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1. 发明授权

US08362244B2 Method for producing nucleoside derivatives 失效
标题翻译：核苷衍生物的制备方法
公开(公告)号：US08362244B2
公开(公告)日：2013-01-29
申请号：US11782695
申请日：2007-07-25
申请人： Satoji Takahashi , Mitsuhiko Kojima , Shouichi Kondou , Tatsuya Ishikawa , Yoshinori Ogawa
发明人： Satoji Takahashi , Mitsuhiko Kojima , Shouichi Kondou , Tatsuya Ishikawa , Yoshinori Ogawa
IPC分类号： C07D473/34 , C07D473/30
CPC分类号： C12P17/182 , C07D473/30 , C07D473/34 , Y02P20/55
摘要： The present invention relates to a method for producing a nucleoside derivative represented by formula (2), comprising the step of reducing a nucleoside of formula (1) in the presence of a noble metal catalyst comprising a carrier and a noble metal supported thereby, selected from the group consisting of (A) a homogeneously supported catalyst where the specific surface area of the noble metal is 95.0 m2/g or more and the particle size of the noble metal is 4.3 nm or less, and (B) a surface-loaded catalyst where the specific surface area of the noble metal is 56.0 m2/g or more and the particle size of the noble metal is 8.0 nm or less, wherein R1 is hydrogen or a protective group, R2 is NH2 or OH, R3 is an acyl group, and X is a chlorine or bromine atom. According to the present invention, the yield can be made equal even when the amount of catalyst is smaller than that used for the conventional products.
摘要翻译：本发明涉及一种制备由式（2）表示的核苷衍生物的方法，包括在贵金属催化剂存在下还原式（1）的核苷的步骤，所述贵金属催化剂包含载体和由其所支持的贵金属，所选择的贵金属被选择由（A）贵金属的比表面积为95.0m 2 / g以上，贵金属的粒径为4.3nm以下的均匀负载的催化剂组成的组，（B）表面负载型贵金属的比表面积为56.0m 2 / g以上，贵金属的粒径为8.0nm以下的催化剂，其中，R1为氢或保护基，R2为NH2或OH，R3为酰基基团，X是氯或溴原子。根据本发明，即使当催化剂的用量小于常规产品所用量时，产率也可以相等。

2. 发明申请

US20070282104A1 METHOD FOR PRODUCING NUCLEOSIDE DERIVATIVES 失效
标题翻译：生产核苷衍生物的方法
公开(公告)号：US20070282104A1
公开(公告)日：2007-12-06
申请号：US11782695
申请日：2007-07-25
申请人： Satoji TAKAHASHI , Mitsuhiko Kojima , Shouichi Kondou , Tatsuya Ishikawa , Yoshinori Ogawa
发明人： Satoji TAKAHASHI , Mitsuhiko Kojima , Shouichi Kondou , Tatsuya Ishikawa , Yoshinori Ogawa
IPC分类号： C07D473/02 , C07D473/10
CPC分类号： C12P17/182 , C07D473/30 , C07D473/34 , Y02P20/55
摘要： The present invention relates to a method for producing a nucleoside derivative represented by formula (2), comprising the step of reducing a nucleoside of formula (1) in the presence of a noble metal catalyst comprising a carrier and a noble metal supported thereby, selected from the group consisting of (A) a homogeneously supported catalyst where the specific surface area of the noble metal is 95.0 m2/g or more and the particle size of the noble metal is 4.3 nm or less, and (B) a surface-loaded catalyst where the specific surface area of the noble metal is 56.0 m2/g or more and the particle size of the noble metal is 8.0 nm or less, wherein R1 is hydrogen or a protective group, R2 is NH2 or OH, R3 is an acyl group, and X is a chlorine or bromine atom. According to the present invention, the yield can be made equal even when the amount of catalyst is smaller than that used for the conventional products.
摘要翻译：本发明涉及一种制备由式（2）表示的核苷衍生物的方法，包括在贵金属催化剂存在下还原式（1）的核苷的步骤，所述贵金属催化剂包含载体和由其所支持的贵金属，所选择的贵金属被选择来自由（A）贵金属的比表面积为95.0m 2 / g以上的均匀负载的催化剂组成的组，贵金属的粒径为4.3nm以下，和（B）贵金属的比表面积为56.0m 2 / g以上，贵金属的粒径为8.0nm以下的表面负载型催化剂，其中，R' R 1是氢或保护基，R 2是NH 2或OH，R 3是酰基， X是氯或溴原子。根据本发明，即使当催化剂的用量小于常规产品所用量时，产率也可以相等。

3. 发明申请

US20090076304A1 METHODS FOR PRODUCING CARBOXYLIC ACID CHLORIDE COMPOUNDS 审中-公开
标题翻译：生产羧酸氯化物的方法
公开(公告)号：US20090076304A1
公开(公告)日：2009-03-19
申请号：US12241796
申请日：2008-09-30
申请人： Tatsuya Ishikawa , Shouichi Kondou , Satoji Takahashi
发明人： Tatsuya Ishikawa , Shouichi Kondou , Satoji Takahashi
IPC分类号： C07C51/58 , C07C237/48
CPC分类号： C07C231/02 , C07B53/00 , C07C51/60 , C07C2601/14 , C07C61/15 , C07C233/63
摘要： The present invention discloses methods for producing a carboxylic acid chloride compound which comprises the step of reacting an alkyl-substituted cyclohexyl carboxylic acid with a chlorinating agent in the presence of a specific urea compound. According to this invention, it is possible to produce a carboxylic acid chloride compound which has high reaction speed, and whose product has high purity or high yield. Thus produced carboxylic acid chloride compound is useful as an intermediate for producing D-phenylalanine derivatives which are used as agents for treating diabetes.
摘要翻译：本发明公开了制备羧酰氯化合物的方法，该方法包括在特定脲化合物存在下使烷基取代的环己基羧酸与氯化剂反应的步骤。根据本发明，可以制备反应速度快的产物具有高纯度或高产率的羧酸酰氯化合物。这样制得的羧酰氯化合物可用作生产D-苯丙氨酸衍生物的中间体，其用作治疗糖尿病的药物。

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