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1. 再颁专利

USRE33188E Peptides for assaying human parathyroid hormone 失效
标题翻译：用于测定人甲状旁腺激素的肽
公开(公告)号：USRE33188E
公开(公告)日：1990-03-27
申请号：US332801
申请日：1989-04-03
申请人： Toshiharu Noda , Kaoru Morita , Sadami Kobari , Nobuaki Nakagawa , Susumu Watanabe , Shigeo Katsuragi , Kunio Ohyama , Masahiko Taniuchi
发明人： Toshiharu Noda , Kaoru Morita , Sadami Kobari , Nobuaki Nakagawa , Susumu Watanabe , Shigeo Katsuragi , Kunio Ohyama , Masahiko Taniuchi
IPC分类号： A61K38/00 , C07K5/06 , C07K5/068 , C07K14/635
CPC分类号： C07K14/635 , C07K5/06052 , C07K5/06069 , C07K5/06086 , A61K38/00 , Y10S530/806
摘要： A peptide of the formulaR--Lys--Lys--Glu--Asp--Asn--Val--Leu--Val--Glu--Ser--His--Glu--Lys--Ser--Leu--Gly--Glu--Ala--Asp--Lys--Ala--Asp--Val--Asp--Val--Leu--Thr--Lys--Ala--Lys--Ser--Gln--OHwherein R is H, H--Tyr-- or R.sub.1 --Pro--Arg--, R.sub.1 is H, H--Tyr-- or R.sub.2 --Ala--Gly--Ser--Gln--Arg--, and R.sub.2 is H, H--Cys-- or H--Tyr--, or a salt thereof, is useful for assaying human parathyroid hormone (h-PTH).

2. 发明授权

US4400316A C-Terminal fragment of human chorionic gonadotropin 失效
标题翻译：人绒毛膜促性腺激素的C-末端片段
公开(公告)号：US4400316A
公开(公告)日：1983-08-23
申请号：US320699
申请日：1981-11-12
申请人： Shigeo Katsuragi , Kaoru Morita , Sadami Kobari , Toshiharu Noda , Nobuaki Nakagawa , Susumu Watanabe
发明人： Shigeo Katsuragi , Kaoru Morita , Sadami Kobari , Toshiharu Noda , Nobuaki Nakagawa , Susumu Watanabe
IPC分类号： G01N33/53 , A61K39/00 , C07K5/06 , C07K5/072 , C07K5/083 , C07K5/103 , C07K7/08 , C07K14/00 , C07K14/575 , C07K14/59 , C07K16/00 , G01N33/74 , C07C103/52
CPC分类号： C07K5/101 , C07K14/59 , C07K5/06069 , C07K5/06095 , C07K5/0808 , A61K39/00 , Y02P20/55 , Y10S930/11
摘要： A peptide of the formulaR-SER-LEU-PRO-SER-PRO-SER-ARG-LEU-PRO-GLY-PRO-SER-ASP-THR-PRO-ILE-LEU-PRO-GLN-OHwhereinR: H or R.sub.1 -Ser-Ser-Ser-Ser-Lys-Ala-Pro-Pro-Pro group,R.sub.1 : H or R.sub.2 -R.sub.3 -Asp-Asp-Pro-Arg-Phe-Gln-Asp group,R.sub.2 : H or R.sub.4 -Asp-His-Pro-Leu-Thr group,R.sub.4 : H-R.sub.5 -Gly-Gly-Pro-Lys group,R.sub.5 : Cys or Tyr group, andR.sub.3 : Cys or S-acetamidemethyl-Cys group,or salt thereof, has utility for the preparation of antibodies for assaying human chorionic gonadotropin or as a labelling reagent.
摘要翻译：式R-SER-LEU-PRO-SER-PRO-SER-ARG-LEU-PRO-GLY-PRO-SER-ASP-THR-PRO-ILE-LEU-PRO-GLN-OH的肽，其中R：H 或R1-Ser-Ser-Ser-Ser-Lys-Ala-Pro-Pro-Pro基团，R1：H或R2-R3-Asp-Asp-Pro-Arg-Phe-Gln-Asp基团，R2：H或R4 -Asp-His-Pro-Leu-Thr组，R4：H-R5-Gly-Gly-Pro-Lys基，R5：Cys或Tyr基，R3：Cys或S-乙酰氨基甲基-Cys基或其盐，可用于制备用于测定人绒毛膜促性腺激素或作为标记试剂的抗体。

3. 发明授权

US4409141A Peptides for assaying human parathyroid hormone 失效
标题翻译：用于测定人甲状旁腺激素的肽
公开(公告)号：US4409141A
公开(公告)日：1983-10-11
申请号：US335401
申请日：1981-12-29
申请人： Toshiharu Noda , Kaoru Morita , Sadami Kobari , Nobuaki Nakagawa , Susumu Watanabe , Shigeo Katsuragi , Kunio Ohyama , Masahiko Taniuchi
发明人： Toshiharu Noda , Kaoru Morita , Sadami Kobari , Nobuaki Nakagawa , Susumu Watanabe , Shigeo Katsuragi , Kunio Ohyama , Masahiko Taniuchi
IPC分类号： A61K38/00 , C07K5/06 , C07K5/068 , C07K14/635 , C07C103/52
CPC分类号： C07K14/635 , C07K5/06052 , C07K5/06069 , C07K5/06086 , A61K38/00 , Y10S530/806
摘要： A peptide of the formulaR--Lys--Lys--Glu--Asp--Asn--Val--Leu--Val--Glu--Ser--His--Glu--Lys--Ser--Leu--Gly--Glu--Ala--Asp--Lys--Ala--Asp--Val--Asp--Val--Leu--Thr--Lys--Ala--Lys--Ser--Gln--Ohwherein R is H, H--Tyr-- or R.sub.1 --Pro--Arg--, R.sub.1 is H, H--Tyr-- or R.sub.2 --Ala--Gly--Ser--Gln--Arg--, and R.sub.2 is H, H--Cys-- or H--Tyr--, or a salt thereof, is useful for assaying human parathyroid hormone (h-PTH)
摘要翻译：式R-Lys-Lys-Glu-Asp-Asn-Val-Leu-Val-Glu-Ser-His-Glu-Lys-Ser-Leu-Gly-Glu-Ala-Asp-Lys-Ala-Asp -Val-Asp-Val-Leu-Thr-Lys-Ala-Lys-Ser-Gln-Oh其中R是H，H-Tyr-或R1-Pro-Arg-，R1是H，H-Tyr-或R2- Ala-Gly-Ser-Gln-Arg-和R2

4. 发明授权

US4423034A Process for the preparation of antibodies 失效
标题翻译：制备抗体的方法
公开(公告)号：US4423034A
公开(公告)日：1983-12-27
申请号：US372824
申请日：1982-04-28
申请人： Nobuaki Nakagawa , Kikuo Kotani , Shigeo Katsuragi , Kaoru Morita , Kunio Ohyama , Toshiharu Noda
发明人： Nobuaki Nakagawa , Kikuo Kotani , Shigeo Katsuragi , Kaoru Morita , Kunio Ohyama , Toshiharu Noda
IPC分类号： C07K14/605 , A61K39/00 , C07C103/52 , C07G7/00
CPC分类号： C07K14/605
摘要： A novel peptide of the formulaH--Ser--Arg--Arg--Ala--Gln--Asp--Phe--Val--Gln--Trp--Leu--Met--Asn--Thr--OHis the 16-29 fragment of glucagon and can be conjugated with a protein such as albumin or modified albumin using glutaraldehyde or 3-(2'-benzothiazolyl-dithio) propionate succinimide ester as a conjugation reagent. The conjugated peptide can be used to sensitize a mammal by administering the conjugated peptide subcutaneously, after which the blood is collected from the mammal and antibodies concentrated from the blood, which antibodies are then useful in assay methods for trace amounts of glucagon in human blood.
摘要翻译：式H-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-OH的新型肽是胰高血糖素的16-29片段，可与使用戊二醛或3-（2'-苯并噻唑基 - 二硫代）丙酸酯琥珀酰亚胺酯作为共轭试剂的蛋白质如白蛋白或改性白蛋白。缀合的肽可用于通过皮下施用缀合的肽来使哺乳动物敏化，之后从哺乳动物收集血液和从血液中浓缩的抗体，然后该抗体可用于人血液中微量胰高血糖素的测定方法。

5. 发明授权

US4495151A Element for immunoassay 失效
标题翻译：免疫测定的要素
公开(公告)号：US4495151A
公开(公告)日：1985-01-22
申请号：US394473
申请日：1982-07-01
申请人： Kunio Ohyama , Nobuaki Nakagawa , Susumu Watanabe
发明人： Kunio Ohyama , Nobuaki Nakagawa , Susumu Watanabe
IPC分类号： G01N33/543 , G01N33/54
CPC分类号： G01N33/54366 , Y10S436/81
摘要： Apparatus for performing an immunoassay, comprises in combination a reaction tube closed at its bottom, and in the reaction tube a molded element having on its surface material having specific binding ability for a component in a liquid specimen to be assayed. The shape of the surface of the element adjacent the interior surface of the tube is the complement of the shape of the interior surface of the tube. A spacer rib is provided on the element, in contact with the interior surface of the tube. This rib holds the element in such position in the tube that the surfaces of complementary shape of the element and tube are shaped from each other a small but constant distance. A thin layer of constant thickness of a liquid specimen for immunoassay is thus receivable between the complementary surfaces. This arrangement increases the contact surface of the liquid medium in the reaction tube by the element, by establishing a homogeneous uniform layer of liquid medium. This avoids the need for stirring and shaking and reduces the required volume of the specimen to be assayed.
摘要翻译：用于进行免疫测定的装置包括在其底部封闭的反应管，反应管中的模制元件在其表面上具有对要测定的液体样品中的组分的特异性结合能力的材料。邻近管内表面的元件表面的形状是管的内表面形状的互补。间隔肋设置在元件上，与管的内表面接触。该肋将元件保持在管中的这种位置，元件和管的互补形状的表面彼此成一个小但恒定的距离。因此，可以在互补表面之间接收用于免疫测定的液体样本的恒定厚度的薄层。这种布置通过构成均匀均匀的液体介质层，增加了反应管中液体介质的接触表面。这避免了搅拌和摇动的需要，并且减少要测定的样品的所需体积。

6. 发明授权

US4287345A Polyfunctional disulfide compounds having S--S exchange reactivity 失效
标题翻译：具有S-S交换反应性的多官能二硫化物
公开(公告)号：US4287345A
公开(公告)日：1981-09-01
申请号：US111482
申请日：1980-01-11
申请人： Kikuo Kotani , Kunio Ohyama , Nobuaki Nakagawa , Tadashiro Fujii , Susumu Watanabe
发明人： Kikuo Kotani , Kunio Ohyama , Nobuaki Nakagawa , Tadashiro Fujii , Susumu Watanabe
IPC分类号： C07D213/71 , C07D213/89 , C07D277/78 , G01N33/535 , C07D213/70
CPC分类号： C07D213/89 , C07D213/71 , C07D277/78 , G01N33/535
摘要： A polyfunctional disulfide compound, useful as a cross-linking reagent having S--S exchange reactivity, of the formula ##STR1## wherein R is 2-benzothiazolyl or 2-pyridyl-N-oxide and X is a spacer group having an alkylene group directly bonded to each S--S group.
摘要翻译：可用作具有SS交换反应性的交联剂的多官能二硫化物化合物，其中R是2-苯并噻唑基或2-吡啶基-N-氧化物，X是具有亚烷基直接键合到每个SS组。

7. 发明申请

US20050026253A1 Novel protein and processes for producing the same 审中-公开
标题翻译：新型蛋白质及其生产方法
公开(公告)号：US20050026253A1
公开(公告)日：2005-02-03
申请号：US10900423
申请日：2004-07-28
申请人： Masaaki Goto , Akihiro Tomoyasu , Kazuki Yano , Fumie Kobayashi , Nobuaki Nakagawa , Hisataka Yasuda , Kyoji Yamaguchi , Masahiko Kinosaki , Shin-ichi Mochizuki , Tadashi Nakakarumai , Tomonori Morinaga , Eisuke Tsuda , Kanji Higashio
发明人： Masaaki Goto , Akihiro Tomoyasu , Kazuki Yano , Fumie Kobayashi , Nobuaki Nakagawa , Hisataka Yasuda , Kyoji Yamaguchi , Masahiko Kinosaki , Shin-ichi Mochizuki , Tadashi Nakakarumai , Tomonori Morinaga , Eisuke Tsuda , Kanji Higashio
IPC分类号： A61K38/00 , C07K14/47 , C12N5/08 , C07H21/04
CPC分类号： C07K14/47 , A61K38/00
摘要： A novel protein and a process of producing the protein is provided. The protein is a glycoprotein having activity of suppressing the differentiation and/or maturation of adipocyte, having a molecular weight of about 45 kD under non-reducing conditions and about 28 kD and/or 23 kD under reducing conditions, and exhibiting affinity to heparin. A process of producing the protein comprising culturing human fibroblasts and purifying the culture broth by chromatography using an ion exchange column, affinity column, and reverse phase column. A cDNA encoding the protein and a process of producing the protein using the cDNA are also provided. The protein of the present invention is useful as a pharmaceutical composition for preventing or treating obesity or as an antigen for establishing immunological diagnosis, etc.,
摘要翻译：提供了一种新的蛋白质和产生该蛋白质的方法。蛋白质是具有抑制脂肪细胞分化和/或成熟的活性的糖蛋白，在还原条件下，分子量约为45kD，在还原条件下具有约28kD和/或23kD，并且对肝素具有亲和力。一种生产蛋白质的方法，包括培养人成纤维细胞，并使用离子交换柱，亲和柱和反相柱通过色谱法纯化培养液。还提供了编码蛋白质的cDNA和使用cDNA产生蛋白质的方法。本发明的蛋白质可用作预防或治疗肥胖的药物组合物或用作建立免疫诊断等的抗原，

8. 发明申请

US20050003457A1 Antibodies to OCIF-binding molecules 有权
标题翻译： OCIF结合分子的抗体
公开(公告)号：US20050003457A1
公开(公告)日：2005-01-06
申请号：US10854300
申请日：2004-05-27
申请人： Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
发明人： Kyoji Yamaguchi , Hisataka Yasuda , Nobuaki Nakagawa , Nobuyuki Shima , Masahiko Kinosaki , Eisuke Tsuda , Masaaki Goto , Kazuki Yano , Akihiro Tomoyasu , Fumie Kobayashi , Naohiro Washida , Ken Takahashi , Tomonori Morinaga , Kanji Higashio
IPC分类号： C07K14/715 , A61K20060101 , A61K38/00 , A61K39/395 , A61K45/00 , A61P3/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P19/10 , A61P29/00 , B01J20/281 , C07K20060101 , C07K1/22 , C07K14/47 , C07K14/525 , C07K14/705 , C07K16/18 , C07K16/28 , C12N20060101 , C12N5/10 , C12N5/20 , C12N15/02 , C12N15/09 , C12N15/12 , C12P20060101 , C12P21/02 , C12P21/08 , C12Q20060101 , G01N20060101 , G01N30/88 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N33/577 , G01N33/567 , C12Q1/68
CPC分类号： C07K16/2875 , A61K38/00 , A61K2039/505 , C07K14/525 , C07K14/705 , C07K14/70578 , C07K16/28 , C07K16/2878 , C07K2317/76 , C07K2317/92 , C07K2319/00 , G01N33/566 , G01N2333/525 , G01N2333/70578 , G01N2800/108
摘要： A novel protein which binds to Osteoclastogenesis Inhibitory Factor (OCIF-binding molecule; OBM), a process for preparing the same, DNA encoding said protein, a protein having an amino acid sequence encoded by this DNA, a method for producing said protein by genetic engineering technique, and a pharmaceutical composition containing said protein. Screening methods for a substance for controlling expression of said protein using said protein and the DNA, a substance which inhibits or modulates the biological activity of said protein, or a receptor which transmits the action of said protein through binding to said protein, the substance obtained by the screening methods, and a pharmaceutical composition which contains this substance. An antibody for said protein, a process for preparing the same, a measuring method of said protein using the antibody, and a medicine comprising this antibody.
摘要翻译：结合破骨细胞发生抑制因子（OCIF-结合分子; OBM）的新型蛋白质，其制备方法，编码所述蛋白质的DNA，由该DNA编码的氨基酸序列的蛋白质，通过遗传学生产所述蛋白质的方法工程技术和含有该蛋白质的药物组合物。使用所述蛋白质和DNA控制所述蛋白质的表达的物质的筛选方法，抑制或调节所述蛋白质的生物活性的物质，或通过与所述蛋白质结合而转移所述蛋白质的作用的受体，获得的物质通过筛选方法和含有该物质的药物组合物。所述蛋白质的抗体，其制备方法，使用该抗体的所述蛋白质的测定方法，以及包含该抗体的药物。

9. 发明授权

US07276344B2 Methods for using the osteoclastogenesis inhibitory factor (OCIF) protein 失效
标题翻译：破骨细胞发生抑制因子（OCIF）蛋白的使用方法
公开(公告)号：US07276344B2
公开(公告)日：2007-10-02
申请号：US10785114
申请日：2004-02-25
申请人： Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
发明人： Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
IPC分类号： G01N33/53 , A61K38/00 , A61K41/00 , C07K1/00
CPC分类号： C07K14/70578
摘要： A protein which inhibits osteoclast differentiation and/or maturation and a method of production of the protein. The protein is produced by human embryonic lung fibroblasts and has molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis, respectively.The protein can be isolated and purified from culture medium of the said fibroblasts. Furthermore, the protein can be produced by gene engineering.The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity to the protein or a method for determination of the protein concentration using the antibodies.
摘要翻译：抑制破骨细胞分化和/或成熟的蛋白质和蛋白质的生产方法。蛋白质由人类胚胎肺成纤维细胞产生，分子量分别为非还原条件下约60kD，约120kD，还原条件下SDS-聚丙烯酰胺凝胶电泳约60kD。可以从所述成纤维细胞的培养基中分离和纯化蛋白质。此外，蛋白质可以通过基因工程产生。本发明包括通过基因工程产生蛋白质的cDNA，对蛋白质具有特异性亲和力的抗体或使用该抗体测定蛋白质浓度的方法。

10. 发明申请

US20050124054A1 Novel proteins and methods for producing the proteins 审中-公开
标题翻译：用于生产蛋白质的新型蛋白质和方法
公开(公告)号：US20050124054A1
公开(公告)日：2005-06-09
申请号：US10979654
申请日：2004-11-03
申请人： Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
发明人： Masaaki Goto , Eisuke Tsuda , Shin'ichi Mochizuki , Kazuki Yano , Fumie Kobayashi , Nobuyuki Shima , Hisataka Yasuda , Nobuaki Nakagawa , Tomonori Morinaga , Masatsugu Ueda , Kanji Higashio
IPC分类号： C07K14/52 , A61K38/19 , A61P19/10 , C07K14/705 , C07K16/24 , C12N1/21 , C12N5/08 , C12N15/12 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/68 , C12N9/99 , G01N33/53 , G01N33/567
CPC分类号： C07K14/70578
摘要： A protein which inhibits osteoclast differentiation and/or maturation and a method for producing the protein. The protein is produced by human embryonic lung fibroblasts and has a molecular weight of about 60 kD and about 120 kD under non-reducing conditions and about 60 kD under reducing conditions on SDS-polyacrylamide gel electrophoresis. The protein can be isolated and purified from the culture medium of fibroblasts. Furthermore, the protein can be produced by gene engineering. The present invention includes cDNA for producing the protein by gene engineering, antibodies having specific affinity for the protein or a method for determining protein concentration using these antibodies.
摘要翻译：抑制破骨细胞分化和/或成熟的蛋白质和制备蛋白质的方法。蛋白质由人类胚胎肺成纤维细胞产生，在非还原条件下分子量约为60kD，约120kD，SDS-聚丙烯酰胺凝胶电泳时还原条件下分子量约为60kD。蛋白质可以从成纤维细胞的培养基中分离和纯化。此外，蛋白质可以通过基因工程产生。本发明包括通过基因工程产生蛋白质的cDNA，对蛋白质具有特异性亲和性的抗体或使用这些抗体测定蛋白质浓度的方法。

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