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1. 发明授权

US07612212B2 Substituted hydantoins 失效
标题翻译：取代乙内酰脲
公开(公告)号：US07612212B2
公开(公告)日：2009-11-03
申请号：US11657800
申请日：2007-01-25
申请人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , Steven Gregory Mischke , John Anthony Moliterni , Hong Wang , Zhuming Zhang
发明人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , Steven Gregory Mischke , John Anthony Moliterni , Hong Wang , Zhuming Zhang
IPC分类号： C07D233/02 , A61K31/4166
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
摘要翻译：本发明涉及其制备方法的化合物及其使用方法。该化合物可用于治疗以MEK多动症为特征的疾病。因此，该化合物可用于治疗诸如癌症，认知和CNS疾病以及炎性/自身免疫性疾病的疾病。

2. 发明申请

US20070197617A1 Substituted hydantoins 失效
标题翻译：取代乙内酰脲
公开(公告)号：US20070197617A1
公开(公告)日：2007-08-23
申请号：US11657800
申请日：2007-01-25
申请人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , Steven Gregory Mischke , John Anthony Moliterni , Hong Wang , Zhuming Zhang
发明人： Shaoqing Chen , Nicholas J. S. Huby , Norman Kong , Steven Gregory Mischke , John Anthony Moliterni , Hong Wang , Zhuming Zhang
IPC分类号： A61K31/4178 , A61K31/4166 , C07D403/02
CPC分类号： C07D233/76 , C07D233/78 , C07D401/04 , C07D401/06 , C07D403/06 , C07D405/04 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D409/06 , C07D417/06
摘要： The present invention relates to compounds of the formula methods for the preparation thereof, and methods for their use. The compounds are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as cancer, cognitive and CNS disorders, and inflammatory/autoimmune diseases.
摘要翻译：本发明涉及其制备方法的化合物及其使用方法。该化合物可用于治疗以MEK多动症为特征的疾病。因此，该化合物可用于治疗诸如癌症，认知和CNS疾病以及炎性/自身免疫性疾病的疾病。

3. 发明授权

US07803816B2 MCH receptor antagonists 失效
标题翻译： MCH受体拮抗剂
公开(公告)号：US07803816B2
公开(公告)日：2010-09-28
申请号：US11526523
申请日：2006-09-25
申请人： Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
发明人： Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
IPC分类号： A61K31/454 , C07D403/02
CPC分类号： C07D401/04 , C07D401/14 , C07D471/04
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
摘要翻译：本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。这些化合物和含有它们的药物组合物可用于治疗肥胖，食欲过盛，焦虑，抑郁和相关疾病和疾病。

4. 发明授权

US10420166B2 Method for avoiding handover failure 有权
公开(公告)号：US10420166B2
公开(公告)日：2019-09-17
申请号：US13542247
申请日：2012-07-05
申请人： Lixiang Xu , Hong Wang , Huarui Liang
发明人： Lixiang Xu , Hong Wang , Huarui Liang
IPC分类号： H04W76/30 , H04W8/08 , H04W36/00
摘要： Methods for avoiding handover failure are provided. The method includes determining, by a source Base Station (BS), to perform a handover of a User Equipment (UE); determining, by the source BS, whether a target BS connects with a user plane node serving the UE at the source BS; and releasing resources, when the target BS does not connect with the user plane node serving the UE at the source BS.

5. 发明授权

US10089263B2 Synchronization of interrupt processing to reduce power consumption 有权
公开(公告)号：US10089263B2
公开(公告)日：2018-10-02
申请号：US15118501
申请日：2014-03-24
申请人： INTEL CORPORATION , Thiam Wah Loh , Gautham N. Chinya , Per Hammarlund , Reza Fortas , Hong Wang , Huajin Sun
发明人： Thiam Wah Loh , Gautham N. Chinya , Per Hammarlund , Reza Fortas , Hong Wang , Huajin Sun
IPC分类号： G06F13/24
摘要： A processor is disclosed and includes at least one core including a first core, and interrupt delay logic. The interrupt delay logic is to receive a first interrupt at a first time and delay the first interrupt from being processed by a first time delay that begins at the first time, unless the first interrupt is pending at a second time when a second interrupt is processed by the first core. If the first interrupt is pending at the second time, the interrupt delay logic is to indicate to the first core to begin to process the first interrupt prior to completion of the first time delay. Other embodiments are disclosed and claimed.

6. 发明申请

US20180225118A1 METHOD AND SYSTEM TO PROVIDE USER-LEVEL MULTITHREADING 审中-公开
公开(公告)号：US20180225118A1
公开(公告)日：2018-08-09
申请号：US15943614
申请日：2018-04-02
申请人： Ed Grochowski , Hong Wang , John P. Shen , Perry H. Wang , Jamison D. Collins , James Held , Partha Kundu , Raya Leviathan , Tin-Fook Ngai
发明人： Ed Grochowski , Hong Wang , John P. Shen , Perry H. Wang , Jamison D. Collins , James Held , Partha Kundu , Raya Leviathan , Tin-Fook Ngai
IPC分类号： G06F9/30 , G06F9/38
CPC分类号： G06F9/30003 , G06F9/30087 , G06F9/3009 , G06F9/30101 , G06F9/3013 , G06F9/384 , G06F9/3851
摘要： A method and system to provide user-level multithreading are disclosed. The method according to the present techniques comprises receiving programming instructions to execute one or more shared resource threads (shreds) via an instruction set architecture (ISA). One or more instruction pointers are configured via the ISA; and the one or more shreds are executed simultaneously with a microprocessor, wherein the microprocessor includes multiple instruction sequencers.

7. 发明授权

US09867157B2 Method for detachment of MS moving between communication systems 有权
公开(公告)号：US09867157B2
公开(公告)日：2018-01-09
申请号：US12527328
申请日：2008-02-13
申请人： Bing Bu , Xiaoqiang Li , Chunying Sun , Hong Wang , Lixiang Xu , Yanmin Zhu
发明人： Bing Bu , Xiaoqiang Li , Chunying Sun , Hong Wang , Lixiang Xu , Yanmin Zhu
IPC分类号： H04W60/06 , H04W76/06
CPC分类号： H04W60/06 , H04W76/32
摘要： A method for detachment of a mobile set within the equivalent route area moving between the communication systems comprising steps of: during the detachment process is implemented between a mobile set and a service node in one communication system, the service node generates one or more messages and transmits it to the service nodes in one or more communication system within the ERA. If the message is transmitted to the service node within the ERA of only one communication system, this service node transmits this message or the message generated according to this message to the service nodes within the ERA of the other communication system. With the method proposed in present invention, when a mobile is detached from two or more communication systems which share the same ERA, the service nodes in all communication systems within the ERA can still correctly manage the relevant information on this mobile set.

8. 发明申请

US20170020717A1 Condom with Side Portals 审中-公开
标题翻译：安全套与侧门
公开(公告)号：US20170020717A1
公开(公告)日：2017-01-26
申请号：US15273117
申请日：2016-09-22
申请人： Hong Wang
发明人： Hong Wang
IPC分类号： A61F6/04
CPC分类号： A61F6/04
摘要： A condom of embodiments of the disclosed technology has a tip and base with cords connecting the two, creating portals where the urethra is exposed and fully capable of feeling abrasion with other objects. The base ring is oppositely disposed from the tip and an extreme other end of the condom. The base ring also extends circumferentially and in parallel to a largest circumference of the solid tip, when the cord extends perpendicularly to the largest circumference of the solid tip and the base ring. The largest circumference of the circle referred to herein, in embodiments of the disclosed technology, is a portion of the tip which is closest to the base ring.
摘要翻译：所公开技术的实施例的避孕套具有尖端和底部，其具有连接两者的线，创建出口的位置，其中尿道被暴露并且完全能够感受到与其它物体的磨损。基座环从尖端和避孕套的极端另一端相对设置。当绳索垂直于固体末端和基环的最大圆周延伸时，基环也周向地并且平行于固体末端的最大圆周延伸。在所公开的技术的实施例中，这里提到的圆的最大圆周是尖端的最靠近基环的部分。

9. 发明授权

US09198891B2 Method of treating cancer by inhibition of protein kinase-like endoplasmic reticulum protein kinase 有权
标题翻译：通过抑制蛋白激酶样内质网蛋白激酶治疗癌症的方法
公开(公告)号：US09198891B2
公开(公告)日：2015-12-01
申请号：US13111769
申请日：2011-05-19
申请人： Timothy Cardozo , Hong Wang , David Ron
发明人： Timothy Cardozo , Hong Wang , David Ron
IPC分类号： A61K49/00 , A61K31/225 , A61K31/24 , A61K31/4166 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/496 , A61K31/519 , A61K31/536 , C07D207/416 , C07D239/42 , C07D249/12 , C07D265/22 , C07D277/44 , C07D277/54 , C07D277/66 , C07D307/54 , C07D317/60 , C07D403/04 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/14 , C07D487/04 , C12Q1/48 , G06F19/00 , G06F19/16
CPC分类号： A61K31/225 , A61K31/24 , A61K31/4166 , A61K31/4245 , A61K31/428 , A61K31/433 , A61K31/496 , A61K31/519 , A61K31/536 , C07D207/416 , C07D239/42 , C07D249/12 , C07D265/22 , C07D277/44 , C07D277/54 , C07D277/66 , C07D307/54 , C07D317/60 , C07D403/04 , C07D403/06 , C07D403/12 , C07D409/12 , C07D417/14 , C07D487/04 , C12Q1/485 , G06F19/16 , G06F19/706
摘要： The present invention relates to a method of identifying compounds useful in inhibiting protein kinase-like endoplasmic reticulum protein kinase (PERK). The method comprises providing a first model comprising PERK active domains, where the said active domains are selected from the group consisting of the peptide spanning from amino acid residue Asp144 to amino acid residue Ser191 of SEQ ID NO: 1 and a peptide comprising the amino acid residue at position 7 of SEQ ID NO: 1, providing one or more candidate compounds, evaluating contact between the candidate compounds and the first model to determine which of the one or more candidate compounds have an ability to bind to and/or fit in the first model, and identifying the compounds which, based on said evaluating, have the ability to bind to and/or fit in the first model as compounds potentially useful for inhibiting PERK. The present invention further relates to compounds that can be used for inhibition of PERK, for example human PERK, and methods related to treatment of PERK-mediated diseases.
摘要翻译：本发明涉及鉴定可用于抑制蛋白激酶样内质网蛋白激酶（PERK）的化合物的方法。该方法包括提供包含PERK活性结构域的第一模型，其中所述活性域选自跨越SEQ ID NO：1的氨基酸残基Asp144至氨基酸残基Ser191的肽和包含氨基酸的肽提供一种或多种候选化合物，评估候选化合物与第一模型之间的接触，以确定一种或多种候选化合物中的哪一种具有结合和/或适合的能力第一模型，以及鉴定基于所述评估具有结合和/或适合第一模型的能力的化合物，作为潜在地可用于抑制PERK的化合物。本发明还涉及可用于抑制PERK的化合物，例如人PERK，以及与治疗PERK介导的疾病有关的方法。

10. 发明申请

US20150153329A1 ASSAY SYSTEM FOR GLP-2 RECEPTOR LIGANDS 审中-公开
标题翻译： GLP-2受体配体的测定系统
公开(公告)号：US20150153329A1
公开(公告)日：2015-06-04
申请号：US14616295
申请日：2015-02-06
申请人： Lidia L. Demchyshyn , Hong Wang
发明人： Lidia L. Demchyshyn , Hong Wang
IPC分类号： G01N33/50 , G01N33/74
CPC分类号： G01N33/5082 , G01N33/5088 , G01N33/74 , G01N2333/605 , G01N2333/726 , G01N2500/04 , G01N2500/10
摘要： Disclosed herein is a method for measuring the contractility of intestinal tissue upon treatment with GLP-2 or a GLP-2 ligand. Also disclosed is an assay which directly measures the activity of GLP-2 or GLP-2 ligands ex vivo and permits the screening of putative GLP-2 ligands in native tissue.
摘要翻译：本文公开了一种用于在用GLP-2或GLP-2配体处理时测量肠组织的收缩性的方法。还公开了一种直接测量GLP-2或GLP-2配体活性的测定法，并允许在天然组织中筛选推定的GLP-2配体。

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