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1. 发明授权

US11077270B2 Patterns for flow control and bioadhesion control 有权
公开(公告)号：US11077270B2
公开(公告)日：2021-08-03
申请号：US15502359
申请日：2015-08-07
申请人： Sharklet Technologies, Inc. , University of Florida Research Foundation, Inc.
发明人： Chelsea Marie Magin , Shravanthi T. Reddy , Anthony B. Brennan , Rhea Marie May , Ethan Eugene Mann , Michael Ryan Mettetal
IPC分类号： A61M16/04 , A61F2/00 , A61F2/16 , A61M25/00 , F16L9/12 , F28F1/00
摘要： An article includes a path that extends across at least a portion of a surface of the article, the path being defined by at least one channel that traverses at least a portion of the surface or a first plurality of spaced features disposed on or in at least a portion of the surface. The first plurality of spaced features are arranged in a plurality of groupings. The groupings of features comprise repeat units, where the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers to define a path that traverses the plurality of spaced features.

2. 发明授权

US09943402B2 Micropatterned intraocular implant 有权
公开(公告)号：US09943402B2
公开(公告)日：2018-04-17
申请号：US14821645
申请日：2015-08-07
申请人： InSight Innovations, LLC , Sharklet Technologies, Inc. , University of Florida Research Foundation, Inc.
发明人： Kevin H. Cuevas , Shravanthi T. Reddy , Chelsea Marie Magin , Michael R. Mettetal , Anthony B. Brennan , Rhea Marie May , Ethan Eugene Mann
IPC分类号： A61F2/16 , A61F2/14 , A61F2/00
CPC分类号： A61F2/16 , A61F2/14 , A61F2/1601 , A61F2/161 , A61F2002/009 , A61L2430/16
摘要： Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid, or a flow of particles suspended in a fluid, or inhibits the growth or migration of cells. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

3. 发明授权

US11458042B2 Bilayered devices for enhanced healing 有权
公开(公告)号：US11458042B2
公开(公告)日：2022-10-04
申请号：US15568767
申请日：2016-04-25
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , SHARKLET TECHNOLOGIES, INC.
发明人： Chelsea Marie Magin , Anthony B. Brennan , Bradley Jay Willenberg , Gregory Scott Schultz , Dylan Burton Neale
IPC分类号： A61F13/00 , A61K35/12 , A61L27/58 , A61L27/60 , A61L27/50 , A61L27/18 , A61L15/42 , A61L15/60 , A61F13/02 , A61L15/64
摘要： Disclosed herein is a multilayered wound dressing comprising a first layer; the first layer including channels that facilitate neovascularization of a wound; and a second layer in contact with the first layer, the second layer having the same or different chemical composition as the first layer; where the second layer comprises at least one surface that has a texture and the direction of the texture is operative to facilitate cell orientation and growth. A method includes forming a first layer of a polymeric material; forming a second layer of the same polymeric material as the first layer on the first layer; and forming a textured surface of the second layer of the same polymeric material as the first layer, the textured surface being operative to facilitate directional cell growth when used in a wound dressing, where the first layer and the second layer are formed using an additive manufacturing process.

4. 发明申请

US20200078160A1 VASCULAR GRAFTS, METHOD OF MANUFACTURING THEREOF AND ARTICLES COMPRISING THE SAME 审中-公开
公开(公告)号：US20200078160A1
公开(公告)日：2020-03-12
申请号：US16346957
申请日：2017-11-07
申请人： Sharklet Technologies, Inc. , University of Florida Research Foundation, Inc.
发明人： Chelsea Marie Magin , Anthony B. Brennan
IPC分类号： A61F2/06 , A61L27/50 , A61L27/36 , A61L27/24 , A61L27/52 , A61L27/38
摘要： Disclosed herein is a method of manufacturing a vascular graft comprising disposing cells of a first cell type on a core having a textured surface, wherein the textured surface comprises a plurality of spaced features, the spaced features being arranged in a plurality of groupings, the groupings of spaced features being arranged with respect to one another so as to define a tortuous path when viewed in a first direction; growing the cells to form a primary cell-seeded construct, wherein the primary cell-seeded construct has a textured inner surface that is a negative image of the textured surface of the core; contacting the primary cell-seeded construct with a second cell type to form a secondary cell-seeded construct; and removing the core to produce the vascular graft.

5. 发明申请

US20170216543A1 PATTERNS FOR FLOW CONTROL AND BIOADHESION CONTROL 审中-公开
公开(公告)号：US20170216543A1
公开(公告)日：2017-08-03
申请号：US15502359
申请日：2015-08-07
申请人： Sharklet Technologies, Inc. , University of Florida Research Foundation, Inc.
发明人： Chelsea Marie Magin , Shravanthi T. Reddy , Anthony B. Brennan , Rhea Marie May , Ethan Eugene Mann , Michael Ryan Mettetal
IPC分类号： A61M16/04 , F16L9/12 , F28F1/00 , A61M25/00
CPC分类号： A61M16/04 , A61F2/0077 , A61F2/1601 , A61F2002/009 , A61F2250/0026 , A61F2250/0051 , A61F2250/0056 , A61F2250/0068 , A61M25/00 , F16L9/12 , F28F1/00
摘要： Disclosed herein is an article including a path that extends across at least a portion of a surface of the article, the path being defined by at least one channel that traverses at least a portion of the surface or a first plurality of spaced features disposed on or in at least a portion of the surface; the spaced features arranged in a plurality of groupings; the groupings of features comprising repeat units; the spaced features within a grouping being spaced apart at an average distance of about 1 nanometer to about 500 micrometers to define a path that traverses the plurality of spaced features; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway.

6. 发明申请

US20170100332A1 SURFACE TOPOGRAPHIES FOR NON-TOXIC BIOADHESION CONTROL 审中-公开
公开(公告)号：US20170100332A1
公开(公告)日：2017-04-13
申请号：US15291441
申请日：2016-10-12
申请人： Sharklet Technologies, Inc. , University of Florida Research Foundation, Inc.
发明人： Leah Tonkin , Anthony B. Brennan , Shravanthi T. Reddy , Chelsea Marie Magin , Ethan Mann , Mark Spiecker , Bryce Stevenson
IPC分类号： A61K9/00 , A61K33/34 , A61K31/567 , A61K31/57 , C09D5/16 , A61K47/34
CPC分类号： A61K9/0039 , A61F6/144 , A61K31/567 , A61K31/57 , A61K33/34 , A61K47/34 , C09D5/1681
摘要： Disclosed herein is an article that includes a first plurality of spaced features. The spaced features are arranged in a plurality of groupings; the groupings of features include repeat units; the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway. The plurality of spaced features provide the article with an engineered roughness index of about 5 to about 20.

7. 发明授权

US09903792B2 Ventilator-endotracheal tube-lung benchtop model 有权
公开(公告)号：US09903792B2
公开(公告)日：2018-02-27
申请号：US14926535
申请日：2015-10-29
申请人： SHARKLET TECHNOLOGIES, INC.
发明人： Chelsea Marie Magin , Shravanthi T. Reddy , Rhea Marie May , Michael Ryan Mettetal , MiKayla Maye Henry
IPC分类号： A61M16/04 , G01M99/00
CPC分类号： G01M99/008 , A61M16/04 , A61M16/0434 , A61M2205/70
摘要： Disclosed herein is a ventilator text fixture comprising a ventilator port that connects to a ventilator through a breathing circuit; where the ventilator delivers air through the ventilator port to a ventilator test fixture at a rate and pressure that can be controlled by a user to simulate inhalation; an input port; where the input port is in fluid communication with the ventilator port; where the input port permits additional simulated secretions or test liquids to be pumped into the ventilator text fixture; one or more bent supports; a liquid reservoir; where the liquid reservoir is operative to hold test fluids; and one or more tubes; where the one or more tubes are in fluid communication with the ventilator port and the input port via the liquid reservoir; and where the one or more bent supports are operative to mimic an anatomy of the trachea.

8. 发明申请

US20160123846A1 VENTILATOR-ENDOTRACHEAL TUBE-LUNG BENCHTOP MODEL 有权
标题翻译：通风管 - 内管式龙骨式底座型号
公开(公告)号：US20160123846A1
公开(公告)日：2016-05-05
申请号：US14926535
申请日：2015-10-29
申请人： SHARKLET TECHNOLOGIES, INC.
发明人： Chelsea Marie Magin , Shravanthi T. Reddy , Rhea Marie May , Michael Ryan Mettetal , MiKayla Maye Henry
IPC分类号： G01M99/00 , A61M16/04
CPC分类号： G01M99/008 , A61M16/04 , A61M16/0434 , A61M2205/70
摘要： Disclosed herein is a ventilator text fixture comprising a ventilator port that connects to a ventilator through a breathing circuit; where the ventilator delivers air through the ventilator port to a ventilator test fixture at a rate and pressure that can be controlled by a user to simulate inhalation; an input port; where the input port is in fluid communication with the ventilator port; where the input port permits additional simulated secretions or test liquids to be pumped into the ventilator text fixture; one or more bent supports; a liquid reservoir; where the liquid reservoir is operative to hold test fluids; and one or more tubes; where the one or more tubes are in fluid communication with the ventilator port and the input port via the liquid reservoir; and where the one or more bent supports are operative to mimic an anatomy of the trachea.
摘要翻译：本文公开了一种通风机文本夹具，其包括通过呼吸机连接到呼吸机的呼吸机端口; 其中呼吸机通过呼吸机端口将空气以可由用户控制以模拟吸入的速率和压力传送到呼吸机测试夹具; 输入端口其中输入端口与呼吸机端口流体连通; 其中输入端口允许额外的模拟分泌物或测试液体被泵送到通气机文本夹具中; 一个或多个弯曲支撑; 液体储存器其中液体储存器用于容纳测试流体; 和一个或多个管; 其中所述一个或多个管经由所述液体储存器与所述通气机端口和所述输入端口流体连通; 并且其中一个或多个弯曲的支撑件可操作以模拟气管的解剖结构。

9. 发明申请

US20150342725A1 Micropatterned Intraocular Implant 有权
标题翻译：微图案眼内植入物
公开(公告)号：US20150342725A1
公开(公告)日：2015-12-03
申请号：US14821645
申请日：2015-08-07
申请人： InSight Innovations, LLC , Sharklet Technologies, Inc. , University of Florida
发明人： Kevin H. Cuevas , Shravanthi T. Reddy , Chelsea Marie Magin , Michael R. Mettetal , Anthony B. Brennan , Rhea Marie May , Ethan Eugene Mann
IPC分类号： A61F2/16
CPC分类号： A61F2/16 , A61F2/14 , A61F2/1601 , A61F2/161 , A61F2002/009 , A61L2430/16
摘要： Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid, or a flow of particles suspended in a fluid, or inhibits the growth or migration of cells. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.
摘要翻译：通常，眼内植入物在外表面上具有以间隔设置的多个图案表面元件，间隔开的关系限定了适于控制流体流动的曲折路径，或悬浮在流体中的颗粒流，或抑制生长或迁移细胞。特别地，植入在眼内晶状体和眼睛后囊的表面之间的眼内植入物通过提供结构障碍以减少眼睛后囊膜混浊而抑制白内障手术后残余晶状体上皮细胞的生长或迁移。

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