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1. 发明授权

US5854407A 15-hydroxy 6,9-hemiacetal erythromycin compounds 失效
标题翻译： 15-羟基6,9-半缩醛红霉素化合物
公开(公告)号：US5854407A
公开(公告)日：1998-12-29
申请号：US475557
申请日：1995-06-07
申请人： Setsuo Harada , Yasunori Funabashi , Nobuhiro Inatomi , Shigeharu Tanayama , Seiichi Tanida
发明人： Setsuo Harada , Yasunori Funabashi , Nobuhiro Inatomi , Shigeharu Tanayama , Seiichi Tanida
IPC分类号： C07H17/08 , C12P19/62
CPC分类号： C12P19/62 , C07H17/08
摘要： Disclosed are (1) a structurally novel 6,9-hemiacetal- erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions br a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal-erythromycin derivative or a salt thereof with an organism-derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.
摘要翻译：公开了（1）结构上新的6,9-半缩醛红霉素衍生物，其在14位和15位的至少一个位上具有羟基，其盐具有优异的胃肠功能促进作用，毒性低 ; （2）制备在14位和15位的至少一个位置具有羟基的6,9-半缩醛红霉素衍生物或其盐的方法，该方法包括使6,9-半缩醛红霉素衍生物或其与生物体衍生的氧化酶的盐; 和（3）包含在14位和15位中的至少一个具有羟基的6,9-半缩醛红霉素衍生物或其盐的胃肠功能促进剂。

2. 发明授权

US5470961A 14 and/or 15-hydroxy 6,9 hemiacetal erythromycin derivatives 失效
标题翻译： 14和/或15-羟基6,9半缩醛红霉素衍生物
公开(公告)号：US5470961A
公开(公告)日：1995-11-28
申请号：US33777
申请日：1993-03-19
申请人： Setsuo Harada , Yasunori Funabashi , Nobuhiro Inatomi , Shigeharu Tanayama , Seiichi Tanida
发明人： Setsuo Harada , Yasunori Funabashi , Nobuhiro Inatomi , Shigeharu Tanayama , Seiichi Tanida
IPC分类号： C07H17/08 , C12P19/62 , A61K31/70
CPC分类号： C12P19/62 , C07H17/08
摘要： Disclosed are (1) a structurally novel 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which has an excellent gastrointestinal function promoting effect and is low in toxicity; (2) a process for preparing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof, which comprises reacting a 6,9-hemiacetal-erythromycin derivative or a salt thereof with an organism-derived oxidase; and (3) a gastrointestinal function promoting agent containing a 6,9-hemiacetal-erythromycin derivative having a hydroxyl group at at least one of the 14- and 15-positions or a salt thereof.
摘要翻译：公开了（1）在14位和15位中的至少一个上具有羟基的结构新颖的6,9-半缩醛红霉素衍生物或其盐，其具有优异的胃肠功能促进作用并且毒性低 ; （2）制备在14位和15位的至少一个位置具有羟基的6,9-半缩醛红霉素衍生物或其盐的方法，该方法包括使6,9-半缩醛红霉素衍生物或其与生物体衍生的氧化酶的盐; 和（3）包含在14位和15位中的至少一个具有羟基的6,9-半缩醛红霉素衍生物或其盐的胃肠功能促进剂。

3. 发明授权

US5478808A 2-amino-6,7-dihydroxy-4-thiaheptanoic acid derivatives, production and use thereof 失效
标题翻译： 2-氨基-6,7-二羟基-4-硫杂庚酸衍生物，的制备和用途
公开(公告)号：US5478808A
公开(公告)日：1995-12-26
申请号：US174374
申请日：1993-12-28
申请人： Seiichi Tanida , Tsuneaki Hida , Mitsuhiro Wakimasu , Setsuo Harada , Koichi Yukishige
发明人： Seiichi Tanida , Tsuneaki Hida , Mitsuhiro Wakimasu , Setsuo Harada , Koichi Yukishige
IPC分类号： A61K38/00 , C07K5/06 , C07K5/083 , C07K5/103 , C07K7/06 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： C07K7/06 , C07K5/0606 , C07K5/081 , C07K5/1013 , A61K38/00
摘要： A compound of the formula: ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or aliphatic acyl, A is amino which may be protected, X is an amino acid sequence consisting of 1 to 10 amino acid residues which contain at least one amino acid residue having a water-solubility enhancing group, or a salt thereof has an activity of remarkably improving hematopoietic disorder and is useful as an immuno-stimulating agent or an agent for treating thrombocytopenia.
摘要翻译：下式化合物：其中R 1和R 2各自为氢或脂族酰基，A为可被保护的氨基，X为含1至10个氨基酸残基的氨基酸序列，其含有至少一个氨基酸具有水溶性增强基团的残基或其盐具有明显改善造血障碍的活性，可用作免疫刺激剂或治疗血小板减少症的药剂。

4. 发明授权

US4971965A Antibiotics TAN-1057 失效
标题翻译：抗生素TAN-1057
公开(公告)号：US4971965A
公开(公告)日：1990-11-20
申请号：US344391
申请日：1989-04-28
申请人： Hideo Ono , Yasunori Funabashi , Setsuo Harada
发明人： Hideo Ono , Yasunori Funabashi , Setsuo Harada
IPC分类号： C12P17/10 , A61K31/505 , A61K31/55 , A61P31/04 , A61P35/00 , C07D239/22 , C07D243/08 , C12N1/20 , C12P13/02 , C12P17/12 , C12R1/01
CPC分类号： C07D239/22 , C07D243/08 , C12P13/02
摘要： Novel antibiotics TAN-1057 represented by the formula: ##STR1## wherein, the absolute configuration at (A) is R or S; R.sub.1 is hydrogen and both R.sub.2 and R.sub.3 taken together form a chemical bond, or R.sub.3 is hydrogen and both R.sub.1 and R.sub.2 taken together form a chemical bond; were produced by microorganisms belonging to the genus Flexibacter. TAN-1057 strongly inhibit the growth of pathogenic microorganisms and malignant tumors, thus being useful as therapeutic agents of infectious diseases or antitumor agents.

5. 发明授权

US07315290B2 Data communication apparatus 有权
标题翻译：数据通信装置
公开(公告)号：US07315290B2
公开(公告)日：2008-01-01
申请号：US10562928
申请日：2004-06-25
申请人： Setsuo Harada , Tadashi Ezaki
发明人： Setsuo Harada , Tadashi Ezaki
IPC分类号： H01Q7/00
CPC分类号： H01Q21/28 , H01Q1/2216 , H01Q1/2225 , H01Q1/243 , H01Q7/00
摘要： Disclosed is a data communication apparatus for non-contact data communication using electromagnetic induction. At least a portion of a conductor 5a of the loop coil antenna (5) of the data communication apparatus, adapted for non-contact data communication, exploiting electromagnetic induction, is arranged for extending along the lateral side of an enclosure (2a) for equalizing the sensitivity of the loop coil antenna (5) across both major surfaces of the enclosure (2a).
摘要翻译：公开了一种使用电磁感应的非接触式数据通信的数据通信装置。数据通信设备的环形线圈天线（5）的导体5a的至少一部分适于非接触式数据通信，利用电磁感应被设置成沿着外壳（2a）的侧面延伸，用于均衡环形线圈天线（5）在外壳（2a）的两个主表面上的灵敏度。

6. 发明授权

US4895864A Antibiotic TAN-950A, its production and use 失效
标题翻译：抗生素TAN-950A，其生产和使用
公开(公告)号：US4895864A
公开(公告)日：1990-01-23
申请号：US184824
申请日：1988-04-22
申请人： Takashi Iwasa , Shigetoshi Tsubotani , Setsuo Harada
发明人： Takashi Iwasa , Shigetoshi Tsubotani , Setsuo Harada
IPC分类号： C12P1/06
CPC分类号： C12P1/06
摘要： As the novel antibiotic TAN-950A having the structural formula ##STR1## and salt thereof of the present invention show antimicrobial action against fungi, they can be used in the therapeutics of fungal infections, in human and other animals etc. by oral, parenteral or external administration.

7. 发明授权

US4164208A Exhaust gas recirculation means 失效
标题翻译：废气再循环装置
公开(公告)号：US4164208A
公开(公告)日：1979-08-14
申请号：US808354
申请日：1977-06-20
申请人： Kingo Okitsu , Koji Asanomi , Setsuo Harada , Yasunori Takemoto
发明人： Kingo Okitsu , Koji Asanomi , Setsuo Harada , Yasunori Takemoto
IPC分类号： F02M25/07 , F02M25/06
CPC分类号： F02M26/57 , F02M26/36 , F02M26/38
摘要： An exhaust gas recirculation device in which exhaust gas from the engine of a vehicle, for example, may be recirculated via two separate lines to portions of a carburetor which are upstream and downstream of a throttle valve, to permit a suitably large amount of exhaust gas to be recirculated when necessary and which includes control means which stops the flow of gas in both lines when the engine is being warmed up, and stops the flow of gas in the upstream recirculation line only when engine load, engine speed, or vehicle speed is high, or when there is a risk of icing in the carburetor, whereby the disadvantages of recirculated exhaust gas during particular engine operating conditions are avoided.
摘要翻译：一种排气再循环装置，其中来自车辆的发动机的废气可以经由两条分开的管线再循环到在节流阀的上游和下游的化油器的部分，以允许适当大量的废气在必要时再循环，并且包括当发动机被加热时停止两条管线中的气体流动的控制装置，并且仅在发动机负荷，发动机转速或车速为止时停止上游再循环管线中的气体流动或者当在化油器中存在结冰的风险时，避免了在特定发动机运行条件期间再循环废气的缺点。

8. 发明授权

US5021439A Cerebral function ameliorating agents related to Tan-950 A 失效
标题翻译：与Tan-950 A相关的脑功能改善剂A
公开(公告)号：US5021439A
公开(公告)日：1991-06-04
申请号：US408389
申请日：1989-09-18
申请人： Setsuo Harada , Akinobu Nagaoka , Katsumi Itoh , Shinji Terao
发明人： Setsuo Harada , Akinobu Nagaoka , Katsumi Itoh , Shinji Terao
IPC分类号： A61K38/00 , C07D207/26 , C07D207/277 , C07D261/12 , C07D405/06 , C07D413/06 , C07K5/02 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/078
CPC分类号： C07D207/277 , C07D261/12 , C07D405/06 , C07D413/06 , C07K5/0215 , C07K5/06026 , C07K5/06078 , C07K5/06086 , C07K5/06139 , A61K38/00 , Y02P20/55
摘要： A compound having the formula (I) or (II) ##STR1## wherein R.sup.1 is a hydrogen atom or an organic residue bonded via a carbon atom, R.sup.2 is a hydrogen atom or a N-protecting group, --COR.sup.3 is an optionally esterified or amidated carboxyl group, R.sup.4 and R.sup.5 are the same or different and respectively a hydrogen atom or an acyl group or a chain or alicyclic hydrocarbon group optionally having an aryl substituent, R.sup.6 is NOH or O, n is an integer of 0 to 3, or R.sup.4 and R.sup.5 together with the adjacent nitrogen atom may form a ring or an optionally substituted benzylidene amino group, which is useful therapeutics of brain dysfunction.

9. 发明授权

US4932368A Suction arrangement for internal combustion engine 失效
标题翻译：内燃机吸气装置
公开(公告)号：US4932368A
公开(公告)日：1990-06-12
申请号：US303658
申请日：1989-01-30
申请人： Ryoji Abe , Setsuo Harada , Kouji Asanomi , Kouichi Hatamura , Toshikazu Kurokawa , Tsuyoshi Goto , Shinji Seike
发明人： Ryoji Abe , Setsuo Harada , Kouji Asanomi , Kouichi Hatamura , Toshikazu Kurokawa , Tsuyoshi Goto , Shinji Seike
IPC分类号： F02B75/22 , F02F1/24 , F02F1/42 , F02M35/116
CPC分类号： F02F1/4235 , F02M35/10157 , F02M35/116 , F02B2275/18 , F02B75/22 , F02F2001/245 , F02M35/10045 , F02M35/10216 , Y02T10/144
摘要： In a V-type internal combustion engine having a pair of upwardly diverging cylinder banks and an auxiliary unit disposed at an upper portion in a space defined between the cylinder banks, a suction arrangement includes intake ports provided at an inner side of the respective cylinder banks, inclined inwardly by a predetermined angle with respect to respective clyinder axes, and extending upwardly in a generally vertical direction so as not to interfere with the auxiliary unit, and cylinder communicating portions connected to upper portions of the intake ports in communication with the respective cylinders to permit the introduction of the intake gas thereto.
摘要翻译：在具有一对向上发散的气缸组的V型内燃机和设置在气缸组之间的空间中的上部的辅助单元中，抽吸装置包括设置在各气缸组的内侧的进气口相对于各自的绞线轴线向内倾斜预定角度，并且在大致垂直的方向上向上延伸，以便不与辅助单元干涉，以及连接到与各个气缸连通的进气口的上部的气缸连通部分以允许将吸入气体引入其中。

10. 发明授权

US4897489A Antibiotic derivatives, their production and use 失效
标题翻译：抗生素衍生物，其生产和使用
公开(公告)号：US4897489A
公开(公告)日：1990-01-30
申请号：US58265
申请日：1987-05-21
申请人： Kouichi Yoshioka , Setsuo Harada , Michihiko Ochiai , Hirotomo Masuya
发明人： Kouichi Yoshioka , Setsuo Harada , Michihiko Ochiai , Hirotomo Masuya
IPC分类号： A61K38/00 , C07D413/04 , C07D413/14 , C07D417/14 , C07D521/00 , C07F7/08 , C07F7/10 , C07F9/6539 , C07F9/6558 , C07K5/06 , C07K5/078
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D413/04 , C07D413/14 , C07D417/14 , C07F7/0812 , C07F7/10 , C07F9/65395 , C07F9/65586 , C07K5/06139 , C07K5/06191 , A61K38/00
摘要： The compounds of the formula: ##STR1## wherein R.sup.1 is hydrogen, amino, isonitrile or an organic residue bonded through nitrogen; R.sup.2 is carboxy or a group derivable therefrom; X is hydrogen, methoxy, formylamino, alkyl which may be substituted, alkylthio in which the sulfur atom may be oxidized or azido, or forms a double bond together with the adjacent carbon atom; provided that when R.sup.1 is acetylamino or amino and X is hydrogen, R.sup.2 is not para-nitrobenzyloxycarbonyl or benzhydryloxycarbonyl, or a pharmaceutically acceptable salt thereof, exhibit excellent antimicrobial activity, and are utilized as antimicrobial agents.
摘要翻译：下式的化合物：其中R 1是氢，氨基，异腈或通过氮键合的有机残基; R2是羧基或可从其衍生的基团; X是氢，甲氧基，甲酰基氨基，可以被取代的烷基，其中硫原子可以被氧化或叠氮基的烷硫基，或与相邻碳原子一起形成双键; 条件是当R1为乙酰氨基或氨基且X为氢时，R2不为对硝基苄氧羰基或二苯甲氧基羰基或其药学上可接受的盐，具有优异的抗微生物活性，并用作抗微生物剂。

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