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1. 发明授权

US07514244B2 Lipid and food compositions containing docosahexaenoic acid and docosapentaenoic acid 失效
标题翻译：含有二十二碳六烯酸和二十二碳五烯酸的脂质和食物组合物
公开(公告)号：US07514244B2
公开(公告)日：2009-04-07
申请号：US10341300
申请日：2003-01-13
申请人： Satohiro Tanaka , Toshiaki Yaguchi , Sakayu Shimizu , Tsutomu Sogo , Shigeaki Fujikawa
发明人： Satohiro Tanaka , Toshiaki Yaguchi , Sakayu Shimizu , Tsutomu Sogo , Shigeaki Fujikawa
IPC分类号： C12P7/64 , A23K1/16
CPC分类号： C12P7/6427 , A23D9/007 , A23K20/158 , A23L33/12 , C11C1/045 , C12P7/6472 , C12R1/645 , C12R1/89
摘要： A process for preparing lipids which contain docosahexaenoic acid (DHA) and/or docosapentaenoic acid (DPA) is disclosed. The process includes the steps of cultivating in a medium a microorganism which belongs to the genus Ulkenia having the ability to produce DHA and/or DPA and recovering the lipids from the culture. The process may further include the step of separating DHA and/or DPA from the lipids.
摘要翻译：公开了一种制备含有二十二碳六烯酸（DHA）和/或二十二碳五烯酸（DPA）的脂质的方法。该方法包括在培养基中培养属于具有产生DHA和/或DPA的能力的乌尔肯尼亚属的微生物并从培养物中回收脂质的步骤。该方法还可以包括从脂质中分离DHA和/或DPA的步骤。

2. 发明授权

US06509178B1 Process for preparing docosahexaenoic acid and docosapentaenoic acid with ulkenia 有权
标题翻译：二十二碳六烯酸和二十二碳五烯酸的制备方法
公开(公告)号：US06509178B1
公开(公告)日：2003-01-21
申请号：US09230212
申请日：1999-05-03
申请人： Satohiro Tanaka , Toshiaki Yaguchi , Sakayu Shimizu , Tsutomu Sogo , Shigeaki Fujikawa
发明人： Satohiro Tanaka , Toshiaki Yaguchi , Sakayu Shimizu , Tsutomu Sogo , Shigeaki Fujikawa
IPC分类号： C12P764
CPC分类号： C12P7/6427 , A23D9/007 , A23K20/158 , A23L33/12 , C11C1/045 , C12P7/6472 , C12R1/645 , C12R1/89
摘要： A process for preparing lipids which contain docosahexaenoic acid (DHA) and/or docosapentaenoic acid (DPA) is disclosed. The process includes the steps of cultivating in a medium a microorganism which belongs to the genus Ulkenia having the ability to produce DHA and/or DPA and recovering the lipids from the culture. The process may further include the step of separating DHA and/or DPA from the lipids.
摘要翻译：公开了一种制备含有二十二碳六烯酸（DHA）和/或二十二碳五烯酸（DPA）的脂质的方法。该方法包括在培养基中培养属于具有产生DHA和/或DPA的能力的乌尔肯尼亚属的微生物并从培养物中回收脂质的步骤。该方法还可以包括从脂质中分离DHA和/或DPA的步骤。

3. 发明申请

US20080269329A1 Process for Production of Microbial Fat/Oil Containing Discretional Amount of Diacylglycerol and Said Fat/Oil 审中-公开
标题翻译：含有二酰基甘油和所述脂肪/油的离散量的微生物脂肪/油的生产方法
公开(公告)号：US20080269329A1
公开(公告)日：2008-10-30
申请号：US11660859
申请日：2005-08-19
申请人： Shigeaki Fujikawa , Eiji Sakuradani , Jun Ogawa , Sakayu Shimizu
发明人： Shigeaki Fujikawa , Eiji Sakuradani , Jun Ogawa , Sakayu Shimizu
IPC分类号： C12P7/64 , A61K31/201 , C07C57/00 , A61K31/202
CPC分类号： A61K8/375 , A23D9/013 , A23K20/158 , A23L33/115 , A23L33/12 , A23V2002/00 , A61K8/67 , A61K8/922 , A61K8/99 , A61Q19/00 , C11B1/10 , C11B3/12 , C12P7/6472 , A23V2250/182 , A23V2250/1882
摘要： In a process for the production of diacylglycerol-containing fat/oil where the ratio of diacylglycerol to the total neutral lipid is more than 20% by weight and a polyunsaturated fatty acid is a constituting fatty acid, a process which is characterized in that a microbe being able to produce said fat/oil is incubated and, if desired, said fat/oil is collected.
摘要翻译：在制备含二酰基甘油的脂肪/油的方法中，其中二酰基甘油与总中性脂质的比例大于20重量％，多不饱和脂肪酸是构成脂肪酸的方法，其特征在于将微生物能够产生所述脂肪/油的温育，如果需要，收集所述脂肪/油。

4. 发明授权

US06248909B1 Triglyceride and composition comprising the same 有权
标题翻译：甘油三酸酯及其组合物
公开(公告)号：US06248909B1
公开(公告)日：2001-06-19
申请号：US09335730
申请日：1999-06-18
申请人： Kengo Akimoto , Toshiaki Yaguchi , Shigeaki Fujikawa
发明人： Kengo Akimoto , Toshiaki Yaguchi , Shigeaki Fujikawa
IPC分类号： C07C5700
CPC分类号： C07C69/587 , A23D9/00 , A23K20/158 , A23L33/115 , C11C3/10 , Y10S426/807
摘要： The present invention provides a novel triglyceride and a composition containing that novel triglyceride having a triglyceride structure of the human breast milk type, which triglyceride has a saturated fatty acid having 16-18 carbon atoms at the position 2, at the position 1 and/or 3; which is and at least one &ohgr;6, &ohgr;9 or &ohgr;3 unsaturated fatty acid manufactured by subjecting a glyceride in which a saturated fatty acid having 16 to 18 carbon atoms is bonded at position 2 to transesterification using a lipase and a &ohgr;6, &ohgr;9 or &ohgr;3-unsaturated fatty acid.
摘要翻译：本发明提供一种新颖的甘油三酸酯和含有具有人母乳型甘油三酯结构的新型甘油三酯的组合物，该甘油三酸酯在位置2具有16-18个碳原子的饱和脂肪酸，位置1和/或 3; 其是通过使其中在位置2处键合具有16至18个碳原子的饱和脂肪酸的甘油酯使用脂肪酶和ω6，ω9或ω3-不饱和脂肪酸进行酯交换而制备的至少一种ω6，ω9或ω3不饱和脂肪酸脂肪酸。

5. 发明授权

US07538238B2 Production method of oil or fat containing polyunsaturated fatty acid-containing triglyceride 有权
标题翻译：含有多不饱和脂肪酸的甘油三酸酯的油脂的生产方法
公开(公告)号：US07538238B2
公开(公告)日：2009-05-26
申请号：US10482373
申请日：2002-07-02
申请人： Kengo Akimoto , Motoo Sumida , Kenichi Higashiyama , Shigeaki Fujikawa
发明人： Kengo Akimoto , Motoo Sumida , Kenichi Higashiyama , Shigeaki Fujikawa
IPC分类号： A23D9/00
CPC分类号： C12P7/6472 , A23C9/1528 , A23C11/04 , A23K20/158 , A23L33/115 , A23L33/12 , C11C3/08 , C11C3/10
摘要： The present invention relates to a production method of an oil containing triglyceride in which medium chain fatty acids are bound to the 1- and 3-positions of the triglyceride and polyunsaturated fatty acid is bound to the 2 position by allowing lipase, which specifically acts on ester bonds at the 1- and 3-positions that has been immobilized on a porous ion exchange resin support having a pore size of about 100 Angstroms or more, to act on a mixture of medium-chain fatty acids and raw material oil containing at least one polyunsaturated fatty acid selected from the group consisting of ω6 series polyunsaturated fatty acid having 18 or more carbon atoms and 3 or more double bonds and ω9 series polyunsaturated fatty acid having 18 or more carbon atoms and 2 or more double bonds, but not containing ω3 series polyunsaturated fatty acid, oils and fats or triglycerides obtained by that method, and the use of the oils and fats or triglycerides in a food, beverage or pharmaceutical composition.
摘要翻译：本发明涉及含有甘油三酯的油的制备方法，其中中链脂肪酸与甘油三酯的1位和3位结合，多不饱和脂肪酸通过使脂肪酶特异性地作用于2位而结合到2位上在固定在孔径为约100埃以上的多孔离子交换树脂载体上的1-位和3-位的酯键作用于中链脂肪酸和至少含有至少一种选自具有18个或更多个碳原子的ω-6系多不饱和脂肪酸和3个或更多个双键的多不饱和脂肪酸和具有18个或更多个碳原子和2个或更多个双键但不含ω3的ω-系列多不饱和脂肪酸系列多不饱和脂肪酸，通过该方法获得的油和脂肪或甘油三酯，以及在食品，饮料或药物中使用油和脂肪或甘油三酸酯 l组成。

6. 发明授权

US4983524A Method of immobilizing enzymes on a support with iridoid aglycone cross-linking agents 失效
标题翻译：将酶固定在带有环烯醚萜苷酸交联剂的载体上的方法
公开(公告)号：US4983524A
公开(公告)日：1991-01-08
申请号：US135354
申请日：1987-12-21
申请人： Shigeaki Fujikawa , Kunimasa Koga , Tomoko Yokota
发明人： Shigeaki Fujikawa , Kunimasa Koga , Tomoko Yokota
IPC分类号： C12N11/04 , C12N11/06 , C12N11/10
CPC分类号： C12N11/04 , C12N11/06 , C12N11/10
摘要： An enzyme is immobilized by contacting the enzyme with a support in a solution containing an iridoid aglycone cross-linking agent. The cross-linking agent may be genipin or an aglycone or an iridoid glycoside such as geniposide, gardenoside or geniposide acid.
摘要翻译：通过使酶与含有环烯醚萜苷酸交联剂的溶液中的载体接触来固定酶。交联剂可以是京尼平或糖苷配基或环烯醚萜苷，如栀子苷，栀子苷或栀子苷酸。

7. 发明申请

US20100113390A1 OLIGOSACCHARIDES DERIVED FROM FUCOIDAN 审中-公开
标题翻译：来自FUCOIDAN的OLIGOSACCHARIDES
公开(公告)号：US20100113390A1
公开(公告)日：2010-05-06
申请号：US12524414
申请日：2007-01-26
申请人： Shigeaki Fujikawa , Yuko Fukui , Hiroshi Watanabe , Yuji Nonaka , Takeshi Yasumoto , Hideo Naoki
发明人： Shigeaki Fujikawa , Yuko Fukui , Hiroshi Watanabe , Yuji Nonaka , Takeshi Yasumoto , Hideo Naoki
IPC分类号： A61K31/715 , C07H3/04 , C07H3/06 , C07H5/10 , A61P3/04
CPC分类号： C07H11/00 , A23L33/10 , A23V2002/00 , A61K8/60 , A61K2800/782 , A61Q5/02 , A61Q19/00 , C07H7/033 , C07H13/06 , A23V2200/326 , A23V2200/332 , A23V2250/50 , A23V2250/28
摘要： The present invention provides a fucoidan-derived low molecular weight compound with a good quality of taste, which has a specified structure and function and is free from problems in absorption, antigenicity, uniformity, an anticoagulant activity and so on, which problems arise when developing fucoidan, a sulfated polysaccharide having an extremely large molecular weight, as drugs or health foods. As a result of analyzing low molecular weight compounds obtained by acid hydrolysis of fucoidan, the inventors have identified fucoidan oligosaccharides (I) to (XI). Further, these oligosaccharides have been found to have anti-obesity and/or blood glucose elevation suppressing effects through inhibition of carbohydrate and/or lipid absorption as a result of α-glucosidase inhibition and/or lipase inhibition.
摘要翻译：本发明提供具有优良品质的岩藻依聚糖衍生的低分子量化合物，其具有特定的结构和功能，并且不存在吸收，抗原性，均匀性，抗凝血活性等问题，当发展时出现问题岩藻依聚糖，分子量极大的硫酸化多糖作为药物或保健食品。通过分析由岩藻依聚糖酸水解获得的低分子量化合物的结果，本发明人鉴定了岩藻依聚糖寡糖（I）至（XI）。此外，已经发现这些寡糖通过由于α-葡糖苷酶抑制和/或脂肪酶抑制而抑制碳水化合物和/或脂质吸收而具有抗肥胖和/或血糖升高抑制作用。

8. 发明授权

US5660838A Skin preparations for external use 失效
标题翻译：外用皮肤准备
公开(公告)号：US5660838A
公开(公告)日：1997-08-26
申请号：US394201
申请日：1995-02-24
申请人： Kunimasa Koga , Takumi Kobayashi , Shigeaki Fujikawa , Masako Sawada
发明人： Kunimasa Koga , Takumi Kobayashi , Shigeaki Fujikawa , Masako Sawada
IPC分类号： C07H3/04 , A61K8/00 , A61K8/60 , A61K8/73 , A61K9/06 , A61K31/00 , A61K31/70 , A61K31/7016 , A61P17/00 , A61Q5/02 , A61Q19/00 , A61K7/06 , A61K7/48
CPC分类号： A61Q19/00 , A61K31/70 , A61K8/60 , A61Q19/007 , A61Q5/02 , A61Q19/001 , Y10S514/873
摘要： Xylobiose-containing skin preparations for external use are disclosed. Skin preparations for external use into which xylobiose may be incorporated include cosmetics such as clear lotions, milky lotions, packs and lip treatments, drugs or quasidrugs such as ointments and cataplasms, hair-care products such as rinses and hair conditions, and detergents such as hair shampoos and body shampoos. Xylobiose is typically contained in an amount of 0.0001-20 wt %, preferably 0.1-10 wt %, of the total amount of the skin preparation on a dry solids basis. The incorporation of xylobiose is effective not only in preventing the occurrence of stickiness, color change and malodor in the skin preparations but also in providing enhanced moisture retention and reducing excessive roughness and dryness of the skin and hair.
摘要翻译：公开了含有二氧化硅的外用皮肤制剂。可以掺入木二糖的外用皮肤制剂包括化妆品如透明乳液，乳液，包装和唇部处理，药物或准药如软膏和粘膜，护发产品如漂洗剂和毛发条件，以及洗涤剂如头发洗发水和身体洗发水。皮质制剂的总量通常以干固体计为0.0001-20重量％，优选0.1-10重量％。结合木二糖不仅有效防止皮肤制剂中的粘着性，变色和恶臭的发生，而且在提供增强的保湿性和减少皮肤和头发的过度粗糙和干燥方面是有效的。

9. 发明授权

US07767427B2 Production method of oil or fat containing polyunsaturated fatty acid-containing triglyceride 有权
标题翻译：含有多不饱和脂肪酸的甘油三酸酯的油脂的生产方法
公开(公告)号：US07767427B2
公开(公告)日：2010-08-03
申请号：US12232851
申请日：2008-09-25
申请人： Kengo Akimoto , Motoo Sumida , Kenichi Higashiyama , Shigeaki Fujikawa
发明人： Kengo Akimoto , Motoo Sumida , Kenichi Higashiyama , Shigeaki Fujikawa
IPC分类号： C12P7/64
CPC分类号： C12P7/6472 , A23C9/1528 , A23C11/04 , A23K20/158 , A23L33/115 , A23L33/12 , C11C3/08 , C11C3/10
摘要： The present invention relates to a production method of an oil containing triglyceride in which medium chain fatty acids are bound to the 1- and 3-positions of the triglyceride and polyunsaturated fatty acid is bound to the 2 position by allowing lipase, which specifically acts on ester bonds at the 1- and 3-positions that has been immobilized on a porous ion exchange resin support having a pore size of about 100 Angstroms or more, to act on a mixture of medium-chain fatty acids and raw material oil containing at least one polyunsaturated fatty acid selected from the group consisting of ω6 series polyunsaturated fatty acid having 18 or more carbon atoms and 3 or more double bonds and ω9 series polyunsaturated fatty acid having 18 or more carbon atoms and 2 or more double bonds, but not containing ω3 series polyunsaturated fatty acid, oils and fats or triglycerides obtained by that method, and the use of the oils and fats or triglycerides in a food, beverage or pharmaceutical composition.
摘要翻译：本发明涉及含有甘油三酯的油的制备方法，其中中链脂肪酸与甘油三酯的1位和3位结合，多不饱和脂肪酸通过使脂肪酶特异性地作用于2位而结合到2位上在已经固定在孔径为约100埃以上的多孔离子交换树脂载体上的1-位和3-位的酯键作用于至少含有至少含有中链脂肪酸和原料油的混合物一种选自具有18个或更多个碳原子的ω6系多不饱和脂肪酸和3个或更多个双键的多不饱和脂肪酸和具有18个以上碳原子和2个以上双键但不含ω3的ω9系多不饱和脂肪酸系列多不饱和脂肪酸，通过该方法获得的油和脂肪或甘油三酯，以及在食品，饮料或药物组合物中使用油和脂肪或甘油三酸酯。

10. 发明申请

US20090076149A1 Production method of oil or fat containing polyunsaturated fatty acid-containing triglyceride 有权
公开(公告)号：US20090076149A1
公开(公告)日：2009-03-19
申请号：US12232851
申请日：2008-09-25
申请人： Kengo Akimoto , Motoo Sumida , Kenichi Higashiyama , Shigeaki Fujikawa
发明人： Kengo Akimoto , Motoo Sumida , Kenichi Higashiyama , Shigeaki Fujikawa
IPC分类号： A61K31/20 , C12P7/64 , C07C53/00 , A23D9/00 , A23K1/00
CPC分类号： C12P7/6472 , A23C9/1528 , A23C11/04 , A23K20/158 , A23L33/115 , A23L33/12 , C11C3/08 , C11C3/10
摘要： The present invention relates to a production method of an oil containing triglyceride in which medium chain fatty acids are bound to the 1- and 3-positions of the triglyceride and polyunsaturated fatty acid is bound to the 2 position by allowing lipase, which specifically acts on ester bonds at the 1- and 3-positions that has been immobilized on a porous ion exchange resin support having a pore size of about 100 Angstroms or more, to act on a mixture of medium-chain fatty acids and raw material oil containing at least one polyunsaturated fatty acid selected from the group consisting of ω6 series polyunsaturated fatty acid having 18 or more carbon atoms and 3 or more double bonds and ω9 series polyunsaturated fatty acid having 18 or more carbon atoms and 2 or more double bonds, but not containing ω3 series polyunsaturated fatty acid, oils and fats or triglycerides obtained by that method, and the use of the oils and fats or triglycerides in a food, beverage or pharmaceutical composition.

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