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1. 发明授权

US08822229B2 Method for assaying keratan sulfate, assay kit therefor and method for detecting joint disease by using the same 有权
标题翻译：用于测定硫酸角质素的方法，其测定试剂盒及其用于检测关节疾病的方法
公开(公告)号：US08822229B2
公开(公告)日：2014-09-02
申请号：US13142262
申请日：2009-12-24
申请人： Shigeyuki Wakitani , Hiroshi Fujita , Takeshi Ishimaru , Koji Yamamoto , Yasuhiro Kurahashi , Junichi Onaya , Hiroyuki Masuda
发明人： Shigeyuki Wakitani , Hiroshi Fujita , Takeshi Ishimaru , Koji Yamamoto , Yasuhiro Kurahashi , Junichi Onaya , Hiroyuki Masuda
IPC分类号： G01N33/564
CPC分类号： G01N33/53 , G01N2400/40 , G01N2800/102
摘要： The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50KS-I/KS-II of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.
摘要翻译：本发明提供了一种免疫测定硫酸角质素水平的方法，该方法包括使硫酸角质素硫酸单克隆抗体与生物样品接触，硫酸角质素-I与硫酸角质素之间呈现相对反应特异性的硫酸角质素单体抗体 -II由IC50KS-I / KS-II表示，为0.4〜5，从而提供信号; 并从信号中检测生物样品中所含的硫酸角质素。在该方法的基础上，本发明还提供了关于联合疾病的检测方法和评估对于关节疾病及其候选物质的补救效果的方法。通过这些方法，可以测定样品中所含的极少量硫酸角质素。特别地，这些方法可以高灵敏度和高特异性地确定通过常规技术难以确定的总硫酸角质素，包括硫酸角质素-I。该方法还能够检测关节疾病并评估对于关节疾病或候选物质的补救的效果。

2. 发明申请

US20110318759A1 METHOD FOR ASSAYING KERATAN SULFATE, ASSAY KIT THEREFOR AND METHOD FOR DETECTING JOINT DISEASE BY USING THE SAME 有权
标题翻译：用于测定硫酸钙的方法，其测定工具及其使用方法检测联合疾病
公开(公告)号：US20110318759A1
公开(公告)日：2011-12-29
申请号：US13142262
申请日：2009-12-24
申请人： Shigeyuki Wakitani , Hiroshi Fujita , Takeshi Ishimaru , Koji Yamamoto , Yasuhiro Kurahashi , Junichi Onaya , Hiroyuki Masuda
发明人： Shigeyuki Wakitani , Hiroshi Fujita , Takeshi Ishimaru , Koji Yamamoto , Yasuhiro Kurahashi , Junichi Onaya , Hiroyuki Masuda
IPC分类号： G01N33/577 , C07K16/18
CPC分类号： G01N33/53 , G01N2400/40 , G01N2800/102
摘要： The inventions provides a method for immunologically determining a keratan sulfate level which method includes bringing an anti-keratan sulfate monoclonal antibody into contact with a biological sample, the anti-keratan sulfate monoclonal antibody exhibiting a relative reaction specificity between keratan sulfate-I and keratan sulfate-II represented by IC50KS-I/KS-II of 0.4 to 5, to thereby provide a signal; and detecting keratan sulfate contained in the biological sample from the signal. On the basis of the method, the invention also provides a joint disease detection method and a method for assessing the effect of a remedy for a joint disease and a candidate substance therefor. Through these methods, a very small amount of keratan sulfate contained in a sample, can be determined. Particularly, these methods can determine, at high-sensitivity and high-specificity, the total keratan sulfate including keratan sulfate-I, which have been difficult to determine through a conventional technique. The methods also enables detect a joint disease and assess the effect of a remedy for a joint disease or a candidate substance therefor.
摘要翻译：本发明提供了一种免疫测定硫酸角质素水平的方法，该方法包括使硫酸角质素硫酸单克隆抗体与生物样品接触，硫酸角质素-I与硫酸角质素之间呈现相对反应特异性的硫酸角质素单体抗体 -II由IC50KS-I / KS-II表示，为0.4〜5，从而提供信号; 并从信号中检测生物样品中所含的硫酸角质素。在该方法的基础上，本发明还提供了关于联合疾病的检测方法和评估对于关节疾病及其候选物质的补救效果的方法。通过这些方法，可以测定样品中所含的极少量硫酸角质素。特别地，这些方法可以高灵敏度和高特异性地确定通过常规技术难以确定的总硫酸角质素，包括硫酸角质素-I。该方法还能够检测关节疾病并评估对于关节疾病或候选物质的补救的效果。

3. 发明授权

US07915389B2 Anti-acharan sulfate antibody and its application 有权
标题翻译：抗沙胺硫酸抗体及其应用
公开(公告)号：US07915389B2
公开(公告)日：2011-03-29
申请号：US12297048
申请日：2007-04-27
申请人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto , Yeong Shik Kim
发明人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto , Yeong Shik Kim
IPC分类号： C12P21/08 , C07K16/18 , C07K16/44 , G01N33/53
CPC分类号： C07K16/44 , Y10S435/81
摘要： An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to acharan sulfate.
摘要翻译：本发明公开了一种抗沙眼硫酸酯抗体，产生抗体的杂交瘤，检测方法和应用该抗体的检测试剂盒。可以通过使用通过将蛋白质化学键合到硫酸阿卡拉酸获得的物质作为抗原来免疫哺乳动物来制备抗沙卡糖硫酸盐抗体。

4. 发明申请

US20090280502A1 ANTI-2-O-DESULFATED ACHARAN SULFATE ANTIBODY AND ITS APPLICATION 有权
标题翻译：抗2-O-脱硫亚硫酸盐抗体及其应用
公开(公告)号：US20090280502A1
公开(公告)日：2009-11-12
申请号：US12297047
申请日：2007-04-27
申请人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto , Yeong Shik Kim
发明人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto , Yeong Shik Kim
IPC分类号： G01N33/53 , C07K16/00 , C12N5/06
CPC分类号： C07K16/44
摘要： An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The antibody that reacts with 2-O-desulfated acharan sulfate can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to 2-O-desulfated acharan sulfate.
摘要翻译：公开了与2-O-脱硫酸阿卡拉酸硫酸反应的抗体，产生抗体的杂交瘤，检测方法和应用抗体的检测试剂盒。与2-O-脱硫酸阿沙拉硫酸盐反应的抗体可以通过使用通过化学键合蛋白质获得的物质作为抗原免疫哺乳动物来制备，所述物质通过将化学键合到2-O-脱硫酸阿卡拉酸硫酸酯。

5. 发明申请

US20090136964A1 NOVEL ANTI-HEPARAN SULFATE ANTIBODY, METHOD FOR DETECTION OF HEPARAN SULFATE, AND KIT FOR DETECTION OF HEPARAN SULFATE 有权
标题翻译：新型抗HEPARAN硫酸抗体，检测HEPARAN SULFATE的方法和用于检测HEPARAN SULFATE的试剂盒
公开(公告)号：US20090136964A1
公开(公告)日：2009-05-28
申请号：US11909956
申请日：2006-03-31
申请人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto
发明人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto
IPC分类号： G01N33/566 , C07K16/18 , C12N5/06
CPC分类号： C07K16/44 , G01N33/5308 , G01N2400/40 , Y10S435/975
摘要： An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine Engelbreath-Holm-Swam tumor tissue, the antibody being produced with a hybridoma which is prepared using a substance composed of a protein and N-acetylheparosan bound to the protein.
摘要翻译：与来自牛肾但不与源自小鼠Engelbreth-Holm-Swarm肿瘤组织的硫酸乙酰肝素基本上反应的N-乙酰肝素和硫酸乙酰肝素反应的抗体，该抗体由使用物质制备的杂交瘤产生由与蛋白质结合的蛋白质和N-乙酰西他班组成。

6. 发明授权

US07842500B2 Anti-heparan sulfate antibody, method for detection of heparan sulfate, and kit for detection of heparan sulfate 有权
标题翻译：硫酸乙酰肝素抗体，硫酸乙酰肝素检测方法，硫酸乙酰肝素检测试剂盒
公开(公告)号：US07842500B2
公开(公告)日：2010-11-30
申请号：US11909956
申请日：2006-03-31
申请人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto
发明人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto
IPC分类号： C07K16/12 , C07K16/18 , C12N5/20 , C12P21/08 , G01N33/53 , G01N33/569 , G01N33/577
CPC分类号： C07K16/44 , G01N33/5308 , G01N2400/40 , Y10S435/975
摘要： An antibody which reacts with N-acetylheparosan and heparan sulfate that is derived from bovine kidney but does not substantially react with heparan sulfate derived from a murine Engelbreath-Holm-Swarn tumor tissue, the antibody being produced with a hybridoma which is prepared using a substance composed of a protein and N-acetylheparosan bound to the protein.
摘要翻译：与来自牛肾但不与源自小鼠Engelbreth-Holm-Swarm肿瘤组织的硫酸乙酰肝素基本上反应的N-乙酰肝素和硫酸乙酰肝素反应的抗体，该抗体由使用物质制备的杂交瘤产生由与蛋白质结合的蛋白质和N-乙酰西他班组成。

7. 发明授权

US08158365B2 Anti-2-O-desulfated acharan sulfate antibody and its application 有权
标题翻译：抗-2-O-脱硫酸阿卡拉酸硫酸抗体及其应用
公开(公告)号：US08158365B2
公开(公告)日：2012-04-17
申请号：US12297047
申请日：2007-04-27
申请人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto , Yeong Shik Kim
发明人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto , Yeong Shik Kim
IPC分类号： G01N33/53 , C07K16/18 , C07K16/44 , C12P21/08
CPC分类号： C07K16/44
摘要： An antibody that reacts with 2-O-desulfated acharan sulfate, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The antibody that reacts with 2-O-desulfated acharan sulfate can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to 2-O-desulfated acharan sulfate.
摘要翻译：公开了与2-O-脱硫酸阿卡拉酸硫酸反应的抗体，产生抗体的杂交瘤，检测方法和应用抗体的检测试剂盒。与2-O-脱硫酸阿沙拉硫酸盐反应的抗体可以通过使用通过化学键合蛋白质获得的物质作为抗原免疫哺乳动物来制备，所述物质通过将化学键合到2-O-脱硫酸阿卡拉酸硫酸酯。

8. 发明申请

US20090275048A1 ANTI-ACHARAN SULFATE ANTIBODY AND ITS APPLICATION 有权
标题翻译：抗ACHARAN硫酸抗体及其应用
公开(公告)号：US20090275048A1
公开(公告)日：2009-11-05
申请号：US12297048
申请日：2007-04-27
申请人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto , Yeong Shik Kim
发明人： Kiyoshi Suzuki , Takeshi Ishimaru , Koji Yamamoto , Yeong Shik Kim
IPC分类号： G01N33/53 , C07K16/00 , C12N5/12
CPC分类号： C07K16/44 , Y10S435/81
摘要： An anti-acharan sulfate antibody, a hybridoma that produces the antibody, a detection method and a detection kit to which the antibody is applied are disclosed. The anti-acharan sulfate antibody can be produced by immunizing a mammal using as an antigen a substance obtained by chemically bonding a protein to acharan sulfate.
摘要翻译：本发明公开了一种抗沙眼硫酸酯抗体，产生抗体的杂交瘤，检测方法和应用该抗体的检测试剂盒。可以通过使用通过将蛋白质化学键合到硫酸阿卡拉酸获得的物质作为抗原来免疫哺乳动物来制备抗沙卡糖硫酸盐抗体。

9. 发明授权

US07722223B2 Line lighting device and image reading device 有权
标题翻译：线路照明装置和图像读取装置
公开(公告)号：US07722223B2
公开(公告)日：2010-05-25
申请号：US12087403
申请日：2006-12-22
申请人： Tomihisa Saito , Hidemitsu Takeuchi , Takeshi Ishimaru
发明人： Tomihisa Saito , Hidemitsu Takeuchi , Takeshi Ishimaru
IPC分类号： F21V5/00
CPC分类号： H04N1/02815 , G02B6/003 , G02B6/0088 , G03B27/54 , H04N1/02835 , H04N1/0284 , H04N1/1017 , H04N1/193 , H04N2201/02462 , H04N2201/02474 , H04N2201/02481 , H04N2201/02485 , H04N2201/03112 , H04N2201/03125 , H04N2201/03141 , H04N2201/03145
摘要： A structure of a line lighting device permits a rod-like light guide to be attached to a case without rubbing against the case. An end portion of the rod-like light guide provided with a pin is inserted into an opening in a case main body and pushed down, thus making the pin engage with a recess in the case main body. At this time, a distal end of the rod-like light guide is inserted, to some extent, into an opening in a light emitting unit fixing portion. Subsequently, the rod-like light guide is pushed down and pivoted around the pin so as to be completely contained within the case main body. In this state, the distal end of the rod-like light guide is fitted into the opening and the end face of the rod-like light guide is flush with the outer side face of the light emitting unit fixing portion.
摘要翻译：线路照明装置的结构允许棒状光导件附接到壳体而不与壳体摩擦。设置有销的棒状光导体的端部插入到壳体主体的开口中并向下推动，从而使销与壳体主体中的凹部接合。此时，杆状导光体的前端在某种程度上插入发光单元固定部的开口部。随后，杆状光导被推下并围绕销枢转，以便完全容纳在壳体主体内。在该状态下，杆状导光体的前端嵌入开口部，杆状导光体的端面与发光单元固定部的外侧面齐平。

10. 发明授权

US07555194B2 Illumination device and image scanning device 失效
标题翻译：照明装置和图像扫描装置
公开(公告)号：US07555194B2
公开(公告)日：2009-06-30
申请号：US11296866
申请日：2005-12-07
申请人： Makoto Ikeda , Hiroyuki Nemoto , Takashi Kishimoto , Takeshi Ishimaru , Hirohiko Iwase , Hidemitsu Takeuchi , Tomihisa Saito
发明人： Makoto Ikeda , Hiroyuki Nemoto , Takashi Kishimoto , Takeshi Ishimaru , Hirohiko Iwase , Hidemitsu Takeuchi , Tomihisa Saito
IPC分类号： G02B6/10
CPC分类号： H04N1/02815 , H04N1/02835
摘要： An improved illumination device shortens a redundant area of insufficient light intensity close to a longitudinal end thereof. The device includes a casing, a bar-shaped light guide housed in the casing to cause a light-emitting surface thereof to be exposed, a light-emitting unit secured to an end section of the casing, wherein light from the light-emitting unit is introduced into the bar-shaped light guide through the end face thereof and is totally reflected within the bar-shaped light guide to be emitted through the light-emitting surface, and a shielding section provided to cover an end section of the bar-shaped light guide including the redundant area at the end section of the casing close to the light-emitting unit. A notch is formed at the end section of the bar-shaped light guide on the light-emitting surface side close to the light-emitting unit, and light from the light-emitting unit is reflected on a rear surface of the shielding section through a gap between this notch and the light-emitting unit to be introduced into the bar-shaped light guide.
摘要翻译：改进的照明装置缩短靠近其纵向端的光强度不足的冗余区域。该装置包括壳体，容纳在壳体中以使其发光表面暴露的条形光导;固定到壳体的端部的发光单元，其中来自发光单元的光通过其端面引入棒形导光体，并且在棒状光导中被全反射以通过发光表面发射;以及屏蔽部，其设置成覆盖棒状导光体的端部导光体包括靠近发光单元的壳体端部处的冗余区域。在靠近发光单元的发光面侧的棒状导光体的端部形成有切口，来自发光单元的光通过遮光部的背面被反射该凹口与发光单元之间的间隙被引入到条形光导中。

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