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1. 发明授权

US06974581B1 Multi-component vaccine comprising at least two antigens from haemophilus influenzae to protect against disease 失效
标题翻译：包含来自流感嗜血杆菌的至少两种抗原的多组分疫苗以防止疾病
公开(公告)号：US06974581B1
公开(公告)日：2005-12-13
申请号：US09210995
申请日：1998-12-15
申请人： Sheena M. Loosmore , Yan-Ping Yang , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Michel H. Klein
IPC分类号： C12N15/09 , A61K39/05 , A61K39/08 , A61K39/10 , A61K39/102 , A61K39/116 , A61K39/13 , A61K39/39 , A61P27/16 , A61P31/04 , C07K14/285 , A61K39/00 , A61K39/38 , A61K39/385 , A61K39/02
CPC分类号： A61K39/102 , Y02A50/466
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.
摘要翻译：多组分免疫原性组合物赋予免疫宿主免受流感嗜血杆菌引起的感染的保护。这种组合物包含流感嗜血杆菌的至少两种不同的抗原，其中一种是粘附素。不可分型流感嗜血杆菌的高分子量（HMW）蛋白增强宿主中这种免疫原性组合物中Hin47蛋白的非蛋白水解类似物的免疫应答，其中一种成分不损害另一种免疫原性。嗜血杆菌疫苗可以与DTP组分疫苗组合以提供多价成分疫苗，而不损害其他抗原的免疫原性。

2. 发明授权

US06358727B1 Haemophilus transferrin receptor genes 失效
标题翻译：嗜血杆菌转铁蛋白受体基因
公开(公告)号：US06358727B1
公开(公告)日：2002-03-19
申请号：US08637654
申请日：1996-08-05
申请人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
发明人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
IPC分类号： C12N121
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C07K16/2881 , C07K2317/34 , C12N2799/021 , Y02A50/466
摘要： Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbpl or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
摘要翻译：提供了纯化和分离的核酸，其编码嗜血杆菌菌株的转铁蛋白受体蛋白或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗的目的，核酸序列可用于产生不含通常含有Tbp1或Tbp2蛋白的细菌的不含污染物的肽。此外，核酸分子可以用于感染的诊断。还提供重组Tbpl或Tbp2及其纯化方法。提供了表达转铁蛋白受体蛋白表位的活载体用于疫苗接种。

3. 发明授权

US06184371B2 Lactoferrin receptor genes of Moraxella 失效
标题翻译： Moraxella的乳铁蛋白受体基因
公开(公告)号：US06184371B2
公开(公告)日：2001-02-06
申请号：US09074658
申请日：1998-05-08
申请人： Sheena M. Loosmore , Run-Pan Du , Quijun Wang , Yan-Ping Yang , Michel H. Klein
发明人： Sheena M. Loosmore , Run-Pan Du , Quijun Wang , Yan-Ping Yang , Michel H. Klein
IPC分类号： C07H2104
CPC分类号： C07K14/79 , A61K39/00
摘要： Purified and isolated nucleic acid molecules are provided which encode lactoferrin receptor proteins of Moraxella, such as M. catarrhalis, or a fragment or an analog of the lactoferrin receptor protein. The nucleic acid sequence may be used to produce recombinant lactoferrin receptor proteins Lbp1, Lbp2 and ORF3 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.
摘要翻译：提供了纯化和分离的核酸分子，其编码莫拉氏杆菌的乳铁蛋白受体蛋白，例如卡他莫拉菌，或乳铁蛋白受体蛋白的片段或类似物。出于诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉菌素菌株的重组乳铁蛋白受体蛋白Lbp1，Lbp2和ORF3。此外，核酸分子可以用于感染的诊断。

4. 发明授权

US5962430A Analog of Haemophilus Hin47 with reduced protease activity 失效
标题翻译：具有减少的蛋白酶活性的嗜血杆菌Hin47的类似物
公开(公告)号：US5962430A
公开(公告)日：1999-10-05
申请号：US801499
申请日：1997-02-18
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , C12N15/31 , A61K39/102 , A01N43/48 , A61K31/495
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases (caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制为用于体内施用于宿主（包括人）的疫苗，以赋予针对疾病（由细菌病原体，包括嗜血杆菌属物种如流感嗜血杆菌引起的）的保护，产生Hin47蛋白或能够在与Hin47蛋白特异性反应的宿主中诱导抗体的蛋白质，Hin47类似物和编码核酸也可用于诊断应用。

5. 发明授权

US5939297A Analog of haemophilus HIN47 with reduced protease activity 失效
标题翻译：具有降低的蛋白酶活性的嗜血杆菌HIN47的类似物
公开(公告)号：US5939297A
公开(公告)日：1999-08-17
申请号：US296149
申请日：1994-08-26
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , C12N15/31 , C12N15/57
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的流感嗜血杆菌Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。可以在重组质粒中提供分离的纯化的编码Hin47类似物的核酸分子，所述重组质粒可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制成用于体内施用于宿主（包括人）的疫苗，以赋予针对由细菌病原体（例如流感嗜血杆菌）产生的细菌病原体引起的疾病的保护， Hin47蛋白或能够诱导与Hin47蛋白特异性反应的宿主中的抗体的蛋白质。 Hin47类似物和编码核酸也可用于诊断应用。

6. 发明授权

US5506139A Analog of haemophilus Hin47 with reduced protease activity 失效
公开(公告)号：US5506139A
公开(公告)日：1996-04-09
申请号：US278091
申请日：1994-07-21
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , A61P31/04 , C07K14/285 , C12N9/52 , C12N15/31 , C12N15/57
CPC分类号： C12N9/52 , C07K14/285 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated an purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.

7. 发明申请

US20080286303A1 Multi-component vaccine comprising at least two antigens from haemophilus influenzae to protect against disease 审中-公开
标题翻译：包含来自流感嗜血杆菌的至少两种抗原的多组分疫苗以防止疾病
公开(公告)号：US20080286303A1
公开(公告)日：2008-11-20
申请号：US11975956
申请日：2007-10-23
申请人： Sheena M. Loosmore , Yan-Ping Yang , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Michel H. Klein
IPC分类号： A61K39/116 , A61P31/04
CPC分类号： A61K39/102 , Y02A50/466
摘要： A multi-component immunogenic composition confers protection on an immunized host against infection caused by Haemophilus influenzae. Such composition comprises at least two different antigens of Haemophilus influenzae, one of which is an adhesin. High molecular weight (HMW) proteins of non-typeable Haemophilus influenzae enhance the immune response in a host to a non-proteolytic analog of Hin47 protein in such immunogenic compositions with one component not impairing the immunogenicity of the other. The Haemophilus vaccine may be combined with DTP component vaccines to provide a multi-valent component vaccine without impairment of the immunogenic properties of the other antigens.
摘要翻译：多组分免疫原性组合物赋予免疫宿主免受流感嗜血杆菌引起的感染的保护。这种组合物包含流感嗜血杆菌的至少两种不同的抗原，其中一种是粘附素。不可分型流感嗜血杆菌的高分子量（HMW）蛋白增强宿主中这种免疫原性组合物中Hin47蛋白的非蛋白水解类似物的免疫应答，其中一种成分不损害另一种免疫原性。嗜血杆菌疫苗可以与DTP组分疫苗组合以提供多价成分疫苗，而不损害其他抗原的免疫原性。

8. 发明授权

US06361779B1 Transferrin receptor genes 失效
标题翻译：转铁蛋白受体基因
公开(公告)号：US06361779B1
公开(公告)日：2002-03-26
申请号：US08649518
申请日：1996-05-17
申请人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
发明人： Sheena M. Loosmore , Robin E. Harkness , Anthony B. Schryvers , Pele Chong , Scott Gray-Owen , Yan-Ping Yang , Andrew D. Murdin , Michel H. Klein
IPC分类号： A61K3821
CPC分类号： C07K14/285 , A61K39/00 , A61K2039/51 , C12N2799/021
摘要： Purified and isolated nucleic acid is provided which encodes a transferrin receptor protein of a strain of Haemophilus or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce peptides free of contaminants derived from bacteria normally containing the Tbp1 or Tbp2 proteins for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection. Also provided are recombinant Tbp1 or Tbp2 and methods for purification of the same. Live vectors expressing epitopes of transferrin receptor protein for vaccination are provided.
摘要翻译：提供了纯化和分离的核酸，其编码嗜血杆菌菌株的转铁蛋白受体蛋白或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗目的，核酸序列可用于产生不含通常含有Tbp1或Tbp2蛋白的细菌的不含污染物的肽。此外，核酸分子可以用于感染的诊断。还提供了重组Tbp1或Tbp2及其纯化方法。提供了表达转铁蛋白受体蛋白表位的活载体用于疫苗接种。

9. 发明授权

US06090576A DNA encoding a transferrin receptor of Moraxella 失效
标题翻译：编码Moraxella转铁蛋白受体的DNA
公开(公告)号：US06090576A
公开(公告)日：2000-07-18
申请号：US613009
申请日：1996-03-08
申请人： Lisa E. Myers , Anthony B. Schryvers , Robin E. Harkness , Sheena M. Loosmore , Run-Pan Du , Yan-Ping Yang , Michel H. Klein
发明人： Lisa E. Myers , Anthony B. Schryvers , Robin E. Harkness , Sheena M. Loosmore , Run-Pan Du , Yan-Ping Yang , Michel H. Klein
IPC分类号： C12N15/09 , A61K39/00 , C07K14/21 , C07K14/22 , C07K14/705 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12N15/31 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/569 , G01N33/68 , C12N15/63
CPC分类号： C07K14/212 , A61K39/00
摘要： Purified and isolated nucleic acid molecules are provided which encode transferrin receptor proteins of Moraxella, such as M. catarrhalis or a fragment or an analog of the transferrin receptor protein. The nucleic acid sequence may be used to produce recombinant transferrin receptor proteins Tbp1 and Tbp2 of the strain of Moraxella free of other proteins of the Moraxella strain for purposes of diagnostics and medical treatment. Furthermore, the nucleic acid molecule may be used in the diagnosis of infection.
摘要翻译：提供纯化和分离的核酸分子，其编码莫拉氏菌的转铁蛋白受体蛋白，例如卡他莫拉菌或转铁蛋白受体蛋白的片段或类似物。为了诊断和治疗的目的，核酸序列可用于产生不含莫拉氏菌属菌株的其它蛋白质的莫拉氏菌属菌株的重组转铁蛋白受体蛋白质Tbp1和Tbp2。此外，核酸分子可以用于感染的诊断。

10. 发明授权

US6025342A Analog of Haemophilus Hin47 with reduced protease activity 失效
标题翻译：具有减少的蛋白酶活性的嗜血杆菌Hin47的类似物
公开(公告)号：US6025342A
公开(公告)日：2000-02-15
申请号：US74659
申请日：1998-05-08
申请人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
发明人： Sheena M. Loosmore , Yan-Ping Yang , Pele Chong , Raymond P. Oomen , Michel H. Klein
IPC分类号： A61K39/00 , C07K14/285 , C12N9/52 , C12N15/31 , A61K48/00 , A61K35/00
CPC分类号： C07K14/285 , C12N9/52 , A61K2039/51 , A61K39/00 , C07K2319/00
摘要： An isolated and purified analog of Haemophilus influenza Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. An isolated and purified nucleic acid molecule encoding the Hin47 analog may be provided in a recombinant plasmid which may be introduced into a cell which is grown to produce the Hin47 analog. Immunogenic compositions comprising the Hin47 analog and the encoding nucleic acid may be formulated as vaccines for in vivo administration to a host, including a human, to confer protection against diseases caused by a bacterial pathogen, including Haemophilus species, such as Haemophilus influenzae, that produces Hin47 protein or a protein capable of inducing antibodies in the host specifically reactive with Hin47 protein. The Hin47 analog and the encoding nucleic acid also may be employed in diagnostic applications.
摘要翻译：分离和纯化的嗜血杆菌流感Hin47蛋白的类似物具有降低的蛋白酶活性，其小于天然Hin47蛋白的约10％，优选与天然Hin47蛋白基本相同的免疫原性。编码Hin47类似物的分离和纯化的核酸分子可以在重组质粒中提供，其可以被引入生长以产生Hin47类似物的细胞中。包含Hin47类似物和编码核酸的免疫原性组合物可以配制成用于体内施用于宿主（包括人）的疫苗，以赋予针对由细菌病原体（例如流感嗜血杆菌）产生的细菌病原体引起的疾病的保护， Hin47蛋白或能够诱导与Hin47蛋白特异性反应的宿主中的抗体的蛋白质。 Hin47类似物和编码核酸也可用于诊断应用。

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