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1. 发明申请

US20060233878A1 Extended release formulation of beta-lactam antibiotics 审中-公开
标题翻译： β-内酰胺抗生素的延长释放制剂
公开(公告)号：US20060233878A1
公开(公告)日：2006-10-19
申请号：US10568325
申请日：2003-09-30
申请人： Shailesh Bhamare , Indu Bhushan , Himadri Sen
发明人： Shailesh Bhamare , Indu Bhushan , Himadri Sen
IPC分类号： A61K31/545 , A61K9/22
CPC分类号： A61K9/2018 , A61K9/2027 , A61K31/545
摘要： A pharmaceutical composition for controlled drug delivery comprising a β-lactam antibiotic or its pharmaceutically acceptable hydrates, salts or esters, and one or more carbomers. The above β-lactam antibiotics formulation avoids the limitations of known β-lactam controlled release form which are found to be either complex and/or cost-extensive to obtain requiring multiphase and/or selective coatings or fail to achieve the desired controlled release for once daily dosage form. Importantly, in the β-lactam antibiotic form of the above the rate-controlling polymer wherein the Cmax of the formulation is substantially the same as that of a single dose of the immediate release formulation. Also advantageously the formulation achieves a rate controlling polymer wherein the T>MIC for the formulation is more than 17 hours when the MIC is 0.25 mcg/ml and more than 10 hours when the MIC is 2 mcg/ml. The above β-lactam antibiotic form is thus directed to serve as the much desired simple and cost-effective controlled release form suitable for once daily administration.
摘要翻译：用于受控药物递送的药物组合物，其包含β-内酰胺抗生素或其药学上可接受的水合物，盐或酯，以及一种或多种卡波姆。上述β-内酰胺抗生素制剂避免了已知的β-内酰胺控制释放形式的限制，其被认为是复杂的和/或成本广泛的以获得需要多相和/或选择性涂层或不能达到期望的一次控制释放日剂量。重要的是，在上述β-内酰胺抗生素形式中，速率控制聚合物，其中制剂的最大值与单剂量的立即释放制剂基本上相同。还有利地，制剂实现速率控制聚合物，其中当MIC为0.25mcg / ml时，制剂的T> MIC大于17小时，当MIC为2mcg / ml时超过10小时。因此，上述β-内酰胺抗生素形式被用作适合于每日一次给药的理想的简单和成本有效的控制释放形式。

2. 发明申请

US20060188568A1 Stable formulations of ace inhibitors and methods for preparation thereof 审中-公开
标题翻译： ace抑制剂的稳定配方及其制备方法
公开(公告)号：US20060188568A1
公开(公告)日：2006-08-24
申请号：US10550181
申请日：2003-10-30
申请人： Shailesh Bhamare , Indu Bhushan , Himadri Sen
发明人： Shailesh Bhamare , Indu Bhushan , Himadri Sen
IPC分类号： A61K31/401 , A61K9/20
CPC分类号： A61K9/2018 , A61K9/4858 , A61K31/403
摘要： Stabilized pharmaceutical solid composition of ACE inhibitor comprising an ACE inhibitor and a selective dosage formulation thereof comprising of meglumine. The ACE inhibitor selectively combined with a dosage form including essentially the meglumine is surprisingly found to avoid the degradation of ACE inhibitor by such dosage forms especially the commonly used pharmaceutical excepients. In particular, the presence of the meglumine in the dosage form for the active along with the active ACE inhibitor surprisingly avoid the degradation of the ACE inhibitor due to a) cyclization via internal nucleophilic attack to form substituted diketopiperazines, b) hydrolysis of the side chain ester group, and c) oxidation to form products having often unwanted coloration.
摘要翻译：稳定的ACE抑制剂的药物固体组合物，其包含ACE抑制剂及其选择性剂量制剂，其包含葡甲胺。令人惊奇地发现，选择性地与包含基本上葡甲胺的剂型组合的ACE抑制剂避免了ACE抑制剂通过这样的剂型，特别是常用的药物的降解。特别地，活性剂剂型中的葡甲胺与活性ACE抑制剂的存在令人惊奇地避免了由于通过内部亲核攻击而环化形成取代的二酮哌嗪的ACE抑制剂的降解，b）侧链的水解酯基，和c）氧化形成通常不需要着色的产品。

3. 发明授权

US06346530B1 Process for the preparation of a bioavailable oral dosage form of cefuroxime axetil 失效
标题翻译：头孢呋辛酯生物利用口服剂型的制备方法
公开(公告)号：US06346530B1
公开(公告)日：2002-02-12
申请号：US09366986
申请日：1999-08-04
申请人： Jitendra Krishan Somani , Indu Bhushan , Himadri Sen
发明人： Jitendra Krishan Somani , Indu Bhushan , Himadri Sen
IPC分类号： A61K3154
CPC分类号： A61K31/546
摘要： This invention relates to a process of mixing of crystalline cefuroxime axetil with amorphous cefuroxime axetil for the preparation of a bioavailable oral dosage form comprising of amorphous cefuroxime axetil containing from 7 to 25% crystalline cefuroxime axetil.
摘要翻译：本发明涉及将结晶头孢呋辛酯与无定形头孢呋辛酯酯混合以制备包含7-25％结晶头孢呋辛酯的无定形头孢呋辛酯的生物可利用口服剂型的方法。

4. 发明授权

US06323193B1 Bioavailable oral dosage form of cefuroxime axetil 失效
标题翻译：头孢呋辛酯的生物利用口服剂型
公开(公告)号：US06323193B1
公开(公告)日：2001-11-27
申请号：US09642402
申请日：2000-08-21
申请人： Jitendra Krishan Somani , Indu Bhushan , Himadri Sen
发明人： Jitendra Krishan Somani , Indu Bhushan , Himadri Sen
IPC分类号： A61K31545
CPC分类号： A61K9/2095 , Y10S514/944
摘要： This invention relates to a bioavailable oral dosage form comprising of amorphous cefuroxime axetil containing from 7 to 25% crystalline cefuroxime axetil.
摘要翻译：本发明涉及一种生物可利用的口服剂型，其包含含有7-25％结晶头孢呋辛酯的无定形头孢呋辛酯。

5. 发明申请

US20090209541A1 APREPITANT COMPOSITIONS 审中-公开
标题翻译： APRIP组成
公开(公告)号：US20090209541A1
公开(公告)日：2009-08-20
申请号：US12305133
申请日：2007-06-18
申请人： Paras Jain , Umesh V. Barabde , Ravinder Kodipyaka , Indu Bhushan , Vijayavitthal Thippannachar Mathad , Pravinchandra Jayantilal Vankawala , Kolla Naveen Kumar , Arunagiri Muthulingam , Gangula Srinivas , Chlamala Subrahmanyeswara Rao , Elati Ravi Ram Chandrasekhar
发明人： Paras Jain , Umesh V. Barabde , Ravinder Kodipyaka , Indu Bhushan , Vijayavitthal Thippannachar Mathad , Pravinchandra Jayantilal Vankawala , Kolla Naveen Kumar , Arunagiri Muthulingam , Gangula Srinivas , Chlamala Subrahmanyeswara Rao , Elati Ravi Ram Chandrasekhar
IPC分类号： A61K31/5377
CPC分类号： A61K31/5377 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1635 , A61K9/1688
摘要： Pharmaceutical compositions comprising aprepitant, wherein aprepitant solubility in aqueous media is enhanced.
摘要翻译：包含助凝剂的药物组合物，其中在水性介质中的助凝剂溶解度增强。

6. 发明申请

US20080182908A1 PHARMACEUTICAL COMPOSITIONS COMPRISING MEMANTINE 审中-公开
标题翻译：包含记忆的药物组合物
公开(公告)号：US20080182908A1
公开(公告)日：2008-07-31
申请号：US12018974
申请日：2008-01-24
申请人： Vinita Umashankar Vyas , Ravi Kumar Namballa , Raghupathi Kandarapu , Srinivas Irukulla , Indu Bhushan
发明人： Vinita Umashankar Vyas , Ravi Kumar Namballa , Raghupathi Kandarapu , Srinivas Irukulla , Indu Bhushan
IPC分类号： A61K31/136
CPC分类号： A61K31/136 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/2866 , A61K9/48
摘要： Pharmaceutical compositions comprising memantine or a salt thereof, from which less than about 80% of the contained memantine dissolves into a pH 1.2 aqueous medium within about 60 minutes.
摘要翻译：包含美金刚或其盐的药物组合物，其中小于约80％的所含的美金刚在约60分钟内溶解于pH1.2水介质中。

7. 发明申请

US20080085311A1 ANTIHISTAMINE-DECONGESTANT COMBINATIONS 审中-公开
标题翻译：抗组胺 - 不合用的组合
公开(公告)号：US20080085311A1
公开(公告)日：2008-04-10
申请号：US11867076
申请日：2007-10-04
申请人： Sanjay Tripathi , Ravi Namballa , Vasanth Shetty , Raghupathi Kandarapu , Srinivas Irukulla , Indu Bhushan , Mailatur Mohan
发明人： Sanjay Tripathi , Ravi Namballa , Vasanth Shetty , Raghupathi Kandarapu , Srinivas Irukulla , Indu Bhushan , Mailatur Mohan
IPC分类号： A61K9/36 , A61K31/445 , A61K9/14 , A61P37/08 , A61K9/16
CPC分类号： A61K31/445 , A61K9/2081 , A61K9/2866 , A61K9/5078 , A61K31/00 , A61K31/137 , A61K2300/00
摘要： Multi-particulate pharmaceutical compositions comprising an antihistamine for immediate release and a decongestant for modified release.
摘要翻译：包含用于立即释放的抗组胺剂和用于改良释放的减充血剂的多颗粒药物组合物。

8. 发明申请

US20080057118A1 DIVALPROEX PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译： DIVALPROEX药物组合物
公开(公告)号：US20080057118A1
公开(公告)日：2008-03-06
申请号：US11847457
申请日：2007-08-30
申请人： Alagumurugan Alagarsamy , Sudeep Kumar Agrawal , Indu Bhushan , Mailatur Sivaraman Mohan
发明人： Alagumurugan Alagarsamy , Sudeep Kumar Agrawal , Indu Bhushan , Mailatur Sivaraman Mohan
IPC分类号： A61K9/52 , A61K31/19 , A61K9/16 , A61P25/00 , A61K9/26
CPC分类号： A61K31/19 , A61K9/2866 , A61K9/4866 , A61K9/5042 , A61K9/5047 , A61K9/5078
摘要： Pharmaceutical compositions comprising a valproic acid drug compound, providing modified release of the drug.
摘要翻译：包含丙戊酸药物化合物的药物组合物，提供药物的改良释放。

9. 发明申请

US20070092568A1 GALANTAMINE COMPOSITIONS 审中-公开
标题翻译：甘氨酸组合物
公开(公告)号：US20070092568A1
公开(公告)日：2007-04-26
申请号：US11539918
申请日：2006-10-10
申请人： Subhash Gore , Arun Kant Rajlakshmy , Kodipyaka Ravinder , Venkata Sreedharala , Indu Bhushan , Mailatur Mohan
发明人： Subhash Gore , Arun Kant Rajlakshmy , Kodipyaka Ravinder , Venkata Sreedharala , Indu Bhushan , Mailatur Mohan
IPC分类号： A61K9/24 , A61K31/55
CPC分类号： A61K31/55 , A61K9/1676 , A61K9/2866 , A61K9/4808 , A61K9/4866 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K9/5084
摘要： The present invention relates to controlled release compositions of galantamine, processes to prepare the compositions, their in-vitro release profiles and method of use and method of treatment using the said compositions.
摘要翻译：本发明涉及加兰他敏的控释组合物，制备组合物的方法，其体外释放曲线和使用方法以及使用所述组合物的治疗方法。

10. 发明申请

US20080187581A1 Delivery System For Mulitple Drugs 审中-公开
标题翻译：多药物输送系统
公开(公告)号：US20080187581A1
公开(公告)日：2008-08-07
申请号：US11908631
申请日：2006-03-16
申请人： Subhash Pandurang Gore , Verma Sanjay , Vijay Dinanath Nasare , Indu Bhushan , Venkata Nookaraju Sreedharala , Harshal Prabhakar Bhagwatwar , Mailatur Sivaraman Mohan
发明人： Subhash Pandurang Gore , Verma Sanjay , Vijay Dinanath Nasare , Indu Bhushan , Venkata Nookaraju Sreedharala , Harshal Prabhakar Bhagwatwar , Mailatur Sivaraman Mohan
IPC分类号： A61K9/48 , A61K31/135 , A61P43/00
CPC分类号： A61K9/209 , A61K9/2072 , A61K9/2893 , A61K9/4891
摘要： A solid pharmaceutical dosage form comprises a substrate containing an active agent and a solid composition deposited onto areas of a surface of the substrate and containing an active agent.
摘要翻译：固体药物剂型包含含有活性剂和固体组合物的底物，其沉积在基底表面的区域上并含有活性剂。

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