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1. 发明授权

US5760246A Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method 失效
标题翻译：构象限制的微粒体甘油三酯转运蛋白的芳香族抑制剂和方法
公开(公告)号：US5760246A
公开(公告)日：1998-06-02
申请号：US767923
申请日：1996-12-17
申请人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Jeffrey A. Robl , William A. Slusarchyk , Richard B. Sulsky , Joseph A. Tino
发明人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Jeffrey A. Robl , William A. Slusarchyk , Richard B. Sulsky , Joseph A. Tino
IPC分类号： C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C233/78 , C07C235/40 , C07C237/12 , C07C237/24 , C07C255/41 , C07C259/08 , C07C271/22 , C07C271/24 , C07C291/04 , C07C307/06 , C07C311/21 , C07C311/46 , C07C317/12 , C07C317/44 , C07C321/22 , C07C323/60 , C07D207/32 , C07D207/335 , C07D213/40 , C07D213/64 , C07D213/75 , C07D221/16 , C07D233/88 , C07D233/90 , C07D233/92 , C07D295/185 , C07D307/52 , C07D311/82 , C07D333/20 , C07D405/12 , C07D407/12 , C07D409/12 , C07F7/18 , C07F9/40 , C07F9/576 , C07F9/58 , C07F9/6506 , C07F9/655 , C07F9/6571 , C07D235/16
CPC分类号： C07D207/335 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C233/78 , C07C235/40 , C07C237/12 , C07C237/24 , C07C255/41 , C07C259/08 , C07C271/22 , C07C271/24 , C07C291/04 , C07C307/06 , C07C311/21 , C07C311/46 , C07C317/12 , C07C317/44 , C07C321/22 , C07C323/60 , C07D213/40 , C07D213/64 , C07D213/75 , C07D221/16 , C07D233/88 , C07D233/90 , C07D233/92 , C07D295/185 , C07D307/52 , C07D311/82 , C07D333/20 , C07D405/12 , C07D407/12 , C07D409/12 , C07F7/1856 , C07F9/4006 , C07F9/4018 , C07F9/5765 , C07F9/582 , C07F9/588 , C07F9/65061 , C07F9/65062 , C07F9/65067 , C07F9/65068 , C07F9/65515 , C07F9/6552 , C07F9/65522 , C07F9/657181 , C07C2101/02 , C07C2101/14 , C07C2103/18 , C07C2103/32 , C07C2103/76
摘要： Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure ##STR1## including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; R.sup.x is H, alkyl, aryl or halogen; A is (1) a bond; (2) --O--; or (3) ##STR2## B is: ##STR3## and wherein L.sup.2, L.sup.1, R.sup.1, R.sup.2, R.sup.3, R.sup.3', R.sup.3a, R.sup.3b, R.sup.4, R.sup.4', R.sup.5, X, ##STR4## are as defined herein.
摘要翻译：提供了新的化合物，其是MTP的抑制剂，因此可用于降低血清脂质和治疗动脉粥样硬化和相关疾病，并且具有包含其药学上可接受的盐或前药酯的结构（图）其中q为0,1或2; Rx是H，烷基，芳基或卤素; A是（1）债券; （2）-O- 或（3） B是：或或或或或或，其中L2，L1，R1，R2，R3，R3 '，R3a，R3b，R4，R4'，R5，X，如本文所定义。

2. 发明授权

US06472414B1 Conformationally restricted aromatic inhibitors of microsomal triglyceride transfer protein and method 有权
标题翻译：构象限制的微粒体甘油三酯转运蛋白的芳香族抑制剂和方法
公开(公告)号：US06472414B1
公开(公告)日：2002-10-29
申请号：US09313883
申请日：1999-05-18
申请人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Jeffrey A. Robl , William A. Slusarchyk , Richard B. Sulsky , Joseph A. Tino
发明人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Jeffrey A. Robl , William A. Slusarchyk , Richard B. Sulsky , Joseph A. Tino
IPC分类号： C07D23516
CPC分类号： C07D207/335 , C07C233/58 , C07C233/59 , C07C233/60 , C07C233/62 , C07C233/63 , C07C233/78 , C07C235/40 , C07C237/12 , C07C237/24 , C07C255/41 , C07C259/08 , C07C271/22 , C07C271/24 , C07C291/04 , C07C307/06 , C07C311/21 , C07C311/46 , C07C317/12 , C07C317/44 , C07C321/22 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07C2603/18 , C07C2603/32 , C07C2603/76 , C07D213/40 , C07D213/64 , C07D213/75 , C07D221/16 , C07D233/88 , C07D233/90 , C07D233/92 , C07D295/185 , C07D307/52 , C07D311/82 , C07D333/20 , C07D405/12 , C07D407/12 , C07D409/12 , C07F7/1804 , C07F9/4006 , C07F9/4018 , C07F9/5765 , C07F9/58 , C07F9/6506 , C07F9/65068 , C07F9/65515 , C07F9/6552 , C07F9/65522 , C07F9/657181
摘要： Novel compounds are provided which are inhibitors of MTP and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases, and have the structure including pharmaceutically acceptable salts thereof or prodrug esters thereof, wherein q is 0, 1 or 2; Rx is H, alkyl, aryl or halogen; A is (1) a bond; (2) —O—; or (3) B is: and wherein L2, L1, R1, R2, R3, R3′, R3a, R3b, R4, R4′, R5, X, are as defined herein.
摘要翻译：提供了作为MTP抑制剂的新型化合物，因此可用于降低血清脂质和治疗动脉粥样硬化及相关疾病，并且其结构包括其药学上可接受的盐或其前药酯，其中q为0,1或2; Rx为H，烷基，芳基或卤素; A是（1）键;（2）-O-; 或（3）B是：并且其中L2，L1，R1，R2，R3，R3'，R3a，R3b，R4，R4'，R5，X如本文所定义。

3. 发明授权

US5712279A Inhibitors of microsomal triglyceride transfer protein and method 失效
标题翻译：微粒体甘油三酯转运蛋白抑制剂及方法
公开(公告)号：US5712279A
公开(公告)日：1998-01-27
申请号：US548811
申请日：1996-01-11
申请人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Jeffrey A. Robl , Richard B. Sulsky , Joseph A. Tino
发明人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Jeffrey A. Robl , Richard B. Sulsky , Joseph A. Tino
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/52 , A61K31/535 , A61P3/06 , A61P9/10 , A61P43/00 , C07D211/00 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/94 , C07D211/98 , C07D215/38 , C07D217/00 , C07D217/22 , C07D221/16 , C07D241/04 , C07D401/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12
CPC分类号： C07D401/04 , C07D211/58 , C07D211/60 , C07D211/94 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12 , G01N2800/044
摘要： Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein Z, X.sup.1, X.sup.2, x and R.sup.5 are as defined herein.
摘要翻译：提供抑制微粒体甘油三酯转运蛋白的化合物，因此可用于降低血清脂质和治疗动脉粥样硬化及相关疾病。化合物具有结构，其中Z，X1，X2，X和R5如本文所定义。

4. 发明授权

US6066650A Inhibitors of microsomal triglyceride transfer protein and method 失效
标题翻译：微粒体甘油三酯转运蛋白抑制剂及方法
公开(公告)号：US6066650A
公开(公告)日：2000-05-23
申请号：US898303
申请日：1997-07-21
申请人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Richard B. Sulsky , Joseph A. Tino , John E. Lawson , Henry M. Holava , Richard A. Partyka
发明人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Richard B. Sulsky , Joseph A. Tino , John E. Lawson , Henry M. Holava , Richard A. Partyka
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/52 , A61K31/535 , A61P3/06 , A61P9/10 , A61P43/00 , C07D211/00 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/94 , C07D211/98 , C07D215/38 , C07D217/00 , C07D217/22 , C07D221/16 , C07D241/04 , C07D401/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12
CPC分类号： C07D401/04 , C07D211/58 , C07D211/60 , C07D211/94 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12 , G01N2800/044
摘要： Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.
摘要翻译：提供抑制微粒体甘油三酯转运蛋白的化合物，因此可用于降低血清脂质和治疗动脉粥样硬化及相关疾病。化合物具有其中R 1至R 7，Q，X和Y如本文所定义的结构。

5. 发明授权

US6034098A Inhibitors of microsomal triglyceride transfer protein and method 失效
公开(公告)号：US6034098A
公开(公告)日：2000-03-07
申请号：US898304
申请日：1997-07-21
申请人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Richard B. Sulsky , Joseph A. Tino , John E. Lawson , Henry M. Holava , Richard A. Partyka
发明人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Richard B. Sulsky , Joseph A. Tino , John E. Lawson , Henry M. Holava , Richard A. Partyka
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/52 , A61K31/535 , A61P3/06 , A61P9/10 , A61P43/00 , C07D211/00 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/94 , C07D211/98 , C07D215/38 , C07D217/00 , C07D217/22 , C07D221/16 , C07D241/04 , C07D401/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12
CPC分类号： C07D401/04 , C07D211/58 , C07D211/60 , C07D211/94 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12 , G01N2800/044
摘要： Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.

6. 发明授权

US5883099A Inhibitors of microsomal triglyceride transfer protein and method 失效
标题翻译：微粒体甘油三酯转运蛋白抑制剂及方法
公开(公告)号：US5883099A
公开(公告)日：1999-03-16
申请号：US896872
申请日：1997-07-21
申请人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Richard B. Sulsky , Joseph A. Tino , John E. Lawson , Henry M. Holava , Richard A. Partyka
发明人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Richard B. Sulsky , Joseph A. Tino , John E. Lawson , Henry M. Holava , Richard A. Partyka
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/52 , A61K31/535 , A61P3/06 , A61P9/10 , A61P43/00 , C07D211/00 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/94 , C07D211/98 , C07D215/38 , C07D217/00 , C07D217/22 , C07D221/16 , C07D241/04 , C07D401/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12
CPC分类号： C07D401/04 , C07D211/58 , C07D211/60 , C07D211/94 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12 , G01N2800/044
摘要： Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.
摘要翻译：提供抑制微粒体甘油三酯转运蛋白的化合物，因此可用于降低血清脂质和治疗动脉粥样硬化及相关疾病。化合物具有结构 ein。

7. 发明授权

US5739135A Inhibitors of microsomal triglyceride transfer protein and method 失效
标题翻译：微粒体甘油三酯转运蛋白抑制剂及方法
公开(公告)号：US5739135A
公开(公告)日：1998-04-14
申请号：US472067
申请日：1995-06-06
申请人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Richard B. Sulsky , Joseph A. Tino
发明人： Scott A. Biller , John K. Dickson , R. Michael Lawrence , David R. Magnin , Michael A. Poss , Richard B. Sulsky , Joseph A. Tino
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/52 , A61K31/535 , A61P3/06 , A61P9/10 , A61P43/00 , C07D211/00 , C07D211/56 , C07D211/58 , C07D211/60 , C07D211/94 , C07D211/98 , C07D215/38 , C07D217/00 , C07D217/22 , C07D221/16 , C07D241/04 , C07D401/00 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12
CPC分类号： C07D401/04 , C07D211/58 , C07D211/60 , C07D211/94 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D419/12 , G01N2800/044
摘要： Compounds are provided which inhibit microsomal triglyceride transfer protein and thus are useful for lowering serum lipids and treating atherosclerosis and related diseases. The compounds have the structure ##STR1## wherein R.sup.1 to R.sup.7, Q, X and Y are as defined herein.
摘要翻译：提供抑制微粒体甘油三酯转运蛋白的化合物，因此可用于降低血清脂质和治疗动脉粥样硬化及相关疾病。化合物具有本文定义的结构。

8. 发明授权

US5595872A Nucleic acids encoding microsomal trigyceride transfer protein 失效
标题翻译：编码微粒体三环内酯转运蛋白的核酸
公开(公告)号：US5595872A
公开(公告)日：1997-01-21
申请号：US117362
申请日：1993-09-03
申请人： John R. Wetterau, II , Daru Y. Sharp , Richard E. Gregg , Scott A. Biller , John K. Dickson , R. Michael Lawrence , John E. Lawson , Henry M. Holava , Richard A. Partyka
发明人： John R. Wetterau, II , Daru Y. Sharp , Richard E. Gregg , Scott A. Biller , John K. Dickson , R. Michael Lawrence , John E. Lawson , Henry M. Holava , Richard A. Partyka
IPC分类号： C07D295/08 , A61K31/435 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61K31/495 , A61K38/00 , A61P3/06 , A61P9/10 , C07D211/58 , C07D295/112 , C07D295/18 , C07D295/185 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/04 , C07D417/12 , C07K14/47 , G01N33/92 , C12Q1/70 , C07H21/02 , C12N5/10 , C12N15/79
CPC分类号： C07D295/185 , C07D211/58 , C07D295/112 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D417/12 , C07K14/47 , G01N33/92 , A61K38/00 , C07C2101/02 , C07C2101/08 , C07C2101/14 , C07C2103/18 , G01N2800/044
摘要： Nucleic acid sequences, particularly DNA sequences, coding for all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, expression vectors containing the DNA sequences, host cells containing the expression vectors, and methods utilizing these materials. The invention also concerns polypeptide molecules comprising all or part of the high molecular weight subunit of microsomal triglyceride transfer protein, and methods for producing these polypeptide molecules. The invention additionally concerns novel methods for preventing, stabilizing or causing regression of atherosclerosis and therapeutic agents having such activity. The invention concerns further novel methods for lowering serum liquid levels and therapeutic agents having such activity.
摘要翻译：编码微粒体甘油三酯转运蛋白的全部或部分高分子量亚基的核酸序列，特别是DNA序列，含有DNA序列的表达载体，含有表达载体的宿主细胞，以及利用这些材料的方法。本发明还涉及包含微粒体甘油三酯转移蛋白的全部或部分高分子量亚单位的多肽分子，以及产生这些多肽分子的方法。本发明还涉及用于预防，稳定或引起动脉粥样硬化消退的新方法和具有这种活性的治疗剂。本发明涉及降低血清液体水平的进一步新颖方法和具有这种活性的治疗剂。

9. 发明授权

US07265145B2 Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method 有权
公开(公告)号：US07265145B2
公开(公告)日：2007-09-04
申请号：US10854689
申请日：2004-05-26
申请人： John K. Dickson , R. Michael Lawrence , Jacques Y. Roberge , David P. Rotella , Wu Yang
发明人： John K. Dickson , R. Michael Lawrence , Jacques Y. Roberge , David P. Rotella , Wu Yang
IPC分类号： A61K41/40 , C07D207/18
CPC分类号： C07D207/06 , C07D207/08 , C07D207/10 , C07D211/18 , C07D211/22 , C07D333/28
摘要： Compounds are provided which are antagonists of the calcium sensing receptor, and have the general formula wherein m is 0, 1, 2, 3 or 4; each X is independently selected from the group consisting of hydrogen, halo, cyano, nitro, OCF3, hydroxy, amino, carboxyl, alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, haloalkyl, alkoxy, alkoxycarbonylalkyl, hydroxycarbonylalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, cycloalkylalkyl, R1O, R1R2N, R1OCO, R1CO, R1R2NCO, R1R2NCONR2a, R1OCONR2a, R1CONR2a, R1S, R1SO, R1SO2, R1R2NSO2, R1R2NSO2NR2a, and R1SO2NR2a; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; R2 and R2a are the same or different and are independently selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloheteroalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl; n is 1, 2, or 3; W is O or H,R3; R3 is hydrogen or hydroxyl; Ar is a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group; Q is hydrogen, F, or hydroxyl. In addition, a method for using these compounds to treat diseases associated with abnormal or mineral homeostasis is also provided.

10. 发明授权

US4472974A Roller-type ultrasonic inspection devices 失效
标题翻译：滚筒式超声波检测装置
公开(公告)号：US4472974A
公开(公告)日：1984-09-25
申请号：US447580
申请日：1982-12-07
申请人： John K. Dickson , Trevor H. Easter
发明人： John K. Dickson , Trevor H. Easter
IPC分类号： G01N29/24 , G01N29/04
CPC分类号： G01N29/2493
摘要： A roller-type ultrasonic inspection device for inspecting vehicle tires comprises a roller assembly 20 mounted on a non-rotatable hug 16. Two piezoelectric crystals 80,82 are mounted in the hub 16 such that their principal transmitting/receiving axes A and B converge generally radially outwardly of the hub. The angle between the axes A and B is selected such that when the roller assembly 20 is urged into rolling contact with the tread-bearing surface of a tire 90, the axes meet (allowing for refraction effects) in the body of the tire beneath the tread. This ensures that the device can detect defects in the body of the tire, and is relatively insensitive to the tread.
摘要翻译：用于检查车辆轮胎的辊式超声波检查装置包括安装在不可旋转的保持器16上的辊组件20.两个压电晶体80,82安装在毂16中，使得它们的主要发送/接收轴线A和B一般收敛轮毂径向向外。选择轴A和B之间的角度，使得当辊组件20被推动与轮胎90的胎面承载表面滚动接触时，轴线在轮胎下方的轮胎本体内相遇（允许折射效应）踏。这确保了该装置能够检测轮胎体内的缺陷，并且对胎面相对不敏感。

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