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1. 发明授权

US4482485A Method of preparation of human urine origin colony-stimulating factor and kallikrein 失效
标题翻译：制备人尿起源菌群刺激因子和激肽释放酶的方法
公开(公告)号：US4482485A
公开(公告)日：1984-11-13
申请号：US568259
申请日：1984-01-04
申请人： Satoshi Funakoshi , Kazuo Morimoto , Morio Kuboyama , Nobuya Yanai , Muneo Yamada , Hajime Yokota
发明人： Satoshi Funakoshi , Kazuo Morimoto , Morio Kuboyama , Nobuya Yanai , Muneo Yamada , Hajime Yokota
IPC分类号： C07K14/195 , A61K35/22 , A61K38/00 , A61K38/16 , A61K38/48 , C07K14/005 , C07K14/52 , C07K14/53 , C12N9/64 , C07G7/00
CPC分类号： C12N9/6445 , A61K35/22 , Y10S514/929 , Y10S530/834
摘要： Human urine-origin colony-stimulating factor and kallikrein are separated in pure form, respectively, from an aqueous solution thereof, such as a urinary protein-concentrated solution by subjecting the solution added with a stabilizer such as octyl-phenoxypolyethoxyethanaol or polyethylene glycol both having a molecular weight of 1,000-10,000, to high-performance gel filtration effective in molecular exclusive limit of 10.sup.5 -5.times.10.sup.5 as determined with globular protein.
摘要翻译：人尿起源的集落刺激因子和激肽释放酶分别以其形式从其水溶液例如尿蛋白浓缩溶液中分离，通过使添加有稳定剂的溶液，例如辛基 - 苯氧基聚乙氧基乙醇或聚乙二醇，其均具有分子量为1,000-10,000，以高效凝胶过滤效果，分子量极限为105-5×105，用球状蛋白质测定。

2. 发明授权

US4230697A Virus-inactivated HGI-glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same 失效
标题翻译：能够刺激人粒细胞增殖和分化的病毒灭活的HGI-糖蛋白，其制备方法和含有其的白细胞减少症
公开(公告)号：US4230697A
公开(公告)日：1980-10-28
申请号：US37515
申请日：1979-05-09
申请人： Masayuki Nishida , Satoshi Funakoshi , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada
发明人： Masayuki Nishida , Satoshi Funakoshi , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada
IPC分类号： A61K35/22 , A61K38/00 , C07K14/52 , A61K37/00 , C07C103/52
CPC分类号： A61K35/22 , C07K14/52 , A61K38/00 , Y10S530/83 , Y10S530/834 , Y10S530/851
摘要： A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinity chromatography with sugar affinitive adsorbents and electrophoresis. This substance is stable in the presence of a stabilizer such as albumin or urinary proteins, against heat-treatment of virus-inactivation and can be used as a leukopenia curative which is precluded from fear of virus-infection.
摘要翻译：具有确定的物理和化学性质以及刺激人骨髓细胞活性增殖和分化，从而形成粒细胞集落的功能的集落刺激因子通过浓缩尿液相对于其中所含蛋白质的吸附色谱从人尿中获得用硅胶盐析，用硫酸铵等方法盐析，然后通过阳离子交换器上的吸附除去杂质，进一步通过阴离子交换柱上的离子交换色谱，高度交联凝胶的凝胶过滤色谱，糖亲和性吸附剂的亲和层析和电泳进行纯化。这种物质在稳定剂如白蛋白或尿蛋白存在下是稳定的，用于病毒灭活的热处理，并且可以用作免于病毒感染的白细胞减少症治疗剂。

3. 发明授权

US4342828A Method for producing substance capable of stimulating differentiation and proliferation of human granulopoietic stem cells 失效
标题翻译：能够刺激人造粒干细胞分化和增殖的物质生产方法
公开(公告)号：US4342828A
公开(公告)日：1982-08-03
申请号：US169107
申请日：1980-07-15
申请人： Fumimaro Takaku , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada , Yoshiteru Watanabe
发明人： Fumimaro Takaku , Katsuhiro Ogasa , Morio Kuboyama , Nobuya Yanai , Muneo Yamada , Yoshiteru Watanabe
IPC分类号： A61K38/00 , C07K14/535 , C12N1/38 , C12N5/00 , C12P19/26
CPC分类号： C12N1/38 , C07K14/535 , A61K38/00
摘要： A colony stimulating factor effective in treating human granulocytopenia is produced by cultivating monocytes and macrophages isolated from the human peripheral blood in a synthetic medium for tissue culture containing a glycoprotein isolated from human urine and capable of stimulating the formation of human granulocytes or mouse macrophages and granulocytes.
摘要翻译：有效治疗人粒细胞减少症的集落刺激因子是通过在含有从人尿中分离出来的糖蛋白的组织培养物的合成培养基中培养从人外周血中分离的单核细胞和巨噬细胞产生的，并且能够刺激人粒细胞或小鼠巨噬细胞和粒细胞的形成。

4. 发明授权

US5288487A Human monocyte-macrophage-CSF preparations 失效
标题翻译：人单核细胞 - 巨噬细胞CSF制剂
公开(公告)号：US5288487A
公开(公告)日：1994-02-22
申请号：US789431
申请日：1991-11-06
申请人： Takuji Kawashima , Nobuya Yanai , Muneo Yamada , Hajime Yokota , Kunio Ujiie , Katsuo Yoshida , Shinya Suzu , Fumimaro Takaku , Kazuo Motoyoshi , Nobuhiro Yamada
发明人： Takuji Kawashima , Nobuya Yanai , Muneo Yamada , Hajime Yokota , Kunio Ujiie , Katsuo Yoshida , Shinya Suzu , Fumimaro Takaku , Kazuo Motoyoshi , Nobuhiro Yamada
IPC分类号： A61K38/19 , A61K47/26 , A61K47/42 , C07K15/00 , A61K45/05
CPC分类号： A61K47/42 , A61K38/193 , A61K47/26
摘要： Human M-CSF preparations and recombinant human M-CSF preparations against myelodysplastic syndrome, malignant tumor and hyperlipemia and auxiliary therapeutic preparations to be dosed along with platinum-complex anticancer preparations.
摘要翻译：人M-CSF制剂和针对骨髓增生异常综合征，恶性肿瘤和高脂血症的重组人M-CSF制剂和与铂复合物抗癌制剂一起给药的辅助治疗制剂。

5. 发明授权

US4275056A HGI-Glycoprotein capable of stimulating proliferation and differentiation of human granulocyte, process for preparing same and leukopenia curative containing same 失效
标题翻译： HGI-能够刺激人粒细胞增殖和分化的糖蛋白，其制备方法和含有其的白细胞减少症
公开(公告)号：US4275056A
公开(公告)日：1981-06-23
申请号：US22594
申请日：1979-03-19
申请人： Fumimaro Takaku , Katsuhiro Ogasa , Morio Kuboyama , Minoru Saito , Nobuya Yanai , Masayuki Nishida
发明人： Fumimaro Takaku , Katsuhiro Ogasa , Morio Kuboyama , Minoru Saito , Nobuya Yanai , Masayuki Nishida
IPC分类号： C07K1/22 , A61K35/22 , A61K38/00 , A61K38/16 , A61P7/00 , A61P35/02 , A61P37/00 , A61P43/00 , C07G99/00 , C07K14/00 , C07K14/52 , G01N33/50 , C07G7/00
CPC分类号： C07K14/52 , A61K35/22 , A61K38/00 , Y10S530/834
摘要： A colony-stimulating factor having definite physical and chemical properties and a function of stimulating activity on human bone marrow cells to proliferate and differentiate, thereby forming granulocyte colonies, is obtained from human urine by concentrating the urine with respect to proteins contained therein by adsorption chromatography with silica gel, salting out with ammonium sulfate and other means, then removing impurities by adsorption on cation exchanger, and further purifying by ion exchanging chromatography on anion exchanger, gel filtrating chromatography with highly crosslinked gels, affinitive chromatography with sugar affinitire adsorbents and electrophoresis.
摘要翻译：具有确定的物理和化学性质以及刺激人骨髓细胞活性增殖和分化，从而形成粒细胞集落的功能的集落刺激因子通过浓缩尿液相对于其中所含蛋白质的吸附色谱从人尿中获得用硅胶盐析，用硫酸铵等手段进行盐析，然后通过阳离子交换器吸附除去杂质，并进一步通过阴离子交换层析离子交换色谱，高度交联凝胶的凝胶过滤层析，糖亲和吸附剂亲和色谱和电泳进行纯化。

6. 发明申请

US20050250703A1 Antioxidant constituents 有权
标题翻译：抗氧化成分
公开(公告)号：US20050250703A1
公开(公告)日：2005-11-10
申请号：US11118368
申请日：2005-05-02
申请人： Nobuya Yanai , Shigenobu Shiotani , Satoshi Kanazawa
发明人： Nobuya Yanai , Shigenobu Shiotani , Satoshi Kanazawa
IPC分类号： A61K31/198 , A61K31/235 , A61K31/375 , A61K38/04 , A61K38/05 , A61K38/06
CPC分类号： A61K38/05 , A61K31/198 , A61K31/235 , A61K31/375 , A61K38/063 , A61K2300/00
摘要： An object of the present invention is to provide an antioxidant composition that is effective in the living body against active oxygen species produced in the body. The present invention provides an antioxidant composition having the effect of suppressing three active oxygen species, i.e. hypochlorite radicals, hydroxyl radicals, and peroxynitrite radicals, with respect to active oxygen species produced in the body, the antioxidant composition comprising a mixture in which at least 20 mg of vitamin C (L-ascorbic acid or sodium L-ascorbate) as an agent to scavenge peroxynitrite active oxygen, and at least 2 mg of caffeic acid analogue compound(s), at least 10 mg of polyphenyol compound(s) or at least 1.5 mg of carotenoid compound(s) as an agent to scavenge hydroxyl radical active oxygen are combined with 100 mg of histidine-containing dipeptide, or sulfur-containing amino acids or analogues thereof obtained from animal extract as an agent for scavenging hypochlorite active oxygen.
摘要翻译：本发明的目的在于提供一种抗生物体，该抗氧化剂组合物能够抵抗体内产生的活性氧。本发明提供了一种抗氧化剂组合物，其具有相对于体内产生的活性氧，抑制三种活性氧，即次氯酸根，羟基和过氧亚硝酸根的作用，所述抗氧化组合物包含其中至少20 mg维生素C（L-抗坏血酸或L-抗坏血酸钠）作为清除过氧亚硝酸盐活性氧的试剂，以及至少2mg的咖啡酸类似物化合物，至少10mg的多酚化合物或在将至少1.5mg作为清除羟基自由基活性氧的类胡萝卜素化合物与100mg组氨酸的二肽或从动物提取物获得的含硫氨基酸或其类似物作为清除次氯酸盐活性氧的试剂。

7. 发明授权

US07727961B2 Antioxidant constituents 有权
标题翻译：抗氧化成分
公开(公告)号：US07727961B2
公开(公告)日：2010-06-01
申请号：US11118368
申请日：2005-05-02
申请人： Nobuya Yanai , Shigenobu Shiotani , Satoshi Kanazawa
发明人： Nobuya Yanai , Shigenobu Shiotani , Satoshi Kanazawa
IPC分类号： A61K38/05 , A61K38/04
CPC分类号： A61K38/05 , A61K31/198 , A61K31/235 , A61K31/375 , A61K38/063 , A61K2300/00
摘要： An object of the present invention is to provide an antioxidant composition that is effective in the living body against active oxygen species produced in the body. The present invention provides an antioxidant composition having the effect of suppressing three active oxygen species, i.e. hypochlorite radicals, hydroxyl radicals, and peroxynitrite radicals, with respect to active oxygen species produced in the body, the antioxidant composition comprising a mixture in which at least 20 mg of vitamin C (L-ascorbic acid or sodium L-ascorbate) as an agent to scavenge peroxynitrite active oxygen, and at least 2 mg of caffeic acid analogue compound(s), at least 10 mg of polyphenyol compound(s) or at least 1.5 mg of carotenoid compound(s) as an agent to scavenge hydroxyl radical active oxygen are combined with 100 mg of histidine-containing dipeptide, or sulfur-containing amino acids or analogues thereof obtained from animal extract as an agent for scavenging hypochlorite active oxygen.
摘要翻译：本发明的目的在于提供一种抗生物体，该抗氧化剂组合物能够抵抗体内产生的活性氧。本发明提供了一种抗氧化剂组合物，其具有相对于体内产生的活性氧，抑制三种活性氧，即次氯酸根，羟基和过氧亚硝酸根的作用，所述抗氧化组合物包含其中至少20 mg维生素C（L-抗坏血酸或L-抗坏血酸钠）作为清除过氧亚硝酸盐活性氧的试剂，以及至少2mg的咖啡酸类似物化合物，至少10mg的多酚化合物或在将至少1.5mg作为清除羟基自由基活性氧的类胡萝卜素化合物与100mg组氨酸的二肽或从动物提取物获得的含硫氨基酸或其类似物作为清除次氯酸盐活性氧的试剂。

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