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1. 发明授权

US07358347B1 MEN1, the gene associated with multiple endocrine neoplasia type 1, menin polypeptides and uses thereof 失效
标题翻译： MEN1，与多发性内分泌肿瘤1型有关的基因，menin多肽及其用途
公开(公告)号：US07358347B1
公开(公告)日：2008-04-15
申请号：US09380337
申请日：1998-03-04
申请人： Settara Chandrasekharappa , Siradanahalli Guru , Pachiappan Manickam , Francis S. Collins , Michael R. Emmert-Buck , Larisa V. Debelenko , Irina A. Lubensky , Lance A. Liotta , Sunita K. Agarwal , Allen M. Spiegel , A. Lee Burns , Stephen J. Marx , Zhengping Zhuang
发明人： Settara Chandrasekharappa , Siradanahalli Guru , Pachiappan Manickam , Francis S. Collins , Michael R. Emmert-Buck , Larisa V. Debelenko , Irina A. Lubensky , Lance A. Liotta , Sunita K. Agarwal , Allen M. Spiegel , A. Lee Burns , Stephen J. Marx , Zhengping Zhuang
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68 , C12P19/26 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： The invention relates to the discovery of a novel tumor suppressor gene which is associated with multiple endocrine neoplasia type 1. The gene has been designated MEN1 and the gene product is menin. The absence of this protein and associated mutations in the corresponding gene have been identified in individuals suffering from multiple endocrine neoplasia type 1. The identification of this marker for multiple endocrine neoplasia type 1 has diagnostic uses as well as for gene therapy.
摘要翻译：本发明涉及一种与多发性内分泌肿瘤1型相关的新型肿瘤抑制基因的发现。该基因被命名为MEN1，该基因产物是menin。在具有1型多发性内分泌肿瘤1型的个体中已经鉴定了相应基因中不存在该蛋白质和相关突变。鉴定该多重内分泌肿瘤1型的该标志物具有诊断用途以及基因治疗。

2. 发明授权

US5843644A Isolation of cellular material under microscopic visualization using an adhesive/extraction reagent tipped probe 失效
标题翻译：使用粘合剂/提取试剂尖端探针在微观可视化下分离细胞材料
公开(公告)号：US5843644A
公开(公告)日：1998-12-01
申请号：US203780
申请日：1994-03-01
申请人： Lance A. Liotta , Zhengping Zhuang , Michael R. Buck , William G. Stetler-Stevenson , Irina A. Lubensky , Mark J. Roth
发明人： Lance A. Liotta , Zhengping Zhuang , Michael R. Buck , William G. Stetler-Stevenson , Irina A. Lubensky , Mark J. Roth
IPC分类号： G01N33/48 , C12M1/26 , C12M1/34 , G01N1/02 , G01N1/04 , G01N1/08 , G01N1/28 , G01N1/31 , G01N15/14 , G01N33/483 , G01N33/50 , G01N35/00 , G02B21/32 , C12Q1/68
CPC分类号： G02B21/32 , G01N1/2813 , G01N1/286 , G01N33/50 , G01N1/04 , G01N1/08 , G01N1/2806 , G01N1/31 , G01N2001/028 , G01N2001/2833 , G01N2001/284 , G01N2035/00237 , Y10S435/808 , Y10S436/805
摘要： A method of direct extraction of cellular material from a tissue sample which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extracted zone(s) of cells is subjected to analysis. The overall process of identifying, extracting, transporting, and analyzing the extracted zones(s) of cells can be fully automated.
摘要翻译：一种从组织样品直接提取细胞材料的方法，该方法包括：使用显微镜形成组织样品的细胞的图像场，从细胞的图像区域识别感兴趣的细胞的至少一个区域，至少一个区域感兴趣的细胞包括与细胞的相邻区域不同的细胞类型，以及从组织样品提取感兴趣的细胞的至少一个区域。对提取的细胞区进行分析。识别，提取，运送和分析提取的细胞区域的整个过程可以完全自动化。

3. 发明授权

US06204030B1 Isolation of cellular material under microscopic visualization 失效
标题翻译：在微观可视化下分离细胞材料
公开(公告)号：US06204030B1
公开(公告)日：2001-03-20
申请号：US09388805
申请日：1999-09-02
申请人： Lance A. Liotta , Michael E. Buck , Rhonda Ann Weiss , Zhengping Zhuang , Robert F. Bonner
发明人： Lance A. Liotta , Michael E. Buck , Rhonda Ann Weiss , Zhengping Zhuang , Robert F. Bonner
IPC分类号： C12P1912
CPC分类号： G02B21/32 , C12M33/02 , G01N1/04 , G01N1/08 , G01N1/2806 , G01N1/2813 , G01N1/286 , G01N1/31 , G01N15/1468 , G01N33/50 , G01N2001/028 , G01N2001/2833 , G01N2001/284 , G01N2035/00237 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
摘要翻译：一种显微切割的方法，其包括：使用显微镜形成组织样品的细胞的图像场，从细胞的图像区域鉴定感兴趣的细胞的至少一个区域，所述细胞的至少一个区域包括不同类型的细胞而不是相邻的细胞区域，并且从组织样品中提取感兴趣的细胞的至少一个区域。通过使组织样品与可以选择性活化的转移表面接触使得其区域粘附到待提取的感兴趣的细胞区域来实现提取。转移表面包括可激发的粘合剂层，其向组织样品的选定区域提供化学或静电粘附。转移表面被激活后，分离转移表面和组织样品。在分离期间，感兴趣的细胞区域保持粘附到转移表面，并因此与组织样品分离。

4. 发明授权

US6010888A Isolation of cellular material under microscopic visualization 失效
公开(公告)号：US6010888A
公开(公告)日：2000-01-04
申请号：US925894
申请日：1997-09-08
申请人： Lance A. Liotta , Michael E. Buck , Rhonda Ann Weiss , Zhengping Zhuang , Robert F. Bonner
发明人： Lance A. Liotta , Michael E. Buck , Rhonda Ann Weiss , Zhengping Zhuang , Robert F. Bonner
IPC分类号： G01N33/48 , C12M1/26 , C12M1/34 , G01N1/02 , G01N1/04 , G01N1/08 , G01N1/28 , G01N1/31 , G01N15/14 , G01N33/483 , G01N33/50 , G01N35/00 , G02B21/32 , C12P19/12
CPC分类号： G02B21/32 , C12M33/02 , G01N1/2813 , G01N1/286 , G01N33/50 , G01N1/04 , G01N1/08 , G01N1/2806 , G01N1/31 , G01N15/1468 , G01N2001/028 , G01N2001/2833 , G01N2001/284 , G01N2035/00237 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.

5. 发明授权

US06569639B2 Isolation of cellular material under microscopic visualization 失效
标题翻译：在微观可视化下分离细胞材料
公开(公告)号：US06569639B2
公开(公告)日：2003-05-27
申请号：US09765937
申请日：2001-01-18
申请人： Lance A. Liotta , Michael E. Buck , Rhonda Ann Weiss , Zhengping Zhuang , Robert F. Bonner
发明人： Lance A. Liotta , Michael E. Buck , Rhonda Ann Weiss , Zhengping Zhuang , Robert F. Bonner
IPC分类号： G01N130
CPC分类号： G02B21/32 , C12M33/02 , G01N1/04 , G01N1/08 , G01N1/2806 , G01N1/2813 , G01N1/286 , G01N1/31 , G01N15/1468 , G01N33/50 , G01N2001/028 , G01N2001/2833 , G01N2001/284 , G01N2035/00237 , Y10T436/25 , Y10T436/25125 , Y10T436/25375
摘要： A method of microdissection which involves: forming an image field of cells of the tissue sample utilizing a microscope, identifying at least one zone of cells of interest from the image field of cells which at least one zone of cells of interest includes different types of cells than adjacent zones of cells, and extracting the at least one zone of cells of interest from the tissue sample. The extraction is achieved by contacting the tissue sample with a transfer surface that can be selectively activated so that regions thereof adhere to the zone of cells of interest to be extracted. The transfer surface includes an activatable adhesive layer which provides chemical or electrostatic adherence to the selected regions of the tissue sample. After the transfer surface is activated the transfer surface and tissue sample are separated. During separation the zone of cells of interest remains adhered to the transfer surface and is thus separated from the tissue sample.
摘要翻译：一种显微切割的方法，其包括：使用显微镜形成组织样品的细胞的图像场，从细胞的图像区域鉴定感兴趣的细胞的至少一个区域，所述细胞的至少一个区域包括不同类型的细胞而不是相邻的细胞区域，并且从组织样品中提取感兴趣的细胞的至少一个区域。通过使组织样品与可以选择性活化的转移表面接触使得其区域粘附到待提取的感兴趣的细胞区域来实现提取。转移表面包括可激发的粘合剂层，其向组织样品的选定区域提供化学或静电粘附。转移表面被激活后，分离转移表面和组织样品。在分离期间，感兴趣的细胞区域保持粘附到转移表面，并因此与组织样品分离。

6. 发明申请

US20170136008A1 OXABICYCLOHEPTANES AND OXABICYCLOHEPTENES FOR THE TREATMENT OF OVARIAN CANCER 审中-公开
公开(公告)号：US20170136008A1
公开(公告)日：2017-05-18
申请号：US15320153
申请日：2015-06-19
申请人： John S. Kovach , Zhengping Zhuang , Ki-eun Chang , Matthew Hall , Michael M. Gottesman
发明人： John S. Kovach , Zhengping Zhuang , Ki-eun Chang , Matthew Hall , Michael M. Gottesman
IPC分类号： A61K31/496 , A61K31/704 , A61K33/24
CPC分类号： A61K31/496 , A61K31/343 , A61K31/555 , A61K31/704 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： A method of treating ovarian cancer in a subject afflicted therewith comprising administering to the subject an effective amount of an anti-cancer agent and an effective amount of a compound having the structure:

7. 发明申请

US20090035292A1 Use of phosphatases to treat neuroblastomas and medulloblastomas 审中-公开
标题翻译：使用磷酸酶治疗神经母细胞瘤和成神经管细胞瘤
公开(公告)号：US20090035292A1
公开(公告)日：2009-02-05
申请号：US12221360
申请日：2008-08-01
申请人： John S. Kovach , Zhengping Zhuang
发明人： John S. Kovach , Zhengping Zhuang
IPC分类号： A61K38/46 , A61K31/496 , A61K31/34 , A61K38/02 , A61K38/12 , A61P35/00 , A61K31/07 , A61K38/15 , A61K31/44 , A61K33/16
CPC分类号： A61K31/07 , A61K31/34 , A61K31/44 , A61K31/496 , A61K33/16 , A61K33/24 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods of treating neuroblastomas and medulloblastomas in a subject comprising administering to the subject a phosphatase ligand in an amount effective to treat the subject. Also disclosed herein are method of treating neuroblastomas and medulloblastomas in a subject comprising administering to the subject a histone deacteylase ligand in an amount effective to treat the subject.
摘要翻译：本文公开了治疗受试者中神经母细胞瘤和成神经管细胞瘤的方法，包括以有效治疗受试者的量向受试者施用磷酸酶配体。本文还公开了治疗受试者中神经母细胞瘤和成神经管细胞瘤的方法，包括以有效治疗受试者的量向受试者施用组蛋白失活酶配体。

8. 发明申请

US20140235649A1 USE OF PHOSPHATASE INHIBITORS OR HISTONE DEACETYLASE INHIBITORS TO TREAT DISEASES CHARACTERIZED BY LOSS OF PROTEIN FUNCTION 审中-公开
标题翻译：使用磷酸酯酶抑制剂或组蛋白脱乙酰酶抑制剂治疗由蛋白质功能丧失所引起的疾病
公开(公告)号：US20140235649A1
公开(公告)日：2014-08-21
申请号：US14119849
申请日：2012-05-24
申请人： John S. Kovach , Zhengping Zhuang , Jie Lu , Chunzhang Yang , Russell Lonser
发明人： John S. Kovach , Zhengping Zhuang , Jie Lu , Chunzhang Yang , Russell Lonser
IPC分类号： A61K31/34 , A61K31/4406 , A61K31/4178 , A61K31/167 , A61K31/496 , A61K31/4525
CPC分类号： A61K31/34 , A61K31/167 , A61K31/343 , A61K31/4178 , A61K31/4406 , A61K31/4468 , A61K31/4525 , A61K31/496 , A61K45/06 , A61K2300/00
摘要： A method of treating a mammalian subject afflicted with a disease characterized by a loss of protein function caused by a genetic abnormality associated with the disease comprising administering to the subject a therapeutically effective amount of a protein phosphatase 2A inhibitor or a histone deacetylase inhibitor.
摘要翻译：一种治疗以疾病为特征的哺乳动物受试者的方法，其特征在于由与该疾病相关的遗传异常引起的蛋白质功能丧失，其包括向受试者施用治疗有效量的蛋白质磷酸酶2A抑制剂或组蛋白脱乙酰酶抑制剂。

9. 发明申请

US20080214569A1 Use of phosphatases to treat tumors overexpressing N-CoR 审中-公开
标题翻译：使用磷酸酶治疗过度表达N-CoR的肿瘤
公开(公告)号：US20080214569A1
公开(公告)日：2008-09-04
申请号：US11703401
申请日：2007-02-08
申请人： Zhengping Zhuang , Edward H. Oldfield , Deric M. Park , Irina Lubensky , Jie Li , John S. Kovach
发明人： Zhengping Zhuang , Edward H. Oldfield , Deric M. Park , Irina Lubensky , Jie Li , John S. Kovach
IPC分类号： A61K31/496 , C12Q1/02 , G01N33/50 , A61P35/00
CPC分类号： A61K31/496 , G01N33/5011 , G01N33/57407 , G01N33/57484
摘要： This invention provides a method of treating a patient suffering from a tumor overexpressing N—CoR comprising administering to the patient a phosphatase ligand, alone or in combination with a retinoid receptor ligand, a histone deacetylase ligand, or both, in amounts effective to treat the patient. This invention also provides a method of inhibiting tumor growth in a patient suffering from a tumor overexpressing N—CoR. This invention further provides a method of identifying a compound or a mixture of compounds capable of inducing differentiation of cells of a tumor overexpressing N—CoR. This invention still further provides a method of determining the likelihood of successfully treating a subject suffering from a tumor overexpressing N—CoR. This invention also provides a method of assessing the likelihood that a patient is suffering from a tumor overexpressing N—CoR. This invention yet also provides a method of assessing the likelihood that a patient previously suffering from and treated for a tumor overexpressing N—CoR has suffered a recurrence of a tumor overexpressing N—CoR. Finally, this invention provides analogous methods for use on glioblastoma multiforme.
摘要翻译：本发明提供一种治疗患有过表达N-CoR的肿瘤患者的方法，其包括向患者施用有效治疗以下成分的量的单独或与类视色素受体配体，组蛋白脱乙酰酶配体或两者结合的磷酸酶配体患者。本发明还提供了抑制患有过量表达N-CoR的肿瘤患者的肿瘤生长的方法。本发明还提供鉴定能够诱导过表达N-CoR的肿瘤细胞分化的化合物或化合物的混合物的方法。本发明还提供了确定成功治疗患有过量表达N-CoR的肿瘤患者的可能性的方法。本发明还提供了评估患者患有过度表达N-CoR的肿瘤的可能性的方法。本发明还提供了一种评估先前患有和治疗过度表达N-CoR的肿瘤的患者遭受过度表达N-CoR的肿瘤复发的可能性的方法。最后，本发明提供了用于多形性成胶质细胞瘤的类似方法。

10. 发明申请

US20100029683A1 Methods for regulating cell mitosis by inhibiting serine/threonine phosphateses 审中-公开
标题翻译：通过抑制丝氨酸/苏氨酸磷酸盐调节细胞有丝分裂的方法
公开(公告)号：US20100029683A1
公开(公告)日：2010-02-04
申请号：US12460407
申请日：2009-07-17
申请人： John S. Kovach , Zhengping Zhuang , Jie Lu
发明人： John S. Kovach , Zhengping Zhuang , Jie Lu
IPC分类号： A61K31/496 , A61K31/4525 , A61K31/34 , C12Q1/02 , C12N5/06 , A61P35/00
CPC分类号： G01N33/5011 , A61K31/34 , A61K31/4525 , A61K31/496 , G01N2510/00 , G01N2800/52
摘要： Disclosed herein are methods of inhibiting proliferation of a cancer cell or inducing apoptosis of a cancer cell, which does not overexpress N—CoR. Also disclosed herein are methods of inhibiting proliferation or inducing apoptosis of a cancer cell that overexpresses TCTP and methods for determining whether a compound is effective in inducing cell death.
摘要翻译：本文公开了抑制癌细胞增殖或诱导不过度表达N-CoR的癌细胞凋亡的方法。本文还公开了抑制过表达TCTP的癌细胞的增殖或诱导凋亡的方法以及用于确定化合物是否有效诱导细胞死亡的方法。

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