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1. 发明授权

US08301214B1 System and method for providing multi-conductive layer metallic interconnects for superconducting integrated circuits 有权
标题翻译：用于为超导集成电路提供多导电层金属互连的系统和方法
公开(公告)号：US08301214B1
公开(公告)日：2012-10-30
申请号：US12986720
申请日：2011-01-07
申请人： Sergey K. Tolpygo , Denis Amparo , Richard Hunt , John Vivalda , Daniel Yohannes
发明人： Sergey K. Tolpygo , Denis Amparo , Richard Hunt , John Vivalda , Daniel Yohannes
IPC分类号： H01L23/48 , H01L27/00
CPC分类号： H01L39/2493 , H01L23/48 , H01L27/18 , H01L39/025 , H01L39/223 , H01L2924/0002 , H01L2924/00011 , H01L2924/00
摘要： Superconducting integrated circuits require several wiring layers to distribute bias and signals across the circuit, which must cross each other both with and without contacts. All wiring lines and contacts must be fully superconducting, and in the prior art each wiring layer comprises a single metallic thin film. An alternative wiring layer is disclosed that comprises sequential layers of two or more different metals. Such a multi-metallic wiring layer may offer improved resistance to impurity diffusion, better surface passivation, and/or reduction of stress, beyond that which is attainable with a single-metallic wiring layer. The resulting process leads to improved margin and yield in an integrated circuit comprising a plurality of Josephson junctions. Several preferred embodiments are disclosed, for both planarized and non-planarized processes. These preferred and other methods may be applied to digital circuits based on Rapid Single Flux Quantum logic, and to quantum computing using Josephson junction qubits.
摘要翻译：超导集成电路需要多个布线层，以跨越电路分配偏置和信号，这些电路必须彼此交叉，有触点和不带触点。所有布线和触点必须是完全超导的，并且在现有技术中，每个布线层包括单个金属薄膜。公开了包括两种或更多种不同金属的连续层的替代布线层。这样的多金属布线层可以提供改善的杂质扩散阻力，更好的表面钝化和/或应力的减少，超过单金属布线层可达到的。所产生的过程导致包括多个约瑟夫逊结的集成电路中的边缘和产量得到改善。对于平面化和非平面化处理都公开了几个优选实施例。这些优选和其它方法可以应用于基于快速单通量量子逻辑的数字电路，以及使用约瑟夫逊结量子位的量子计算。

2. 发明申请

US20110257224A1 PREPARATION AND THERAPEUTIC APPLICATIONS OF (2S,3R)-N-2-((3-PYRIDINYL)METHYL)-1-AZABICYCLO[2.2.2]OCT-3-YL)-3,5-DIFLUOROBENZAMIDE 有权
标题翻译：（2S，3R）-N-2 - （（3-吡啶基）甲基）-1-亚甲基] [2.2.2] OCT-3-YL）-3,5-二氟硼酰胺的制备和治疗应用
公开(公告)号：US20110257224A1
公开(公告)日：2011-10-20
申请号：US12740970
申请日：2010-01-25
申请人： Merouane Bencherif , Nikolai Fedorov , Terry Hauser , Kristen Jordan , Sharon Rae Letchworth , Anatoly Mazurov , Julio A. Munoz , Jason Speake , Daniel Yohannes
发明人： Merouane Bencherif , Nikolai Fedorov , Terry Hauser , Kristen Jordan , Sharon Rae Letchworth , Anatoly Mazurov , Julio A. Munoz , Jason Speake , Daniel Yohannes
IPC分类号： A61K31/439 , A61P29/00 , C07D453/02
CPC分类号： A61K31/444 , C07D453/02
摘要： The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetyl-choline receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
摘要翻译：本发明涉及结合并调节神经元烟碱乙酰胆碱受体的活性，制备这些化合物的方法，含有这些化合物的药物组合物的化合物，以及使用这些化合物治疗各种病症和疾病，包括与中枢神经系统（CNS）功能障碍相关的疾病。

3. 发明授权

US06911477B2 Muscarinic receptor agonists 失效
标题翻译：毒蕈碱受体激动剂
公开(公告)号：US06911477B2
公开(公告)日：2005-06-28
申请号：US10376138
申请日：2003-02-28
申请人： Anabella Villalobos , Daniel Yohannes , Jolanta Nowakowski , Dane R. Liston
发明人： Anabella Villalobos , Daniel Yohannes , Jolanta Nowakowski , Dane R. Liston
IPC分类号： C07C257/20 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/74 , C07D213/75 , C07D265/02 , C07D277/04 , C07D295/185 , C07D295/195 , C07D295/215 , C07D295/28 , A61K31/135 , A61K31/155
CPC分类号： C07D295/185 , C07C257/20 , C07C2601/14 , C07C2603/74 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/74 , C07D213/75 , C07D265/02 , C07D277/04 , C07D295/195 , C07D295/215 , C07D295/32
摘要： This invention relates to a novel class of partial or full muscarinic receptor agonists intermediates for their preparation, and pharmaceutical compositions and methods of use for the treatment or prevention of diseases the treatment or prevention of which is mediated by muscarinic receptor agonism.
摘要翻译：本发明涉及一类新的部分或全部毒蕈碱受体激动剂的制备中间体，以及用于治疗或预防由毒蕈碱受体激动剂介导的治疗或预防的疾病的药物组合物和方法。

4. 发明授权

US06861529B2 Cycloalkypyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives 失效
标题翻译：环烷基吡咯-3-羧酸衍生物和杂环烷基吡咯-3-羧酸衍生物
公开(公告)号：US06861529B2
公开(公告)日：2005-03-01
申请号：US10131329
申请日：2002-04-24
申请人： Daniel Yohannes , George Maynard , Xiaojun Liu
发明人： Daniel Yohannes , George Maynard , Xiaojun Liu
IPC分类号： C07D487/04 , A61K31/403 , A61K31/407 , A61K31/4439 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D209/42 , C07D209/52 , C07D401/12 , C07D401/14 , C07D471/02 , C07D211/60 , C07D221/02
CPC分类号： C07D401/12 , C07D209/42 , C07D209/52
摘要： This invention relates to cycloalkylpyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives that bind with high selectively and/or high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in the treatment of central nervous system (CNS) diseases. This invention also relates to the use of these cycloalkylpyrrole-3-carboxylic acid derivatives and heterocycloalkylpyrrole-3-carboxylic acid derivatives in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the detection of GABAA receptors in tissue samples.
摘要翻译：本发明涉及以高选择性和/或高亲和力结合GABA A受体的苯并二氮杂位点的环烷基吡咯-3-羧酸衍生物和杂环烷基吡咯-3-羧酸衍生物。本发明还涉及包含这些化合物的药物组合物以及这些化合物在治疗中枢神经系统（CNS）疾病中的用途。本发明还涉及这些环烷基吡咯-3-羧酸衍生物和杂环烷基吡咯-3-羧酸衍生物与一种或多种其它CNS剂组合用于增强其它CNS剂的作用的用途。此外，本发明涉及使用这些化合物作为检测组织样品中GABA A受体的探针。

5. 发明授权

US06949562B2 Heterocyclic compounds as ligands of the GABAA receptor 失效
标题翻译：杂环化合物作为GABA A受体的配体
公开(公告)号：US06949562B2
公开(公告)日：2005-09-27
申请号：US10670077
申请日：2003-09-23
申请人： Daniel Yohannes , George Maynard , Jun Yuan , Linghong Xie , Kyungae Lee , Manuka Ghosh , George Luke , Xiaojun Liu , Arthur Nagal , Lawrence Vincent , Kevin Currie , Zhe-Quing Wang
发明人： Daniel Yohannes , George Maynard , Jun Yuan , Linghong Xie , Kyungae Lee , Manuka Ghosh , George Luke , Xiaojun Liu , Arthur Nagal , Lawrence Vincent , Kevin Currie , Zhe-Quing Wang
IPC分类号： A61K31/4162 , A61K31/4178 , A61K31/4188 , A61K31/429 , A61K31/437 , A61K31/4375 , A61K31/444 , A61K31/4709 , A61K31/4745 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/5377 , A61P25/00 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07D403/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D498/04 , C07D513/04 , A61K31/4353
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D513/04
摘要： Disclosed are heterocyclic compounds of the formula and the pharmaceutically acceptable salts thereof wherein the variables A, V, Y, J, E, X, T, G, Q, W, Z, b, n and m are defined herein. These compounds are highly selective agonists, antagonists or inverse agonists for GABAA brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAA brain receptor.
摘要翻译：公开了下式的杂环化合物及其药学上可接受的盐，其中变量A，V，Y，J，E，X，T，G，Q，W，Z，b，n和m在本文中定义。这些化合物是高度选择性的激动剂，拮抗剂或反义激动剂，用于GABA A / A脑受体或GABA A A受体的激动剂，拮抗剂或反向激动剂的前药。

6. 发明授权

US6093733A Muscarinic receptor agonists 失效
标题翻译：毒蕈碱受体激动剂
公开(公告)号：US6093733A
公开(公告)日：2000-07-25
申请号：US848359
申请日：1997-04-30
申请人： Anabella Villalobos , Daniel Yohannes , Jolanta Nowakowski , Dane R. Liston
发明人： Anabella Villalobos , Daniel Yohannes , Jolanta Nowakowski , Dane R. Liston
IPC分类号： C07D295/14 , A61K31/13 , A61K31/135 , A61K31/40 , A61K31/42 , A61K31/421 , A61K31/445 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61K31/54 , A61K31/55 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P43/00 , C07C257/16 , C07C257/20 , C07C279/24 , C07D211/14 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/74 , C07D213/75 , C07D261/02 , C07D263/04 , C07D265/02 , C07D265/06 , C07D267/08 , C07D277/04 , C07D295/185 , C07D295/195 , C07D295/215 , C07D295/28 , C07D211/28 , C07D265/00
CPC分类号： C07D213/75 , C07C257/20 , C07D211/42 , C07D211/44 , C07D211/46 , C07D211/74 , C07D265/02 , C07D277/04 , C07D295/185 , C07D295/195 , C07D295/215 , C07D295/32 , C07C2101/14 , C07C2103/74
摘要： This invention relates to a novel class of partial or full muscarinic receptor agonists intermediates for their preparation, and pharmaceutical compositions and methods of use for the treatment or prevention of diseases the treatment or prevention of which is mediated by muscarinic receptor agonism.
摘要翻译：本发明涉及一类新的部分或全部毒蕈碱受体激动剂的制备中间体，以及用于治疗或预防由毒蕈碱受体激动剂介导的治疗或预防的疾病的药物组合物和方法。

7. 发明申请

US20140288169A1 NICOTINIC RECEPTOR NON-COMPETITIVE ANTAGONISTS 审中-公开
标题翻译： NICOTINIC RECEPTOR非竞争性拮抗剂
公开(公告)号：US20140288169A1
公开(公告)日：2014-09-25
申请号：US13978583
申请日：2012-01-05
申请人： Srinivasa Rao Akireddy , Scott R. Breining , Matt S. Melvin , Srinivasa V. Murthy , Anatoly A. Mazurov , Balwinder Singh Bhatti , Jon-Paul Strachan , Ronald Joseph Heemstra , Todd Showalter , Yunde Xiao , Philip S. Hammond , Lan Miao , David Kombo , Daniel Yohannes , Jason Speake
发明人： Srinivasa Rao Akireddy , Scott R. Breining , Matt S. Melvin , Srinivasa V. Murthy , Anatoly A. Mazurov , Balwinder Singh Bhatti , Jon-Paul Strachan , Ronald Joseph Heemstra , Todd Showalter , Yunde Xiao , Philip S. Hammond , Lan Miao , David Kombo , Daniel Yohannes , Jason Speake
IPC分类号： C07D493/08 , C07C211/38
CPC分类号： C07D493/08 , C07C211/38 , C07C2602/40 , C07C2602/42 , C07C2602/44
摘要： The present invention relates to compounds that modulate nicotinic receptors as non-competitive antagonists, methods for their synthesis, methods for their use, and their pharmaceutical compositions.
摘要翻译：本发明涉及将烟碱受体调节为非竞争性拮抗剂的化合物，其合成方法，其使用方法及其药物组合物。

8. 发明申请

US20110257168A1 DERIVATIVES OF OXABISPIDINE AS NEURONAL NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS 审中-公开
标题翻译：奥昔布星作为神经激素乙酰胆碱受体配体的衍生物
公开(公告)号：US20110257168A1
公开(公告)日：2011-10-20
申请号：US13055085
申请日：2009-07-01
申请人： Srinivasa R. Akireddy , Scott R. Breining , Nikolai Fedorov , David Kombo , Anatoly A. Mazurov , Lan Miao , Srinivasa V. Murthy , Todd Showalter , Yunde Xiao , Daniel Yohannes
发明人： Srinivasa R. Akireddy , Scott R. Breining , Nikolai Fedorov , David Kombo , Anatoly A. Mazurov , Lan Miao , Srinivasa V. Murthy , Todd Showalter , Yunde Xiao , Daniel Yohannes
IPC分类号： A61K31/5383 , A61P29/00 , C07D498/04
CPC分类号： C07D498/04
摘要： The present invention relates to compounds of formula (I) that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).
摘要翻译：本发明涉及结合并调节神经元烟碱乙酰胆碱受体的活性，制备这些化合物的方法的式（I）化合物，含有这些化合物的药物组合物，以及使用这些化合物治疗多种多样的方法的病症和障碍，包括与中枢神经系统（CNS）功能障碍相关的疾病。

9. 发明授权

US07816356B2 Aryl and heteroaryltetrahydrocyclobutapyrroles as nicotinic acetylcholine receptor ligands 有权
标题翻译：芳基和杂芳基四氢环吡咯吡啶作为烟碱乙酰胆碱受体配体
公开(公告)号：US07816356B2
公开(公告)日：2010-10-19
申请号：US10989145
申请日：2004-11-15
申请人： Daniel Yohannes
发明人： Daniel Yohannes
IPC分类号： A61K31/498 , A61K31/403
CPC分类号： A61K31/498
摘要： Disclosed herein are compounds that bind to a neuronal nicotinic acetylcholine receptor. These compounds posses broad therapeutic use including the treatment of senile dementia, Alzheimer's disease, Parkinson's disease, attention deficit disorder, and the treatment of addictive disorders such as the use of tobacco in smoking or the use of other nicotine containing products. In addition, they have utility as cognitive enhancers, drug therapy for mental and neurological disorders related to a decrease in cholinergic function, for the treatment of obesity, Tourette's syndrome, or ulcerative colitis. Additionally, these compounds have utility as non-opioid analgesics for treatment of acute and chronic pain.
摘要翻译：本文公开的是结合神经元烟碱乙酰胆碱受体的化合物。这些化合物具有广泛的治疗用途，包括治疗老年性痴呆，阿尔茨海默氏病，帕金森病，注意力缺陷障碍，以及治疗成瘾性疾病，例如在吸烟中使用烟草或使用其他含有尼古丁的产品。此外，它们具有作为认知增强剂的用途，与胆碱能功能降低相关的精神和神经障碍的药物治疗，用于治疗肥胖症，Tourette综合征或溃疡性结肠炎。此外，这些化合物可用作治疗急性和慢性疼痛的非阿片类镇痛药。

10. 发明申请

US20090093512A1 1, 2, 3, 3A, 8, 8A-HEXAHYDRO-2, 7A-DIADA-CYCLOPENTA[A]INDEN-7-ONE DERIVATIVES WHICH BIND TO NEURONAL NICOTINIC ACETYLCHOLINE SPECIFIC RECEPTOR SITES AND ARE USEFUL IN MODULATING CHOLINERGIC FUNCTION AND IN THE TREATMENT OF ADDICTIVE DISORDERS 审中-公开
标题翻译： 1,2,3,4,8-8A-HEXAHYDRO-2,7A-DIADA-CYCLOPENTA [A]茚-7-酮衍生物，其与神经酰胺基乙酰基特异性受体位点结合，并且有助于调节胆碱功能和治疗接触性疾病
公开(公告)号：US20090093512A1
公开(公告)日：2009-04-09
申请号：US11814168
申请日：2005-11-30
申请人： Brian T. O'Neill , Kristen J. Procko , Daniel Yohannes
发明人： Brian T. O'Neill , Kristen J. Procko , Daniel Yohannes
IPC分类号： A61K31/437 , C07D471/14 , A61P25/00
CPC分类号： C07D471/14
摘要： The present invention relates to novel fused bicyclicpyrrolidine pyridone compounds of the formula (I) wherein R, RP and n are as defined herein, their pharmaceutically acceptable salts, pharmaceutical compositions and their use in treating addictive disorders such as the use of tobacco or other nicotine containing products and in the treatment of neurological and mental disorders related to a decrease in cholinergic function.
摘要翻译：本发明涉及式（I）的新型稠合双环吡咯烷吡啶酮化合物，其中R，RP和n如本文所定义，其药学上可接受的盐，药物组合物及其在治疗成瘾性疾病如烟草或其他尼古丁中的用途含有产品和治疗与胆碱能功能下降相关的神经和精神障碍。

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