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1. 发明授权

US07776905B2 Modulators of ATP-binding cassette transporters 有权
标题翻译： ATP结合盒转运蛋白的调节剂
公开(公告)号：US07776905B2
公开(公告)日：2010-08-17
申请号：US11786001
申请日：2007-04-09
申请人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Jamel Numa , Xiaoqing Yang
发明人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Jamel Numa , Xiaoqing Yang
IPC分类号： A61K31/404 , C07D209/40
CPC分类号： C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

2. 发明申请

US20100331344A1 Modulators of ATP-Binding Cassette Transporters 有权
公开(公告)号：US20100331344A1
公开(公告)日：2010-12-30
申请号：US12829879
申请日：2010-07-02
申请人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Jamel Numa , Xiaoqing Yang
发明人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Frederick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Jamel Numa , Xiaoqing Yang
IPC分类号： A61K31/496 , A61K31/4184 , A61K31/4045 , A61K31/454 , A61K31/4439 , A61K31/4178 , A61P7/02 , A61P7/00 , A61P3/06 , A61P3/10 , A61P25/00 , A61P25/28 , C12N5/071
CPC分类号： C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

3. 发明授权

US08598181B2 Modulators of ATP-binding cassette transporters 有权
标题翻译： ATP结合盒转运蛋白的调节剂
公开(公告)号：US08598181B2
公开(公告)日：2013-12-03
申请号：US12829879
申请日：2010-07-02
申请人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Jamel Numa , Xiaoqing Yang
发明人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Jamel Numa , Xiaoqing Yang
IPC分类号： A61K31/496 , A61K31/4523 , A61K31/4525 , A61K31/453 , A61K31/454 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/41 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/404 , C07D403/14 , C07D401/14 , C07D211/00 , C07D235/04 , C07D257/02 , C07D249/04 , C07D487/00 , C07D405/02 , C07D405/14
CPC分类号： C07D405/12 , C07B59/002 , C07B2200/05 , C07D403/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5008 , G01N33/6872 , G01N2333/705 , G01N2500/02 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

4. 发明授权

US08575209B2 Modulators of ATP-binding cassette transporters 有权
公开(公告)号：US08575209B2
公开(公告)日：2013-11-05
申请号：US12948162
申请日：2010-11-17
申请人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick F. Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Numa , Xiaoqing Yang
发明人： Sara S. Hadida Ruah , Peter D. J. Grootenhuis , Fredrick F. Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Numa , Xiaoqing Yang
IPC分类号： A61K31/36 , C07D405/12
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

5. 发明申请

US20110071206A1 Modulators of ATP-Binding Cassette Transporters 有权
标题翻译： ATP结合盒转运蛋白的调节剂
公开(公告)号：US20110071206A1
公开(公告)日：2011-03-24
申请号：US12948162
申请日：2010-11-17
申请人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa , Xiaoqing Yang
发明人： Sara S. Hadida Ruah , Peter D.J. Grootenhuis , Fredrick Van Goor , Jinglan Zhou , Brian Bear , Mark T. Miller , Jason McCartney , Mehdi Michel Djamel Numa , Xiaoqing Yang
IPC分类号： A61K31/403 , C07D405/12 , A61P11/00 , A61P25/28
CPC分类号： A61K31/47 , A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/407 , A61K31/41 , A61K31/4184 , A61K31/4192 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D233/64 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , G01N33/5035 , G01N2333/705 , G01N2500/10
摘要： Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.
摘要翻译：本发明的化合物及其药学上可接受的组合物可用作ATP结合盒（“ABC”）转运蛋白或其片段的调节剂，包括囊性纤维化跨膜电导调节剂（“CFTR”）。本发明还涉及使用本发明化合物治疗ABC转运蛋白介导的疾病的方法。

6. 发明授权

US08513282B2 Modulators of cystic fibrosis transmembrane conductance regulator 有权
标题翻译：囊性纤维化跨膜电导调节剂的调节剂
公开(公告)号：US08513282B2
公开(公告)日：2013-08-20
申请号：US12605053
申请日：2009-10-23
申请人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号： A61K31/04
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译：本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。本发明还涉及使用CFTR的调节剂治疗疾病的方法。

7. 发明授权

US08598205B2 Modulators of cystic fibrosis transmembrane conductance regulator 有权
公开(公告)号：US08598205B2
公开(公告)日：2013-12-03
申请号：US13439379
申请日：2012-04-04
申请人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人： Hayley Binch , Lev T. D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D. J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号： C07D215/38 , A61K31/04
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.

8. 发明授权

US09188434B2 Backside alignment apparatus and method 有权
标题翻译：背面对准装置及方法
公开(公告)号：US09188434B2
公开(公告)日：2015-11-17
申请号：US13976376
申请日：2011-12-20
申请人： Bing Xu , Yuefei Chen , Xiang Jia , Xiaoqing Yang
发明人： Bing Xu , Yuefei Chen , Xiang Jia , Xiaoqing Yang
IPC分类号： G01B11/00 , G01B11/26 , G03F9/00 , G01N21/35
CPC分类号： G01B11/26 , G01N21/35 , G03F9/7015 , G03F9/7084 , G03F9/7088
摘要： A backside alignment apparatus and method for determining a position relationship between a substrate (6) and a workpiece stage (24). The backside alignment apparatus includes: an illumination apparatus (1) for emanating infrared light; a workpiece stage assembly (2) for supporting and moving the substrate (6); an imaging apparatus (3) for detecting alignment marks and calculating positions of the alignment marks, the alignment marks including a reference plate alignment mark (41) and a backside alignment mark (20); and a reference plate assembly (4) for setting up a relationship between position coordinates of the imaging apparatus (3) and the workpiece stage assembly (2). The illumination apparatus (1) and the imaging apparatus (3) are able to illuminate and align different alignment marks using only one set of illumination apparatus.
摘要翻译：一种用于确定基板（6）和工件台（24）之间的位置关系的背面对准装置和方法。背面对准装置包括：发出红外光的照明装置（1）; 用于支撑和移动所述基底（6）的工件台组件（2）; 用于检测对准标记并计算对准标记的位置的成像装置（3），所述对准标记包括参考板对准标记（41）和背面对准标记（20）; 以及用于设置成像装置（3）的位置坐标与工件台组件（2）之间的关系的参考板组件（4）。照明装置（1）和成像装置（3）能够仅使用一组照明装置照明和对准不同的对准标记。

9. 发明申请

US20120208841A1 Modulators of Cystic Fibrosis Transmembrane Conductance Regulator 有权
标题翻译：囊性纤维化跨膜电导调节剂的调节剂
公开(公告)号：US20120208841A1
公开(公告)日：2012-08-16
申请号：US13439379
申请日：2012-04-04
申请人： Hayley Binch , Lev T.D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
发明人： Hayley Binch , Lev T.D. Fanning , Dennis Hurley , Urvi Sheth , Alina Silina , Xiaoqing Yang , Martyn Botfield , Peter D.J. Grootenhuis , Fredrick Van Goor , Mehdi Michel Djamel Numa
IPC分类号： A61K31/4709 , C07D487/08 , C07F7/10 , A61P11/06 , A61P11/00 , A61P1/10 , A61P1/18 , A61P1/16 , A61P35/00 , A61P3/10 , A61P25/28 , A61P25/16 , A61P25/14 , C12N5/071 , C07D451/02
CPC分类号： A61K31/4709 , A61K45/06 , C07D215/56 , C07D221/22 , C07D451/02 , C07D471/06 , C07D471/08 , C07D487/04 , C07D487/08 , C07F7/1804 , G01N33/5041 , G01N33/6872 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating diseases using modulators of CFTR.
摘要翻译：本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。本发明还涉及使用CFTR的调节剂治疗疾病的方法。

10. 发明申请

US20110257223A1 Modulators of Cystic Fibrosis Transmembrane Conductance Regulator 审中-公开
标题翻译：囊性纤维化跨膜电导调节剂的调节剂
公开(公告)号：US20110257223A1
公开(公告)日：2011-10-20
申请号：US13092838
申请日：2011-04-22
申请人： Fredrick Van Goor , Hayley Binch , Martyn Botfield , Lev T.D. Fanning , Peter D.J. Grootenhuis , Dennis Hurley , Medhi Michel Djamel Numa , Urvi Sheth , Alina Silina , Xiaoqing Yang , Gregor Zlokarnik
发明人： Fredrick Van Goor , Hayley Binch , Martyn Botfield , Lev T.D. Fanning , Peter D.J. Grootenhuis , Dennis Hurley , Medhi Michel Djamel Numa , Urvi Sheth , Alina Silina , Xiaoqing Yang , Gregor Zlokarnik
IPC分类号： A61K31/4709 , A61P11/06 , A61P11/08 , A61P1/10 , A61P11/00 , A61P15/00 , A61P1/16 , A61P1/18 , A61P3/10 , A61P35/00 , A61P21/00 , A61P25/28 , A61P25/16 , A61P25/00 , A61P27/02 , A61P19/10 , A61P19/08 , A61P25/08 , G01N33/567
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , G01N2800/382
摘要： The present invention relates to modulators of cystic fibrosis transmembrane conductance regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to pharmaceutical compositions comprising a compound of Formula I with one or both of a Compound of Formula II and/or a Compound of Formula III. Further, the present invention relates to methods of treating CFTR mediated diseases, particularly cystic fibrosis, using modulators of CFTR, and compositions and combinations thereof.
摘要翻译：本发明涉及囊性纤维化跨膜传导调节剂（“CFTR”）的调节剂，其组合物及其方法。本发明还涉及包含式I化合物与式II化合物和/或式III化合物中的一种或两种的药物组合物。此外，本发明涉及使用CFTR的调节剂治疗CFTR介导的疾病，特别是囊性纤维化的方法及其组合物及其组合。

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