专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07745649B2 Processes for preparing tetrahydropyran-4-one and pyran-4-one 有权
标题翻译：制备四氢吡喃-4-酮和吡喃-4-酮的方法
公开(公告)号：US07745649B2
公开(公告)日：2010-06-29
申请号：US10583562
申请日：2004-12-17
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
IPC分类号： C07D309/30
CPC分类号： C07D309/38 , C07C45/00 , C07C49/185 , C07D309/30
摘要： The present invention relates to a process for preparing tetrahydropyran-4-one represented by the formula (1): which comprises reacting at least one kind of dihydropyran-4-one and pyran-4-one represented by the formula (2): wherein represents a single bond or a double bond, and hydrogen (a) in the presence of a metal catalyst, in a mixed solvent of an aprotic solvent and an alcohol solvent, or (b) in the presence of an anhydrous metal catalyst in which a hydrated metal catalyst is subjected to dehydration treatment, in a hydrophobic organic solvent.
摘要翻译：本发明涉及一种由式（1）表示的四氢吡喃-4-酮的制备方法：其包括使由式（2）表示的至少一种二氢吡喃-4-酮和吡喃-4-酮：其中表示单键或双键，氢（a）在金属催化剂的存在下，在非质子溶剂和醇溶剂的混合溶剂中，或（b）在无水金属催化剂存在下，其中水合金属催化剂在疏水性有机溶剂中进行脱水处理。

2. 发明申请

US20070078272A1 Processes for preparing tetrahydropyran-4-one and pyran-4-one 有权
标题翻译：制备四氢吡喃-4-酮和吡喃-4-酮的方法
公开(公告)号：US20070078272A1
公开(公告)日：2007-04-05
申请号：US10583562
申请日：2004-12-17
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
IPC分类号： C07D315/00
CPC分类号： C07D309/38 , C07C45/00 , C07C49/185 , C07D309/30
摘要： The present invention relates to a process for preparing tetrahydropyran-4-one represented by the formula (1): which comprises reacting at least one kind of dihydropyran-4-one and pyran-4-one represented by the formula (2): wherein represents a single bond or a double bond, and hydrogen (a) in the presence of a metal catalyst, in a mixed solvent of an aprotic solvent and an alcohol solvent, or (b) in the presence of an anhydrous metal catalyst in which a hydrated metal catalyst is subjected to dehydration treatment, in a hydrophobic organic solvent.
摘要翻译：本发明涉及一种由式（1）表示的四氢吡喃-4-酮的制备方法：其包括使由式（2）表示的至少一种二氢吡喃-4-酮和吡喃-4-酮：其中 “img id =”custom-character-00001“he =”3.13mm“wi =”6.35mm“file =”US20070078272A1-20070405-P00900.TIF“alt =”custom character“img-content =”character“img-format =“tif”/>表示单键或双键，氢（a）在金属催化剂存在下，在非质子溶剂和醇溶剂的混合溶剂中，或（b）在在疏水性有机溶剂中，将水合金属催化剂进行脱水处理的无水金属催化剂。

3. 发明授权

US07304169B2 Process for producing tetrahydropyran-4-ol, intermediate therefor, and process for producing the same 有权
标题翻译：其中间产生四氢吡喃-4-醇的方法及其制备方法
公开(公告)号：US07304169B2
公开(公告)日：2007-12-04
申请号：US10516756
申请日：2003-06-10
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
IPC分类号： C07D309/12
CPC分类号： C07D309/12
摘要： The present invention relates to a process for preparing tetrahydropyran-4-ol which comprises the steps of (A) a cyclization step of preparing tetrahydropyranyl-4-formate represented by the formula (1): by reacting 3-buten-1-ol, a formaldehyde compound and formic acid, and (B) then, a solvolysis step of subjecting the tetrahydropyranyl-4-formate to solvolysis to obtain tetrahydropyran-4-ol represented by the formula (2): and an intermediate and a process for preparing the same.
摘要翻译：本发明涉及一种制备四氢吡喃-4-醇的方法，其包括以下步骤：（A）制备由式（1）表示的四氢吡喃基-4-甲酸盐的环化步骤：

4. 发明授权

US08133999B2 Process for preparation of 6, 7-bis(2-methoxyethoxy) quinazolin-4-one 有权
标题翻译：制备6,7-双（2-甲氧基乙氧基）喹唑啉-4-酮的方法
公开(公告)号：US08133999B2
公开(公告)日：2012-03-13
申请号：US12484632
申请日：2009-06-15
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Hiroyuki Oda , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Hiroyuki Oda , Shinobu Suzuki
IPC分类号： C07D239/72
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92
摘要： 6,7-Bis(2-methoxyethoxy)quinazolin-4-one of formula (5) useful in synthesis of an anti-cancer drug can be prepared by a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate of formula (4) with an orthoformic acid in the presence of an ammonium acetate:
摘要翻译：可用于合成抗癌药物的式（5）的6,7-双（2-甲氧基乙氧基）喹唑啉-4-酮可以通过2-氨基-4,5-双（2-甲氧基乙氧基）苯甲酸酯与原甲酸在乙酸铵存在下反应：

5. 发明申请

US20070106083A1 Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same 有权
标题翻译：制备4-氨基四氢吡喃化合物及其酸式盐的合成中间体及其制备方法
公开(公告)号：US20070106083A1
公开(公告)日：2007-05-10
申请号：US10564709
申请日：2004-07-14
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
IPC分类号： C07D309/14
CPC分类号： C07D309/10 , C07D309/14
摘要： The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (2): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (1): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, noble metal catalyst and metal oxide, and a synthetic intermediate thereof and a process for preparing the same.
摘要翻译：本发明涉及一种由式（2）表示的4-氨基四氢吡喃化合物及其酸式盐的制备方法：其中R表示氢原子或烃基，其包括使4-肼基四氢吡喃化合物或其酸式盐由式（1）表示：其中R具有与上述相同的含义，在至少一种选自阮内镍，贵金属催化剂和金属氧化物的化合物及其合成中间体存在下进行分解反应，以及其制备方法准备一样

6. 发明申请

US20060270849A1 Process for producing pyrimidin-4-one compound 审中-公开
标题翻译：制备嘧啶-4-酮化合物的方法
公开(公告)号：US20060270849A1
公开(公告)日：2006-11-30
申请号：US10561042
申请日：2004-06-18
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Shinobu Suzuki
IPC分类号： C07D487/02
CPC分类号： C07D487/04 , C07D239/90 , C07D239/91 , C07D471/04 , C07D495/04
摘要： A pyrimidin-4-one compound can be prepared in a high yield by reacting an aminoarylcarboxylic acid compound with an organic acid compound in the presence of a nitrogen atom-containing compound under relatively simple and moderate reaction conditions.
摘要翻译：通过使氨基芳基羧酸化合物与有机酸化合物在含氮原子化合物的存在下，在相对简单和适中的反应条件下反应，可以高收率地制备嘧啶-4-酮化合物。

7. 发明申请

US20050080262A1 Process for producing quinazolin-4-one derivative 失效
标题翻译：喹唑啉-4-酮衍生物的制备方法
公开(公告)号：US20050080262A1
公开(公告)日：2005-04-14
申请号：US10502734
申请日：2003-01-28
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda , Takeshi Takahashi , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada , Hiroyuki Oda , Takeshi Takahashi , Shinobu Suzuki
IPC分类号： C07C201/08 , C07C205/59 , C07C205/60 , C07C227/04 , C07C229/56 , C07C229/64 , C07D239/88 , C07D239/90 , C07D239/72
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92 , C07C201/08 , C07C205/59 , C07C205/60 , C07C227/04 , C07C229/56 , C07C229/64 , C07D239/90
摘要： A process for producing a quinazolin-4-one compound having the formula: [wherein R1, R2, R3 and R4 each represents a group not participating in the below-mentioned reaction, and R1, R2, R3 and R4 can be combined together to form a ring] which comprises reacting an anthranilic acid derivative having the formula: [wherein R5 is a hydrogen atom or a hydrocarbyl group] with a formic acid derivative in the presence of an ammonium carboxylate.
摘要翻译：制备具有下式的喹唑啉-4-酮化合物的方法：其中R 1，R 2，R 3和R 4各自表示不参与下述反应的基团，和 R 1，R 2，R 3和R 4可以组合在一起形成环]，其包括使具有下式的邻氨基苯甲酸衍生物：其中R 5是氢原子或烃基]与甲酸衍生物在羧酸铵存在下反应。

8. 发明授权

US07365215B2 Process for preparing 4-aminotetrahydropyran compound and an acid salt thereof, synthetic intermediate thereof and process for preparing the same 有权
标题翻译：制备4-氨基四氢吡喃化合物及其酸式盐的合成中间体及其制备方法
公开(公告)号：US07365215B2
公开(公告)日：2008-04-29
申请号：US10564709
申请日：2004-07-14
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Keiji Iwamoto , Takashi Harada , Shinobu Suzuki
IPC分类号： C07D315/00
CPC分类号： C07D309/10 , C07D309/14
摘要： The present invention relates to a process for preparing 4-aminotetrahydropyran compound and an acid salt thereof represented by the formula (1): wherein R represents a hydrogen atom or a hydrocarbon group, which comprises subjecting a 4-hydrazinotetrahydropyran compound or an acid salt thereof represented by the formula (2): wherein R has the same meaning as defined above, to decomposition reaction in the presence of at least one compound selected from Raney nickel, a noble metal catalyst and a metal oxide, and a synthetic intermediate thereof and a process for preparing the same.
摘要翻译：本发明涉及一种由式（1）表示的4-氨基四氢吡喃化合物及其酸式盐的制备方法：其中R表示氢原子或烃基，其包括使4-肼基四氢吡喃化合物或其酸式盐由式（2）表示：其中R具有与上述相同的含义，在至少一种选自阮内镍，贵金属催化剂和金属氧化物的化合物及其合成中间体存在下进行分解反应，和制备方法

9. 发明申请

US20060276647A1 Process for producing 6, 7-bis (2-methoxyethoxy)-quinazolin-4-one 审中-公开
标题翻译：制备6,7-双（2-甲氧基乙氧基） - 喹唑啉-4-酮的方法
公开(公告)号：US20060276647A1
公开(公告)日：2006-12-07
申请号：US10565981
申请日：2004-07-30
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Hiroyuki Oda , Shinobu Suzuki
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Hiroyuki Oda , Shinobu Suzuki
IPC分类号： C07D239/80
CPC分类号： C07D239/88 , C07C67/31 , C07C69/92
摘要： A process comprising a reaction of ethyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate with a formic acid compound in the presence of an ammonium carboxylate gives 6,7-bis(2-methoxyethoxy)quinazolin-4-one in a high yield.
摘要翻译：在羧酸铵存在下，将2-氨基-4,5-双（2-甲氧基乙氧基）苯甲酸乙酯与甲酸化合物反应的方法得到6,7-双（2-甲氧基乙氧基）喹唑啉-4-酮以高收益。

10. 发明授权

US07619084B2 Process for preparing 4-aminopyrimidine compound 失效
标题翻译： 4-氨基嘧啶化合物的制备方法
公开(公告)号：US07619084B2
公开(公告)日：2009-11-17
申请号：US11666510
申请日：2005-10-28
申请人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada
发明人： Shigeyoshi Nishino , Kenji Hirotsu , Hidetaka Shima , Takashi Harada
IPC分类号： C07D239/02
CPC分类号： C07D239/42
摘要： The present invention is to provide a process for preparing a 4-aminopyrimidine compound represented by the formula (3): wherein R1 and R2 each represent a hydrogen atom or group which does not participate in the reaction and which may have a substituent(s), and R1 and R2 may be bonded to each other to form a ring, and R4 represents a hydrogen atom or a hydrocarbon group, which comprises reacting ammonia, a 3-substituted or unsubstituted acrylonitrile compound represented by the formula (1): CR1(CN)═CR2Y (1) wherein R1 and R2 have the same meanings as defined above, and Y represents an amino group or OR, where R represents a hydrogen atom or a hydrocarbon group, and an organic acid compound represented by the formula (2): (R3O)3CR4 (2) wherein R3 represents a hydrocarbon group, and R4 has the same meaning as defined above.
摘要翻译：本发明提供一种制备式（3）表示的4-氨基嘧啶化合物的方法：其中R1和R2各自表示氢原子或不参与反应的基团，并且可以具有取代基， R 1和R 2可以彼此键合形成环，R 4表示氢原子或烃基，其包括使氨，3-取代或未取代的由式（1）表示的丙烯腈化合物：CR1（ CN）-CR2Y（1）其中R1和R2具有与上述相同的含义，Y表示氨基或OR，其中R表示氢原子或烃基，和由式（2）表示的有机酸化合物）：（R3O）3CR4（2）其中R3表示烃基，R4具有与上述相同的含义。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式