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1. 发明授权

US4582928A Process for producing optically active phenylalanine 失效
标题翻译：光学活性苯丙氨酸的制备方法
公开(公告)号：US4582928A
公开(公告)日：1986-04-15
申请号：US716400
申请日：1985-03-27
申请人： Shigeru Aoki , Mamoru Katagiri , Ryoichi Hasegawa , Akikazu Mitsunobu , Yasuhisa Tashiro
发明人： Shigeru Aoki , Mamoru Katagiri , Ryoichi Hasegawa , Akikazu Mitsunobu , Yasuhisa Tashiro
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07C227/34 , C07C229/36 , C07C101/08
CPC分类号： C07C227/34
摘要： This invention relates to a process for producing optically active phenylalanine, characterized by optically resolving DL-phenylalanine.optically active mandelic acid complexes in an aqueous solvent in the presence of an acidic compound having a pKa value of 0.90 to 2.10 and isolating optically active phenylalanine from the obtained optically active phenylalanine.optically active mandelic acid complex.According to the process of the present invention, it is possible to decrease the amount of a mother liquor of resolution to 1/5 to 1/10 of that when no acidic compound is used and to obtain optically active phenylalanine having an optical purity of as high as 96.5% or above without a step of optical purification when optically active phenylalanine is isolated from the obtained optically active phenylalanine.optically active mandelic acid complex.
摘要翻译：本发明涉及一种光学活性苯丙氨酸的制备方法，其特征在于在pKa值为0.90至2.10的酸性化合物存在下，在水性溶剂中光学拆分DL-苯丙氨酸光学活性扁桃酸配合物，并将光学活性苯丙氨酸从所得光学活性苯丙氨酸光学活性扁桃酸复合物。根据本发明的方法，可以将分辨率降低至不使用酸性化合物时的1/5至1/10的量，并获得具有光学纯度的光学活性苯丙氨酸光学活性苯丙氨酸光学活性苯丙氨酸复合物中分离出光学活性苯丙氨酸时，不需要光学纯化步骤，高达96.5％以上。

2. 发明授权

US4730076A Process for producing .alpha.-aspartyl-phenylalanine ester 失效
标题翻译： α-天门冬酰基 - 苯丙氨酸酯的制备方法
公开(公告)号：US4730076A
公开(公告)日：1988-03-08
申请号：US942146
申请日：1986-12-16
申请人： Tadashi Fujii , Hiroshi Yagiuchi , Akikazu Mitsunobu , Shigeru Aoki , Makoto Tsuda
发明人： Tadashi Fujii , Hiroshi Yagiuchi , Akikazu Mitsunobu , Shigeru Aoki , Makoto Tsuda
IPC分类号： C07K5/075 , C07C101/02
CPC分类号： C07K5/0613
摘要： The present invention relates to a process for producing .alpha.-aspartyl-phenylalanine ester represented by the general formula ##STR1## wherein R' represents an alkyl group having 1 to 4 carbon atoms, by reducing an N-protected-N-hydroxymethyl-.alpha.-aspartyl-phenylalanine ester represented by the general formula ##STR2## wherein R represents an organic mioety which can be substituted reductively by hydrogen, and R' is as defined above, with hydrogen gas or formic acid, in the presence of a reduction catalyst and an aromatic primary amine. According to the present invention, there can be obtained a high purity .alpha.-aspartyl-phenylalanine ester with a high yield.
摘要翻译：本发明涉及通过还原N-保护的N-羟甲基-α-谷氨酰胺来制备由通式“IMAGE”表示的α-天门冬酰胺 - 苯丙氨酸酯的方法，其中R'代表具有1至4个碳原子的烷基，由通式表示的天冬氨酰基 - 苯丙氨酸酯，其中R表示可在氢还原催化剂和还原催化剂存在下用氢气或甲酸还原的氢被还原反应的R'和R'定义的有机二氧化物，芳族伯胺。根据本发明，可以高产率地得到高纯度的α-天冬氨酰基苯丙氨酸酯。

3. 发明授权

US4542236A Process for preparing optically active phenylalanine 失效
标题翻译：制备光学活性苯丙氨酸的方法
公开(公告)号：US4542236A
公开(公告)日：1985-09-17
申请号：US634228
申请日：1984-07-25
申请人： Yasuhisa Tashiro , Shigeru Aoki
发明人： Yasuhisa Tashiro , Shigeru Aoki
IPC分类号： C07B57/00 , C07C101/08
CPC分类号： C07C227/34
摘要： The present invention relates to a process for preparing optically active phenylalanine which comprises resolving mixture of a complex of D-phenylalanine and optically active mandelic acid and a complex of L-phenylalanine and optically active mandelic acid in a solvent containing hydrochloric acid, carboxylic acid, phosphoric acid or a salt thereof to obtain the complex having lower solubility, and removing said optically active mandelic acid from the obtained complex to obtain an optically active phenylalanine.In the case of resolving DL-phenylalanine by the process according to the present invention, the amount of mother liquor used in resolution can be made to about 1/2 to 1/6 as compared to the amount of mother liquor of which the acidic compound or the salt thereof is not used in the resolution. Accordingly, the process according to the present invention is extremely profitable as an industrial process for producing an optically active phenylalanine.
摘要翻译：本发明涉及一种光学活性苯丙氨酸的制备方法，其包括将D-苯丙氨酸和光学活性扁桃酸的配合物与L-苯丙氨酸和光学活性扁桃酸的配合物在含有盐酸，羧酸，磷酸或其盐以获得具有较低溶解度的络合物，并从所得络合物中除去所述光学活性扁桃酸，得到光学活性苯丙氨酸。在通过根据本发明的方法分解DL-苯丙氨酸的情况下，与其中酸性化合物的母液的量相比，分辨率中使用的母液的量可以制成约1/2至1/6 或其盐不在分辨率中使用。因此，根据本发明的方法作为用于制备光学活性苯丙氨酸的工业方法是非常有利的。

4. 发明授权

US4224239A Process for preparing optically active amino acid or mandelic acid 失效
标题翻译：光学活性氨基酸或扁桃酸的制备方法
公开(公告)号：US4224239A
公开(公告)日：1980-09-23
申请号：US33021
申请日：1979-04-24
申请人： Yasuhisa Tashiro , Takashi Nagashima , Shigeru Aoki , Rinzo Nishizawa
发明人： Yasuhisa Tashiro , Takashi Nagashima , Shigeru Aoki , Rinzo Nishizawa
IPC分类号： C07B57/00 , C07B31/00 , C07C59/50 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/34 , C07C229/08 , C07C313/00 , C07C323/58 , C07C101/04 , C07B19/00 , C07C101/08
CPC分类号： C07C59/50
摘要： Two optically active amino acid-mandelic acid complexes are obtained by interacting in a solvent under pH conditions of 1.0-4.0 an amino acid expressed by a general formula ##STR1## (in which R represents a methyl group, an ethyl group or a methylthioethyl group) and mandelic acid, one of the acids being an optically active substance and the other being a racemic modification, and optically resolving the resulting complexes into two diastereoisomers by using solubility difference therebetween. The optically active complexes are each decomposed by means of an acid, a strongly acidic ion-exchange resin, or a weakly basis ion-exchange resin to obtain optically active amino acids or optically active mandelic acid.
摘要翻译：通过在1.0-4.0的pH条件下在溶剂中相互作用获得两个光学活性的氨基酸 - 扁桃酸复合物，所述氨基酸由通式“IMAGE”（其中R表示甲基，乙基或甲硫基乙基））和扁桃酸，其中一种酸是光学活性物质，另一种是外消旋体改性，并通过使用它们之间的溶解度差异将所得的络合物光学拆分成两个非对映异构体。光学活性复合物各自通过酸，强酸性离子交换树脂或弱碱离子交换树脂分解，得到光学活性氨基酸或光学活性扁桃酸。

5. 发明授权

US4115439A Process for the preparation of optically active .alpha.-phenylglycine and intermediates thereof 失效
标题翻译：光学活性{60-苯基甘氨酸及其中间体的制备方法
公开(公告)号：US4115439A
公开(公告)日：1978-09-19
申请号：US670420
申请日：1976-03-25
申请人： Shigeru Aoki , Yasuhisa Tashiro , Yuzo Aboshi , Toshiro Narita , Tadashi Shirai
发明人： Shigeru Aoki , Yasuhisa Tashiro , Yuzo Aboshi , Toshiro Narita , Tadashi Shirai
IPC分类号： C07C227/34 , C07B57/00 , C07C229/36 , C07C101/04 , C07C143/26
CPC分类号： C07B57/00
摘要： DL- .alpha.-phenylglycine can be combined with benzene-sulfonic acid, p-ethylbenzenesulfonic acid or m-xylenesulfonic acid to give the salt. The salt of the racemate may be more soluble in a sulfuric acid solution than the salt of the optically active isomer by suitably choosing the concentration of the sulfuric acid solution, and then the optical resolution by fractional crystallization is carried out. The D- or L- .alpha.-phenylglycine sulfonate is easily liberated of the sulfonic acid portion to give optically active D- or L- .alpha.-phenylglycine.
摘要翻译： DL-α-苯基甘氨酸可与苯磺酸，对乙基苯磺酸或间二甲苯磺酸组合，得到盐。通过适当选择硫酸溶液的浓度，外消旋体的盐可以比硫酸溶液更好地溶解于光学活性异构体的盐中，然后通过分级结晶进行光学拆分。 D-或L-α-苯基甘氨酸磺酸盐容易释放出磺酸部分，得到光学活性的D-或L-α-苯基甘氨酸。

6. 发明授权

US4667054A Process for producing optically active valine 失效
标题翻译：光学活性缬氨酸的制备方法
公开(公告)号：US4667054A
公开(公告)日：1987-05-19
申请号：US824089
申请日：1986-01-30
申请人： Yoshinobu Miyazawa , Noriko Ooishi , Shigeru Aoki , Yasuhisa Tashiro
发明人： Yoshinobu Miyazawa , Noriko Ooishi , Shigeru Aoki , Yasuhisa Tashiro
IPC分类号： C07B57/00 , C07B31/00 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/34 , C07C229/08
CPC分类号： C07C227/34
摘要： This invention relates to a process for producing optically active valine, characterized by optically resolving DL-valine hydrochloride in a solvent containing an amine salt, a sulfonic acid or a carboxylic acid and isolating optically active valine after the decomposition of the obtained optically active valine hydrochloride.
摘要翻译：本发明涉及一种光学活性缬氨酸的制备方法，其特征在于将光学活性缬氨酸盐酸盐分解后，在含有胺盐，磺酸或羧酸的溶剂中光学拆分DL-缬氨酸盐酸盐，并分离光学活性缬氨酸。

7. 发明授权

US4198524A Optically active amino acid-mandelic acid complexes 失效
标题翻译：光活性氨基酸 - 扁桃酸复合物
公开(公告)号：US4198524A
公开(公告)日：1980-04-15
申请号：US886745
申请日：1978-03-15
申请人： Yasuhisa Tashiro , Takashi Nagashima , Shigeru Aoki , Rinzo Nishizawa
发明人： Yasuhisa Tashiro , Takashi Nagashima , Shigeru Aoki , Rinzo Nishizawa
IPC分类号： C07B57/00 , C07B31/00 , C07C59/50 , C07C67/00 , C07C227/00 , C07C227/18 , C07C227/34 , C07C229/08 , C07C313/00 , C07C323/58 , C07C65/135
CPC分类号： C07C59/50
摘要： Two optically active amino acid-mandelic acid complexes are obtained by reacting in a solvent under pH conditions of 1.0-4.0, an amino acid expressed by a general formula ##STR1## (in which R represents a methyl group, an ethyl group or a methylthioethyl group) and mandelic acid, one of the acids being an optically active substance and the other being a racemic modification, and optically resolving the resulting complexes into two diastereomers by using a solubility difference therebetween. The optically active complexes are each decomposed by means of an acid, a strongly acidic ion-exchange resin, or a weakly basic ion-exchange resin to obtain optically active amino acids or optically active mandelic acid.
摘要翻译：两种光学活性的氨基酸 - 扁桃酸配合物通过在溶剂中在1.0-4.0的pH条件下反应得到，该通式为通式（IMAGE）表示的氨基酸（其中R表示甲基，乙基或甲基硫代乙基基团）和扁桃酸，其中一种酸是光学活性物质，另一种是外消旋体改性，并通过使用它们之间的溶解度差异将所得复合物光学拆分成两种非对映异构体。光学活性复合物各自通过酸，强酸性离子交换树脂或弱碱性离子交换树脂分解，得到光学活性氨基酸或光学活性扁桃酸。

8. 发明授权

US4002666A Process for the preparation of optically active p-hydroxyphenylglycine 失效
标题翻译：光学活性对羟基苯基甘氨酸的制备方法
公开(公告)号：US4002666A
公开(公告)日：1977-01-11
申请号：US516963
申请日：1974-10-22
申请人： Tadashi Shirai , Yasuhisa Tashiro , Shigeru Aoki
发明人： Tadashi Shirai , Yasuhisa Tashiro , Shigeru Aoki
IPC分类号： C07B57/00 , C07B31/00 , C07C19/00 , C07C67/00 , C07C227/00 , C07C227/20 , C07C227/34 , C07C229/36 , C07C231/00 , C07C231/12 , C07C231/20 , C07C233/47 , C07C103/46 , C07C103/84 , C07C125/06
CPC分类号： C07C271/06
摘要： Optically active p-hydroxyphenylglycine is prepared by reacting a racemic compound of a specified p-hydroxyphenylglycine derivative with optically active .alpha.-phenylethylamine to form a corresponding salt, obtaining two types of optically active salts therefrom by fractional crystallization, and obtaining optically active p-hydroxyphenylglycine by decomposition and hydrolysis of at least one of the optically active salts.
摘要翻译：通过使特定的对羟基苯基甘氨酸衍生物的外消旋化合物与光学活性α-苯乙胺反应形成相应的盐，通过分级结晶获得两种类型的光学活性盐，得到光学活性对羟基苯基甘氨酸，制备光学活性对羟基苯基甘氨酸通过至少一种光学活性盐的分解和水解。

9. 发明授权

US3994962A Method of manufacturing optically active p-hydroxyphenylglycine 失效
标题翻译：光学活性对羟基苯基甘氨酸的制造方法
公开(公告)号：US3994962A
公开(公告)日：1976-11-30
申请号：US544899
申请日：1975-01-28
申请人： Tadashi Shirai , Yasuhisa Tashiro , Shigeru Aoki
发明人： Tadashi Shirai , Yasuhisa Tashiro , Shigeru Aoki
IPC分类号： C07C143/28
摘要： Optically active p-hydroxyphenylglycine is manufactured by inoculating a supersaturated solution of a p-hydroxyphenylglycine sulfonic acid derivative salt comprising a mixture of the two optically active enantiomers of said salt with an optically active enantiomer of the same salt, said mixture being either racemic or else one in which the predominant enantiomer is that of the inoculant. In this manner the enantiomer having the form of the inoculant is selectively crystallized. The selectively crystallized salt is thereafter treated for removal of the sulfonic acid derivative.
摘要翻译：通过将包含所述盐的两种光学活性对映异构体的混合物的对羟基苯基甘氨酸磺酸衍生物盐的过饱和溶液与相同盐的光学活性对映体接触来制备光学活性对羟基苯基甘氨酸，所述混合物是外消旋的其中主要的对映异构体是孕育剂的对映异构体。以这种方式，具有孕育剂形式的对映体被选择性结晶。然后处理选择性结晶的盐以除去磺酸衍生物。

10. 发明授权

US09021522B2 Concurrent interactive television for network connected devices 有权
标题翻译：用于网络连接设备的并发交互式电视
公开(公告)号：US09021522B2
公开(公告)日：2015-04-28
申请号：US12332208
申请日：2008-12-10
申请人： Shigeru Aoki , Azmee Carlton Lane , Kenichiro Tanaka , Michimune Kono
发明人： Shigeru Aoki , Azmee Carlton Lane , Kenichiro Tanaka , Michimune Kono
IPC分类号： G06F3/01 , G06F13/12 , H04N7/173 , H04N21/436 , H04N21/433 , H04N21/434 , H04N21/4722 , H04N21/8543
CPC分类号： H04N21/43615 , H04N21/4334 , H04N21/4348 , H04N21/4722 , H04N21/8543
摘要： Techniques are disclosed herein for processing iTV. A request to play a first interactive television signal at a first electronic device is received. A first virtual machine for processing the first interactive television signal is instantiated at the first electronic device. A first file that includes information associated with playing interactive TV on the first electronic device is accessed from non-volatile storage on the first electronic device. A request to play a second interactive television signal at a second electronic device that is communicatively coupled to the first electronic device is received. A second virtual machine for processing the second interactive television signal is instantiated at the first device. A second file that includes information associated with playing interactive TV on the second electronic device is stored in non-volatile storage on the first electronic device.
摘要翻译：本文公开了用于处理iTV的技术。接收在第一电子设备播放第一交互式电视信号的请求。用于处理第一交互式电视信号的第一虚拟机在第一电子设备处被实例化。从第一电子设备上的非易失性存储器访问包括与在第一电子设备上播放交互式电视相关联的信息的第一文件。接收在通信地耦合到第一电子设备的第二电子设备处播放第二交互式电视信号的请求。用于处理第二交互式电视信号的第二虚拟机在第一设备处被实例化。包括与在第二电子设备上播放交互式电视相关联的信息的第二文件被存储在第一电子设备上的非易失性存储器中。

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