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    • 1. 发明申请
    • METHOD OF PREPARING siRNAs FOR SELECTIVE INHIBITION OF TARGET mRNA ISOTYPES
    • 制备用于选择性抑制靶标mRNA同功酶的siRNA的方法
    • US20090325291A1
    • 2009-12-31
    • US12304707
    • 2007-06-12
    • Seong Min ParkYoung Joo KimYoung Chul ChoiHan Oh ParkSo Rim Choung
    • Seong Min ParkYoung Joo KimYoung Chul ChoiHan Oh ParkSo Rim Choung
    • C12N5/02G01N33/48C07H21/02
    • C12N15/111C12N2320/10
    • A method of preparing siRNAs for selective inhibition of target mRNA isotypes comprises: dividing target mRNA isotypes intended to inhibit the expression thereof and non-target mRNA isotypes from the mRNA isotypes of a gene; allotting a common location information region (A) of exons on genome DNA corresponding to the target mRNA isotypes; allotting a location information region (B) present specifically in exons of genome DNA corresponding to target mRNAs by excluding the location information region of exons on genome DNA corresponding to non-target mRNA from the location information region (A); determining base sequences in the target mRNAs corresponding to the location information region (B); and obtaining siRNA sequences for inhibiting the determined base sequences specifically. The method of the present invention can be used to prepare siRNAs for selective inhibition of specific target mRNA isotypes in a gene having several isotypes by alternative splicing, and enables siRNA design for all the genes in genome, making good tool for functional genomics study.
    • 制备用于选择性抑制靶mRNA同种型的siRNA的方法包括:从基因的mRNA同种型分离旨在抑制其表达的靶mRNA同种型和非靶mRNA同种型; 在对应于靶mRNA同种型的基因组DNA上分配外显子的共同位置信息区(A); 通过从所述位置信息区域(A)中排除与非靶mRNA相对应的基因组DNA上的外显子的位置信息区,分配特定存在于与靶mRNA相对应的基因组DNA外显子中的位置信息区(B)。 确定对应于位置信息区域(B)的目标mRNA中的碱基序列; 并获得特异性抑制所确定的碱基序列的siRNA序列。 本发明的方法可用于制备用于通过选择性剪接在具有多个同种型的基因中特异性靶mRNA同种型的选择性抑制的siRNA,并且使得能够对基因组中所有基因进行siRNA设计,为功能基因组学研究提供了良好的工具。
    • 5. 发明申请
    • Dispenser device
    • 分配器装置
    • US20070175922A1
    • 2007-08-02
    • US10598715
    • 2005-03-10
    • Young Chul Choi
    • Young Chul Choi
    • B67D5/60
    • B05B11/0005B05B11/30
    • The invention relates to a dispenser device which may convert water into silver ionized water and may dispense the silver ionized water to necessary part of human body which may be easily contaminated by germs like as the affected part so that the necessary part of human body may be sterilized and the human body may be kept healthy. According to an aspect of the invention, there is provided a dispenser device 1 comprising a container 30, a silver foam block 10 which is contained in the container 30, and a pumping unit 20 which is combined at the upper portion of the container 30.
    • 本发明涉及一种分配器装置,其可以将水转化成银离子水,并且可以将银离子水分配到人体的必要部分,这可能容易被诸如受影响部分的细菌污染,使得人体的必要部分可能 灭菌,人体保持健康。 根据本发明的一个方面,提供了一种分配器装置1,其包括容器30,容纳在容器30中的银泡沫块10和在容器30的上部组合的抽吸单元20。
    • 6. 发明申请
    • Silver Ion Water Generating Apparatus
    • 银离子水发生器
    • US20080190774A1
    • 2008-08-14
    • US11910424
    • 2006-03-31
    • Young Chul Choi
    • Young Chul Choi
    • C02F1/68
    • C02F1/4606C02F1/46114C02F2001/46133C02F2001/46161
    • Disclosed is a silver ion water generating apparatus which can improve sterilizing and purifying forces even in a large water tank by widening the contact surface of silver as same weight increasing the amount of the generated silver ions, can be easily maintained by facilitating the exchange of a silver foam, and can prevent the silver ion water from not being properly generated due to the inferiority of current flow between the silver foam and the electrode terminal in use. The silver ion generating apparatus is consist of a water tank for storing water and positive and negative electrodes installed in the interior of the water tank. The positive electrode includes a silver foam in which open cells are formed. A plurality of conductive net bodies connected to an exterior positive electrode terminal are detachably installed in the interior of the water tank. Each silver foam is accommodated in the interior of the conductive net body.
    • 公开了一种银离子水生成装置,其能够通过扩大银的接触面而改善消毒和净化力,同时增加产生的银离子的量,可以通过促进交换 银泡沫,并且可以防止银离子水由于在使用中的泡沫体和电极端子之间的电流流动而不适当地产生。 银离子发生装置由用于储存水的水箱和安装在水箱内部的正极和负极构成。 正极包括形成开孔的银泡沫体。 连接到外部正极端子的多个导电网体可拆卸地安装在水箱的内部。 每个银泡沫容纳在导电网体的内部。