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1. 发明申请

US20090266719A1 Potentiometric Urea Sensor Based on Ion-Selective Electrode 审中-公开
标题翻译：基于离子选择性电极的电位尿素传感器
公开(公告)号：US20090266719A1
公开(公告)日：2009-10-29
申请号：US12498473
申请日：2009-07-07
申请人： Shen-Kan HSIUNG , Jung-Chuan Chou , Tai-Ping Sun , Chien-Wei Pan , Nien-Hsuan Chou
发明人： Shen-Kan HSIUNG , Jung-Chuan Chou , Tai-Ping Sun , Chien-Wei Pan , Nien-Hsuan Chou
IPC分类号： G01N27/26 , C12N11/14
CPC分类号： C12Q1/002 , C12Q1/005 , C12Q1/58
摘要： A sensor for sensing and measuring a concentration of urea in a sample has an ammonium ion selective membrane and urease enzymes immobilized on the ammonium ion selective membrane. The urease enzymes enzymatically convert urea into ammonium ions, which is sensed by said ammonium ion selective membrane and transformed into a signal. A detector system is used for processing signal from said ammonium ion selective membrane to generate a response potential that corresponds to the concentration of urea in the sample.
摘要翻译：用于感测和测量样品中尿素浓度的传感器具有铵离子选择性膜和固定在铵离子选择性膜上的脲酶。尿素酶将尿素酶转化为铵离子，其由所述铵离子选择性膜感测并转化为信号。检测器系统用于处理来自所述铵离子选择性膜的信号以产生对应于样品中尿素浓度的响应电位。

2. 发明申请

US20090119026A1 PORTABLE MULTI-IONS SENSING SYSTEM AND FABRICATION THEREOF 审中-公开
标题翻译：便携式多离子感测系统及其制造方法
公开(公告)号：US20090119026A1
公开(公告)日：2009-05-07
申请号：US11933809
申请日：2007-11-01
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Gin-Chou Yang
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Gin-Chou Yang
IPC分类号： G01N31/00 , G01N27/416 , G06F19/00
CPC分类号： G01N27/4148 , G01N27/333
摘要： A portable multi-ions sensing system is provided. The sensing system includes: a sensing unit for sensing a pH value and a plurality of ion concentrations of a solution and outputting a sensing signal, wherein the sensing unit includes: a substrate; an ITO layer on the substrate; a sensing layer on the ITO layer and connected with an extended lead; a packaging layer encapsulating the sensing layer, the ITO layer and a portion of the substrate with a sensing window for exposing a portion of the sensing layer; a multi-ions selective layer on the portion of the sensing layer exposed by the sensing window for sensing the ion concentrations; and a reference electrode for providing a reference potential for the sensing layer; an analog signal processing unit for receiving, filtering, amplifying and adjusting the level of the sensing signal and outputting a front-end signal; a microcontroller unit for receiving and performing analog/digital converting and two-point correcting processes on the front-end signal and outputting a measurement data; and a real-time display unit for receiving and displaying the measurement data.
摘要翻译：提供便携式多离子感测系统。感测系统包括：感测单元，用于感测溶液的pH值和多个离子浓度并输出感测信号，其中感测单元包括：基底; 衬底上的ITO层; ITO层上的传感层，并与延伸引线连接; 封装层，其将所述感测层，所述ITO层和所述衬底的一部分封装以具有用于暴露所述感测层的一部分的感测窗口; 感测层暴露在感测窗口的部分上的多离子选择层，用于感测离子浓度; 以及用于为感测层提供参考电位的参考电极; 模拟信号处理单元，用于接收，滤波，放大和调整感测信号的电平并输出前端信号; 微控制器单元，用于接收并执行前端信号的模拟/数字转换和两点校正处理，并输出测量数据; 以及用于接收和显示测量数据的实时显示单元。

3. 发明申请

US20090038940A1 Reference Electrode 审中-公开
标题翻译：参考电极
公开(公告)号：US20090038940A1
公开(公告)日：2009-02-12
申请号：US12168992
申请日：2008-07-08
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou
IPC分类号： G01N27/30
CPC分类号： G01N27/301
摘要： The present invention discloses a reference electrode. According to the invention, a capillary structure is plugged in a solid state electrolyte layer of the reference electrode. By capillary phenomenon, a test solution is sucked to the solid state electrolyte layer to have reaction. Therefore, according to the invention, a test solution can be measured by simply placing the capillary structure of the reference electrode into the test solution. The lifetime of the reference electrode can be greatly extended.
摘要翻译：本发明公开了一种参比电极。根据本发明，毛细管结构被插入参考电极的固态电解质层中。通过毛细管现象，将测试溶液吸入固态电解质层进行反应。因此，根据本发明，可以通过简单地将参考电极的毛细结构置于测试溶液中来测量测试溶液。参考电极的寿命可以大大延长。

4. 发明申请

US20090021740A1 OPTICAL SENSOR AND METHOD FOR MEASURING BLOOD GAS 审中-公开
标题翻译：光学传感器和测量血液气体的方法
公开(公告)号：US20090021740A1
公开(公告)日：2009-01-22
申请号：US11778672
申请日：2007-07-17
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chih-Wei Lai , Nien-Hsuan Chou
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chih-Wei Lai , Nien-Hsuan Chou
IPC分类号： G01N33/49 , G01N21/77
CPC分类号： G01N33/4915 , G01N21/78 , G01N33/4925
摘要： The present invention discloses an optical sensor for measuring blood gas, used to measure gas concentration in a liquid, comprising: an indicator solution; a first conduit for filling with the indicator solution wherein the first conduit passes through the liquid and the gas in the liquid can diffuse into the first conduit to react with the indicator solution so as to change the color of the indicator solution; a second conduit for receiving the reacted indicator solution in the first conduit; and a light emitter and a photodetector provided in opposition to each other at the two sides of the second conduit wherein the light emitter emits light towards the second conduit and the photodetector receives the light passing through the second conduit and the reacted indicator solution and thereby outputs a sensing signal depending on the received light intensity.
摘要翻译：本发明公开了一种用于测量血液中的气体浓度的血液测量用光学传感器，包括：指示剂溶液; 用于填充指示剂溶液的第一管道，其中第一管道通过液体并且液体中的气体可以扩散到第一管道中以与指示剂溶液反应以改变指示剂溶液的颜色; 用于在第一导管中接收反应的指示剂溶液的第二导管; 以及在第二导管的两侧彼此相对设置的光发射器和光电检测器，其中光发射器朝向第二导管发射光，并且光电检测器接收通过第二导管和反应的指示剂溶液的光，从而输出感测信号取决于接收的光强度。

5. 发明申请

US20080194040A1 Optical Blood Gas Sensor for Real Time Measurement 有权
标题翻译：用于实时测量的光学血液气体传感器
公开(公告)号：US20080194040A1
公开(公告)日：2008-08-14
申请号：US11949563
申请日：2007-12-03
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Chih-Wei Lai
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Chih-Wei Lai
IPC分类号： G01N21/00
CPC分类号： G01N21/783
摘要： An optical gas concentration sensor and method for measuring blood gas based on the light adsorption sensing technique are disclosed. The optical gas concentration sensor comprises a light source, a photo detector, and a gas filtering membrane for separating the indicator and a liquid. A gas in the liquid diffuses to the indicator through the gas filtering membrane so as to change the color of the indicator due to the chemical reaction occurred between the indicator and the gas. Then, the photo detector receives the light passing though the reacted indicator from the light source. The gas concentration is determined based on pH-sensitive absorbance spectrum of the indicator.
摘要翻译：公开了一种基于光吸收传感技术测量血液气体的光学气体浓度传感器和方法。光学气体浓度传感器包括用于分离指示剂和液体的光源，光电检测器和气体过滤膜。液体中的气体通过气体过滤膜扩散到指示器，以便由于指示剂和气体之间发生化学反应而改变指示器的颜色。然后，光检测器从光源接收通过反应指示器的光。基于指示剂的pH敏感吸收光谱确定气体浓度。

6. 发明申请

US20080061792A1 MULTI-FUNCTIONAL PH METER AND FABRICATION THEREOF 失效
标题翻译：多功能电位计及其制造方法
公开(公告)号：US20080061792A1
公开(公告)日：2008-03-13
申请号：US11465776
申请日：2006-08-18
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Gin-Chou Yang
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Gin-Chou Yang
IPC分类号： G01N27/416
CPC分类号： G01N27/4167
摘要： A multi-functional PH meter and the fabrication thereof are disclosed. The multi-functional pH meter comprises a sensor unit, an analog signal processing unit, a microprocessor unit, a liquid crystal display unit, a compact flash card unit and a data transmission unit. The sensor unit includes an electrode, a substrate, an indium tin oxide film on the substrate, a sensing film on the indium tin oxide film and connecting to a conductive wire, a package material covering the sensing film, the indium tin oxide film and a portion of the substrate and exposing the sensing film via a sensing window. The analog signal processing unit processes analog signals from the sensing unit via the conductive wire. The microprocessor unit receives the signals from the analog signal processing unit and generates a pH value of a solution being detected. The liquid crystal display unit displays the pH value and the compact flash card unit saves the pH value. The data transmission unit transmits the pH value to a computer via Universal Serial Bus (USB) and Universal Asynchronous Receiver/Transmitter (UART) interfaces.
摘要翻译：公开了一种多功能PH计及其制造方法。多功能pH计包括传感器单元，模拟信号处理单元，微处理器单元，液晶显示单元，小型闪存卡单元和数据传输单元。传感器单元包括基板上的电极，基板，氧化铟锡膜，铟锡氧化物膜上的感应膜，并与导线连接，覆盖感测膜的封装材料，氧化铟锡膜和并且经由感测窗露出感测膜。模拟信号处理单元经由导线处理来自感测单元的模拟信号。微处理器单元接收来自模拟信号处理单元的信号，并产生正在检测的溶液的pH值。液晶显示单元显示pH值，紧凑型闪存卡单元可节省pH值。数据传输单元通过通用串行总线（USB）和通用异步收发器（UART）接口将pH值传输到计算机。

7. 发明申请

US20070175769A1 Potentiometric pCO2 Sensor and the Fabrication Method thereof 审中-公开
标题翻译：电位式pCO2传感器及其制造方法
公开(公告)号：US20070175769A1
公开(公告)日：2007-08-02
申请号：US11458100
申请日：2006-07-18
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Szu-Ping Chen
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Szu-Ping Chen
IPC分类号： G01F1/64 , G01N27/26
CPC分类号： G01N27/4162 , G01N33/004
摘要： This invention provides a pCO2 sensor, and more particularly, a potentiometric pCO2 sensor. The potentiometric pCO2 sensor has a substrate, a solid ion-sensing layer on the substrate, a solid electrolyte layer on the solid ion-sensing layer, and a gas-permeable layer on the solid electrolyte layer. In addition, the gas-permeable layer allows air molecules to diffuse through, the solid electrolyte layer change the pH value thereof according to the CO2 concentration in the diffusing air molecules, and the solid ion-sensing layer senses the pH change of the solid electrolyte layer to generate a sensing signal. By doing so, the quantity of the CO2 dissolved in the liquid can be measured.
摘要翻译：本发明提供了一种pCO 2传感器，更具体地说，提供了一种电位计pCO 2传感器。电位计pCO 2传感器具有衬底，衬底上的固体离子感测层，固体离子感测层上的固体电解质层和固体电解质层上的透气层。此外，透气层允许空气分子扩散通过，固体电解质层根据扩散空气分子中的CO 2浓度改变其pH值，并且固体离子感测层感测固体电解质层的pH变化以产生感测信号。通过这样做，可以测量溶解在液体中的CO 2 2的量。

8. 发明申请

US20070158213A1 Dual Type Potentiometric Creatinine Biosensor 失效
标题翻译：双电位电生理传感器
公开(公告)号：US20070158213A1
公开(公告)日：2007-07-12
申请号：US11457589
申请日：2006-07-14
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-Wei Pan , Nien-Hsuan Chou
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-Wei Pan , Nien-Hsuan Chou
IPC分类号： C12Q1/00 , G01F1/64
CPC分类号： C12Q1/002 , C12Q1/005 , G01N33/70
摘要： In this invention, a separative structure of the ion-selecting electrode is applied to fabricate the dual type potentiometric biosensor for creatinine detection. According to the fabrication process, the creatinine enzyme is immobilized onto a conductive layer of a substrate of pH sensing membrane and ammonium ion-selecting membrane. The conductive layer provides with a sensing region and a non-sensing region. A conductive line is extended from the conductive layer for using as an external electrical contact point. The dual type potentiometric creatinine biosensor was fabricated by using the enzyme immobilization method onto the surface of the selecting membrane of sensing membrane of pH sensing electrode and creatinine sensor.
摘要翻译：在本发明中，应用离子选择电极的分离结构来制造用于肌酸酐检测的双重电位生物传感器。根据制造方法，将肌酸酐酶固定在pH感应膜和铵离子选择膜的底物的导电层上。导电层提供感测区域和非感测区域。导电线从导电层延伸以用作外部电接触点。通过使用酶固定法在pH感应电极和肌酐传感器的感应膜选择膜的表面上制作双电位电位生物传感器。

9. 发明申请

US20060096858A1 Potentiometric urea sensor based on ion-selective electrode 审中-公开
标题翻译：基于离子选择电极的电位式尿素传感器
公开(公告)号：US20060096858A1
公开(公告)日：2006-05-11
申请号：US10984495
申请日：2004-11-08
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan , Nien-Hsuan Chou
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Chung-We Pan , Nien-Hsuan Chou
IPC分类号： G01N33/487 , C12Q1/00
CPC分类号： C12Q1/005 , C12Q1/002
摘要： The present invention is a sensor for detecting urea using a separating-style structure of ion-selective electrode, in which an ammonium ion-selective membrane is immobilized on a conductive layer on the surface of a substrate, said conductive layer has a sensing region and a non-sensing region after packaged, and a conductive line is used to retrieve a sensing signal from said conductive layer. In the end, employing the enzyme immobilization method to immobilize a urea enzyme onto ammonium ion-selective membrane, thus the fabrication of a potentiometric urea sensor is completed.
摘要翻译：本发明是一种使用离子选择性电极的分离型结构检测尿素的传感器，其中铵离子选择性膜固定在基板表面上的导电层上，所述导电层具有感测区域和封装后的非感测区域和导线用于从所述导电层检索感测信号。最后，采用酶固定方法将尿素酶固定在铵离子选择性膜上，从而完成电位尿素传感器的制造。

10. 发明授权

US07883668B2 Optical blood gas sensor for real time measurement 有权
标题翻译：光学血液气体传感器，用于实时测量
公开(公告)号：US07883668B2
公开(公告)日：2011-02-08
申请号：US11949563
申请日：2007-12-03
申请人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Chih-Wei Lai
发明人： Shen-Kan Hsiung , Jung-Chuan Chou , Tai-Ping Sun , Nien-Hsuan Chou , Chih-Wei Lai
IPC分类号： G01J1/48
CPC分类号： G01N21/783
摘要： An optical gas concentration sensor and method for measuring blood gas based on the light adsorption sensing technique are disclosed. The optical gas concentration sensor comprises a light source, a photo detector, and a gas filtering membrane for separating the indicator and a liquid. A gas in the liquid diffuses to the indicator through the gas filtering membrane so as to change the color of the indicator due to the chemical reaction occurred between the indicator and the gas. Then, the photo detector receives the light passing though the reacted indicator from the light source. The gas concentration is determined based on pH-sensitive absorbance spectrum of the indicator.
摘要翻译：公开了一种基于光吸收传感技术测量血液气体的光学气体浓度传感器和方法。光学气体浓度传感器包括用于分离指示剂和液体的光源，光电检测器和气体过滤膜。液体中的气体通过气体过滤膜扩散到指示器，以便由于指示剂和气体之间发生化学反应而改变指示器的颜色。然后，光检测器从光源接收通过反应指示器的光。基于指示剂的pH敏感吸收光谱确定气体浓度。

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