 发明授权

US07960394B2 Quinazoline derivative 失效
标题翻译：喹唑啉衍生物
公开(公告)号：US07960394B2
公开(公告)日：2011-06-14
申请号：US11628087
申请日：2005-05-30
申请人： Takashi Mizutani , Tsuyoshi Nagase , Nagaaki Sato , Akio Kanatani , Shigeru Tokita
发明人： Takashi Mizutani , Tsuyoshi Nagase , Nagaaki Sato , Akio Kanatani , Shigeru Tokita
IPC分类号： A01N43/00 , C07D239/70
CPC分类号： C07D239/91 , C07D401/12 , C07D403/04 , C07D471/04
摘要： This invention provides a compound or its pharmaceutically-acceptable salt of formula (I) wherein R1 represents a lower alkyl group et al; R2 and R3 are same and different and represents hydrogen atm et al; R4 represents the substituent of the formula (II) et al; X1 represents NH, O or S; Y represents N or C; Ar is a divalent substituent derived from aryl et al, by removing two hydrogen atoms therefrom; the ring A represents a 5- or 6-membered heteroaryl group; this compounds has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for preventive or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.
摘要翻译：本发明提供式（I）的化合物或其药学上可接受的盐，其中R 1表示低级烷基等; R2和R3相同且不同，代表氢原子; R4表示式（II）等的取代基; X1表示NH，O或S; Y表示N或C; Ar是通过从其中除去两个氢原子而衍生自芳基等的二价取代基; 环A表示5-或6-元杂芳基; 该化合物具有组胺H3受体拮抗作用或组胺H3受体反向激动作用，可用于预防或治疗代谢系统疾病，循环系统疾病或神经系统疾病。

4. 发明申请

US20080275069A1 Quinazoline Derivative 失效
标题翻译：喹唑啉衍生物
公开(公告)号：US20080275069A1
公开(公告)日：2008-11-06
申请号：US11628087
申请日：2005-05-30
申请人： Takashi Mizutani , Tsuyoshi Nagase , Nagaaki Sato , Akio Kanatani , Shigeru Tokita
发明人： Takashi Mizutani , Tsuyoshi Nagase , Nagaaki Sato , Akio Kanatani , Shigeru Tokita
IPC分类号： A61K31/519 , C07D239/91 , A61P1/16 , A61P3/04 , A61P9/00 , A61P9/12 , A61P25/00 , A61P25/14 , A61P25/18 , C07D471/04 , C07D401/12 , A61P43/00 , A61P25/32 , A61P25/28 , A61P25/24 , A61P25/22 , A61P25/16 , A61P25/02 , A61P13/12 , A61P9/10 , A61P3/10 , A61P3/00 , A61K31/517
CPC分类号： C07D239/91 , C07D401/12 , C07D403/04 , C07D471/04
摘要： This invention provides a compound or its pharmaceutically-acceptable salt of formula (I) wherein R1 represents a lower alkyl group et al; R2 and R3 are same and different and represents hydrogen atm et al; R4 represents the substituent of the formula (I) et al; X1 represents NH, O or S; Y represents N or C; Ar is a divalent substituent derived from aryl et al, by removing two hydrogen atoms therefrom; the ring A represents a 5- or 6-membered heteroaryl group; this compounds has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for preventive or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.
摘要翻译：本发明提供式（I）的化合物或其药学上可接受的盐，其中R 1表示低级烷基等; R 2和R 3相同且不同，表示氢原子; R 4表示式（I）等的取代基; X 1表示NH，O或S; Y表示N或C; Ar是通过从其中除去两个氢原子而衍生自芳基等的二价取代基; 环A表示5-或6-元杂芳基; 该化合物具有组胺H3受体拮抗作用或组胺H3受体反向激动作用，可用于预防或治疗代谢系统疾病，循环系统疾病或神经系统疾病。

5. 发明授权

US08163770B2 Benzoxathiin derivative 失效
标题翻译：苯并硫堇衍生物
公开(公告)号：US08163770B2
公开(公告)日：2012-04-24
申请号：US12084017
申请日：2006-10-25
申请人： Takashi Mizutani , Nagaaki Sato , Takahide Sasaki , Toshiyuki Takahashi
发明人： Takashi Mizutani , Nagaaki Sato , Takahide Sasaki , Toshiyuki Takahashi
IPC分类号： C07D513/02 , C07D515/02 , C07D211/22 , C07D327/06 , A01N43/42 , A01N43/40 , A61K31/44 , A61K31/445
CPC分类号： C07D327/06 , C07D497/04
摘要： Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent —CH—, a nitrogen atom or the like.
摘要翻译：公开了由下式（I）表示的化合物及其药学上可接受的盐。该化合物可用于治疗肥胖症，糖尿病等。 [式（I）中，Ar表示苯环等， X1表示氮原子，硫原子等; R1表示芳基等; X2表示由下式（II）表示的基团：（其中R4和R5分别表示低级烷基等，m表示2-4的数）等; X和Y中的一个表示氧原子，另一个表示硫烷基等; X3-X6分别表示-CH-，氮原子等。

6. 发明申请

US20120028990A1 3 ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE 审中-公开
标题翻译： 3 ARYL或HETEROARYL取代的INDOLE DERIVATIVE
公开(公告)号：US20120028990A1
公开(公告)日：2012-02-02
申请号：US13260746
申请日：2010-04-14
申请人： Takashi Fujimura , Hiroyuki Kishino , Takashi Mizutani , Shunji Sakuraba , Takahide Sasaki , Nagaaki Sato
发明人： Takashi Fujimura , Hiroyuki Kishino , Takashi Mizutani , Shunji Sakuraba , Takahide Sasaki , Nagaaki Sato
IPC分类号： A61K31/404 , A61K31/4439 , A61K31/4725 , A61P3/04 , C07D403/12 , A61K31/496 , C07D417/14 , C07D409/14 , C07D405/14 , A61K31/454
CPC分类号： C07D405/04 , C07D209/18 , C07D405/14 , C07D409/04 , C07D417/04
摘要： A 3-aryl or heteroaryl-substituted indole derivative which is effective as a preventive or remedy for various diseases is provided. [Means for Resolution] A compound represented by a formula (I) or a pharmaceutically acceptable salt thereof is provided. In the formula, R1 represents a hydrogen atom, C1-6 alkyl et al; R2 represents a hydrogen atom, C1-6 alkyl et al; Z represents aryl or heteroaryl (with the proviso that imidazolyl is excluded); and W represents a group represented by the formula (w-1) or (w-2). In the formula, R3 represents C1-6 alkyl et al; Yl and Y2 both represent a hydrogen atom or Y1 and Y2 together form —CH2-CH2-; Q represents CH or N; Ar represents phenyl, furyl et al; R4 and R5 each independently represent a hydrogen atom or C1-6 alkyl or R4 and R5 together with the nitrogen atom form pyrrolidine et al.
摘要翻译：提供作为各种疾病的预防或治疗有效的3-芳基或杂芳基取代的吲哚衍生物。 [解决方法]提供由式（I）表示的化合物或其药学上可接受的盐。在该式中，R 1表示氢原子，C 1-6烷基等; R2表示氢原子，C1-6烷基等; Z表示芳基或杂芳基（条件是不包括咪唑基）; W表示由式（w-1）或（w-2）表示的基团。在该式中，R 3表示C 1-6烷基等; Y 1和Y 2均表示氢原子或Y 1和Y 2一起形成-CH 2 -CH 2 - ; Q表示CH或N; Ar表示苯基，呋喃基等; R4和R5各自独立地表示氢原子或C1-6烷基或R4和R5以及氮原子形成吡咯烷等。

7. 发明申请

US20100168156A1 Novel Benzoxathiine Derivative 失效
标题翻译：新型苯并噻嗪衍生物
公开(公告)号：US20100168156A1
公开(公告)日：2010-07-01
申请号：US12084017
申请日：2006-10-25
申请人： Takashi Mizutani , Nagaaki Sato , Takahide Sasaki , Toshiyuki Takahashi
发明人： Takashi Mizutani , Nagaaki Sato , Takahide Sasaki , Toshiyuki Takahashi
IPC分类号： A61K31/4365 , A61K31/4523 , A61K31/4436 , A61K31/39 , C07D497/04 , C07D401/12 , C07D411/04 , C07D411/12 , A61P25/30 , A61P3/06 , A61P19/06 , A61P1/16 , A61P9/10 , A61P25/28 , A61P25/16 , A61P25/18 , A61P25/32 , A61P25/08
CPC分类号： C07D327/06 , C07D497/04
摘要： Disclosed is a compound represented by the formula (I) below and a pharmaceutically acceptable salt thereof. This compound is useful for treatment of obesity, diabetes and the like. [In the formula (I), Ar represents a benzene ring or the like; X1 represents a nitrogen atom, a sulfur atom or the like; R1 represents an aryl group or the like; X2 represents a group represented by the following formula (II): (wherein R4 and R5 respectively represent a lower alkyl group or the like, and m represents a number of 2-4) or the like; one of X and Y represents an oxygen atom and the other represents a sulfanyl group or the like; and X3-X6 respectively represent —CH—, a nitrogen atom or the like.
摘要翻译：公开了由下式（I）表示的化合物及其药学上可接受的盐。该化合物可用于治疗肥胖症，糖尿病等。 [式（I）中，Ar表示苯环等， X1表示氮原子，硫原子等; R1表示芳基等; X2表示由下式（II）表示的基团：（其中R4和R5分别表示低级烷基等，m表示2-4的数）等; X和Y中的一个表示氧原子，另一个表示硫烷基等; X3-X6分别表示-CH-，氮原子等。

8. 发明授权

US08496883B2 Honeycomb filter 有权
标题翻译：蜂窝过滤器
公开(公告)号：US08496883B2
公开(公告)日：2013-07-30
申请号：US13292827
申请日：2011-11-09
申请人： Takashi Mizutani , Koji Nagata , Yukio Miyairi
发明人： Takashi Mizutani , Koji Nagata , Yukio Miyairi
IPC分类号： B01D50/00
CPC分类号： B01J35/04 , B01D53/944 , B01D2255/1021 , B01D2255/2065 , B01D2255/2092 , B01D2255/9032 , F01N3/022 , F01N3/0222 , F01N3/035 , F01N3/2842 , F01N2330/60 , F01N2510/0682
摘要： A honeycomb filter includes a cell having one open end and another closed end that serves as a fluid flow path and a cell having one closed end and another open end, wherein the cells are alternately disposed. The honeycomb filter includes an undeposited region in an upstream region of a partition portion, which has no trapping layer and has a length of 5% or more and 30% or less of the length of the inlet cell. The upstream region of the partition portion includes an undeposited region having an area of 10% or more of that of the cell in a cross-section perpendicular to the exhaust gas flow direction. The undeposited region with no trapping layer in the upstream region decreases the permeation resistance of the partition portion in the upstream region and facilitates fluid passage through the partition portion in the upstream region.
摘要翻译：蜂窝过滤器包括具有一个开口端的单元和用作流体流动通道的另一个封闭端，以及具有一个封闭端和另一个开口端的单元，其中所述单元交替布置。蜂窝过滤器包括在分隔部分的上游区域中的未沉积区域，其没有捕获层，并且具有入口池的长度的5％以上且30％以下的长度。分隔部的上游区域包括与废气流动方向垂直的截面的面积为电池单元面积的10％以上的未沉积区域。在上游区域中没有捕获层的未沉积区域降低了上游区域中的分隔部分的渗透阻力，并且便于流体通过上游区域中的分隔部分。

9. 发明申请

US20120157201A1 Game Device 有权
标题翻译：游戏设备
公开(公告)号：US20120157201A1
公开(公告)日：2012-06-21
申请号：US13382041
申请日：2010-03-15
申请人： Takashi Mizutani , Yuji Yamada , Tomoyuki Takahashi
发明人： Takashi Mizutani , Yuji Yamada , Tomoyuki Takahashi
IPC分类号： A63F13/00
CPC分类号： A63F13/577 , A63F13/10 , A63F13/211 , A63F13/213 , A63F13/28 , A63F13/42 , A63F2300/105 , A63F2300/1093 , A63F2300/6045 , A63F2300/643 , G06F3/017 , G06F3/0346
摘要： A frame image acquiring unit acquires a captured image of an input device that is provided with an illuminator. A device information deriving unit derives position information of the input device from the captured image. An input receiving unit acquires attitude information of the input device. An operation object control unit controls the motion of an operation object in accordance with the position information and the attitude information of the input device. A non-operation object control unit controls the motion of a non-operation object. A collision control unit determines the motion of at least one of the operation object and the non-operation object in accordance with a collision mode for the collision between the operation object and the non-operation object.
摘要翻译：帧图像获取单元获取具有照明器的输入装置的拍摄图像。设备信息导出单元从捕获的图像中导出输入设备的位置信息。输入接收单元获取输入设备的姿态信息。操作对象控制单元根据输入装置的位置信息和姿态信息来控制操作对象的运动。非操作对象控制单元控制非操作对象的运动。冲突控制单元根据用于操作对象和非操作对象之间的冲突的冲突模式来确定操作对象和非操作对象中的至少一个的运动。

10. 发明申请

US20120009093A1 HONEYCOMB FILTER AND METHOD FOR PRODUCING HONEYCOMB FILTER 有权
标题翻译：蜂窝状过滤器和蜂窝过滤器生产方法
公开(公告)号：US20120009093A1
公开(公告)日：2012-01-12
申请号：US13240229
申请日：2011-09-22
申请人： Takashi Mizutani , Shingo Iwasaki , Yukio Miyairi
发明人： Takashi Mizutani , Shingo Iwasaki , Yukio Miyairi
IPC分类号： B01D53/34 , C04B33/32 , B01D39/20
CPC分类号： B01J35/04 , B01J23/002 , B01J23/63 , B01J35/0006 , B01J35/023 , B01J37/0215 , B01J2523/00 , C04B28/24 , C04B35/565 , C04B35/573 , C04B35/63416 , C04B37/005 , C04B38/0009 , C04B38/0019 , C04B41/009 , C04B41/5059 , C04B41/87 , C04B2111/00793 , C04B2111/0081 , C04B2235/3826 , C04B2235/428 , C04B2235/5228 , C04B2235/528 , C04B2235/5436 , C04B2235/5472 , C04B2235/656 , C04B2235/6567 , C04B2235/6583 , C04B2237/083 , C04B2237/09 , C04B2237/365 , C04B2237/62 , C04B2237/704 , F01N3/0222 , F01N2330/60 , B01J2523/36 , B01J2523/3712 , B01J2523/3718 , B01J2523/48 , B01J2523/72 , C04B38/0054 , C04B38/0074 , C04B14/324 , C04B14/4656 , C04B16/0641 , C04B35/00 , C04B38/0006 , C04B41/0072 , C04B41/4515 , C04B41/4547 , C04B41/457
摘要： There is provided a honeycomb filter wherein particles having an average particle diameter smaller than the average pore diameter of partition walls are deposited at least in open pores formed in the surface layer of the partition wall and in the pores of the partition wall in a surface layer portion of the partition walls on the exhaust gas inflow side, thereby forming a composite region. The average pore diameter of the partition walls is 5 to 40 μm, and the porosity of the partition wall is 35 to 75%. The particles to be deposited have an average particle diameter of 1 to 15 μm, and the height of the composite region is not more than 80 μm in the direction from the outermost contour line of the partition walls to the surface of the partition walls.
摘要翻译：提供了一种蜂窝过滤器，其中平均粒径小于分隔壁的平均孔径的颗粒至少沉积在形成在分隔壁的表层中的开孔中和在表层中的分隔壁的孔中在废气流入侧的分隔壁的一部分，从而形成复合区域。隔壁的平均孔径为5〜40μm，分隔壁的孔隙率为35〜75％。要沉积的颗粒的平均粒径为1-15μm，并且复合区域的高度在从分隔壁的最外层轮廓线到分隔壁表面的方向上不大于80μm。

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