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1. 发明授权

US10384015B2 Auto-injector 有权
公开(公告)号：US10384015B2
公开(公告)日：2019-08-20
申请号：US15471926
申请日：2017-03-28
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/20 , A61M5/24
摘要： An auto-injector for administering a dose of a liquid medicament includes a tubular chassis telescopable in an elongate chassis, a carrier subassembly including a tubular carrier slidably arranged partially inside the chassis and inside the case, the carrier adapted to contain a syringe with a hollow injection needle, a drive spring, a plunger for forwarding load of the drive spring to a stopper of the syringe, a control spring arranged around the carrier, a needle insertion control mechanism for coupling a proximal end of the control spring to either the carrier for advancing it for needle insertion or to the chassis, wherein the syringe is lockable for joint axial translation with the carrier, wherein the needle insertion control mechanism includes a first collar biased by the control spring in a proximal direction, and wherein at least one fifth clip is arranged on one of the chassis or the first collar.

2. 发明授权

US11484655B2 Auto-injector 有权
公开(公告)号：US11484655B2
公开(公告)日：2022-11-01
申请号：US16667008
申请日：2019-10-29
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/32 , A61M5/20 , A61M5/50 , A61M5/46
摘要： An auto-injector includes a chassis and a carrier subassembly. The carrier subassembly includes a carrier arranged inside a case, a drive spring, a plunger comprising a ramp member, the plunger configured to be pushed in a proximal direction by the drive spring, and a ramp attached to the carrier, wherein the ramp member on the plunger in an initial state is locked to the ramp on the carrier to form a ramped engagement to the carrier, the plunger prevented from rotating out of the ramped engagement depending on a relative longitudinal position of the carrier relative to the chassis, wherein the plunger is arranged to be released and to rotate out of the ramped engagement upon the carrier translating a pre-defined distance in a proximal direction relative to the chassis.

3. 发明授权

US10376642B2 Auto-injector 有权
公开(公告)号：US10376642B2
公开(公告)日：2019-08-13
申请号：US15706131
申请日：2017-09-15
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Mark Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/20 , A61M5/24 , A61M5/315
摘要： An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case.

4. 发明申请

US20180169352A1 Auto-Injector 审中-公开
公开(公告)号：US20180169352A1
公开(公告)日：2018-06-21
申请号：US15897872
申请日：2018-02-15
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/46 , A61M5/32 , A61M5/20 , A61M5/315
CPC分类号： A61M5/46 , A61M5/20 , A61M5/2033 , A61M5/3157 , A61M5/326 , A61M2005/206 , A61M2205/581 , A61M2205/582
摘要： An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

5. 发明申请

US20180093046A1 AUTOINJECTOR WITH AN INNER PLUNGER WHICH DISENGAGES THE OUTER PLUNGER TO RETRACT THE SYRINGE CARRIER 审中-公开
公开(公告)号：US20180093046A1
公开(公告)日：2018-04-05
申请号：US15821166
申请日：2017-11-22
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： Yannick Hourmand , Simon Brereton , Thomas Mark Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/32 , A61M5/20
CPC分类号： A61M5/326 , A61M5/2033 , A61M2005/2013 , A61M2005/206
摘要： Described is an autoinjector comprising a case, a chassis slidably arranged in the case, a syringe carrier operably coupled to the chassis, an outer plunger selectively engaged to the chassis, an inner plunger selectively engaged to the outer plunger, and a drive spring applying a biasing force to the outer plunger. The biasing force is applied to the inner plunger when the inner plunger is engaged to the outer plunger. Rotation of the chassis causes the inner plunger to rotate relative to the outer plunger and disengage the outer plunger to remove the biasing force from the drive spring on the inner plunger. When the inner plunger disengages the outer plunger, the biasing force of the drive spring pushes the chassis to retract the syringe carrier relative to the case.

6. 发明申请

US20180001026A1 Auto-Injector 审中-公开
公开(公告)号：US20180001026A1
公开(公告)日：2018-01-04
申请号：US15706131
申请日：2017-09-15
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Mark Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/20 , A61M5/24 , A61M5/315
CPC分类号： A61M5/3157 , A61M5/20 , A61M5/2033 , A61M5/2429 , A61M5/31501 , A61M5/31511 , A61M5/3158 , A61M5/3202 , A61M5/3204 , A61M5/3257 , A61M5/326 , A61M5/46 , A61M5/5086 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2005/208 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , F04C2270/0421 , Y10T403/32501
摘要： An auto-injector for administering a dose of a liquid medicament (M) is presented having an elongate case arranged to be held by a user, a tubular chassis telescoped in the case and biased against the case so as to protrude from the case. The injector also includes a syringe with a hollow injection needle, a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe. A trigger button is distally arranged in or on the case, wherein the trigger button is initially coupled to the case in a manner to protrude distally from the case and interlocked to the chassis in a manner preventing the trigger button from disengaging the case.

7. 发明申请

US20170197036A1 Auto-Injector 审中-公开
公开(公告)号：US20170197036A1
公开(公告)日：2017-07-13
申请号：US15471926
申请日：2017-03-28
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/24 , A61M5/20
CPC分类号： A61M5/3157 , A61M5/20 , A61M5/2033 , A61M5/2429 , A61M5/31501 , A61M5/31511 , A61M5/3158 , A61M5/3202 , A61M5/3204 , A61M5/3257 , A61M5/326 , A61M5/46 , A61M5/5086 , A61M2005/2013 , A61M2005/206 , A61M2005/2073 , A61M2005/208 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , F04C2270/0421 , Y10T403/32501
摘要： The invention relates to an auto-injector (1) for administering a dose of a liquid medicament (M), comprising: a tubular chassis (2) telescopable in an elongate chassis (12), a carrier subassembly comprising a tubular carrier (7) slidably arranged partially inside the chassis (2) and inside the case (12), the carrier (7) adapted to contain a syringe (3) with a hollow injection needle (4), a drive spring (8) and a plunger (9) for forwarding load of the drive spring (8) to a stopper (6) of the syringe (3), wherein the syringe (3) is lockable for joint axial translation with the carrier (7), a control spring (19) arranged around the carrier (7), a needle insertion control mechanism (24) for coupling a proximal end of the control spring (19) to either the carrier (7) for advancing it for needle insertion or to the chassis (2), wherein the needle insertion control mechanism (24) comprises a first collar (20) biased by the control spring in a proximal direction (P), wherein at least one fifth clip (2.10) is arranged on one of the chassis (2) or the first collar (20) initially abutting a block (20.7) on the other of the chassis (2) or the first collar (20), wherein a ramped engagement between the fifth clip (2.10) and the carrier (7) is provided for outwardly deflecting the fifth clip (2.10) on translation of the carrier (7) in the proximal direction (P), wherein outward deflection of the fifth clip (2.10) and translation of the carrier (7) in the proximal direction (P) is initially prevented by the case (12) outwardly abutting the fifth clip (2.10), wherein the case (12) is at least initially biased in the distal direction (D), wherein the case (12) is arranged to translate against the bias in the proximal direction (P) relative to the chassis (2) into an advanced position thereby translating a second window (12.8) in the case (12) outwardly behind the fifth clip (2.10) thus allowing outward deflection so as to decouple the fifth clip (2.10) from the block (20.7) and to allow the first collar (20) to abut against the carrier (7) and advance it under load of the control spring (19).

8. 发明申请

US20160129194A1 Detent Mechanism 有权
标题翻译：止血机制
公开(公告)号：US20160129194A1
公开(公告)日：2016-05-12
申请号：US14982555
申请日：2015-12-29
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315
CPC分类号： A61M5/3158 , A61M5/2033 , A61M5/31501 , A61M5/31511 , A61M5/3157 , A61M5/3202 , A61M5/3204 , A61M5/3257 , A61M5/326 , A61M5/46 , A61M5/5086 , A61M2005/2013 , A61M2005/206 , A61M2005/208 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , F04C2270/0421 , Y10T403/32501
摘要： A detent mechanism for controlling translation between two components in a longitudinal direction includes a resilient beam on one of the components and a rhomboid ramp member on the other component. The resilient beam is essentially straight when relaxed and has a first beam head and is arranged to interact in a ramped engagement with respectively one of two ramps. Each ramp is on one longitudinal side of the rhomboid ramp member such that application of a translative force between the components in one longitudinal direction with the first beam head engaged to one of the ramps in a first state deflects the resilient beam in one transversal direction and such that application of a translative force between the components in the other longitudinal direction with the first beam head engaged to the other one of the ramps deflects the resilient beam in the other transversal direction.
摘要翻译：用于控制纵向方向上的两个部件之间的平移的制动机构包括在其中一个部件上的弹性梁和另一部件上的菱形斜坡部件。弹性梁在松弛时基本上是直的，并且具有第一梁头并且被布置成与两个坡道中的一个分别以斜坡接合相互作用。每个斜坡在菱形斜坡构件的一个纵向侧上，使得在一个纵向方向上的部件之间的平移力与在第一状态下与一个斜面接合的第一梁头在一个横向上偏转弹性梁，使得在另一个纵向方向上的部件之间施加平移力与与另一个斜面接合的第一梁头在另一横向方向上使弹性梁偏转。

9. 发明授权

US10894132B2 Auto-injector 有权
公开(公告)号：US10894132B2
公开(公告)日：2021-01-19
申请号：US15897872
申请日：2018-02-15
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/46 , A61M5/20 , A61M5/32 , A61M5/315
摘要： An auto-injector for administering a dose of a liquid medicament (M) is present having a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier is adapted to contain a syringe with a hollow injection needle. The injector also has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. A control spring is arranged around the carrier for translating the carrier in a proximal direction (P) for insertion of the needle through the chassis into an injection site.

10. 发明授权

US10556064B2 Auto-injector 有权
公开(公告)号：US10556064B2
公开(公告)日：2020-02-11
申请号：US15480026
申请日：2017-04-05
申请人： Sanofi-Aventis Deutschland GMBH
发明人： Simon Francis Brereton , Thomas Kemp , Rosie Burnell , Matthew Ekman
IPC分类号： A61M5/315 , A61M5/32 , A61M5/46 , A61M5/50 , A61M5/20
摘要： An auto-injector for administering a dose of a liquid medicament has a tubular chassis telescopable in a tubular case, a carrier subassembly comprising a tubular carrier slidably arranged relative to the chassis inside the case, where the carrier adapted to contain a syringe with a hollow injection needle. The injector has a drive spring and a plunger for forwarding load of the drive spring to a stopper of the syringe, wherein the syringe is lockable for joint axial translation with the carrier. There is also a trigger button arranged distally or laterally in or on the case, a control spring arranged around the carrier, and a needle extension control mechanism for coupling a proximal end of the control spring to either the carrier for advancing it for needle extension or to the chassis for needle retraction depending on the relative axial position of the carrier and the chassis.

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