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1. 发明授权

US07572599B2 Metalloprotease activation of myostatin, and methods of modulating myostatin activity 失效
标题翻译：肌生成抑制素的金属蛋白酶激活和调节肌生成抑制素活性的方法
公开(公告)号：US07572599B2
公开(公告)日：2009-08-11
申请号：US10665374
申请日：2003-09-16
申请人： Se-Jin Lee , Alexandra C. McPherron , Daniel S. Greenspan , William N. Pappano , Neil Wolfman , Kathy Tomkinson
发明人： Se-Jin Lee , Alexandra C. McPherron , Daniel S. Greenspan , William N. Pappano , Neil Wolfman , Kathy Tomkinson
IPC分类号： C12Q1/37
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
摘要翻译：已经确定肌生成抑制素前肽的金属蛋白酶切割导致潜在失活的肌生成抑制素活化为活性形式。因此，提供了鉴定调节金属蛋白酶介导的肌生成抑制素激活的试剂的方法，以及使用这些方法鉴定的试剂。还提供了通过增加或减少金属蛋白酶介导的肌生成抑制素前肽切割来调节生物体中肌肉生长的方法。

2. 发明申请

US20050043232A1 Metalloprotease activation of myostatin, and methods of modulating myostatin activity 失效
标题翻译：肌生成抑制素的金属蛋白酶激活和调节肌生成抑制素活性的方法
公开(公告)号：US20050043232A1
公开(公告)日：2005-02-24
申请号：US10665374
申请日：2003-09-16
申请人： Se-Jin Lee , Alexandra McPherron , Daniel Greenspan , William Pappano , Neil Wolfman , Kathy Tomkinson
发明人： Se-Jin Lee , Alexandra McPherron , Daniel Greenspan , William Pappano , Neil Wolfman , Kathy Tomkinson
IPC分类号： A61K38/00 , A61K38/16 , A61K38/18 , C07K14/475 , C12N9/64
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
摘要翻译：已经确定肌生成抑制素前肽的金属蛋白酶切割导致潜在失活的肌生成抑制素活化为活性形式。因此，提供了鉴定调节金属蛋白酶介导的肌生成抑制素激活的试剂的方法，以及使用这些方法鉴定的试剂。还提供了通过增加或减少金属蛋白酶介导的肌生成抑制素前肽切割来调节生物体中肌肉生长的方法。

3. 发明申请

US20060275280A1 Metalloprotease activation of myostatin, and methods of modulating myostatin activity 审中-公开
公开(公告)号：US20060275280A1
公开(公告)日：2006-12-07
申请号：US11498498
申请日：2006-08-02
申请人： Se-Jin Lee , Alexandra McPherron , Daniel Greenspan , William Pappano , Neil Wolfman , Kathy Tomkinson
发明人： Se-Jin Lee , Alexandra McPherron , Daniel Greenspan , William Pappano , Neil Wolfman , Kathy Tomkinson
IPC分类号： A61K38/46 , C12P21/06
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.

4. 发明申请

US20080089897A1 ActRIIB Fusion Polypeptides and Uses Therefor 审中-公开
标题翻译： ActRIIB融合多肽及其用途
公开(公告)号：US20080089897A1
公开(公告)日：2008-04-17
申请号：US11835248
申请日：2007-08-07
申请人： Neil Wolfman
发明人： Neil Wolfman
IPC分类号： A61K39/395 , A61P21/00 , A61P25/00 , A61P3/00
CPC分类号： G01N33/6887 , A61K38/00 , A61K38/1796 , C07K14/71 , C07K2319/30 , G01N2500/02 , G01N2800/108
摘要： Methods and compositions for inhibiting growth and differentiation factor-8 (GDF-8) activity in vitro and in vivo are provided. The methods and composition can be used for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or glucose homeostasis.
摘要翻译：提供了体外和体内抑制生长和分化因子-8（GDF-8）活性的方法和组合物。方法和组合物可用于诊断，预防或治疗肌肉，骨骼或葡萄糖体内平衡的退行性疾病。

5. 发明申请

US20070004005A1 Tendon-inducing compositions 失效
标题翻译：肌腱诱导组合物
公开(公告)号：US20070004005A1
公开(公告)日：2007-01-04
申请号：US11154826
申请日：2005-06-17
申请人： Anthony Celeste , John Wozney , Vicki Rosen , Neil Wolfman , Gerald Thomsen , Douglas Melton
发明人： Anthony Celeste , John Wozney , Vicki Rosen , Neil Wolfman , Gerald Thomsen , Douglas Melton
IPC分类号： A61K38/18 , C07K14/475 , C07H21/04 , C12P21/06
CPC分类号： C07K14/51 , A61K38/1875 , A61L27/227 , A61L27/386 , A61L27/54 , C07K2319/02
摘要： Compositions of proteins with tendon/ligament-like tissue inducing activity are disclosed. The compositions are useful in the treatment of tendinitis and tendon or ligament defects and in related tissue repair.
摘要翻译：公开了具有肌腱/类韧带组织诱导活性的蛋白质组成。该组合物可用于治疗腱炎和腱或韧带缺陷以及相关组织修复。

6. 发明申请

US20080070842A1 RECOMBINANT BONE MORPHOGENETIC PROTEIN HETERODIMERS, COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：重组骨形态蛋白质异构体，组合物和使用方法
公开(公告)号：US20080070842A1
公开(公告)日：2008-03-20
申请号：US11930082
申请日：2007-10-30
申请人： David Israel , Neil Wolfman
发明人： David Israel , Neil Wolfman
IPC分类号： A61K38/16 , A61P19/08 , C07K14/51
CPC分类号： C07K14/51 , A61K38/00 , C07K16/22
摘要： The present invention relates to methods for producing recombinant heterodimeric BMP proteins useful in the field of treating bone defects, healing bone injury and in wound healing in general. The invention also relates to the recombinant heterodimers and compositions containing them.
摘要翻译：本发明涉及用于治疗骨缺损，愈合骨损伤和伤口愈合领域的重组异二聚体BMP蛋白的方法。本发明还涉及包含它们的重组异源二聚体和组合物。

7. 发明申请

US20070238683A1 MODIFIED AND STABILIZED GDF PROPEPTIDES AND USES THEREOF 失效
标题翻译：修改和稳定的GDF预测及其用途
公开(公告)号：US20070238683A1
公开(公告)日：2007-10-11
申请号：US11614594
申请日：2006-12-21
申请人： Neil Wolfman , Soo-Peang Khor , Kathleen Tomkinson
发明人： Neil Wolfman , Soo-Peang Khor , Kathleen Tomkinson
IPC分类号： A61K31/7052 , C07H21/04 , C12N15/00 , C12N5/06
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译：公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。这些疾病包括肌肉或神经肌肉疾病（例如肌萎缩性侧索硬化症，肌营养不良症，肌肉萎缩，充血性阻塞性肺病，肌肉萎缩综合症，肌营养不良或恶病质），代谢疾病或病症（如2型糖尿病，非胰岛素依赖性糖尿病高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。

8. 发明申请

US20070149455A1 MODIFIED AND STABILIZED GDF PROPEPTIDES AND USES THEREOF 失效
标题翻译：修改和稳定的GDF预测及其用途
公开(公告)号：US20070149455A1
公开(公告)日：2007-06-28
申请号：US11614702
申请日：2006-12-21
申请人： Neil Wolfman , Soo-Peang Khor , Kathleen Tomkinson
发明人： Neil Wolfman , Soo-Peang Khor , Kathleen Tomkinson
IPC分类号： A61K38/18 , C07K14/475
CPC分类号： C07K14/475 , C07K14/51 , C07K16/18 , C07K2319/00
摘要： Modified and stabilized propeptides of Growth Differentiation Factor proteins, such as GDF-8 and Bone Morphogenetic Protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial. Such disorders include muscle or neuromuscular disorders (such as amyotrophic lateral sclerosis, muscular dystrophy, muscle atrophy, congestive obstructive pulmonary disease, muscle wasting syndrome, sarcopenia, or cachexia), metabolic diseases or disorders (such as such as type 2 diabetes, noninsulin-dependent diabetes mellitus, hyperglycemia, or obesity), adipose tissue disorders (such as obesity), and bone degenerative diseases (such as osteoporosis).
摘要翻译：公开了生长分化因子蛋白如GDF-8和骨形态发生蛋白-11的修饰和稳定的前肽。还公开了制备和使用经修饰的前肽以预防或治疗其中肌肉组织增加在治疗上有益的人或动物疾病的方法。这些疾病包括肌肉或神经肌肉疾病（如肌萎缩性侧索硬化，肌营养不良，肌肉萎缩，充血性阻塞性肺疾病，肌肉萎缩综合征，肌营养不良或恶病质），代谢疾病或病症（例如2型糖尿病，依赖性糖尿病，高血糖或肥胖），脂肪组织障碍（如肥胖症）和骨退行性疾病（如骨质疏松症）。

9. 发明申请

US20080090768A1 RECOMBINANT BONE MORPHOGENETIC PROTEIN HETERODIMERS, COMPOSITIONS AND METHODS OF USE 审中-公开
公开(公告)号：US20080090768A1
公开(公告)日：2008-04-17
申请号：US11930104
申请日：2007-10-31
申请人： David Israel , Neil Wolfman
发明人： David Israel , Neil Wolfman
IPC分类号： A61K38/00 , A61P19/00 , C07K16/00
CPC分类号： C07K14/51 , A61K38/00 , C07K16/22
摘要： The present invention relates to methods for producing recombinant heterodimeric BMP proteins useful in the field of treating bone defects, healing bone injury and in wound healing in general. The invention also relates to the recombinant heterodimers and compositions containing them.

10. 发明申请

US20070134258A1 GASP1: A FOLLISTATIN DOMAIN CONTAINING PROTEIN 失效
标题翻译： GASP1：含有蛋白质的蛋白质域
公开(公告)号：US20070134258A1
公开(公告)日：2007-06-14
申请号：US11669531
申请日：2007-01-31
申请人： Jennifer Hill , Neil Wolfman
发明人： Jennifer Hill , Neil Wolfman
IPC分类号： A61K39/395 , A61K38/18 , G01N33/567
CPC分类号： A61K38/1709 , Y10S435/81
摘要： The present invention relates to the use of a protein, GASP1, comprising at least one follistatin domain to modulate the level or activity of growth and differentiation factor-8 (GDF-8). More particularly, the invention relates to the use of GASP1 for treating disorders that are related to modulation of the level or activity of GDF-8. The invention is useful for treating muscular diseases and disorders, particularly those in which an increase in muscle tissue would be therapeutically beneficial. The invention is also useful for treating diseases and disorders related to metabolism, adipose tissue, and bone degeneration.
摘要翻译：本发明涉及包含至少一个卵泡抑素结构域的蛋白质GASP1在调节生长和分化因子-8（GDF-8）的水平或活性中的用途。更具体地，本发明涉及GASP1用于治疗与调节GDF-8的水平或活性相关的疾病的用途。本发明可用于治疗肌肉疾病和病症，特别是肌肉组织增加在治疗上有益的那些。本发明也可用于治疗与代谢，脂肪组织和骨变性相关的疾病和病症。

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