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1. 发明申请

US20110182849A1 COMPOSITIONS AND METHODS FOR TREATING AN INTERVERTEBRAL DISC USING BULKING AGENTS OR SEALING AGENTS 有权
标题翻译：用于处理破裂剂或密封剂的椎间盘的组合物和方法
公开(公告)号：US20110182849A1
公开(公告)日：2011-07-28
申请号：US12695904
申请日：2010-01-28
申请人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
发明人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
IPC分类号： A61K31/60 , A61K31/165 , A61K31/445 , A61K31/485 , A61K31/5377 , A61K31/215 , A61K31/415 , A61K31/56 , A61K38/22 , A61K38/20 , A61P29/00 , A61P23/02 , A61P25/00
CPC分类号： A61K31/00 , A61K9/0024 , A61K47/34
摘要： Effective compositions and methods for treating an intervertebral disc are provided. The compositions and methods comprise a bulking agent or sealing agent, the bulking agent or sealing agent adapted to be administered at or within the intervertebral disc, the bulking or sealing agent having a drug depot comprising an effective amount of a therapeutic agent disposed therein, wherein the drug depot is capable of releasing an effective amount of the therapeutic agent over a period of at least one day.
摘要翻译：提供了治疗椎间盘的有效组合物和方法。组合物和方法包括填充剂或密封剂，适于在椎间盘内或内部施用的填充剂或密封剂，具有药物贮库的膨胀或密封剂，其包含有效量的置于其中的治疗剂，其中药物贮库能够在至少一天的时间内释放有效量的治疗剂。

2. 发明授权

US09050274B2 Compositions and methods for treating an intervertebral disc using bulking agents or sealing agents 有权
标题翻译：使用填充剂或密封剂治疗椎间盘的组合物和方法
公开(公告)号：US09050274B2
公开(公告)日：2015-06-09
申请号：US12695904
申请日：2010-01-28
申请人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
发明人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
IPC分类号： A61K31/60 , A61K31/165 , A61K31/00 , A61K9/00 , A61K47/34
CPC分类号： A61K31/00 , A61K9/0024 , A61K47/34
摘要： Effective compositions and methods for treating an intervertebral disc are provided. The compositions and methods comprise a bulking agent or sealing agent, the bulking agent or sealing agent adapted to be administered at or within the intervertebral disc, the bulking or sealing agent having a drug depot comprising an effective amount of a therapeutic agent disposed therein, wherein the drug depot is capable of releasing an effective amount of the therapeutic agent over a period of at least one day.
摘要翻译：提供了治疗椎间盘的有效组合物和方法。组合物和方法包括填充剂或密封剂，适于在椎间盘内或内部施用的填充剂或密封剂，具有药物贮库的膨胀或密封剂，其包含有效量的置于其中的治疗剂，其中药物贮库能够在至少一天的时间内释放有效量的治疗剂。

3. 发明授权

US07879009B1 Variable opening delivery system for intervertebral disc therapies 有权
标题翻译：用于椎间盘治疗的可变开放输送系统
公开(公告)号：US07879009B1
公开(公告)日：2011-02-01
申请号：US12696153
申请日：2010-01-29
申请人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
发明人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
IPC分类号： A61M5/178 , A61M29/00 , A61B1/32
CPC分类号： A61B1/32 , A61B17/0218 , A61B17/34 , A61B17/3439 , A61B2017/00261 , A61B2017/00473 , A61B2017/0256 , A61M5/158 , A61M2025/0024
摘要： The disclosure is directed to a needle system configured to enlarge an access path in a patient without further cutting into the tissue of the patient so as to reduce recovery time and trauma to the patient. Also provided are methods of using the needle system provided.
摘要翻译：本公开涉及一种被配置成在患者体内扩大进入路径而不进一步切入患者组织的针系统，以减少对患者的恢复时间和创伤。还提供了使用提供的针系统的方法。

4. 发明申请

US20110189253A1 BIOMATERIAL COMPOSITION AND METHOD 审中-公开
标题翻译：生物组合物和方法
公开(公告)号：US20110189253A1
公开(公告)日：2011-08-04
申请号：US12696124
申请日：2010-01-29
申请人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
发明人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
IPC分类号： A61K47/32 , C08F2/46 , A61K38/17 , A61K38/18
CPC分类号： A61K38/17 , A61K38/18 , A61K47/32 , C08F2/46
摘要： The disclosure is directed to a composition includes a macromer having a polymeric backbone comprising units with a 1,2-diol or 1,3-diol structure and at least two pendant chains bearing crosslinkable groups, an amphiphilic comonomer, and a crosslinking initiator, wherein the composition has a setting time of less than about 3 minutes. The disclosure is further directed to a kit and a method of making the above-mentioned composition.
摘要翻译：本公开涉及一种组合物，其包含具有包含具有1,2-二醇或1,3-二醇结构的单元的聚合物主链和至少两个带有可交联基团的侧链的大分子单体，两亲共聚单体和交联引发剂，其中组合物的凝固时间小于约3分钟。本公开进一步涉及制备上述组合物的试剂盒和方法。

5. 发明申请

US20110184037A1 METHODS FOR TREATING AN INTERVERTEBRAL DISC USING LOCAL ANALGESICS 有权
标题翻译：使用本地化学治疗椎间盘的方法
公开(公告)号：US20110184037A1
公开(公告)日：2011-07-28
申请号：US12695888
申请日：2010-01-28
申请人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
发明人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
IPC分类号： A61K47/30 , A61K31/4168 , A61P25/00 , A61K47/32
CPC分类号： A61K31/4168 , A61K9/0024 , A61K47/34
摘要： Effective methods of treating back pain from an intervertebral disc are provided. The methods of treatment include administering an immediate release analgesic at or near the intervertebral disc; administering a bulking agent or sealing agent within the intervertebral disc; and administering a sustained release analgesic within the intervertebral disc, wherein the sustained release analgesic releases the analgesic over a period of at least one day.
摘要翻译：提供了从椎间盘治疗背痛的有效方法。治疗方法包括在椎间盘处或附近施用立即释放止痛剂; 在椎间盘内施用填充剂或密封剂; 以及在椎间盘内施用持续释放止痛剂，其中持续释放止痛剂在至少一天的时间段内释放止痛剂。

6. 发明授权

US09125902B2 Methods for treating an intervertebral disc using local analgesics 有权
标题翻译：使用局部镇痛药治疗椎间盘的方法
公开(公告)号：US09125902B2
公开(公告)日：2015-09-08
申请号：US12695888
申请日：2010-01-28
申请人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
发明人： Sean M. Haddock , Susan J. Drapeau , Thomas Andrew Simonton
IPC分类号： A61K31/30 , A61K31/4168 , A61K47/32 , A61K9/00 , A61K47/34
CPC分类号： A61K31/4168 , A61K9/0024 , A61K47/34
摘要： Effective methods of treating back pain from an intervertebral disc are provided. The methods of treatment include administering an immediate release analgesic at or near the intervertebral disc; administering a bulking agent or sealing agent within the intervertebral disc; and administering a sustained release analgesic within the intervertebral disc, wherein the sustained release analgesic releases the analgesic over a period of at least one day.
摘要翻译：提供了从椎间盘治疗背痛的有效方法。治疗方法包括在椎间盘处或附近施用立即释放止痛剂; 在椎间盘内施用填充剂或密封剂; 以及在椎间盘内施用持续释放止痛剂，其中持续释放止痛剂在至少一天的时间段内释放止痛剂。

7. 发明申请

US20080097229A1 Hygroscopic treatment for degenerating discs 审中-公开
标题翻译：退化光盘的吸湿处理
公开(公告)号：US20080097229A1
公开(公告)日：2008-04-24
申请号：US11511701
申请日：2006-08-29
申请人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx , Sean M. Haddock
发明人： Josee Roy , Susan J. Drapeau , Jeffrey C. Marx , Sean M. Haddock
IPC分类号： A61M31/00 , B65D69/00
CPC分类号： A61L27/50 , A61F2002/30075 , A61F2002/444 , A61F2210/0061 , A61L27/14 , A61L2430/38
摘要： Early treatment for a degenerated disc includes identifying a non-ruptured, dehydrated disc. A hygroscopic agent is then selected. This agent should pull water towards itself and have a hygroscopic compound with a molecular weight of at least 400 Daltons. Additionally, it may be desirable to selected hygroscopic compounds that are anionic or electrically neutral. The hygroscopic agent is then injected into the nucleus pulposus of the disc without any prior removal of the nucleus pulposus material. Because the surrounding disc structure allows for the passive diffusion of water into the nucleus pulposus, the hygroscopic agent will draw water into the nucleus pulposus, thus promoting tissue hydration within the disc. The hygroscopic agent may also include a biological agent and/or an imaging agent.
摘要翻译：退化椎间盘的早期治疗包括鉴定未破裂的脱水椎间盘。然后选择吸湿剂。该试剂应将水拉向自身并具有分子量至少为400道尔顿的吸湿性化合物。另外，可能需要选择阴离子或电中性的吸湿化合物。然后将吸湿剂注射到盘的髓核中，而无需先前去除髓核成分材料。因为周围的圆盘结构允许水被钝化地扩散到髓核中，吸湿剂会将水吸入髓核，从而促进椎间盘内的组织水合作用。吸湿剂还可以包括生物制剂和/或成像剂。

8. 发明授权

US09757476B2 Compositions and methods for diagnosis of axial pain with or without radiculopathy 有权
公开(公告)号：US09757476B2
公开(公告)日：2017-09-12
申请号：US11449309
申请日：2006-06-08
申请人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
发明人： William F. McKay , Jeffrey M. Gross , Hai Trieu , Josee Roy , Susan J. Drapeau , Michael J. Schendel , Andrew J. Lowenthal Walsh
IPC分类号： A61K49/00
CPC分类号： A61K49/0004 , A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.

9. 发明授权

US09526600B2 Biodegradable stents and methods for treating periodontal disease 有权
标题翻译：可生物降解的支架和治疗牙周病的方法
公开(公告)号：US09526600B2
公开(公告)日：2016-12-27
申请号：US12839940
申请日：2010-07-20
申请人： Susan J. Drapeau , Daniel Andrew Shimko , Kelly Brook Emerton
发明人： Susan J. Drapeau , Daniel Andrew Shimko , Kelly Brook Emerton
IPC分类号： A61C5/00 , A61C19/06 , A61C8/02 , A61K6/00 , A61L31/06 , A61L31/14 , A61L31/16
CPC分类号： A61C19/06 , A61C8/0006 , A61K6/0044 , A61L31/06 , A61L31/148 , A61L31/16 , A61L2300/00 , C08L67/04
摘要： The disclosure describes biodegradable stents and methods for selectively guided tissue regeneration in treating a periodontal defect adjacent to a root of a tooth. The biodegradable stents and methods have a coronal portion and a transverse portion or shelf, which reduce unwanted migration of gingival epithelium, gingival connective tissue, and soft tissue and enable the cementum and periodontal ligament cells to re-establish the periodontal ligament in a proper sequence resulting in a new periodontal attachment.
摘要翻译：本公开描述了可生物降解的支架和用于选择性地引导组织再生以治疗邻近牙根的牙周缺损的方法。可生物降解的支架和方法具有冠状部分和横向部分或架子，其减少牙龈上皮，牙龈结缔组织和软组织的不期望的迁移，并使牙骨质和牙周韧带细胞以适当的顺序重新建立牙周韧带导致新的牙周附着。

10. 发明授权

US09504698B2 Flowable composition that sets to a substantially non-flowable state 有权
标题翻译：可流动的组合物设定为基本上不可流动的状态
公开(公告)号：US09504698B2
公开(公告)日：2016-11-29
申请号：US12608300
申请日：2009-10-29
申请人： Susan J. Drapeau
发明人： Susan J. Drapeau
IPC分类号： A61K31/573 , A61K9/00
CPC分类号： A61K31/573 , A61K9/0024
摘要： Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent, (ii) a polymer and (iii) an effective amount of the therapeutic agent, the flowable composition being capable of setting to form a substantially non-flowable composition at a physiological temperature or as the solvent contacts bodily fluid at or near the target tissue site, wherein the substantially non-flowable composition is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal.
摘要翻译：提供可流动组合物和方法用于在患者皮肤下方的靶组织部位处或附近递送治疗剂，所述可流动组合物包含（i）溶剂，（ii）聚合物和（iii）有效量的治疗所述可流动组合物能够在生理温度下凝固形成基本上不可流动的组合物，或者当溶剂与目标组织部位处或附近的体液接触时，其中基本上不可流动的组合物能释放治疗剂在至少一天的时间段内，目标组织部位包括至少一个肌肉，韧带，肌腱，软骨，脊椎盘，脊髓神经根附近的脊柱孔隙空间，小面或滑膜关节或椎管。

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