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1. 发明授权

US5803925A IOL insertion apparatus with covalently bonded lubricant 失效
标题翻译：具有共价键合润滑剂的IOL插入装置
公开(公告)号：US5803925A
公开(公告)日：1998-09-08
申请号：US769324
申请日：1996-12-19
申请人： Shih-Liang Stanley Yang , Crystal M. Cunanan , Thomas M. McNicholas
发明人： Shih-Liang Stanley Yang , Crystal M. Cunanan , Thomas M. McNicholas
IPC分类号： A61F9/007 , A61B17/00 , A61F2/16 , A61L31/00 , A61L31/10 , A61F9/00
CPC分类号： A61L31/10 , A61F2/1664 , A61B2017/00845 , A61L2430/16 , Y10S623/907
摘要： Apparatus for inserting intraocular lenses (IOLs) into eyes are disclosed. In one embodiment, such apparatus includes a hollow tube including an interior wall defining a hollow space through which an IOL is passed and an outlet through which the IOL is passed from the hollow space into an eye, and a lubricity enhancing component covalently bonded to the hollow tube at the interior wall in an amount effective to at least assist in facilitating the passage of the IOL through the hollow space.
摘要翻译：公开了将眼内透镜（IOL）插入眼睛的装置。在一个实施例中，这种装置包括中空管，该中空管包括限定中空空间的内壁，IOL通过该中空空间和IOL从中空空间通过眼睛的出口，以及共价键合到中空管在内壁上有效地至少有助于促进IOL通过中空空间。

2. 发明授权

US06258123B1 IOL for reducing secondary opacification 失效
公开(公告)号：US06258123B1
公开(公告)日：2001-07-10
申请号：US08844428
申请日：1997-04-18
申请人： Craig Young , Glenn R. Sussman , Crystal M. Cunanan
发明人： Craig Young , Glenn R. Sussman , Crystal M. Cunanan
IPC分类号： A61F216
CPC分类号： A61F2/16 , A61F2/1613 , A61F2002/009 , A61F2002/1683 , A61F2002/1699
摘要： An IOL implantable in an eye comprising an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.

3. 发明授权

US06214054B1 Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby 有权
公开(公告)号：US06214054B1
公开(公告)日：2001-04-10
申请号：US09157546
申请日：1998-09-21
申请人： Crystal M. Cunanan , Lillian Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
发明人： Crystal M. Cunanan , Lillian Quintero , Michael N. Helmus , Christine Loshbaugh , H. Chris Sarner
IPC分类号： A61F224
CPC分类号： A61L27/3691 , A61L2/0088 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L33/12 , A61L2400/02 , A61L2430/40 , Y10S623/901 , Y10S623/915 , Y10S623/917 , Y10S623/92
摘要： A method for fixation of biological tissues, and bioprosthetic devices prepared by such method. The method generally comprises the steps of A) fixing the tissue, B) treating the tissue with a mixture of i) a denaturant, ii) a surfactant and iii) a crosslinking agent, C) fabricating or forming the bioprosthesis (e.g., forming the tissue and attaching any non-biological components thereto) and D) subjecting the bioprosthesis to terminal sterilization.

4. 发明授权

US06656222B2 IOL for reducing secondary opacification 失效
公开(公告)号：US06656222B2
公开(公告)日：2003-12-02
申请号：US09859658
申请日：2001-05-17
申请人： Craig Young , Glenn R. Sussman , Crystal M. Cunanan
发明人： Craig Young , Glenn R. Sussman , Crystal M. Cunanan
IPC分类号： A61F216
CPC分类号： A61F2/16 , A61F2/1613 , A61F2002/009 , A61F2002/1683 , A61F2002/1699
摘要： An IOL implantable in an eye comprising an optic having an optical portion for directing light toward the retina of the eye and a cell barrier portion for inhibiting cell growth from the eye in front of or in back of the optical portion. The cell barrier portion circumscribes the optical portion, is incapable of focusing light on the retina and includes an irregularly configured structure, for example, irregular grooves. At least one elongated fixation member is coupled to the optic for use in fixing the optic in the eye.

5. 发明授权

US06648922B2 Method for producing improved medical devices and devices so produced 有权
标题翻译：用于生产如此制造的改进的医疗装置和装置的方法
公开(公告)号：US06648922B2
公开(公告)日：2003-11-18
申请号：US09790395
申请日：2001-02-21
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
IPC分类号： A61F236
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

6. 发明授权

US5632773A Biostable corneal implants 失效
标题翻译：生物稳定性角膜植入物
公开(公告)号：US5632773A
公开(公告)日：1997-05-27
申请号：US616786
申请日：1996-03-15
申请人： Richard S. Graham , Crystal M. Cunanan
发明人： Richard S. Graham , Crystal M. Cunanan
IPC分类号： A61F2/00 , A61F2/14 , A61L27/24
CPC分类号： A61F2/14 , A61L27/24 , A61F2310/00365
摘要： Corneal implants and methods for producing such implants are disclosed. The present corneal implants comprise a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, the lens body including a hydrogel composition containing water, a collagen component and a polymeric material covalently bonded to the collagen component. The hydrogel composition has enhanced biostability relative to an identical hydrogel composition without the polymeric material.
摘要翻译：公开了角膜植入物和用于生产这种植入物的方法。本发明的角膜植入物包括光学透明的透镜体，其被构造成手术附着在哺乳动物眼睛的角膜中或上面，所述透镜体包括水凝胶组合物，所述水凝胶组合物含有水，胶原组分和共价键合到胶原成分。相对于没有聚合物材料的相同的水凝胶组合物，水凝胶组合物具有增强的生物稳定性。

7. 发明授权

US5433745A Corneal implants and methods for producing same 失效
标题翻译：角膜植入物及其生产方法
公开(公告)号：US5433745A
公开(公告)日：1995-07-18
申请号：US135875
申请日：1993-10-13
申请人： Richard S. Graham , Crystal M. Cunanan , James E. Francese
发明人： Richard S. Graham , Crystal M. Cunanan , James E. Francese
IPC分类号： A61F2/14 , A61F2/16
CPC分类号： A61F2/142 , A61F2/14
摘要： New corneal implants and methods for producing such implants are disclosed. The present corneal implants comprise a lens body which is optically clear and is structured to be surgically attached in or on the cornea of a mammalian eye, the lens body including a core having an outer surface and made of a hydrogel composition containing water and a hydrophilic polymeric material, and a coating comprising a synthetic polymeric component located on the outer surface, covalently bonded to the hydrogel composition and having enhanced ability to support epithelial cell growth and/or adhesion relative to the hydrogel composition.
摘要翻译：公开了新的角膜植入物和用于生产这种植入物的方法。本发明的角膜植入物包括光学透明的透镜体，其被构造成手术附着在哺乳动物眼睛的角膜中或上面，所述透镜体包括具有外表面并且由含有水和亲水性的水凝胶组合物制成的芯聚合物材料和包含位于外表面上的合成聚合物组分的涂层，共价键合到水凝胶组合物上，并具有增强的相对于水凝胶组合物支持上皮细胞生长和/或粘附的能力。

8. 发明授权

US07989157B2 Solution for storing bioprosthetic tissue used in a biological prosthesis 有权
标题翻译：用于存储生物假体中使用的生物假体组织的溶液
公开(公告)号：US07989157B2
公开(公告)日：2011-08-02
申请号：US11032923
申请日：2005-01-11
申请人： Crystal M. Cunanan , Alexandro Ochoa , Ronald E. Cambron
发明人： Crystal M. Cunanan , Alexandro Ochoa , Ronald E. Cambron
IPC分类号： A01N1/00 , A01N1/02
CPC分类号： A01N1/02 , A01N1/0226
摘要： A method for processing biological tissue used in biological prostheses includes providing a tissue procurement solution formed from a phosphate buffered saline (PBS) solution and a chelating agent. The tissue is transferred from the tissue procurement solution and undergoes chemical fixation. The fixed tissue is then immersed in a series of fresh bioburden reduction process (BRP) solutions to extract phospholipids. The tissue procurement solution reduces the bioburden on the stored tissue and preserves tissue architecture by minimizing tissue swelling. The tissue procurement solution further reduces calcium from the incoming water and/or tissue, and inhibits enzymes that digest the collagen matrix. The serial immersion of the tissue in the fresh bioburden solutions ensures optimal extraction of phospholipids thereby mitigating subsequent calcification of the tissue.
摘要翻译：用于处理生物假体中使用的生物组织的方法包括提供由磷酸盐缓冲盐水（PBS）溶液和螯合剂形成的组织采购溶液。组织从组织采购溶液转移并进行化学固定。然后将固定的组织浸入一系列新鲜的生物负载降低过程（BRP）溶液中以提取磷脂。组织采购解决方案减少存储组织的生物负载，并通过最小化组织肿胀来保持组织结构。组织采购解决方案进一步减少来自进入的水和/或组织的钙，并且抑制消化胶原蛋白基质的酶。将组织连续浸入新鲜的生物负载溶液中确保磷脂的最佳提取，从而减轻随后的组织钙化。

9. 发明授权

US07422606B2 Medical devices and products having coatings applied thereto 失效
标题翻译：带有涂层的医疗器械和产品
公开(公告)号：US07422606B2
公开(公告)日：2008-09-09
申请号：US10678875
申请日：2003-10-03
申请人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
发明人： Neng S. Ung-Chhun , Richard J. Johnson , Dean Laurin , Crystal M. Cunanan
IPC分类号： A61F2/02
CPC分类号： A61L33/0041 , A61L27/34 , A61L29/085 , A61L31/10 , A61L33/0011 , A61M1/3679 , A61M2202/0439 , B01D39/1623 , B01D39/1692 , C08L89/00 , C08L71/02 , A61M2202/0057
摘要： Medical devices and methods of producing same are provided. The medical device comprising a body member and a coating on at least a portion of the body member comprising an insitu condensation product of a first electrophilically active, high molecular weight polyalkylene oxide and a second high molecular weight polyoxyalkylene derivative.
摘要翻译：提供医疗装置及其制造方法。所述医疗装置包括主体构件和在所述主体构件的至少一部分上的涂层，其包含第一亲电活性的高分子量聚环氧烷和第二高分子量聚氧化烯衍生物的原位缩合产物。

10. 发明授权

US06783988B1 Methods for quantitative and qualitative analyses of phospholipids using one-dimensional thin layer chromatography 有权
标题翻译：使用一维薄层色谱定量和定性分析磷脂的方法
公开(公告)号：US06783988B1
公开(公告)日：2004-08-31
申请号：US09693186
申请日：2000-10-19
申请人： Tan Thanh Dinh , Patrice Tremble , Crystal M. Cunanan , Christine May Cabiling
发明人： Tan Thanh Dinh , Patrice Tremble , Crystal M. Cunanan , Christine May Cabiling
IPC分类号： G01N3392
CPC分类号： G01N30/90 , G01N33/92
摘要： A highly sensitive and specific method for the detection and quantification of lipids is provided. Specifically, methods for the simultaneous detection and quantification of phospholipids extracted from mammalian tissues is described. The analytical methods provided disclose a modified one-dimensional thin-layer chromatography technique specifically developed to rapidly and accurantely detect and quantify phospholipids from mammalian cardiac tissues.
摘要翻译：提供了一种用于检测和定量脂质的高灵敏度和具体方法。具体地说，描述了从哺乳动物组织中提取的同时检测和定量磷脂的方法。所提供的分析方法公开了专门开发用于快速且精确地检测和定量来自哺乳动物心脏组织的磷脂的修饰的一维薄层色谱技术。

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