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1. 发明申请

US20120244079A1 TRACEABLE RETINOID ACID FOR IMAGING, DISEASE PREVENTION AND THERAPY 审中-公开
标题翻译：用于成像，疾病预防和治疗的可追踪的抗感染药
公开(公告)号：US20120244079A1
公开(公告)日：2012-09-27
申请号：US13319012
申请日：2010-05-06
申请人： Shi Ke , Michel Mawad , Wei Wang
发明人： Shi Ke , Michel Mawad , Wei Wang
IPC分类号： C07D403/08 , A61K49/04 , A61K49/00
CPC分类号： A61K49/0052 , A61K49/0032 , G01N33/5008 , G01N33/5014 , G01N33/5088 , G01N33/574 , G01N33/582 , G01N2800/56
摘要： The present invention provides nonradioactive NIR optical imaging agents based up on the structure of retinoid acid derivatives. The nonradioactive NIR optical imaging agent has been evaluated at the cellular level by confocal microscopy, and in vivo in a whole animal using a various xenograft models. The specific uptake of this agent in human cancer cells and multiple xenograft models demonstrate that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for early stage cancer studies and diagnoses. Also, the present invention provides that nonradioactive near infrared dye labeled retinoid metabolites and/or analogs are useful for visualization of drug redistribution within the body which is useful in determining the optimal biological dose. Ultimately, the visualization data can be used as an analytical tool to reduce any systemic toxicity.
摘要翻译：本发明提供了基于类视黄酸衍生物结构的非放射性近红外光学成像剂。已经通过共聚焦显微镜在细胞水平上评估了非放射性近红外光学成像剂，并且在使用各种异种移植模型的整个动物体内进行了评估。该药物在人类癌细胞和多种异种移植物模型中的特异性摄取表明，非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于早期癌症研究和诊断。此外，本发明提供非放射性近红外染料标记的类视黄醇代谢物和/或类似物可用于体内药物再分布的可视化，其可用于确定最佳生物剂量。最终，可视化数据可用作分析工具，以减少任何全身毒性。

2. 发明申请

US20130224115A1 NON-RADIOACTIVE AGENTS FOR NEUROBLASTOMA IMAGING 审中-公开
标题翻译：非放射性药物用于神经细胞成像
公开(公告)号：US20130224115A1
公开(公告)日：2013-08-29
申请号：US13638060
申请日：2011-04-01
申请人： Wei Wang , Jason Shohet , Michel Mawad , Shi Ke
发明人： Wei Wang , Jason Shohet , Michel Mawad , Shi Ke
IPC分类号： C07D209/26
CPC分类号： C07D209/26 , A61K49/0032 , A61K49/0052 , C09B23/0025 , C09B23/0066 , C09B23/086
摘要： Multi-modal tumor imaging of neuroblastoma is essential for tumor staging, response evaluation and detection of relapsed diseased. The present invention provides a norepinephine analogue with a near-infrared (near-IR) dye, W765-BG, that efficiently and stably detects neuroblastoma in vivo using near-IR optical imaging. Confocal microscopy and optical imaging of neuroblastoma xenografts shows cell specific uptake and reveals exceptional tumor retention with a high tumor-to-tissue ratio up to 7 days after injection of W765-BG.
摘要翻译：神经母细胞瘤的多形态肿瘤成像对肿瘤分期，应答评估和复发性疾病的检测至关重要。本发明提供了具有近红外（近红外）染料W765-BG的去甲肾上腺素类似物，其使用近红外光学成像在体内有效且稳定地检测神经母细胞瘤。神经母细胞瘤异种移植物的共聚焦显微镜和光学成像显示细胞特异性摄取，并在注射W765-BG后7天内显示具有高肿瘤组织比的特殊肿瘤保留。

3. 发明申请

US20050165379A1 Microcatheter including swellable tip 审中-公开
标题翻译：微导管包括可膨胀的尖端
公开(公告)号：US20050165379A1
公开(公告)日：2005-07-28
申请号：US10755249
申请日：2004-01-12
申请人： Michel Mawad
发明人： Michel Mawad
IPC分类号： A61M29/00 , A61M31/00
CPC分类号： A61M29/00 , A61M2025/0042
摘要： A catheter for providing an embolic material at a desired location comprises a flexible tubular member having a proximal end and a distal end, the tubular member including at least one ring of expansible material affixed to its outer surface less than 25 mm from the distal end. The ring preferably comprises a material that expands in volume when in contact with a liquid, such as a hydrogel or hydrogel foam, or in response to an application of heat. The ring is fully expanded after between 10 and 30 minutes of contact with a liquid. The catheter may also include further including a plurality of radioopaque markers spaced along the tubular member at predetermined intervals.
摘要翻译：用于在期望位置提供栓塞材料的导管包括具有近端和远端的柔性管状构件，所述管状构件包括固定到其远端距离远端25mm的外表面的至少一个可膨胀材料环。环优选地包括当与液体例如水凝胶或水凝胶泡沫接触时或响应于加热而膨胀的材料。在与液体接触10至30分钟之后，环完全膨胀。导管还可以包括进一步包括多个不规则间隔的沿着管状构件间隔开的不透射线标记。

4. 发明申请

US20060184066A1 Method for aiding stent-assisted coiling of intracranial aneurysms by virtual parent artery reconstruction 审中-公开
标题翻译：通过虚拟母体动脉重建来帮助支架辅助卷积颅内动脉瘤的方法
公开(公告)号：US20060184066A1
公开(公告)日：2006-08-17
申请号：US11058131
申请日：2005-02-15
申请人： Christof Karmonik , Michel Mawad
发明人： Christof Karmonik , Michel Mawad
IPC分类号： A61B5/103
CPC分类号： A61B5/103 , A61B17/12022 , A61B2017/00712 , A61B2017/00725
摘要： A method of creating a surface model of an intracranial aneurysm in an artery having a lumen, the aneurysm having a neck and a dome and the virtual reconstruction of the parent artery across the lateral extension of the aneurysm neck. The method includes the steps of: determining a center and radius of the artery over the lateral extension of the aneurysm; determining the boundary points that mark the boundary between the aneurysm neck and the artery; determining the angle of the aneurysm neck with respect to the artery, for various cross sections of the neck; determining the length of the neck; determining the height of the dome; estimating the area of the neck; and creating the surface model of the intracranial aneurysm in the artery, using the results from the previous steps.
摘要翻译：在具有内腔的动脉中产生颅内动脉瘤的表面模型的方法，具有颈部和穹顶的动脉瘤以及穿过动脉瘤颈部的横向延伸的母体动脉的虚拟重建。该方法包括以下步骤：确定在动脉瘤的横向延伸上的动脉的中心和半径; 确定标记动脉瘤颈部和动脉之间边界的边界点; 确定颈动脉瘤颈部相对于动脉的角度; 确定颈部的长度; 确定圆顶的高度; 估计颈部的面积; 并使用上述步骤的结果创建动脉颅内动脉瘤的表面模型。

5. 发明申请

US20140003687A1 METHOD AND SYSTEM FOR EVALUATING HEMODYNAMICS OF A BLOOD VESSEL 审中-公开
标题翻译：用于评估血液动力血液动力学的方法和系统
公开(公告)号：US20140003687A1
公开(公告)日：2014-01-02
申请号：US13979173
申请日：2012-01-13
申请人： Liang-Der Jou , Michel Mawad
发明人： Liang-Der Jou , Michel Mawad
IPC分类号： A61B5/00
CPC分类号： A61B5/0033 , A61B5/02014 , A61B5/026 , A61B6/481 , A61B6/504 , A61B6/5217
摘要： A method of angiographic evaluation of a flow diverter in a region of interest having abnormal flow in a vessel of interest, the method using digital division angiogram images at a first segment at or near a proximal end of the region of interest and at a second segment at or near a distal end of the region of interest, and observing differences in flow seen at said first and second segments.
摘要翻译：一种在感兴趣的血管中具有异常流动的感兴趣区域中的分流器的血管造影评估方法，在感兴趣区域的近端处或附近的第一区段处使用数字分割血管造影图像的方法，以及在第二区段在感兴趣区域的远端处或附近，并且观察在所述第一和第二段处观察到的流动差异。

6. 发明申请

US20080208160A9 Microcatheter including swellable tip 审中-公开
标题翻译：微导管包括可膨胀的尖端
公开(公告)号：US20080208160A9
公开(公告)日：2008-08-28
申请号：US10755249
申请日：2004-01-12
申请人： Michel Mawad
发明人： Michel Mawad
IPC分类号： A61M31/00
CPC分类号： A61M29/00 , A61M2025/0042
摘要： A catheter for providing an embolic material at a desired location comprises a flexible tubular member having a proximal end and a distal end, the tubular member including at least one ring of expansible material affixed to its outer surface less than 25 mm from the distal end. The ring preferably comprises a material that expands in volume when in contact with a liquid, such as a hydrogel or hydrogel foam, or in response to an application of heat. The ring is fully expanded after between 10 and 30 minutes of contact with a liquid. The catheter may also include further including a plurality of radioopaque markers spaced along the tubular member at predetermined intervals.
摘要翻译：用于在期望位置提供栓塞材料的导管包括具有近端和远端的柔性管状构件，所述管状构件包括固定到其远端距离远端25mm的外表面的至少一个可膨胀材料环。环优选地包括当与液体例如水凝胶或水凝胶泡沫接触时或响应于加热而膨胀的材料。在与液体接触10至30分钟之后，环完全膨胀。导管还可以包括进一步包括多个不规则间隔的沿着管状构件间隔开的不透射线标记。

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