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1. 发明授权

US5510511A Process for preparing N,O-dialkylhydroxylamine, its salts or intermediates in their synthesis 失效
标题翻译：在其合成中制备N，O-二烷基羟胺，其盐或中间体的方法
公开(公告)号：US5510511A
公开(公告)日：1996-04-23
申请号：US97225
申请日：1993-07-27
申请人： Satoshi Inoki , Mitsuyuki Takesue , Isao Hashimoto , Noriaki Kihara , Kiyoaki Sugi
发明人： Satoshi Inoki , Mitsuyuki Takesue , Isao Hashimoto , Noriaki Kihara , Kiyoaki Sugi
IPC分类号： C07C239/20 , C07C271/12 , C07C261/00
CPC分类号： C07C271/12 , C07C239/20
摘要： A process for preparing N,O-dialkylhydroxycarbamic acid ester which comprises reacting hydroxylamine or its salt with dihydrocarbyl carbonate in the presence of a basic compound to prepare hydroxycarbamic acid ester and subsequently alkylating this compound with an alkylating agent; a process for recovering N,O-dialkylhydroxycarbamic acid ester which comprises azeotropically distilling the ester with water from a solution containing the ester; a process for preparing N,O-dialkylhydroxylamine which comprises hydrolyzing N,O-dialkylhydroxycarbamic acid ester in an aqueous solution or a hydrous solvent in the presence of an alkali; a process for purifying N,O-dialkylhydroxylamine hydrochloride which comprises adding aldehyde or ketone to a solution of N,O-dialkylhydroxylamine hydrochloride containing O-alkylhydroxylamine hydrochloride as impurities to convert the O-alkylhydroxylamine hydrochloride into O-alkyl aldoxime or O-alkyl ketoxime and subsequently separating the N,O-dialkylhydroxylamine hydrochloride from the reaction system; and a process for separating N,O-dialkylhydroxylamine hydrochloride which comprises (i) adding benzene or alkylated benzene to an aqueous solution containing N,O-dialkylhydroxylamine hydrochloride, azeotropically removing water or a hydrochloride solution, and, subsequently (ii)adding alcohol thereto to obtain N,O-dialkylhydroxylamine hydrochloride in the form of crystal.
摘要翻译：一种制备N，O-二烷基羟基氨基甲酸酯的方法，其包括使羟胺或其盐与二烃基碳酸酯在碱性化合物的存在下反应以制备羟基氨基甲酸酯，随后用烷基化剂烷基化该化合物; 一种回收N，O-二烷基羟基氨基甲酸酯的方法，该方法包括从含有酯的溶液中用水共沸蒸馏该酯; 一种制备N，O-二烷基羟胺的方法，其包括在碱存在下水溶液或含水溶剂中N，O-二烷基羟基氨基甲酸酯水解; 一种纯化N，O-二烷基羟胺盐酸盐的方法，其包括将醛或酮加入到含有O-烷基羟胺盐酸盐的N，O-二烷基羟胺盐酸盐的溶液中作为杂质，以将O-烷基羟胺盐酸盐转化为O-烷基羟基肟或O-烷基酮肟随后从反应体系中分离出N，O-二烷基羟胺盐酸盐; 以及分离N，O-二烷基羟胺盐酸盐的方法，其包括（i）将苯或烷基化苯加入到含有N，O-二烷基羟胺盐酸盐的水溶液中，共沸除去水或盐酸盐溶液，随后（ii）向其中加入醇得到晶体形式的N，O-二烷基羟胺盐酸盐。

2. 发明授权

US5147876A 2,6-di,2,4,6-, 2,5,6-tri and 2,4,5,6-tetra-substituted pyrimidines, their pharmaceutically acceptable salts, pharmaceutical compositions containing same and their use in the treatment of neurological diseases 失效
标题翻译： 2,6-DI，2,4,6-，2,5,6-TRI和2,4,5,6-四取代的吡咯烷酮，它们的药物接受性盐，含有它们的药物组合物及其在治疗中的用途神经病
公开(公告)号：US5147876A
公开(公告)日：1992-09-15
申请号：US459376
申请日：1989-12-29
申请人： Akira Mizuchi , Kazutoshi Horikomi , Tadayuki Sasaki , Akira Awaya , Ikuo Tomino , Mitsuyuki Takesue , Noriaki Kihara
发明人： Akira Mizuchi , Kazutoshi Horikomi , Tadayuki Sasaki , Akira Awaya , Ikuo Tomino , Mitsuyuki Takesue , Noriaki Kihara
IPC分类号： C07D213/75 , C07D239/28 , C07D239/48 , C07D401/04 , C07D401/12 , C07D405/14 , C07D409/12 , C07D453/02 , C07D487/04
CPC分类号： C07D213/75 , C07D239/28 , C07D239/48 , C07D401/04 , C07D401/12 , C07D405/14 , C07D409/12 , C07D453/02 , C07D487/04
摘要： 2,6-di-, 2,4,6-, 2,5,6-tri- or 2,4,5,6-tetra-substituted pyrimidines, and 2,6-di-substituted pyridines. These compounds are useful for treatment of neurological diseases.

3. 发明授权

US4973588A Imidazole derivatives having anti-hypoxia properties 失效
标题翻译：具有抗缺氧性的咪唑衍生物
公开(公告)号：US4973588A
公开(公告)日：1990-11-27
申请号：US308523
申请日：1989-02-10
申请人： Noriaki Kihara , Ikuo Tomino , Mitsuyuki Takesue , Takafumi Ishihara
发明人： Noriaki Kihara , Ikuo Tomino , Mitsuyuki Takesue , Takafumi Ishihara
IPC分类号： C07D233/60 , A61K31/415 , A61K31/44 , A61K31/4427 , A61P25/28 , C07D233/54 , C07D233/61 , C07D233/64 , C07D233/84 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D513/04
CPC分类号： C07D233/54 , C07D233/84 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D513/04
摘要： A novel N-substituted imidazole or thioimidazole derivative and a pharmacologically acceptable acid addition salt thereof, which have a brain function-improving action, are disclosed. The derivative or salt is used as an effective ingredient of a brain function-improving medicine.
摘要翻译：公开了具有脑功能改善作用的新型N-取代咪唑或硫代咪唑衍生物及其药理学上可接受的酸加成盐。衍生物或盐被用作脑功能改善药物的有效成分。

4. 发明授权

US4808726A Process for preparation of guanidine derivative 失效
标题翻译：胍衍生物的制备方法
公开(公告)号：US4808726A
公开(公告)日：1989-02-28
申请号：US91849
申请日：1987-09-01
申请人： Isao Hashimoto , Ikuo Tomino , Houji Kato , Noriaki Kihara , Teruaki Mukaiyama
发明人： Isao Hashimoto , Ikuo Tomino , Houji Kato , Noriaki Kihara , Teruaki Mukaiyama
IPC分类号： C07D233/54 , C07D233/64
CPC分类号： C07D233/64
摘要： N-cyano-N'-methyl-N"-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidine (Cimetidine), which is valuable as an agent for controlling secretion of gastric acid, is prepared in a high yield by reacting N-cyano-N'-methyl-N"-(2-(butane-2,3-dionyl)thioethyl)-guanidine as the starting compound with an ammonium salt of a carboxylic acid and formaldehyde.

5. 发明申请

US20120155524A1 PULSE SIGNAL RECEIVING APPARATUS AND TRANSMISSION SYSTEM 有权
标题翻译：脉冲信号接收装置和传输系统
公开(公告)号：US20120155524A1
公开(公告)日：2012-06-21
申请号：US13313887
申请日：2011-12-07
申请人： Yoshio YOSHIDA , Noriaki Kihara
发明人： Yoshio YOSHIDA , Noriaki Kihara
IPC分类号： H03K7/08 , H04B17/00 , H03K9/08
CPC分类号： H04L25/4902 , H01L2924/0002 , H04L25/03834 , H01L2924/00
摘要： A pulse signal receiving apparatus may include a reception unit that receives a pulse signal modulated by a double-edge modulation scheme, a measurement unit that measures an edge interval of the pulse signal, which has been received by the reception unit, a detection unit that detects a deviation of the edge interval, which has been measured by the measurement unit, for a pulse-width reference value indicating a reference value of a width of the pulse signal, a correction unit that corrects the edge interval, which is to be measured next by the measurement unit, by using the deviation, which has been detected by the detection unit, and a decoding unit that decodes the pulse signal, of which the edge interval has been corrected by the correction unit, so as to output a digital signal.
摘要翻译：脉冲信号接收装置可以包括接收由双边缘调制方式调制的脉冲信号的接收单元，测量单元，其测量由接收单元接收的脉冲信号的边缘间隔;检测单元，检测由测量单元测量的边缘间隔的偏差，对于指示脉冲信号的宽度的参考值的脉冲宽度参考值，修正要测量的边缘间隔的校正单元接下来由测量单元通过使用由检测单元检测到的偏差和解码单元，其解码由校正单元校正了边缘间隔的脉冲信号，以便输出数字信号。

6. 发明申请

US20110062943A1 TIMING DETECTION DEVICE 有权
标题翻译：时序检测装置
公开(公告)号：US20110062943A1
公开(公告)日：2011-03-17
申请号：US12882727
申请日：2010-09-15
申请人： Noriaki Kihara , Shunsuke Hayashi , Kenji Habaguchi , Takayuki Ooshima
发明人： Noriaki Kihara , Shunsuke Hayashi , Kenji Habaguchi , Takayuki Ooshima
IPC分类号： G01R23/02
CPC分类号： H04L7/033 , H03K5/01 , H03K5/1252 , H04L7/0087 , H04L25/063
摘要： A timing detection device includes a draw back amount acquiring unit and a detecting unit. The draw back amount acquiring unit is configured to acquire a draw back amount of a received signal with respect to a peak value of the signal. The detecting unit is configured to detect the timing at which the draw back amount acquired by the draw back amount acquiring unit has exceeded a constant value as the timing at which a value of the signal is switched.
摘要翻译：定时检测装置包括抽取量获取单元和检测单元。拉出量获取单元被配置为相对于该信号的峰值获取接收信号的回退量。检测单元被配置为检测由缩回量获取单元获取的回退量已超过常数值的定时，作为切换信号值的定时。

7. 发明申请

US20070289690A1 Method for manufacturing a ceramic stack 审中-公开
标题翻译：制造陶瓷叠层的方法
公开(公告)号：US20070289690A1
公开(公告)日：2007-12-20
申请号：US11808977
申请日：2007-06-14
申请人： Eturo Yasuda , Noriaki Kihara , Hirokatsu Mukai , Daisuke Makino
发明人： Eturo Yasuda , Noriaki Kihara , Hirokatsu Mukai , Daisuke Makino
IPC分类号： C03B29/00
CPC分类号： B32B18/00 , C04B35/632 , C04B35/64 , C04B35/645 , C04B2235/9607 , C04B2235/9615 , C04B2237/343
摘要： A method for manufacturing a ceramic stack is provided, which can suppress distortion, separation, cracking and the like that may be caused in plural types of ceramic sheets after being stacked and baked for integration. The method includes a step of obtaining a relation between volume rates of organic materials contained in the ceramic sheets and baking shrinkages of the sheets, resulting from baking the sheets at a predetermined temperature, a step of selecting a volume rate of organic materials for each of the ceramic sheets based on the relation obtained at the previous step, so that all the sheets may have substantially the same baking shrinkage as desired, a step of forming the plural types of ceramic sheets based on the volume rate selected at the previous step, and a step of stacking and baking for integration the plural types of ceramic sheets to fabricate a ceramic stack.
摘要翻译：提供了一种制造陶瓷堆叠的方法，其可以抑制在堆叠和烘烤一体化之后可能在多种类型的陶瓷片中引起的变形，分离，开裂等。该方法包括获得陶瓷片中所含的有机材料的体积率与片材的烘烤收缩率之间的关系的步骤，其是在预定温度下对片材进行烘烤而得到的步骤，选择有机材料的体积比为基于上述步骤获得的关系，使得所有的片材可以具有基本上相同的烘烤收缩率，基于在前一步骤选择的体积率形成多种陶瓷片材的步骤，以及堆叠和烘烤用于整合多种类型的陶瓷片以制造陶瓷叠层的步骤。

8. 发明授权

US4973703A Process for purification of N-cyano-N'-methyl-N"-(2-((5-methyl-1Himidazol-4-yl)methylthio)ethyl)guan idine 失效
标题翻译：纯化N-氰基-N'-甲基-N“ - （2 - （（5-甲基-1H-咪唑-4-基）甲硫基）乙基）胍的方法
公开(公告)号：US4973703A
公开(公告)日：1990-11-27
申请号：US267379
申请日：1988-11-04
申请人： Junichi Imuta , Noriaki Kihara , Takeshi Ishitoku
发明人： Junichi Imuta , Noriaki Kihara , Takeshi Ishitoku
IPC分类号： C07D233/54 , C07D233/64
CPC分类号： C07D233/64
摘要： A process for the purification of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylthio}-ethyl]guanidine, which comprises bringing a crude product of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)-methylthio}ethyl]guanidine into contact with activated carbon in water in the presence of an organic acid.

9. 发明授权

US4886910A Cyanoguanidine derivative and process for preparation thereof 失效
公开(公告)号：US4886910A
公开(公告)日：1989-12-12
申请号：US156658
申请日：1988-02-17
申请人： Hiroaki Tan , Koji Kato , Junichi Imuta , Noriaki Kihara
发明人： Hiroaki Tan , Koji Kato , Junichi Imuta , Noriaki Kihara
IPC分类号： C07C319/20 , C07C67/00 , C07C313/00 , C07C323/44 , C07D233/54 , C07D233/64
CPC分类号： C07D233/64 , C07C323/44
摘要： The present invention provides a cyanoguanidine derivtive which is a precursor for the synthesis of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylothio}ethyl]-guanidine (Cimetidine) or its relted compound, which has an action of controlling secretion of acid in the stomach based on the histamine H.sub.2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting a haloketone derivative with an ammonium salt and a lower fatty acid salt or by reacting other cyanoguanidine derivative with an ammonium salt.

10. 发明授权

US07819996B2 Method of manufacturing ceramic sheet and method of manufacturing gas sensing element 有权
标题翻译：制造陶瓷片的方法和制造气体传感元件的方法
公开(公告)号：US07819996B2
公开(公告)日：2010-10-26
申请号：US11976735
申请日：2007-10-26
申请人： Eturo Yasuda , Noriaki Kihara , Daisuke Makino , Makoto Shirai , Hirokatsu Mukai , Takumi Ushikubo
发明人： Eturo Yasuda , Noriaki Kihara , Daisuke Makino , Makoto Shirai , Hirokatsu Mukai , Takumi Ushikubo
IPC分类号： C03B29/00 , A61F13/15 , B29C65/00 , C04B38/00
CPC分类号： C04B38/0074 , B32B18/00 , C04B35/111 , C04B35/46 , C04B35/486 , C04B35/6264 , C04B35/632 , C04B35/6342 , C04B2235/3217 , C04B2235/5445 , C04B2235/5472 , C04B2235/6025 , C04B2235/604 , C04B2235/77 , C04B2237/343 , C04B2237/348 , C04B2237/62 , C04B2237/86 , C04B35/00
摘要： Methods of manufacturing a ceramic sheet and a gas sensing element are disclosed. At least ceramic powder, a binder and a plasticizer are blended and mixed in slurry. The slurry is formed into unfired green sheets, on which paste is printed. Each of the unfired green sheets has porosity greater than 5%. In the manufacturing methods, the unfired green sheets are pressurized with a pressure of 10 MPa at a temperature above 60° C., after which the paste is printed on surfaces of the unfired green sheets. In the method of manufacturing the gas sensing element, a shielding layer, a porous diffusion resistance layer and the unfired green sheets for a sensing layer, a reference gas airspace forming layer and a heating layer are stacked to form a stacked ceramic body, whish is fired to obtain the gas sensing element.
摘要翻译：公开了制造陶瓷片和气体感测元件的方法。将至少陶瓷粉末，粘合剂和增塑剂混合并在浆料中混合。将浆料形成未印刷的生片，印刷糊状物。每个未生坯的生片具有大于5％的孔隙率。在制造方法中，将未烧成的生片在10℃以上的压力下在60℃以上的压力下进行加压，然后将糊状物印刷在未烧成的生片的表面上。在制造气体感测元件的方法中，层叠有屏蔽层，多孔扩散电阻层和用于感测层的未烧成的生片，参考气体空间形成层和加热层，以形成堆叠的陶瓷体，燃烧以获得气体感测元件。

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