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    • 1. 发明授权
    • Particle pattern judging method
    • 粒子模式判断方法
    • US5389555A
    • 1995-02-14
    • US80592
    • 1993-06-24
    • Haruhisa WatanabeSatoshi TanakaShinya MatsuyamaKeita Sembu
    • Haruhisa WatanabeSatoshi TanakaShinya MatsuyamaKeita Sembu
    • G01N21/75G01N33/80
    • G01N21/75G01N33/80Y10S436/805
    • Particle pattern judging method in which a particle pattern formed on the bottom surface of a reaction vessel by an immunological agglutinated reaction is measured in an optical manner; a variation ratio of light intensity of the border of the particle pattern is obtained and the particle pattern is judged whether it is agglutinated or not on the basis of the variation ratio: or a two-dimensional image of the particle pattern is picked up; the two-dimensional image of the particle pattern is differentiated to obtain differentiated values concerning pixel compositions consisting of the particle pattern; and the particle pattern is judged whether it is agglutinated or not on the basis of a distribution of the thus obtained differentiated values. By the method according to the invention, it is possible to judge whether the particle pattern is agglutinated or not in an exact manner, even when bubbles are included in the particle pattern, or the particle pattern is destroyed, or the particle pattern is torn or the agglutinating force of the particle pattern is weak.
    • 以光学方式测量通过免疫凝集反应形成在反应容器的底面上的粒子图案的粒子图案判断方法; 获得粒子图案的边界的光强度的变化率,并根据变化比判断粒子图案是否凝集,或者取出粒子图案的二维图像; 将粒子图案的二维图像分化以获得关于由粒子图案组成的像素组成的差分值; 并且基于由此获得的微分值的分布来判断粒子图案是否凝集。 通过根据本发明的方法,即使在颗粒图案中包含气泡或者颗粒图案被破坏或者颗粒图案被撕裂或者颗粒图案被撕裂或者颗粒图案被破坏,也可以以精确的方式判断颗粒图案是否凝集 粒子图案的凝集力弱。
    • 3. 发明授权
    • Method for automatic chemical analyzing
    • 自动化学分析方法
    • US5116765A
    • 1992-05-26
    • US510883
    • 1990-04-18
    • Haruhisa WatanabeSatoshi TanakaShinya Matsuyama
    • Haruhisa WatanabeSatoshi TanakaShinya Matsuyama
    • G01N21/82G01N33/53G01N35/00G01N35/02
    • G01N33/5304G01N21/82G01N35/00G01N2201/0446G01N2201/0461G01N35/028
    • A method for detecting and measuring the image of an agglutination particle pattern produced in a test liquid in which the existence of hemolysis in a test liquid is judged at the same time as an analysis is conducted of particle patterns produced in the test liquid in response to an immunological agglutination reaction. By this method, it is possible to increase the precision of the analysis of the particle pattern by feeding back the result of the judgement of the existence of hemolysis in the test liquid. A reaction apparatus suitable for use in the method according to the invention is also disclosed. In this apparatus, a plurality of wells for containing the test liquid are formed, and a plurality of marks are formed in positions where the marks can be read through the test liquid by an optical system for detecting the particle patterns produced in the test liquid. Therefore, hemolysis existing in the test liquid can be objectively judged.
    • 用于检测和测量在测试液体中产生的凝集颗粒图案的图像,其中在与测试液体同时判断在测试液体中溶血的存在的同时进行响应于测试液体中产生的颗粒图案 免疫凝集反应。 通过该方法,可以通过反馈检测液中溶血存在的判断结果来提高粒子图案的分析精度。 还公开了适用于根据本发明的方法的反应装置。 在该装置中,形成容纳测试液体的多个孔,并且通过用于检测在测试液中产生的颗粒图案的光学系统通过测试液体读取标记的位置形成多个标记。 因此,可以客观地判断存在于测试液中的溶血。
    • 4. 发明授权
    • Particle agglutination pattern judgment method
    • 粒子凝集图案判断方法
    • US5225350A
    • 1993-07-06
    • US941752
    • 1992-09-03
    • Haruhisa WatanabeSatoshi TanakaShinya Matuyama
    • Haruhisa WatanabeSatoshi TanakaShinya Matuyama
    • G01N21/82G06K9/62
    • G01N21/82G06K9/6217Y10T436/11
    • Particle pattern images of the sample are optically measured by an image reader of a particle agglutination pattern judgment apparatus, and the measured particle pattern images are retrieved by a data processing controller to be able to execute pattern judgment processing. The data processing controller obtains predetermined parameters on the basis of the particle pattern images read by the image reader, and automatically judges an agglutination, non-agglutination, or unidentified attribute of each particle pattern on the basis of the obtained parameters. An operator visually observes the particle pattern images of the sample to visually determine an agglutination, non-agglutination, or unidentified attribute of each particle pattern of the sample. The operator inputs the visual judgment results in the particle agglutination pattern judgment apparatus using an input unit. The data processing controller changes at least one of the automatic judgment results and a threshold value according to the input visual judgment results.
    • 通过粒子凝集图案判断装置的图像读取器对样品的粒子图像进行光学测量,并且通过数据处理控制器检索测量的粒子图像图像,以能够执行图案判断处理。 数据处理控制器基于由图像读取器读取的粒子图案图像获得预定参数,并且基于获得的参数自动判断每个粒子图案的凝集,非凝集或未识别的属性。 操作者可视地观察样品的颗粒图案图像,目视确定样品的每个颗粒图案的凝集,非凝集或不明确的属性。 操作者使用输入单元在粒子凝集图案判断装置中输入视觉判断结果。 数据处理控制器根据输入的视觉判断结果改变自动判断结果和阈值中的至少一个。