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1. 发明申请

US20130307520A1 MICROELECTRODE ARRAY AND METHOD FOR MODIFYING CARBON NANOTUBE ELECTRODE INTERFACE OF THE SAME ARRAY 有权
标题翻译：微电极阵列和修改同一阵列碳纳米管电极接口的方法
公开(公告)号：US20130307520A1
公开(公告)日：2013-11-21
申请号：US12638429
申请日：2009-12-15
申请人： Shiang-Jie YEN , Huan-Chieh Su , Tri-Rung Yew , Yen-Chung Chang , Wei-Lun Hsu , Shih-Rung Yeh
发明人： Shiang-Jie YEN , Huan-Chieh Su , Tri-Rung Yew , Yen-Chung Chang , Wei-Lun Hsu , Shih-Rung Yeh
IPC分类号： C01B31/02 , A61N1/05
CPC分类号： C01B31/0273 , A61N1/0502 , A61N1/0551 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/174
摘要： The present invention discloses a method for modifying a carbon nanotube electrode interface, which modifies carbon nanotubes used as a neuron-electrode interface by performing three stages of modifications and comprises the steps of: carboxylating carbon nanotubes to provide carboxyl functional groups and improve the hydrophilicity of the carbon nanotubes; acyl-chlorinating the carboxylated carbon nanotubes to replace the hydroxyl functional groups of the carboxyl functional groups with chlorine atoms; and aminating the acyl-chlorinated carbon nanotubes to replace the chlorine atoms with a derivative having amine functional groups at the terminal thereof. The modified carbon nanotubes used as the neuron-electrode interface has lower impedance and higher adherence to nerve cells. Thus is improved the quality of neural signal measurement. The present invention also discloses a microelectrode array, wherein the neuron-electrode interface uses carbon nanotubes modified according to the method of the present invention.
摘要翻译：本发明公开了一种修饰碳纳米管电极界面的方法，其通过进行三个阶段的修饰来改变用作神经元 - 电极界面的碳纳米管，并且包括以下步骤：使碳纳米管羧化以提供羧基官能团并提高其亲水性碳纳米管; 酰化氯化羧化碳纳米管以用氯原子代替羧基官能团的羟基官能团; 并将酰基氯化碳纳米管胺化以在其末端具有胺官能团的衍生物代替氯原子。用作神经元 - 电极界面的改性碳纳米管具有较低的阻抗和较高的对神经细胞的依从性。因此提高了神经信号测量的质量。本发明还公开了一种微电极阵列，其中神经电极界面使用根据本发明的方法改性的碳纳米管。

2. 发明授权

US08593052B1 Microelectrode array and method for modifying carbon nanotube electrode interface of the same array 有权
标题翻译：微电极阵列和相同阵列碳纳米管电极界面的修饰方法
公开(公告)号：US08593052B1
公开(公告)日：2013-11-26
申请号：US12638429
申请日：2009-12-15
申请人： Shiang-Jie Yen , Huan-Chieh Su , Tri-Rung Yew , Yen-Chung Chang , Wei-Lun Hsu , Shih-Rung Yeh
发明人： Shiang-Jie Yen , Huan-Chieh Su , Tri-Rung Yew , Yen-Chung Chang , Wei-Lun Hsu , Shih-Rung Yeh
IPC分类号： H01J1/63 , H01J63/04 , H01J17/49
CPC分类号： C01B31/0273 , A61N1/0502 , A61N1/0551 , B82Y15/00 , B82Y30/00 , B82Y40/00 , C01B32/174
摘要： The present invention discloses a method for modifying a carbon nanotube electrode interface, which modifies carbon nanotubes used as a neuron-electrode interface by performing three stages of modifications and comprises the steps of: carboxylating carbon nanotubes to provide carboxyl functional groups and improve the hydrophilicity of the carbon nanotubes; acyl-chlorinating the carboxylated carbon nanotubes to replace the hydroxyl functional groups of the carboxyl functional groups with chlorine atoms; and aminating the acyl-chlorinated carbon nanotubes to replace the chlorine atoms with a derivative having amine functional groups at the terminal thereof. The modified carbon nanotubes used as the neuron-electrode interface has lower impedance and higher adherence to nerve cells. Thus is improved the quality of neural signal measurement. The present invention also discloses a microelectrode array, wherein the neuron-electrode interface uses carbon nanotubes modified according to the method of the present invention.
摘要翻译：本发明公开了一种修饰碳纳米管电极界面的方法，其通过进行三个阶段的修饰来改变用作神经元 - 电极界面的碳纳米管，并且包括以下步骤：使碳纳米管羧化以提供羧基官能团并提高其亲水性碳纳米管; 酰化氯化羧化碳纳米管以用氯原子代替羧基官能团的羟基官能团; 并将酰基氯化碳纳米管胺化以在其末端具有胺官能团的衍生物代替氯原子。用作神经元 - 电极界面的改性碳纳米管具有较低的阻抗和较高的对神经细胞的依从性。因此提高了神经信号测量的质量。本发明还公开了一种微电极阵列，其中神经电极界面使用根据本发明的方法改性的碳纳米管。

3. 发明申请

US20080140195A1 MULTIFUNCTIONAL NANO-PROBE INTERFACE STRUCTURE FOR NEURAL PROSTHESES AND MANUFACTURING METHOD THEREOF 审中-公开
标题翻译：用于神经遗传的多功能纳米探针接口结构及其制造方法
公开(公告)号：US20080140195A1
公开(公告)日：2008-06-12
申请号：US11775878
申请日：2007-07-11
申请人： Huan-Chieh Su , Hsieh Chen , Hsin Chen , Yen-Chung Chang , Shih-Rung Yeh , Weileun Fang , Chien-Chung Fu , Shiang-Cheng Lu , Tri-Rung Yew
发明人： Huan-Chieh Su , Hsieh Chen , Hsin Chen , Yen-Chung Chang , Shih-Rung Yeh , Weileun Fang , Chien-Chung Fu , Shiang-Cheng Lu , Tri-Rung Yew
IPC分类号： A61F2/02
CPC分类号： A61N1/05 , A61B5/04001 , A61B2562/0285 , A61N1/0536 , A61N1/0551
摘要： A novel multifunctional nano-probe interface is proposed for applications in neural stimulation and detecting. The nano-probe interface structure consists of a carbon nanotube coated with a thin isolation layer, a micro-electrode substrate array, and a controller IC for neural cell recording and stimulation. The micro-electrode substrate array contains wires connecting the carbon nanotube with the controller IC, as well as microfluidic channels for supplying neural tissues with essential nutrition and medicine. The carbon nanotube is disposed on the micro-electrode substrate array made by silicon, coated with a thin isolation layer around thereof, and employed as a nano-probe for neural recording and stimulation.
摘要翻译：提出了一种新颖的多功能纳米探针接口，用于神经刺激和检测。纳米探针界面结构由涂覆有薄隔离层的碳纳米管，微电极基板阵列和用于神经细胞记录和刺激的控制器IC组成。微电极基板阵列包含连接碳纳米管与控制器IC的电线，以及用于向神经组织提供必需营养和药物的微流体通道。碳纳米管设置在由硅制成的微电极基板阵列上，在其周围涂覆有薄的隔离层，并用作用于神经记录和刺激的纳米探针。

4. 发明授权

US08280479B2 Flexible 3D microprobe structure 有权
标题翻译：灵活的3D微探针结构
公开(公告)号：US08280479B2
公开(公告)日：2012-10-02
申请号：US12637485
申请日：2009-12-14
申请人： Da-Jeng Yao , Chang-Hsiao Chen , Shih-Chang Chuang , Yen-Chung Chang
发明人： Da-Jeng Yao , Chang-Hsiao Chen , Shih-Chang Chuang , Yen-Chung Chang
IPC分类号： A61B5/04 , A61N1/00
CPC分类号： A61B5/04001 , A61B5/685
摘要： The present invention discloses a flexible 3D microprobe structure, which comprises at least one probe, a base and a hinge portion. The probe is connected to the base via the hinge portion. The probe forms a bend angle with respect to a normal of the base by attracting the probe through an electrostatic force to make the hinge portion bend with respect to the base, and thus to form a 3D structure having the bend angle. The probe, the base and the hinge portion are made of a flexible polymeric material to reduce the inflammation response of creatures. Further, a fixing element is used to enhance the structural strength of the flexible 3D microprobe structure.
摘要翻译：本发明公开了一种灵活的3D微探针结构，其包括至少一个探针，基座和铰链部分。探头通过铰链部连接到基座。通过使探针通过静电力使探针相对于基部弯曲，探针相对于基部的法线形成弯曲角度，从而形成具有弯曲角度的3D结构。探针，基部和铰链部分由柔性聚合材料制成，以减少生物的炎症反应。此外，固定元件用于增强柔性3D微探针结构的结构强度。

5. 发明申请

US20120229311A1 DEVICE AND METHOD FOR COMPRESSING FEATURE DESCRIPTOR 有权
标题翻译：用于压缩特征描述符的装置和方法
公开(公告)号：US20120229311A1
公开(公告)日：2012-09-13
申请号：US13410517
申请日：2012-03-02
申请人： Yen-Chung Chang , Jiun-Yan Chen , Hung-Hsiu Yu
发明人： Yen-Chung Chang , Jiun-Yan Chen , Hung-Hsiu Yu
IPC分类号： H03M7/30
CPC分类号： H03M7/46 , H03M7/3082
摘要： A method and a device for compressing a feature descriptor are disclosed. The device includes a non-uniform quantizer and a run-length encoder. The non-uniform quantizer accesses a source feature descriptor from a storage device, and non-uniformly quantizes the source feature descriptor having source vectors into an intermediate feature descriptor having intermediate vectors according to a vector default value. The run-length encoder executes run-length coding for the intermediate feature descriptor to generate a compressed feature descriptor.
摘要翻译：公开了一种用于压缩特征描述符的方法和装置。该装置包括非均匀量化器和游程长度编码器。非均匀量化器从存储设备访问源特征描述符，并且将具有源向量的源特征描述符不均匀地量化为具有根据向量默认值的中间向量的中间特征描述符。游程长度编码器对中间特征描述符执行游程长度编码以生成压缩特征描述符。

6. 发明授权

US07375788B2 Liquid crystal display device with hollow semi-columnar photo spacers 有权
标题翻译：液晶显示装置采用中空半柱状照相间隔
公开(公告)号：US07375788B2
公开(公告)日：2008-05-20
申请号：US11120424
申请日：2005-05-02
申请人： Ching-Wei Chiang , Yen-Chung Chang
发明人： Ching-Wei Chiang , Yen-Chung Chang
IPC分类号： G02F1/1339
CPC分类号： G02F1/13394 , G02F1/133514
摘要： An LCD device (10) includes a liquid crystal layer (17) interposed between the first (11) and second (19) substrates, a sealant (18) disposed at a peripheral region of the LCD between the first and second substrates for sealing a space between the first and second substrates, and a color filter layer (123) at the first substrate opposite to the second substrate. Furthermore, a photo spacer pattern (15) including a plurality of photo spacers being provided at the color filter layer. The photo spacers are provided within the space and outside the sealant at peripheral portions of the first and second substrates. A distributive density of photo spacers (152) within the space near an interior side of the sealant is larger than a distributive density of photo spacers (153) within the space distal from the interior side of the sealant.
摘要翻译： LCD装置（10）包括介于第一（11）和第二（19）基板之间的液晶层（17），设置在第一和第二基板之间的LCD周边区域处的密封剂（18）第一和第二基板之间的空间以及与第二基板相对的第一基板处的滤色器层（123）。此外，在滤色器层设置包括多个光隔离物的光隔离图案（15）。在第一和第二基板的周边部分的空间内和密封剂的外部设置有光隔离物。在密封剂内侧附近的空间内的光隔离物（152）的分布密度大于远离密封剂内侧的空间内的光隔离物（153）的分布密度。

7. 发明申请

US20050243261A1 Liquid crystal display device with photo spacers 有权
标题翻译：具有光隔离器的液晶显示装置
公开(公告)号：US20050243261A1
公开(公告)日：2005-11-03
申请号：US11120424
申请日：2005-05-02
申请人： Ching-Wei Chiang , Yen-Chung Chang
发明人： Ching-Wei Chiang , Yen-Chung Chang
IPC分类号： G02F1/1335 , G02F1/1339
CPC分类号： G02F1/13394 , G02F1/133514
摘要： An LCD device (10) includes a liquid crystal layer (17) interposed between the first (11) and second (19) substrates, a sealant (18) disposed at a peripheral region of the LCD between the first and second substrates for sealing a space between the first and second substrates, and a color filter layer (123) at the first substrate opposite to the second substrate. Furthermore, a photo spacer pattern (15) including a plurality of photo spacers being provided at the color filter layer. The photo spacers are provided within the space and outside the sealant at peripheral portions of the first and second substrates. A distributive density of photo spacers (152) within the space near an interior side of the sealant is larger than a distributive density of photo spacers (153) within the space distal from the interior side of the sealant.
摘要翻译： LCD装置（10）包括介于第一（11）和第二（19）基板之间的液晶层（17），设置在第一和第二基板之间的LCD周边区域处的密封剂（18）第一和第二基板之间的空间以及与第二基板相对的第一基板处的滤色器层（123）。此外，在滤色器层设置包括多个光隔离物的光隔离图案（15）。在第一和第二基板的周边部分的空间内和密封剂的外部设置有光隔离物。在密封剂内侧附近的空间内的光隔离物（152）的分布密度大于远离密封剂内侧的空间内的光隔离物（153）的分布密度。

8. 发明授权

US08576098B2 Device and method for compressing feature descriptor 有权
标题翻译：用于压缩特征描述符的设备和方法
公开(公告)号：US08576098B2
公开(公告)日：2013-11-05
申请号：US13410517
申请日：2012-03-02
申请人： Yen-Chung Chang , Jiun-Yan Chen , Hung-Hsiu Yu
发明人： Yen-Chung Chang , Jiun-Yan Chen , Hung-Hsiu Yu
IPC分类号： H03M7/30
CPC分类号： H03M7/46 , H03M7/3082
摘要： A device for compressing a feature descriptor includes a non-uniform quantizer and a run-length encoder. The non-uniform quantizer accesses a source feature descriptor from a storage device, and non-uniformly quantizes the source feature descriptor having source vectors into an intermediate feature descriptor having intermediate vectors according to a vector default value. The run-length encoder executes run-length coding for the intermediate feature descriptor to generate a compressed feature descriptor.
摘要翻译：用于压缩特征描述符的装置包括非均匀量化器和游程长度编码器。非均匀量化器从存储设备访问源特征描述符，并且将具有源向量的源特征描述符不均匀地量化为具有根据向量默认值的中间向量的中间特征描述符。游程长度编码器对中间特征描述符执行游程长度编码以生成压缩特征描述符。

9. 发明授权

US08261428B2 Method for assembling a 3-dimensional microelectrode structure 有权
标题翻译：组装三维微电极结构的方法
公开(公告)号：US08261428B2
公开(公告)日：2012-09-11
申请号：US12626303
申请日：2009-11-25
申请人： Weileun Fang , Yu-Tao Lee , Yen-Chung Chang
发明人： Weileun Fang , Yu-Tao Lee , Yen-Chung Chang
IPC分类号： G01R3/00
CPC分类号： A61B5/0478 , A61B5/685 , A61B2562/028 , A61B2562/125 , Y10T29/49002 , Y10T29/49007 , Y10T29/4908 , Y10T29/49128 , Y10T29/49155 , Y10T156/10
摘要： The present invention discloses a method for assembling a 3D microelectrode structure. Firstly, 2D microelectrode arrays are stacked to form a 3D microelectrode array via an auxiliary tool. Then, the 3D microelectrode array is assembled to a carrier chip to form a 3D microelectrode structure. The present invention uses an identical auxiliary tool to assemble various types of 2D microelectrode arrays having different shapes of probes to the same carrier chip. Therefore, the method of the present invention increases the design flexibility of probes. The present invention also discloses a 3D microelectrode structure, which is fabricated according to the method of the present invention and used to perform 3D measurement of biological tissues.
摘要翻译：本发明公开了一种组装3D微电极结构的方法。首先，通过辅助工具堆叠2D微电极阵列以形成3D微电极阵列。然后，将3D微电极阵列组装到载体芯片上以形成3D微电极结构。本发明使用相同的辅助工具将具有不同形状的探针的各种类型的2D微电极阵列组装到相同的载体芯片上。因此，本发明的方法增加了探针的设计灵活性。本发明还公开了根据本发明的方法制造并用于进行生物组织的3D测量的3D微电极结构。

10. 发明授权

US06859255B2 Method of fabricating a liquid crystal liquid display panel 有权
标题翻译：制造液晶显示面板的方法
公开(公告)号：US06859255B2
公开(公告)日：2005-02-22
申请号：US10604833
申请日：2003-08-20
申请人： Shih-Hong Liao , Yen-Chung Chang , Ying-Jyh Liao
发明人： Shih-Hong Liao , Yen-Chung Chang , Ying-Jyh Liao
IPC分类号： G02F1/13 , G02F1/1339 , G02F1/1341
CPC分类号： G02F1/1341 , G02F1/1339 , G02F2001/13415
摘要： A method of fabricating a liquid crystal display (LCD) panel. The LCD includes a first substrate positioned on an upper stage in a vacuum chamber, and a second substrate positioned on a lower stage in the vacuum chamber. A predetermined gap remains between the first substrate and the second substrate. The method includes vacuuming the vacuum chamber and horizontally aligning the first substrate with the second substrate. Following that, a first affixing process is performed to press a first portion of the first substrate on at least a dummy sealant on the second substrate. A second affixing process is then performed to press a second portion of the first substrate on a main sealant on the second substrate, thus completing combination of the first substrate and the second substrate.
摘要翻译：一种制造液晶显示器（LCD）面板的方法。 LCD包括位于真空室中的上级的第一衬底和位于真空室中的下级上的第二衬底。在第一基板和第二基板之间留有预定的间隙。该方法包括将真空室抽真空并使第一基板与第二基板水平对准。之后，执行第一贴附工艺，以将第一衬底的第一部分压在第二衬底上的至少一个虚拟密封剂上。然后执行第二贴附过程以将第一衬底的第二部分压在第二衬底上的主密封剂上，从而完成第一衬底和第二衬底的组合。

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