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1. 发明申请

US20150104811A1 METHOD FOR PRETREATING BIOLOGICAL SAMPLE CONTAINING PROTEIN 审中-公开
标题翻译：用于预测含有蛋白质的生物样品的方法
公开(公告)号：US20150104811A1
公开(公告)日：2015-04-16
申请号：US14238050
申请日：2012-08-10
申请人： Sei Sasaki , Yasukazu Ohmoto , Toyoki Mori , Fusako Iwata , Masahiro Muraguchi
发明人： Sei Sasaki , Yasukazu Ohmoto , Toyoki Mori , Fusako Iwata , Masahiro Muraguchi
IPC分类号： G01N33/53 , G01N33/68
CPC分类号： G01N33/5306 , G01N1/42 , G01N33/6872
摘要： The present invention provides a method for pretreatment of a biological sample in the immunoassay of a protein contained in the biological sample. The method includes the steps of: (1) freezing the biological sample at a temperature higher than −80° C., in particular at −70° C. or higher; (2) thawing the frozen biological sample; and (3) solubilizing the biological sample using a surfactant.
摘要翻译：本发明提供了在生物样品中包含的蛋白质的免疫测定中预处理生物样品的方法。该方法包括以下步骤：（1）在高于-80℃，特别是-70℃或更高的温度下冷冻生物样品; （2）解冻冷冻生物样品; 和（3）使用表面活性剂增溶生物样品。

2. 发明申请

US20110281284A1 NOVEL LIVER CANCER MARKER 审中-公开
标题翻译：新肝癌标志
公开(公告)号：US20110281284A1
公开(公告)日：2011-11-17
申请号：US12673346
申请日：2008-08-07
申请人： Hideji Nakamura , Youichi Yabuuchi , Yasukazu Ohmoto , Toyoki Mori , Masahiro Muraguchi , Keiko Oga , Fusako Iwata , Kaori Murata
发明人： Hideji Nakamura , Youichi Yabuuchi , Yasukazu Ohmoto , Toyoki Mori , Masahiro Muraguchi , Keiko Oga , Fusako Iwata , Kaori Murata
IPC分类号： G01N33/566 , C07K16/22 , C07K14/475
CPC分类号： G01N33/57438 , C07K14/4748 , C07K16/22 , C07K2317/56
摘要： According to the present invention, HDGF in the blood of patients with chronic liver disease is measured to diagnose whether the patients have liver cancer. A measurement kit for the diagnosis is also provided.
摘要翻译：根据本发明，测量慢性肝病患者血液中的HDGF，以诊断患者是否患有肝癌。还提供了用于诊断的测量套件。

3. 发明授权

US06140330A Thiazole derivative 失效
标题翻译：噻唑衍生物
公开(公告)号：US06140330A
公开(公告)日：2000-10-31
申请号：US43642
申请日：1998-03-24
申请人： Toyoki Mori , Michiaki Tominaga , Fujio Tabusa , Kazuyoshi Nagami , Kaoru Abe , Kenji Nakaya , Isao Takemura , Tomoichi Shinohara , Yoshihisa Tanada , Takahito Yamauchi
发明人： Toyoki Mori , Michiaki Tominaga , Fujio Tabusa , Kazuyoshi Nagami , Kaoru Abe , Kenji Nakaya , Isao Takemura , Tomoichi Shinohara , Yoshihisa Tanada , Takahito Yamauchi
IPC分类号： C07D277/46 , C07D277/82 , C07D317/64 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/495 , A61K31/445 , C07D413/02
CPC分类号： C07D417/12 , C07D277/46 , C07D277/82 , C07D317/64 , C07D417/14 , C07D471/04 , C07D487/04
摘要： A thiazole compound of the formula: ##STR1## wherein T is lower alkylene; u is 0 or 1; R.sup.1 and R.sup.2 are the same or different and are each H, or lower alkyl, etc.; R.sup.3 is ##STR2## R.sup.4 is H or lower alkanoyloxy-lower alkyl, which shows inhibitory activity on protein kinase C (PKC, Ca.sup.2+ /phospholipid-depending serine/threonine protein phosphatase), and are useful as a protein kinase C inhibitor.
摘要翻译： PCT No.PCT / JP97 / 02609 Sec。 371日期：1998年3月24日 102（e）1998年3月24日PCT PCT 1997年7月29日PCT公布。第WO98 / 04536号公报日期：1998年2月5日A下式的噻唑化合物：其中T是低级亚烷基; 你是0或1; R1和R2相同或不同，各自为H或低级烷基等; R3是R4是H或低级烷酰氧基 - 低级烷基，它对蛋白激酶C（PKC，Ca2 + /磷脂依赖性丝氨酸/苏氨酸蛋白磷酸酶）具有抑制活性，可用作蛋白激酶C抑制剂。

4. 发明授权

US5886010A TNF-.alpha.inhibitor 失效
标题翻译： TNF-α抑制剂
公开(公告)号：US5886010A
公开(公告)日：1999-03-23
申请号：US875056
申请日：1997-07-03
申请人： Toyoki Mori , Michiaki Tominaga , Yukihisa Ono
发明人： Toyoki Mori , Michiaki Tominaga , Yukihisa Ono
IPC分类号： A61K31/4704 , A61K31/47
CPC分类号： A61K31/4704
摘要： A method for the prophylaxis and treatment of diseases induced by accelerated INF-.alpha. secretion, such as rheumatoid arthritis, endotoxin shock, adult respiratory distress syndrome, thermal burn, asthma, myocardial infarction, acute phase of viral myocardiosis, etc. which comprises administering a carbostyril compound of the formula: ##STR1## wherein R.sup.1 is H or lower alkyl, and R.sup.2 is phenyl(lower)alkyl having optionally 1 to 3 lower alkoxy substituents on the phenyl ring, or a pharmaceutically acceptable salt thereof to a subject.
摘要翻译： PCT No.PCT / JP95 / 02592 Sec。 371日期1997年7月3日 102（e）日期1997年7月3日PCT 1995年12月18日PCT PCT。 WO96 / 21447 PCT出版物日期1996年7月18日预防和治疗由加速的INF-α分泌引起的疾病的方法，如类风湿性关节炎，内毒素休克，成人呼吸窘迫综合征，热灼伤，哮喘，心肌梗死，病毒性心肌病急性期等其包括施用下式的喹诺酮化合物：其中R 1是H或低级烷基，并且R 2是在苯环上具有任选1至3个低级烷氧基取代基的苯基（低级）烷基，或其药学上可接受的其盐。

5. 发明申请

US20090187025A1 Pharmaceutical composition for promoting angiogenesis 失效
标题翻译：用于促进血管生成的药物组合物
公开(公告)号：US20090187025A1
公开(公告)日：2009-07-23
申请号：US10587045
申请日：2005-01-26
申请人： Ayako Hashimoto , Takashi Imaizumi , Goro Miyakoda , Toyoki Mori
发明人： Ayako Hashimoto , Takashi Imaizumi , Goro Miyakoda , Toyoki Mori
IPC分类号： C07D211/34
CPC分类号： A61K31/4468
摘要： The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; R1 represents a hydrogen atom or a lower alkyl group; and R2 represents a phenyl lower alkyl group).
摘要翻译：本发明提供一种用于促进血管生成的药物组合物，即使在不影响微循环的血管培养系统中也具有血管生成促进作用。用于促进本发明的血管发生的药物组合物包含至少一种选自由通式（1）表示的哌啶化合物或其盐的化合物：其中R表示可以具有作为取代基的苯甲酰基苯基环，可以具有低级烷酰基的氨基和低级烷基中的1〜3个基团; R 1表示氢原子或低级烷基; R 2表示苯基低级烷基组）。

6. 发明申请

US20070105911A1 Agent for inhibition of cytokine production and agent for inhibition of cell adhesion 失效
标题翻译：抑制细胞因子产生的药剂和细胞粘附抑制剂
公开(公告)号：US20070105911A1
公开(公告)日：2007-05-10
申请号：US11637125
申请日：2006-12-12
申请人： Masatoshi Chihiro , Takayuki Matsuzani , Hisashi Nagamoto , Goro Miyakoda , Shinobu Sueyoshi , Toyoki Mori , Kazuyoshi Kitano , Isao Takemura , Hiroshi Yamashita , Muneaki Jurimura , Fujio Tabusa
发明人： Masatoshi Chihiro , Takayuki Matsuzani , Hisashi Nagamoto , Goro Miyakoda , Shinobu Sueyoshi , Toyoki Mori , Kazuyoshi Kitano , Isao Takemura , Hiroshi Yamashita , Muneaki Jurimura , Fujio Tabusa
IPC分类号： A61K31/4439 , A61K31/426
CPC分类号： A61K31/506 , A61K31/426 , A61K31/427 , A61K31/4439 , Y10S977/904
摘要： The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: (wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.
摘要翻译：本发明提供抑制细胞因子产生或细胞粘附的试剂，其包含至少一种选自由以下通式表示的噻唑衍生物的化合物：（其中R 1是苯基，可以在苯环上具有作为取代基的低级烷氧基，R 2是由以下通式表示的基团：（其中R 3 O / 可以相同或不同，分别为羧基，低级烷氧基等）和其盐。

7. 发明授权

US6096736A Benzazepine derivatives with vasopressin agonistic activity 失效
标题翻译：苯并氮平衍生物与血管加压素的激动作用
公开(公告)号：US6096736A
公开(公告)日：2000-08-01
申请号：US91295
申请日：1998-06-12
申请人： Hidenori Ogawa , Kazumi Kondo , Tomoichi Shinohara , Keizo Kan , Yoshihisa Tanada , Muneaki Kurimura , Seiji Morita , Minoru Uchida , Toyoki Mori , Michiaki Tominaga , Yoichi Yabuuchi
发明人： Hidenori Ogawa , Kazumi Kondo , Tomoichi Shinohara , Keizo Kan , Yoshihisa Tanada , Muneaki Kurimura , Seiji Morita , Minoru Uchida , Toyoki Mori , Michiaki Tominaga , Yoichi Yabuuchi
IPC分类号： C07D223/16 , C07D401/12 , C07D403/12 , C07D417/12 , C07D521/00 , A61K31/55
CPC分类号： C07D223/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D417/12
摘要： Novel benzazepine derivative of the formula [1]: ##STR1## wherein R.sup.1 is H or halogen, A is lower alkylene, R.sup.2 and R.sup.3 are the same or different and each H, lower alkoxy, lower alkyl having optionally a lower alkoxy substituent, etc., or R.sup.2 and R.sup.3 may combine together with the nitrogen to which they bond to form a 5- to 7-membered saturated heterocyclic group which may optionally be substituted by a lower alkyl, etc., R.sup.4 is H, lower alkyl, OH, etc., R.sup.5 is --NHR.sup.6 (R.sup.6 is lower alkyl) or pyrrolidinyl, or a salt thereof, which show excellent anti-vasopressin activity, oxytocin antagonistic activity and vasopressin agonistic activity, and are useful as a vasopressin antagonist, a vasopressin agonist and an oxytocin antagonist.
摘要翻译： PCT No.PCT / JP96 / 03652 Sec。 371日期：1998年6月12日 102（e）1998年6月12日PCT PCT 1996年12月13日PCT公布。公开号WO97 / 22591 日期：1997年6月26日通式[1]的新型苯并氮杂衍生物：其中R1为H或卤素，A为低级亚烷基，R2和R3相同或不同，每个H，低级烷氧基，任选具有低级烷氧基取代基的低级烷基等等，或者R 2和R 3可以与它们键合的氮一起结合形成可任选地被低级烷基等取代的5-至7-元饱和杂环基，R 4是H，低级烷基， OH等，R5是表现出优异的抗血管加压素活性，催产素拮抗活性和加压素激动活性的-NHR6（R6是低级烷基）或吡咯烷基或其盐，并且可用作加压素拮抗剂，加压素激动剂和催产素拮抗剂。

8. 发明申请

US20070238758A1 Agent for inhibition of cytokine production and agent for inhibition of cell adhesion 审中-公开
标题翻译：抑制细胞因子产生的药剂和细胞粘附抑制剂
公开(公告)号：US20070238758A1
公开(公告)日：2007-10-11
申请号：US11798729
申请日：2007-05-16
申请人： Masatoshi Chihiro , Takayuki Matsuzaki , Hisashi Nagamoto , Goro Miyakoda , Shinobu Sueyoshi , Toyoki Mori , Kazuyoshi Kitano , Isao Takemura , Hiroshi Yamashita , Muneaki Kurimura , Fujio Tabusa
发明人： Masatoshi Chihiro , Takayuki Matsuzaki , Hisashi Nagamoto , Goro Miyakoda , Shinobu Sueyoshi , Toyoki Mori , Kazuyoshi Kitano , Isao Takemura , Hiroshi Yamashita , Muneaki Kurimura , Fujio Tabusa
IPC分类号： A61K31/4439 , A61K31/4427 , A61P43/00 , A61K31/4436
CPC分类号： A61K31/506 , A61K31/426 , A61K31/427 , A61K31/4439 , Y10S977/904
摘要： The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.
摘要翻译：本发明提供了抑制细胞因子产生或细胞粘附的试剂，其包含至少一种选自由以下通式表示的噻唑衍生物的化合物：其中R 1是苯基，可以在苯环上具有作为取代基的低级烷氧基，R 2是由以下通式表示的基团：（其中R 3 O / 可以相同或不同，分别为羧基，低级烷氧基等）和其盐。

9. 发明授权

US06583163B2 Agent for inhibition of cytokine production and agent for inhibition of cell adhesion 有权
标题翻译：抑制细胞因子产生的药剂和细胞粘附抑制剂
公开(公告)号：US06583163B2
公开(公告)日：2003-06-24
申请号：US09887143
申请日：2001-06-25
申请人： Masatoshi Chihiro , Takayuki Matsuzaki , Hisashi Nagamoto , Goro Miyakoda , Shinobu Sueyoshi , Toyoki Mori , Kazuyoshi Kitano , Isao Takemura , Hiroshi Yamashita , Muneaki Kurimura , Fujio Tabusa
发明人： Masatoshi Chihiro , Takayuki Matsuzaki , Hisashi Nagamoto , Goro Miyakoda , Shinobu Sueyoshi , Toyoki Mori , Kazuyoshi Kitano , Isao Takemura , Hiroshi Yamashita , Muneaki Kurimura , Fujio Tabusa
IPC分类号： A61K31381
CPC分类号： A61K31/506 , A61K31/426 , A61K31/427 , A61K31/4439 , Y10S977/904
摘要： The present invention provides an agent for inhibiting cytokine production or cell adhesion, comprising at least one compound selected from the group consisting of thiazole derivatives represented by the following general formula: [wherein R1 is a phenyl group which may have a lower alkoxy group(s) as a substituent(s) on the phenyl ring, and R2 is a group represented by the following general formula: (wherein R3's, which may be the same or different, are each a carboxyl group, a lower alkoxy group or the like) or the like] and salts thereof.
摘要翻译：本发明提供抑制细胞因子产生或细胞粘附的试剂，其包含至少一种选自下列通式表示的噻唑衍生物的化合物：其中R 1为可具有低级烷氧基的苯基（s ）作为苯环上的取代基，R2是由以下通式表示的基团：（其中R3可以相同或不同，分别为羧基，低级烷氧基等）或类似物]及其盐。

10. 发明授权

US08445516B2 Pharmaceutical composition for promoting angiogenesis 失效
公开(公告)号：US08445516B2
公开(公告)日：2013-05-21
申请号：US10587045
申请日：2005-01-26
申请人： Ayako Hashimoto , Takashi Imaizumi , Goro Miyakoda , Toyoki Mori
发明人： Ayako Hashimoto , Takashi Imaizumi , Goro Miyakoda , Toyoki Mori
IPC分类号： A61K31/4468
CPC分类号： A61K31/4468
摘要： The present invention provides a pharmaceutical composition for promoting angiogenesis, which has an angiogenesis promoting action even in a vascular culturing system without effect of microcirculation. A pharmaceutical composition for promoting angiogenesis of the present invention comprises at least one compound selected from a group consisting of a piperidine compound represented by the general formula (1) or salts thereof: (wherein R represents a benzoyl group which may have, as substituents on the phenyl ring, 1 to 3 groups selected from a group consisting of an amino group, which may have a lower alkanoyl group, and a lower alkyl group; R1 represents a hydrogen atom or a lower alkyl group; and R2 represents a phenyl lower alkyl group).

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