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1. 发明申请

US20140057893A1 SUBSTITUTED CYCLOPROPLY COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF TREATMENT 有权
标题翻译：取代的环状化合物，包含这些化合物的组合物和处理方法
公开(公告)号：US20140057893A1
公开(公告)日：2014-02-27
申请号：US14110332
申请日：2012-04-05
申请人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
发明人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
IPC分类号： C07D513/04 , C07D413/14 , C07D413/04 , C07D498/04 , C07D405/04 , C07D471/04 , C07D487/04 , C07D401/12 , C07D211/22
CPC分类号： C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included
摘要翻译：公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病状。该化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法

2. 发明授权

US08957062B2 Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment 有权
标题翻译：取代的环丙基化合物，含有这些化合物的组合物和处理方法
公开(公告)号：US08957062B2
公开(公告)日：2015-02-17
申请号：US14110332
申请日：2012-04-05
申请人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
发明人： Scott Edmondson , Zhiqiang Guo , Harold B. Wood , Andrew W. Stamford , Michael W. Miller , Duane E. DeMong , Gregori J. Morriello , Rajan Anand , Vincent J. Colandrea , Megan Macala , Milana Maletic , Cheng Zhu , Yuping Zhu , Wanying Sun , Kake Zhao , Yong Huang , Joel M. Harris , Lehua Chang , Nam Fung Kar , Zhiyong Hu , Liping Wang , Bowei Wang , Ping Liu , Jason W. Szewczyk , William B. Geiss
IPC分类号： C07D513/04 , C07D401/12 , C07D413/14 , C07D413/04 , C07D211/22 , C07D405/04 , C07D471/04 , C07D487/04 , C07D498/04 , A61K9/48 , C07D417/14 , C07D495/04
CPC分类号： C07D513/04 , A61K9/4858 , C07D211/22 , C07D401/12 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D495/04 , C07D498/04
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。该化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。

3. 发明授权

US09006228B2 Substituted cyclopropyl compounds, compositions containing such compounds, and methods of treatment 有权
标题翻译：取代的环丙基化合物，含有这些化合物的组合物和治疗方法
公开(公告)号：US09006228B2
公开(公告)日：2015-04-14
申请号：US14126685
申请日：2012-06-11
申请人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
发明人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
IPC分类号： C07D417/14 , C07D211/24 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D211/22
CPC分类号： C07D211/24 , C07D211/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病症。该化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。

4. 发明申请

US20140128368A1 SUBSTITUTED CYCLOPROPYL COMPOUNDS, COMPOSITIONS CONTAINING SUCH COMPOUNDS, AND METHODS OF TREATMENT 有权
标题翻译：取代的环丙基化合物，包含这些化合物的组合物和处理方法
公开(公告)号：US20140128368A1
公开(公告)日：2014-05-08
申请号：US14126685
申请日：2012-06-11
申请人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
发明人： Michael Miller , Andrew Stamford , Kallol Basu , Harold B. Wood , Duane DeMong , Wanying Sun , Joie Garfunkle , Christopher Moyes , Zhiyong Hu , Ping Liu , Scott D. Edmondson , Xing Dai , Byron Gabriel DuBois
IPC分类号： C07D417/14 , C07D211/24 , C07D405/14 , C07D413/04 , C07D413/14 , C07D401/14 , C07D401/04
CPC分类号： C07D211/24 , C07D211/22 , C07D401/04 , C07D401/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要翻译：公开了取代的式I的环丙基化合物及其药学上可接受的盐可用于治疗或预防2型糖尿病和类似病状。该化合物可用作G蛋白偶联受体GPR-119的激动剂。还包括药物组合物和治疗方法。

5. 发明授权

US09221834B2 Cyclic amine substituted oxazolidinone CETP inhibitor 有权
标题翻译：环胺取代的恶唑烷酮CETP抑制剂
公开(公告)号：US09221834B2
公开(公告)日：2015-12-29
申请号：US13881896
申请日：2011-10-25
申请人： Zhijian Lu , Yi-Heng Chen , Cameron Smith , Hong Li , Christopher F. Thompson , Julianne Hunt , Florida Kallashi , Ramzi Sweis , Peter Sinclair , Samantha E. Adamson , Guizhen Dong , Debra L. Ondeyka , Xiaoxia Qian , Wanying Sun , Petr Vachal , Kake Zhao
发明人： Zhijian Lu , Yi-Heng Chen , Cameron Smith , Hong Li , Christopher F. Thompson , Julianne Hunt , Florida Kallashi , Ramzi Sweis , Peter Sinclair , Samantha E. Adamson , Guizhen Dong , Debra L. Ondeyka , Xiaoxia Qian , Wanying Sun , Petr Vachal , Kake Zhao
IPC分类号： A61K31/4439 , A61K31/506 , A61K31/5377 , A61K31/4545 , A61K31/497 , A61K31/444 , C07D491/08 , C07D417/14 , C07D413/14 , A61K31/42 , A61K45/06 , C07D413/06
CPC分类号： C07D491/08 , A61K31/42 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/06 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substituted phenyl group or indanyl group. Formula (I).
摘要翻译：具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于培养HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。在式I的化合物中，A3是取代的苯基或茚满基。式（I）。

6. 发明申请

US20130331372A1 Cyclic Amine Substituted Oxazolidinone CETP Inhibitor 有权
标题翻译：环胺取代的恶唑烷酮CETP抑制剂
公开(公告)号：US20130331372A1
公开(公告)日：2013-12-12
申请号：US13881896
申请日：2011-10-25
申请人： Zhijian Lu , Yi-Heng Chen , Cameron Smith , Hong Li , Christopher F. Thompson , Julianne Hunt , Florida Kallashi , Ramzi Sweis , Peter Sinclair , Samantha E. Adamson , Guizhen Dong , Debra L. Ondeyka , Xiaoxia Qian , Wanying Sun , Petr Vachal , Kake Zhao
发明人： Zhijian Lu , Yi-Heng Chen , Cameron Smith , Hong Li , Christopher F. Thompson , Julianne Hunt , Florida Kallashi , Ramzi Sweis , Peter Sinclair , Samantha E. Adamson , Guizhen Dong , Debra L. Ondeyka , Xiaoxia Qian , Wanying Sun , Petr Vachal , Kake Zhao
IPC分类号： C07D491/08 , A61K31/5377 , A61K31/4545 , A61K31/444 , A61K31/497 , C07D417/14 , C07D413/14 , A61K45/06 , A61K31/4439 , A61K31/506
CPC分类号： C07D491/08 , A61K31/42 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/06 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis. In the compound of Formula I, A3 is a substituted phenyl group or indanyl group. Formula (I).
摘要翻译：具有式I结构的化合物，包括化合物的药学上可接受的盐，是CETP抑制剂，可用于培养HDL-胆固醇，降低LDL-胆固醇，以及用于治疗或预防动脉粥样硬化。在式I的化合物中，A3是取代的苯基或茚满基。式（I）。

7. 发明授权

US5670646A Monomeric and polymeric cyclic amine and-halamine compounds 失效
标题翻译：单体和聚合环胺和卤胺化合物
公开(公告)号：US5670646A
公开(公告)日：1997-09-23
申请号：US474302
申请日：1995-06-07
申请人： Shelby D. Worley , Gang Sun , Wanying Sun , Tay-Yuan Chen
发明人： Shelby D. Worley , Gang Sun , Wanying Sun , Tay-Yuan Chen
IPC分类号： A01N59/00 , C07D233/74 , C07D251/10 , C07D251/20 , C07D263/22 , C08F8/30 , C08F8/48 , C08F12/26 , C07D235/02
CPC分类号： C07D233/74 , A01N59/00 , C07D251/20 , C08F12/26 , C08F8/30 , C08F8/48 , Y02W10/37
摘要： Cyclic amine monomers and polymers and N-halamine biocidal polymer compounds are provided. Methods of making and using the same wherein the functional groups unhalogenated or halogenated hydantoins, triazine diones, imidazolidinones, and pyrimidinones are substituted onto inexpensive polymer units such as polystyrene, polyethylene, and modified polymethacrylamide are provided. The cyclic amine monomers and polymers can be utilized to form the biocidal N-halamine polymers. These N-halamine polymers are stable, insoluble biocides which release only small amounts of free halogen and other impurities. They can be useful as disinfectants for potable water, swimming pools, hot tubs, industrial water systems, cooling towers, air-conditioning systems, gas streams, paints, oils, ointments, fabrics, rubber materials, sterile bandages, coatings, hard surfaces, liners of containers, and the like.
摘要翻译：提供了环胺单体和聚合物以及N-卤胺杀生物聚合物化合物。提供了制备和使用其的方法，其中将官能团的未卤化或卤代乙内酰脲，三嗪二酮，咪唑烷酮和嘧啶酮取代到廉价的聚合物单元如聚苯乙烯，聚乙烯和改性的聚甲基丙烯酰胺上。环胺单体和聚合物可用于形成杀生物N-卤代胺聚合物。这些N-卤代胺聚合物是仅释放少量游离卤素和其它杂质的稳定的不溶性杀生物剂。它们可用作饮用水，游泳池，热水浴缸，工业水系统，冷却塔，空调系统，气体流，油漆，油，软膏，织物，橡胶材料，无菌绷带，涂层，硬表面的消毒剂，容器内衬等。

8. 发明授权

US5808089A Substituted heterocyclic amine monomers 失效
标题翻译：取代的杂环胺单体
公开(公告)号：US5808089A
公开(公告)日：1998-09-15
申请号：US482747
申请日：1995-06-07
申请人： Shelby D. Worley , Gang Sun , Wanying Sun , Tay-Yuan Chen
发明人： Shelby D. Worley , Gang Sun , Wanying Sun , Tay-Yuan Chen
IPC分类号： A01N59/00 , C07D233/74 , C07D251/10 , C07D251/20 , C07D263/22 , C08F8/30 , C08F8/48 , C08F12/26 , C07D233/02
CPC分类号： C07D233/74 , A01N59/00 , C07D251/20 , C08F12/26 , C08F8/30 , C08F8/48 , Y02W10/37
摘要： Substituted 5- to 6-membered heterocyclic amine monomers are provided. Methods of making the same, wherein a polymer is heated under vacuum to crack it into monomeric units and the aceto moiety is converted to a selected moiety, are provided. Monomers including unhalogenated or halogenated hydantoins, triazine diones, imidazolidinones, or pyrimidinones are provided. The heterocyclic amine monomers can be utilized to form biocidal N-halamine polymers which are stable, insoluble biocides which release only small amounts of free halogen and other impurities.
摘要翻译：提供了取代的5至6元杂环胺单体。制备其的方法，其中将聚合物在真空下加热以将其裂解成单体单元，并将乙酰部分转化为选定的部分。提供包括非卤化或卤代乙内酰脲，三嗪二酮，咪唑啉酮或嘧啶酮的单体。杂环胺单体可用于形成杀生物N-卤代胺聚合物，其为仅释放少量游离卤素和其它杂质的稳定的不溶性杀生物剂。

9. 发明授权

US06294185B1 Monomeric and polymeric cyclic amine and N-halamine compounds 失效
标题翻译：单体和聚合环胺和N-卤代胺化合物
公开(公告)号：US06294185B1
公开(公告)日：2001-09-25
申请号：US08310657
申请日：1994-09-22
申请人： Shelby D. Worley , Gang Sun , Wanying Sun , Tay-Yuan Chen
发明人： Shelby D. Worley , Gang Sun , Wanying Sun , Tay-Yuan Chen
IPC分类号： A01N2500
CPC分类号： C07D233/74 , A01N59/00 , C07D251/20 , C08F8/30 , C08F8/48 , C08F12/26 , Y02W10/37
摘要： Cyclic amine monomers and polymers and N-halamine biocidal polymer compounds are provided. Methods of making and using the same wherein the functional groups unhalogenated or halogenated hydantoins, triazine diones, imidazolidinones, and pyrimidinones are substituted onto inexpensive polymer units such as polystyrene, polyethylene, and modified polymethacrylamide are provided. The cyclic amine monomers and polymers can be utilized to form the biocidal N-halamine polymers. These N-halamine polymers are stable, insoluble biocides which release only small amounts of free halogen and other impurities. They can be useful as disinfectants for potable water, swimming pools, hot tubs, industrial water systems, cooling towers, air-conditioning systems, gas streams, paints, oils, ointments, fabrics, rubber materials, sterile bandages, coatings, hard surfaces, liners of containers, and the like.
摘要翻译：提供了环胺单体和聚合物以及N-卤胺杀生物聚合物化合物。提供了制备和使用其的方法，其中将官能团的未卤化或卤代乙内酰脲，三嗪二酮，咪唑烷酮和嘧啶酮取代到廉价的聚合物单元如聚苯乙烯，聚乙烯和改性的聚甲基丙烯酰胺上。环胺单体和聚合物可用于形成杀生物N-卤代胺聚合物。这些N-卤代胺聚合物是仅释放少量游离卤素和其它杂质的稳定的不溶性杀生物剂。它们可用作饮用水，游泳池，热水浴缸，工业水系统，冷却塔，空调系统，气体流，油漆，油，软膏，织物，橡胶材料，无菌绷带，涂层，硬表面的消毒剂，容器内衬等。

10. 发明授权

US6020491A Monomeric and polymeric cyclic amine and N-halamine compounds 失效
标题翻译：单体和聚合环胺和N-卤代胺化合物
公开(公告)号：US6020491A
公开(公告)日：2000-02-01
申请号：US110899
申请日：1998-07-07
申请人： Shelby D. Wonley , Gang Sun , Wanying Sun , Tay-Yuan Chen
发明人： Shelby D. Wonley , Gang Sun , Wanying Sun , Tay-Yuan Chen
IPC分类号： A01N59/00 , C07D233/74 , C07D251/10 , C07D251/20 , C07D263/22 , C08F8/30 , C08F8/48 , C08F12/26 , C07D238/10
CPC分类号： C07D233/74 , A01N59/00 , C07D251/20 , C08F12/26 , C08F8/30 , C08F8/48 , Y02W10/37
摘要： Cyclic amine monomers and polymers and N-halamine biocidal polymer compounds are provided. Representative monomers have the structure: ##STR1## wherein R.sup.1 is selected from the group consisting of hydrogen and from C.sub.1 to C.sub.4 alkyl; R.sup.10 is a bond or parasubstituted phenyl; and R.sup.11 is cyclic amine unit of a 5- to 6-membered heterocyclic ring selected from the group consisting of: (a) 1,3,5-triazine-2,4-dione; (b) 3,4,5,6-tetrahydro(1H)pyrimidin-2-one; and (c) 2-oxazolidinone; R.sup.10 is attached to a linkage carbon of R.sup.11, wherein said linkage carbon of R.sup.11 is a carbon located on the ring of R.sup.11 and is substituted with a substituent selected from the group consisting of C.sub.1 -C.sub.4 alkyl, benzyl, and alkyl-substituted benzyl; from 0 to 2 non-linkage carbon members are a carbonyl group; and from 0 to 1 non-linkage carbon member is substituted with a moiety selected from the group consisting of C.sub.1 -C.sub.4 alkyl, phenyl, alkyl-substituted phenyl, benzyl, alkyl-substituted benzyl, pentamethylene in spirosubstituted form and tetramethylene in spirosubstituted form. The cyclic amine monomers and polymers can be utilized to form the biocidal N-halamine polymers. These N-halamine polymers are stable, insoluble biocides which release only small amounts of free halogen and other impurities. They can be useful as disinfectants for potable water, swimming pools, hot tubs, industrial water systems, cooling towers, air-conditioning systems, gas streams, paints, oils, ointments, fabrics, rubber materials, sterile bandages, coatings, hard surfaces, liners of containers, and the like.
摘要翻译：提供了环胺单体和聚合物以及N-卤胺杀生物聚合物化合物。代表性的单体具有以下结构：其中R 1选自氢和C 1至C 4烷基; R10是键或取代的苯基; 和R11是选自以下的5-至6-元杂环的环胺单元：（a）1,3,5-三嗪-2,4-二酮; （b）3,4,5,6-四氢（1H）嘧啶-2-酮; 和（c）2-恶唑烷酮; R 10连接到R 11的连接碳上，其中R 11的连接碳是位于R 11的环上的碳，并被选自C 1 -C 4烷基，苄基和烷基取代的苄基的取代基取代; 0至2个非连接碳成员为羰基; 0至1个非连接性碳成员被选自C 1 -C 4烷基，苯基，烷基取代的苯基，苄基，烷基取代的苄基，螺甲取代的五亚甲基和螺旋取代的四亚甲基中的一部分取代。环胺单体和聚合物可用于形成杀生物N-卤代胺聚合物。这些N-卤代胺聚合物是仅释放少量游离卤素和其它杂质的稳定的不溶性杀生物剂。它们可用作饮用水，游泳池，热水浴缸，工业水系统，冷却塔，空调系统，气体流，油漆，油，软膏，织物，橡胶材料，无菌绷带，涂层，硬表面的消毒剂，容器内衬等。

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