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1. 发明申请

US20070119814A1 APPARATUS AND METHOD FOR DETECTING AN ENDPOINT IN A VAPOR PHASE ETCH 审中-公开
标题翻译：用于检测蒸气相蚀刻中的端点的装置和方法
公开(公告)号：US20070119814A1
公开(公告)日：2007-05-31
申请号：US11627026
申请日：2007-01-25
申请人： Satyadev Patel , Gregory Schaadt , Douglas MacDonald , Niles MacDonald , Hongqin Shi
发明人： Satyadev Patel , Gregory Schaadt , Douglas MacDonald , Niles MacDonald , Hongqin Shi
IPC分类号： C03C25/68 , G01L21/30 , H01L21/306 , H01L21/461 , B44C1/22
CPC分类号： H01J37/32963 , B81C1/00476 , B81C1/00587 , B81C99/0065 , B81C2201/0132 , B81C2201/0138 , H01J37/32449 , H01J37/32935
摘要： Processes for the removal of a layer or region from a workpiece material by contact with a process gas in the manufacture of a microstructure are enhanced by the ability to accurately determine the endpoint of the removal step. A vapor phase etchant is used to remove a material that has been deposited on a substrate, with or without other deposited structure thereon. By creating an impedance at the exit of an etching chamber (or downstream thereof), as the vapor phase etchant passes from the etching chamber, a gaseous product of the etching reaction is monitored; and the endpoint of the removal process can be determined. The vapor phase etching process can be flow through, a combination of flow through and pulse, or recirculated back to the etching chamber
摘要翻译：通过与制造微结构中的工艺气体接触从工件材料去除层或区域的工艺通过精确地确定去除步骤的终点的能力增强。气相蚀刻剂用于去除已经沉积在基底上的材料，其上具有或不具有其它沉积结构。通过在蚀刻室（或其下游）的出口处产生阻抗，当气相蚀刻剂从蚀刻室通过时，监测蚀刻反应的气态产物; 并且可以确定去除过程的终点。气相蚀刻工艺可以流过，流过和脉冲的组合，或再循环回蚀刻室

2. 发明授权

US08501184B2 High affinity human antibodies to PCSK9 有权
标题翻译：对PCSK9的高亲和力人抗体
公开(公告)号：US08501184B2
公开(公告)日：2013-08-06
申请号：US12949846
申请日：2010-11-19
申请人： Mark W. Sleeman , Joel H. Martin , Tammy T. Huang , Douglas MacDonald
发明人： Mark W. Sleeman , Joel H. Martin , Tammy T. Huang , Douglas MacDonald
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21061
摘要： An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
摘要翻译：特异性结合并抑制人前体蛋白转化酶枯草杆菌蛋白酶/ kexin 9型（hPCSK9）的人抗体的人抗体或抗原结合片段，其特征在于能够在24,60或90天将血清LDL胆固醇降低40-80％相对于前期水平，血清HDL胆固醇几乎没有或没有降低和/或通过ALT和AST测量确定对肝功能具有很小或没有可测量的影响。

3. 发明申请

US20120069054A1 ELECTRONIC DISPLAY SYSTEMS HAVING MOBILE COMPONENTS 审中-公开
标题翻译：具有移动组件的电子显示系统
公开(公告)号：US20120069054A1
公开(公告)日：2012-03-22
申请号：US13320742
申请日：2010-05-12
申请人： Douglas MacDonald , Peter W. Hildebrandt , Dale Miller , William Christopher Pollitt , Robert J. Hawkins , Michael Boyle
发明人： Douglas MacDonald , Peter W. Hildebrandt , Dale Miller , William Christopher Pollitt , Robert J. Hawkins , Michael Boyle
IPC分类号： G09G5/00
CPC分类号： G06F3/03545 , G06F3/0321
摘要： Electronic display systems include mobile units for remotely modifying a displayed image. An electronic display system can include a display surface, a processing device, a mobile unit, and an input device. The display surface can receive and display an image rendered by the processing device. The display image on the display surface can be modified through interaction of the input device and the mobile unit. The input device can sense its position relative to the mobile unit and can transmit data relating to its position to the processing device. The processing device can interpret the position data as operations on the displayed image. Accordingly, the processing device can modify the displayed image on the display surface based on interactions between the input device and the mobile unit.
摘要翻译：电子显示系统包括用于远程修改显示图像的移动单元。电子显示系统可以包括显示面，处理装置，移动单元和输入装置。显示表面可以接收和显示由处理装置呈现的图像。可以通过输入设备和移动单元的交互来改变显示表面上的显示图像。输入设备可以感测其相对于移动单元的位置，并且可以将与其位置相关的数据传送到处理设备。处理装置可以将位置数据解释为对所显示的图像的操作。因此，处理装置可以基于输入装置和移动单元之间的交互来修改显示表面上的显示图像。

4. 发明申请

US20120064503A1 DISPLAY MOUNTING SYSTEMS 有权
标题翻译：显示安装系统
公开(公告)号：US20120064503A1
公开(公告)日：2012-03-15
申请号：US13320739
申请日：2010-05-13
申请人： John Helton , Peter W. Hildebrant , Michael Boyle , Douglas MacDonald , Paul A. Balogh , Dale Miller , Robert Bergman
发明人： John Helton , Peter W. Hildebrant , Michael Boyle , Douglas MacDonald , Paul A. Balogh , Dale Miller , Robert Bergman
IPC分类号： B43L1/00 , A47F5/00 , A47F5/08
CPC分类号： G09F7/04 , G09F7/18
摘要： Mounting systems can releasably secure display devices to preexisting surfaces for convenient installation and removal without external tools. A mounting system can comprise lower magnetic assemblies, upper magnetic assemblies, and a mounting sheet. The lower magnetic assemblies can be secured to a rear surface of a display device, for releasably attaching the display device to a preexisting surface. A bottom portion of the mounting sheet can be secured to the rear surface of the display device, while a top portion of the mounting sheet can remain loose from the rear surface. The upper magnetic assemblies can be provided along the loose top portion of the mounting sheet, for releasably attaching the display device to the preexisting surface. The upper magnetic assemblies can retain their connection to the preexisting surface as the display device is pulled away from the preexisting surface, until a threshold condition is met.
摘要翻译：安装系统可以将显示设备可释放地固定到预先存在的表面，以便在没有外部工具的情况下方便地安装和拆卸。安装系统可以包括下磁组件，上磁组件和安装板。下部磁性组件可以固定到显示装置的后表面，用于将显示装置可释放地附接到预先存在的表面。安装片的底部可以固定到显示装置的后表面，而安装片的顶部可以从后表面保持松动。上部磁性组件可以沿着安装片的松散的顶部设置，用于将显示装置可释放地附接到预先存在的表面。当显示装置从预先存在的表面拉开时，上部磁性组件可以保持它们与预先存在的表面的连接，直到满足阈值条件。

5. 发明申请

US20110065902A1 HIGH AFFINITY HUMAN ANTIBODIES TO PCSK9 有权
标题翻译：对PCSK9的高亲和力人体抗体
公开(公告)号：US20110065902A1
公开(公告)日：2011-03-17
申请号：US12949846
申请日：2010-11-19
申请人： Mark W. Sleeman , Joel H. Martin , Tammy T. Huang , Douglas MacDonald
发明人： Mark W. Sleeman , Joel H. Martin , Tammy T. Huang , Douglas MacDonald
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12Y304/21061
摘要： An human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human proprotein convertase subtilisin/kexin type 9 (hPCSK9) characterized by the ability to reduce serum LDL cholesterol by 40-80% over a 24, 60 or 90 day period relative to predose levels, with little or no reduction in serum HDL cholesterol and/or with little or no measurable effect on liver function, as determined by ALT and AST measurements.
摘要翻译：特异性结合并抑制人前体蛋白转化酶枯草杆菌蛋白酶/ kexin 9型（hPCSK9）的人抗体的人抗体或抗原结合片段，其特征在于能够在24,60或90天将血清LDL胆固醇降低40-80％相对于前期水平，血清HDL胆固醇几乎没有或没有降低和/或通过ALT和AST测量确定对肝功能具有很小或没有可测量的影响。

6. 发明申请

US20050149712A1 Post-install configuration of modules during startup of a modular application platform 失效
标题翻译：在模块化应用平台启动期间安装模块的安装后配置
公开(公告)号：US20050149712A1
公开(公告)日：2005-07-07
申请号：US10740319
申请日：2003-12-18
申请人： Melaquias Martinez , Douglas MacDonald , Thomas Guyette
发明人： Melaquias Martinez , Douglas MacDonald , Thomas Guyette
IPC分类号： G06F9/00 , G06F9/445
CPC分类号： G06F9/44505
摘要： Described is a configuration module useful for configuring modules of a modular application platform during run-time of the modular application platform. The configuration module produces a graphical dialog that displays a sequence of one or more configuration pages to a user to obtain from the user configuration information for each displayed configuration page. The configuration module defines an abstraction of a configuration page, and other modules of the modular application platform provide implementations of the configuration page abstraction to include at least one configuration page in the graphical dialog produced by the configuration module.
摘要翻译：描述了一种配置模块，用于在模块化应用平台的运行期间配置模块化应用平台的模块。配置模块产生图形对话框，其向用户显示一个或多个配置页面的序列，以从每个显示的配置页面的用户配置信息中获得。配置模块定义了配置页面的抽象，模块化应用程序平台的其他模块提供了配置页面抽象的实现，以在配置模块生成的图形对话框中包括至少一个配置页面。

7. 发明申请

US20060236625A1 Panel system 审中-公开
公开(公告)号：US20060236625A1
公开(公告)日：2006-10-26
申请号：US11438346
申请日：2006-05-22
申请人： Douglas MacDonald , Steven Sanders , Mark Slager , Dean Hubbard , Roy Fink , Steven Throndset , David Battey , Robert Jeffers , Allen Hager
发明人： Douglas MacDonald , Steven Sanders , Mark Slager , Dean Hubbard , Roy Fink , Steven Throndset , David Battey , Robert Jeffers , Allen Hager
IPC分类号： E04H1/00
CPC分类号： E04B2/7425 , E04B2002/7418 , E04B2002/7446 , E04B2002/7462 , E04B2002/7483 , E04B2002/7487 , E04B2002/7488 , E04B2002/749
摘要： An office panel partition includes a panel frame having at least two uprights and a horizontal structural member rigidly interconnecting the uprights. The panel frame has a first side and a second opposite side, and the panel frame defines at least four apertures on the first side thereof. The partition also includes a cover member having a major planar surface defining an exterior surface of the partition. The cover member includes at least four projections that are removably insertable into the at least four apertures to removably secure the cover member to the frame. The apertures are arranged in at least two vertically spaced horizontal rows and at least two horizontally spaced vertical columns. The apertures in a first one of the columns have different horizontal dimensions than those of the apertures located in the other of the columns. Each of the projections has a range of lateral positions when inserted into a respective one of the apertures. The range of lateral positions provided by the apertures in the first one of the columns is less than the range of lateral positions provided by the apertures in the other row of the columns. The apertures located in a first one of the rows has vertical dimensions that are different than those located in the other of the rows. The range of vertical positions provided by the apertures in the first one of the rows is less than the range of vertical positions provided by the apertures in the other of the rows.

8. 发明授权

US08889716B2 Transglutaminase TG2 inhibitors, pharmaceutical compositions, and methods of use thereof 有权
标题翻译：转谷氨酰胺酶TG2抑制剂，药物组合物及其使用方法
公开(公告)号：US08889716B2
公开(公告)日：2014-11-18
申请号：US13466018
申请日：2012-05-07
申请人： Michael Prime , Stephen Martin Courtney , Richard Marston , Celia Dominguez , Douglas MacDonald , John Wityak
发明人： Michael Prime , Stephen Martin Courtney , Richard Marston , Celia Dominguez , Douglas MacDonald , John Wityak
IPC分类号： A61K31/445 , C07D211/96 , C07D409/12 , C07D205/04 , C07D405/12 , C07D405/14 , C07D207/48 , C07D401/14 , C07D401/12
CPC分类号： C07D205/04 , C07D207/48 , C07D211/96 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12
摘要： Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.
摘要翻译：本文提供了某些化合物和药学上可接受的盐。还提供了包含至少一种化合物或其药学上可接受的盐的药物组合物和一种或多种药学上可接受的载体。描述了治疗患有某种疾病状态的患者对抑制转谷氨酰胺酶TG2活性有反应的方法。这些疾病状态包括神经变性疾病如亨廷顿病。还描述了治疗方法，包括给予至少一种化合物或其药学上可接受的盐作为单一活性剂，或者与一种或多种其它治疗剂组合施用至少一种化合物或其药学上可接受的盐。

9. 发明申请

US20120162870A1 CONVENIENTLY ASSEMBLABLE INTERACTIVE SYSTEMS 失效
标题翻译：便捷的可组合交互系统
公开(公告)号：US20120162870A1
公开(公告)日：2012-06-28
申请号：US13168627
申请日：2011-06-24
申请人： Douglas MacDonald , John Helton , Dale Miller , Michael Boyle , Peter W. Hildebrandt , Johnny Fuglsang Jessen , Edgar B. Montague , JeanLuc Camarda , Heinrik Soerensen Prang
发明人： Douglas MacDonald , John Helton , Dale Miller , Michael Boyle , Peter W. Hildebrandt , Johnny Fuglsang Jessen , Edgar B. Montague , JeanLuc Camarda , Heinrik Soerensen Prang
IPC分类号： H05K7/00 , B65B13/00
CPC分类号： F16M11/42 , F16M11/08 , F16M11/18 , F16M11/24 , G03B21/10 , G03B21/132 , G03B21/145 , G03B21/30 , G06F3/0321 , G06F3/03545
摘要： Interactive systems can include various components that are packaged together and easily assemblable. An interactive system can comprise a mount, a display device, a projector, an input device, and a processing device. The display device, the projector, the input device, and the processing device can together provide an electronic display system, while the mount can carry these other various components and assist in connecting them to one another. The mount and the other components of the interactive system can be conveniently packaged and sold as group for convenient installation by one or two persons.
摘要翻译：交互式系统可以包括封装在一起并易于组装的各种组件。交互式系统可以包括安装件，显示装置，投影仪，输入装置和处理装置。显示装置，投影仪，输入装置和处理装置可以一起提供电子显示系统，而安装件可以携带这些其他各种部件并且有助于彼此连接。交互式系统的安装和其他部件可以方便地进行组装和出售，方便一人或两人安装。

10. 发明授权

US08053458B2 Dipyrazole compounds and their use as central nervous system agents 失效
标题翻译：二吡唑类化合物及其作为中枢神经系统药物的用途
公开(公告)号：US08053458B2
公开(公告)日：2011-11-08
申请号：US11855521
申请日：2007-09-14
申请人： Raymond W. Kosley , Douglas MacDonald , Rosy Sher
发明人： Raymond W. Kosley , Douglas MacDonald , Rosy Sher
IPC分类号： A61K31/455 , C07D231/26
CPC分类号： C07D401/14 , C07D231/22 , C07D231/26
摘要： The present invention is directed to dipyrazole compounds of formula I and their pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I. The compounds of this invention modulate AMPA and NMDA receptor function, and therefore are useful as pharmaceutical agents, especially for the treatment of neuropsychiatric disorders.
摘要翻译：本发明涉及式I的二吡唑化合物及其药学上可接受的盐，立体异构体，互变异构体或溶剂化物。新型化合物包括式I化合物。本发明化合物调节AMPA和NMDA受体功能，因此可用作药剂，特别是用于治疗神经精神障碍。

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