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1. 发明授权

US08112230B2 Method of network-based identification of multicomponent synergy and compositions for use as effective component of anti-angiogenesis medicines 有权
标题翻译：多组分协同作用的网络鉴定方法和用作抗血管生成药物有效成分的组合物
公开(公告)号：US08112230B2
公开(公告)日：2012-02-07
申请号：US12436844
申请日：2009-05-07
申请人： Ningbo Zhang , Shao Li , Bo Zhang
发明人： Ningbo Zhang , Shao Li , Bo Zhang
IPC分类号： G01N33/48 , G01N31/00 , C12Q3/00
CPC分类号： A61K45/06 , A61K31/485 , G06F19/12 , G06F19/18 , A61K2300/00
摘要： A method for determining synergistic effect of a medicine combination including two medicines relating to a disease on the basis of a gene network and medicine-effective genes of each and/or any of said two medicines, comprising: determining a synergy factor (ST1,2) of two medicines on the basis of distribution of medicine-effective genes of two medicines; determining a medicine similarity factor (AS1,2) of two medicines on the basis of similarity between a set of symptoms which two medicines relates to; and, determining synergistic effect of two medicines according to a product of the synergy factor and similarity factor. Proposed is constructing a disease-related gene network, mapping medicine-effective genes onto the network, and determining the synergistic effect of medicines on the basis of the genes. The present invention also relates to medicine composition of sinomenine and honokiol and of sinomenine and luteolin, each with anti-angiogenesis effect and having good synergistic effect.
摘要翻译：一种用于基于基因网络的两种与疾病相关的药物和所述两种药物和/或任何一种药物有效的基因来确定药物组合的协同效应的方法，包括：确定协同因子（ST1,2 ）两种药物在药物有效基因分布的基础上的两种药物; 根据两种药物相关的一组症状的相似性，确定两种药物的药物相似性因子（AS1,2）; 并根据协同因子和相似因子的乘积确定两种药物的协同效应。拟建疾病相关基因网络，将药用有效基因映射到网络上，并根据基因确定药物的协同效应。本发明还涉及青藤碱和和厚朴酚，青藤碱，木犀草素的药物组合物，具有抗血管生成作用，具有良好的协同作用。

2. 发明申请

US20100144777A1 Method of Network-Based Identification of Multicomponent Synergy and Compositions for Use as Effective Component of Anti-Angiogenesis Medicines 有权
标题翻译：多组分协同作用和组合物网络鉴定方法作为抗血管生成药物的有效成分
公开(公告)号：US20100144777A1
公开(公告)日：2010-06-10
申请号：US12436844
申请日：2009-05-07
申请人： Shao Li , Ningbo Zhang , Bo Zhang
发明人： Shao Li , Ningbo Zhang , Bo Zhang
IPC分类号： A61K31/485 , G06F19/00
CPC分类号： A61K45/06 , A61K31/485 , G06F19/12 , G06F19/18 , A61K2300/00
摘要： A method was provided for determining synergistic effect of a medicine combination including two medicines relating to a disease on the basis of a gene network and medicine-effective genes of each and/or any of said two medicines, comprising: determining a synergy factor (ST1,2) of said two medicines on the basis of distribution of medicine-effective genes of said two medicines; determining a medicine similarity factor (AS1,2) of said two medicines on the basis of similarity between set of symptoms which said two medicines relates to; and, determining extent of synergistic effect of said two medicines according to a product of said synergy factor and said similarity factor. Proposed were constructing a disease-related gene network, mapping medicine-effective genes onto the network, and determining extent of synergistic effect of medicines on the basis of the genes the present invention also relates to medicine composition of sinomenine and honokiol and medicine composition of sinomenine and luteolin, each with anti-angiogenesis effect having good synergistic effect. Effectiveness of the method of the invention had been verified by cell proliferation verification experiments.
摘要翻译：提供了一种用于根据基因网络和每种和/或任何所述两种药物的药用有效基因确定包括两种与疾病有关的药物的药物组合的协同效应的方法，包括：确定协同作用因子（ST1 ，2）所述两种药物在所述两种药物的药用有效基因的分布的基础上; 根据所述两种药物相关的症状组之间的相似性，确定所述两种药物的药物相似性因子（AS1,2）; 以及根据所述协同因子和所述相似因子的乘积确定所述两种药物的协同效应的程度。拟建疾病相关基因网络，将药物有效基因映射到网络上，并根据本发明的基因确定药物协同效应的程度，还涉及青藤碱和和厚朴酚的药物组成以及青藤碱的药物组成和木犀草素，各具有抗血管生成作用，具有良好的协同作用。通过细胞增殖验证实验验证了本发明方法的有效性。

3. 发明申请

US20120035855A1 METHOD OF NETWORK-BASED IDENTIFICATION FOR DRUG ACTION AND/OR SYNERGY EFFECT OF MEDICINE COMBINATION 审中-公开
标题翻译：基于网络识别药物联合作用和/或协同效应的方法
公开(公告)号：US20120035855A1
公开(公告)日：2012-02-09
申请号：US13133321
申请日：2009-10-09
申请人： Shao Li , Ningbo Zhang
发明人： Shao Li , Ningbo Zhang
IPC分类号： G06F19/00
CPC分类号： G16B5/00
摘要： The invention provides a network-based method for confirming drug action (drug effect, synergistic reaction). The method be carried out by mapping a first drug genes/gene products subset and a second genes/gene products subset in a gene network. The second genes/gene products subset can be a second drug genes/gene products subset or a biological process genes/gene products subset. The invention also provides a tool for pre-clinical drug screening.
摘要翻译：本发明提供了一种用于确认药物作用（药物作用，协同反应）的基于网络的方法。该方法通过在基因网络中映射第一药物基因/基因产物子集和第二个基因/基因产物子集进行。第二个基因/基因产物子集可以是第二个药物基因/基因产物子集或生物过程基因/基因产物子集。本发明还提供用于临床前药物筛选的工具。

4. 发明申请

US20080024047A1 DECORATIVE DOOR FOR COOLER 审中-公开
标题翻译：冷藏柜装饰门
公开(公告)号：US20080024047A1
公开(公告)日：2008-01-31
申请号：US11782339
申请日：2007-07-24
申请人： Chun Juo , Shao Li , Jin Lai
发明人： Chun Juo , Shao Li , Jin Lai
IPC分类号： F25D23/02 , A47F3/04 , F25D13/00 , F25D23/00
CPC分类号： F25D23/02 , A47F3/043 , F21W2131/305 , F21Y2115/10 , F25D27/00 , F25D2327/001 , F25D2400/18
摘要： A decorative door for a cooler includes a frame featuring a circumferential slot and a circumferential chamber that are in communication with one another. The frame is adapted for mounting to a cooler in a hinged fashion. An interior transparent panel is secured by its edges within the circumferential slot of the frame and features a decorative channel formed therein. A number of light-emitting diodes serve as light sources positioned in the circumferential chamber and illuminate the decorative channel of the interior transparent panel. Inner surface and outer surface transparent panels are mounted to the frame on opposite sides of the interior transparent panel and the spaces there between are at least partially evacuated of air. The frame also includes a circumferential passage containing an insulating material, such as molecular mesh.
摘要翻译：用于冷却器的装饰门包括具有彼此连通的圆周槽和周向室的框架。框架适于以铰接方式安装到冷却器。内部透明板通过其边缘固定在框架的周向槽内，并具有形成在其中的装饰通道。多个发光二极管用作位于周向室中的光源，并照亮内部透明板的装饰通道。内表面和外表面透明面板在内部透明板的相对侧上安装到框架上，并且其间的空间至少部分地被抽空。该框架还包括包含绝缘材料的圆周通道，例如分子网。

5. 发明申请

US20070119799A1 Beverage container shelf management system 失效
标题翻译：饮料容器货架管理系统
公开(公告)号：US20070119799A1
公开(公告)日：2007-05-31
申请号：US11374869
申请日：2006-03-14
申请人： Peter Hanretty , Shao Li
发明人： Peter Hanretty , Shao Li
IPC分类号： A47F1/04
CPC分类号： A47F1/12 , A47F5/0025 , A47F5/0037
摘要： A gravity feed display rack for supporting and displaying merchandise is provided. The rack has a merchandise channel support structure featuring a number of rods. Inner and outer dividers featuring merchandise supports and longitudinally extending walls are positioned on the rods in a sliding fashion. End portions of the rods feature adjustable latch slots and at least one outer divider features connectors with locking projections that engage the adjustable latch slots of the merchandise channel support structure. As a result, the dividers are located in spaced apart relationship upon the merchandise channel support structure and may be adjusted to accommodate varying sizes of merchandise.
摘要翻译：提供了用于支撑和显示商品的重力进给显示架。机架上有一个商品通道支持结构，具有许多杆。具有商品支撑和纵向延伸壁的内部和外部分隔件以滑动的方式定位在杆上。杆的端部具有可调节的锁定槽，并且至少一个外部分隔件具有与锁定突起相连的连接器，其与商品通道支撑结构的可调节锁定槽接合。结果，分隔件在商品通道支撑结构上处于间隔开的关系中，并且可以被调整以适应不同尺寸的商品。

6. 发明申请

US20050148695A1 Moisture resistant, flexible epoxy/cyanate ester formulation 审中-公开
标题翻译：防水，柔性环氧/氰酸酯配方
公开(公告)号：US20050148695A1
公开(公告)日：2005-07-07
申请号：US11035391
申请日：2005-01-13
申请人： Xiao-Qi Zhou , Henry Wevick , Nancy Iwamoto , Shao Li , Alan Grieve
发明人： Xiao-Qi Zhou , Henry Wevick , Nancy Iwamoto , Shao Li , Alan Grieve
IPC分类号： C08G59/24 , C08G59/38 , C08G59/40 , C08G73/06 , C08L63/00 , G03F7/038 , H01L21/56 , H01L23/29 , H01L23/485
CPC分类号： H01L23/293 , C08G59/24 , C08G59/38 , C08G59/4014 , C08G73/0655 , C08L63/00 , G03F7/038 , H01L21/563 , H01L24/10 , H01L2924/00014 , H01L2924/01019 , H01L2924/0102 , H01L2924/01078 , H01L2924/01079 , H01L2924/10253 , H01L2924/15747 , H01L2924/00 , H01L2224/0401
摘要： Compositions having high moisture resistance and flexibility comprise an organic component and a filler. The organic component comprises a long-chain cycloaliphatic epoxy resin, a short-chain cycloaliphatic epoxy resin, a cyanate ester, and a lewis acid catalyst. Preferably the organic component further comprises a bronsted acid co-catalyst and/or a flexibilizing modifier. The compositions are useful in various semiconductor applications, including as die attach adhesives, underfills, encapsulants, via fills, prepreg binders, polymer solder masks and polymer bumps on flip chip or BGA assemblies.
摘要翻译：具有高耐湿性和柔软性的组合物包含有机组分和填料。有机组分包括长链脂环族环氧树脂，短链脂环族环氧树脂，氰酸酯和路易斯酸催化剂。优选地，有机组分还包含青铜酸助催化剂和/或增韧改性剂。该组合物可用于各种半导体应用，包括作为芯片附着粘合剂，底部填充剂，密封剂，通孔填充物，预浸料粘合剂，聚合物焊接掩模和倒装芯片或BGA组件上的聚合物凸块。

7. 发明申请

US20080108642A1 Composition and its use as effective constituent of a medicine having anti-angiogenesis synergy effect 审中-公开
标题翻译：组合物及其作为具有抗血管生成协同作用的药物的有效成分的用途
公开(公告)号：US20080108642A1
公开(公告)日：2008-05-08
申请号：US11975320
申请日：2007-10-18
申请人： Shao Li , Min Wu
发明人： Shao Li , Min Wu
IPC分类号： A61K31/4375 , A61P35/00
CPC分类号： A61K31/4375 , A61K31/438 , A61K31/55 , A61K2300/00
摘要： The present invention relates to a composition as effective constituent of a medicine having anti-angiogenesis synergy effect and belongs to the field of medicine compositions. The recipe is composed of matrine and sinomenine hydrochloride with a content ratio of matrine:sinomenine hydrochloride=1:0.05 to 1. The recipe of the present invention has synergic actions of efficacy enhancing and toxicity reducing, has obvious therapy effect to angiogenesis-related diseases such as rheumatoid arthritis and cancer, has clear base of medicine effective substance, and maintain the characteristic of traditional Chinese medicine of recipe association.
摘要翻译：本发明涉及作为具有抗血管发生协同作用的药物的有效成分的组合物，属于医药组合物领域。该配方由苦参碱和盐酸青藤碱组成，盐酸青蒿素含量比为：盐酸青藤碱= 1：0.05〜1。本发明的配方具有增效功效和毒性降低的协同作用，对血管生成相关疾病具有明显疗效如类风湿关节炎和癌症，具有明显的药物基础有效物质，并保持中药配方协会的特点。

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