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1. 发明授权

US08795628B2 Molecular imaging of living subjects using Raman spectroscopy and labeled Raman nanoparticles 有权
标题翻译：使用拉曼光谱和标记拉曼纳米粒子的活体受体的分子成像
公开(公告)号：US08795628B2
公开(公告)日：2014-08-05
申请号：US12598780
申请日：2008-05-05
申请人： Sanjiv S. Gambhir , Shay Keren , Ian Walton , David Guagliardo
发明人： Sanjiv S. Gambhir , Shay Keren , Ian Walton , David Guagliardo
IPC分类号： A61K51/00 , A61K49/00
CPC分类号： G01N21/658 , B82Y30/00
摘要： Methods of imaging a living host using Raman nanoparticles; methods of generating a true image of a living host having been administered Raman nanoparticles; methods of multiplex imaging of a living host using a plurality of Raman nanoparticles; methods of generating multimodality images by combining Raman images with other functional/anatomical images; labeled Raman nanoparticles; and the like, are provided.
摘要翻译：使用拉曼纳米颗粒成像活体的方法; 产生已经施用拉曼纳米粒子的活体的真实图像的方法; 使用多个拉曼纳米粒子对活体进行多重成像的方法; 通过将拉曼图像与其他功能/解剖图像组合来产生多模态图像的方法; 标记的拉曼纳米颗粒; 等等。

2. 发明授权

US06603537B1 Optical architectures for microvolume laser-scanning cytometers 失效
标题翻译：用于微体积激光扫描细胞仪的光学架构
公开(公告)号：US06603537B1
公开(公告)日：2003-08-05
申请号：US09378259
申请日：1999-08-20
申请人： Louis J. Dietz , Ian Walton , Scott Norton
发明人： Louis J. Dietz , Ian Walton , Scott Norton
IPC分类号： G01J330
CPC分类号： G01N15/1475 , G01N15/1434 , G01N15/1484
摘要： Methods and instrumentation for performing charge coupled device (CCD)-based confocal spectroscopy with a laser spot array are provided. The methods and instruments of the invention are useful in any spectroscopic application, including, but not limited to, microscopy and microvolume laser scanning cytometry (MLSC).
摘要翻译：提供了一种用激光点阵进行基于电荷耦合器件（CCD）的共聚焦光谱法的方法和仪器。本发明的方法和仪器在任何光谱应用中是有用的，包括但不限于显微镜和微体积激光扫描细胞计数（MLSC）。

3. 发明授权

US06025601A Method and apparatus for imaging a sample on a device 失效
公开(公告)号：US06025601A
公开(公告)日：2000-02-15
申请号：US871269
申请日：1997-06-09
申请人： Mark Trulson , David Stern , Peter Fiekowsky , Richard Rava , Ian Walton , Stephen P. A. Fodor
发明人： Mark Trulson , David Stern , Peter Fiekowsky , Richard Rava , Ian Walton , Stephen P. A. Fodor
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01N21/6428 , G01N21/6456 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , G01N2021/6417 , G01N2021/6423 , G01N2021/6441
摘要： Labeled targets on a support synthesized with polymer sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, can be detected by exposing selected regions of sample 1500 to radiation from a source 1100 and detecting the emission therefrom, and repeating the steps of exposition and detection until the sample is completely examined.

4. 发明授权

US08540024B2 Perforation strategy for heterogeneous proppant placement in hydraulic fracturing 有权
$Perforation strategy for heterogeneous proppant placement in hydraulic fracturing$
标题翻译：水力压裂中异质支撑剂放置穿孔策略
公开(公告)号：US08540024B2
公开(公告)日：2013-09-24
申请号：US12667073
申请日：2007-07-03
申请人： Ivan Vitalievich Kosarev , Oleg Olegovich Medvedev , Anatoly Vladimirovich Medvedev , Ian Walton
发明人： Ivan Vitalievich Kosarev , Oleg Olegovich Medvedev , Anatoly Vladimirovich Medvedev , Ian Walton
IPC分类号： E21B43/267
CPC分类号： E21B43/267 , E21B43/11
摘要： Hydraulic fracturing an individual reservoir fracturing layer of a subterranean formation to produce heterogeneous proppant placement is given in which pillars of proppant are placed such that the pillars do not extend the entire height of the fracture (for a vertical fracture) but are themselves interrupted by channels so that the channels between the pillars form pathways that lead to the wellbore. The method combines methods of introducing slugs of proppant-carrying and proppant-free fluids through multiple clusters of perforations within a single fracturing layer of rock, with methods of ensuring that the slugs exiting the individual clusters do not merge.
摘要翻译：给出地下地层单个储层压裂层的水力压裂以产生不均匀的支撑剂放置，其中支撑剂的支柱被放置成使得支柱不延伸断裂的整个高度（对于垂直断裂），但是本身被通道所中断使得柱之间的通道形成通向井筒的通路。该方法结合了通过在单个岩石压裂层内的多个穿孔簇引入支撑剂载体和不含支撑剂的流体的lug combines的方法，确保离开各个簇的s do不合并的方法。

5. 发明授权

US07336812B2 System for microvolume laser scanning cytometry 失效
标题翻译：微体积激光扫描细胞计数系统
公开(公告)号：US07336812B2
公开(公告)日：2008-02-26
申请号：US10771585
申请日：2004-02-03
申请人： Louis J Dietz , Ian Walton , Chih-Hua Chung , Scott Norton , James L Winkler , Aaron B Kantor , Byron Lee , Shalom Tsur
发明人： Louis J Dietz , Ian Walton , Chih-Hua Chung , Scott Norton , James L Winkler , Aaron B Kantor , Byron Lee , Shalom Tsur
IPC分类号： G06K9/00 , G06K9/46 , G06K99/66 , G06K9/38
CPC分类号： G01N15/1475
摘要： The present invention provides an improved integrated system for biological marker identification. The system uses Microvolume Laser Scanning Microscopy (MLSC) in order to measure patterns of expression of biological markers in biological fluids. The system includes improved instrumentation for performing MLSC, and also includes improved particle detection and analysis methods. The system further comprises an informatics architecture for the analysis of data obtained from the MLSC in tandem with other medical information.
摘要翻译：本发明提供了用于生物标志物鉴定的改进的集成系统。该系统使用微量激光扫描显微镜（MLSC）来测量生物液体中生物标志物的表达模式。该系统包括用于执行MLSC的改进仪器，还包括改进的粒子检测和分析方法。该系统还包括用于分析从MLSC获得的数据与其他医疗信息的信息架构。

6. 发明申请

US20070050144A1 Perforating Optimized for Stress Gradients Around Wellbore 有权
标题翻译：孔眼周围应力梯度的穿孔优化
公开(公告)号：US20070050144A1
公开(公告)日：2007-03-01
申请号：US11162195
申请日：2005-08-31
申请人： Brenden Grove , Ian Walton
发明人： Brenden Grove , Ian Walton
IPC分类号： G01V1/40
CPC分类号： E21B43/119
摘要： A technique includes determining a stress tensor in a formation that surrounds a wellbore. The stress tensor varies with respect to the wellbore. The technique includes running a perforating charge into the wellbore to perforate the formation and performing at least one of selecting the perforating charge and orienting the perforating charge in the wellbore based at least in part on the determination of the stress tensor.
摘要翻译：一种技术包括确定围绕井筒的地层中的应力张量。应力张量相对于井筒变化。该技术包括将穿孔电荷运送到井筒中以使地层穿孔，并且至少部分地基于应力张量的确定，执行选择射孔荷载和使钻孔中的射孔荷载定向中的至少一种。

7. 发明申请

US20060038979A1 Nanoparticles as covert taggants in currency, bank notes, and related documents 审中-公开
标题翻译：纳米颗粒作为货币，纸币和相关文件中的隐蔽标签
公开(公告)号：US20060038979A1
公开(公告)日：2006-02-23
申请号：US11198870
申请日：2005-08-05
申请人： Michael Natan , Scott Norton , Richard Freeman , Sharron Penn , Ian Walton
发明人： Michael Natan , Scott Norton , Richard Freeman , Sharron Penn , Ian Walton
IPC分类号： G06K9/74 , G01J3/44
CPC分类号： G06K9/00577 , G01J3/44 , G01N21/658 , G01N2201/129 , G07D7/1205
摘要： Methods for applying security tags and/or data to currency and other documents and systems for use are provided.
摘要翻译：提供了将安全标签和/或数据应用于货币和其他文件和系统以供使用的方法。

8. 发明申请

US20050236183A1 Method and Apparatus for Reducing Pressure in a Perforating Gun 有权
标题翻译：用于降低穿孔枪压力的方法和装置
公开(公告)号：US20050236183A1
公开(公告)日：2005-10-27
申请号：US10709250
申请日：2004-04-23
申请人： Brenden Grove , Lawrence Behrmann , Ian Walton , Philip Kneisl , Andrew Werner
发明人： Brenden Grove , Lawrence Behrmann , Ian Walton , Philip Kneisl , Andrew Werner
IPC分类号： E21B20060101 , E21B7/00 , E21B43/116 , E21B43/119
CPC分类号： E21B43/119 , Y10S102/704
摘要： An apparatus for reducing the post-detonation pressure of a perforating gun, the apparatus including a perforating gun carrying at least one explosive charge, wherein when the explosive charge is detonated the explosive charge produces a pressurized detonation gas, and a mechanism for reducing the pressure of the detonation gas proximate the perforating gun. The detonation gas pressure is desirably reduced in a time frame sufficient to create a dynamic underbalance condition to facilitate a surge flow of fluid from a reservoir into a wellbore. The pressure reduction mechanism may include singularly or in combination a heat sink to reduce the temperature of the detonation gas, a reactant to recombine with the reactant gas and reduce the molar density of the detonation gas, and a physical compression mechanism to utilize the waste energy of the detonation gas to create work, simultaneously reducing the temperature of the gas and the molar density of the detonation gas.
摘要翻译：一种用于降低射孔枪的爆震后压力的装置，该装置包括一个携带至少一种炸药的射孔枪，其中当炸药被引爆时，炸药产生加压的爆震气体，以及用于降低压力的机构靠近射孔枪的爆炸气体。期望在足以产生动态不平衡条件的时间框架内减小爆震气体压力，以促进流体从储层涌入井眼的浪涌流。减压机构可以单独地或组合地使用散热器来降低爆震气体的温度，与反应气体重新组合的反应物并降低爆震气体的摩尔密度，以及物理压缩机构以利用废能的爆炸气体以产生作用，同时降低气体的温度和爆震气体的摩尔密度。

9. 发明授权

US06252236B1 Method and apparatus for imaging a sample on a device 有权
标题翻译：用于在装置上成像样品的方法和装置
公开(公告)号：US06252236B1
公开(公告)日：2001-06-26
申请号：US09348216
申请日：1999-07-06
申请人： Mark Trulson , David Stern , Peter Fiekowsky , Richard Rava , Ian Walton , Stephen P. A. Fodor
发明人： Mark Trulson , David Stern , Peter Fiekowsky , Richard Rava , Ian Walton , Stephen P. A. Fodor
IPC分类号： G01N2164
CPC分类号： G01N21/6452 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00637 , B01J2219/00659 , B01J2219/00702 , G01N21/6428 , G01N21/6456 , G01N2021/6417 , G01N2021/6423 , G01N2021/6441
摘要： A method and apparatus for imaging a sample are provided. An electromagnetic radiation source generates excitation radiation which is sized by excitation optics to a line. The line is directed at a sample resting on a support and excites a plurality of regions on the sample. Collection optics collect response radiation reflected from the sample I and image the reflected radiation. A detector senses the reflected radiation and is positioned to permit discrimination between radiation reflected from a certain focal plane in the sample and certain other planes within the sample.
摘要翻译：提供了一种用于成像样品的方法和装置。电磁辐射源产生激发辐射，该激发辐射通过激发光学器件被定尺寸至线路。该线指向搁置在支撑体上的样品并激发样品上的多个区域。采集光学器件收集从样品I反射的反射辐射并对反射的辐射进行成像。检测器感测反射的辐射，并且被定位成允许区分从样品中的某个焦平面反射的辐射和样品内的某些其它平面。

10. 发明授权

US07909115B2 Method for perforating utilizing a shaped charge in acidizing operations 有权
标题翻译：在酸化操作中利用成形装料穿孔的方法
公开(公告)号：US07909115B2
公开(公告)日：2011-03-22
申请号：US11851891
申请日：2007-09-07
申请人： Brenden Grove , Ian Walton , Lawrence A. Behrmann
发明人： Brenden Grove , Ian Walton , Lawrence A. Behrmann
IPC分类号： E21B43/116 , E21B43/263 , E21B29/00 , F42D3/02
CPC分类号： E21B43/117 , E21B43/119 , E21B43/26
摘要： A shaped charge includes: a charge case; an explosive disposed inside the charge case; and a liner for retaining the explosive in the charge case, wherein the liner is fabricated from a material soluble with a selected dissolving fluid (e.g., an acid, an acid matrix, an injection fluid, a completion fluid, and/or a wellbore fluid). A method for perforating in a well includes the steps of: disposing a perforating gun in the well, wherein the perforating gun comprises a shaped charge having a charge case, an explosive disposed inside the charge case, and a liner for retaining the explosive in the charge case, wherein the liner is fabricated from a material soluble with a selected dissolving fluid; detonating the shaped charge to form a perforation tunnel in a formation zone; and exposing the material comprising the liner to the selected dissolving fluid.
摘要翻译：成型费用包括：收费箱; 装在充电箱内的炸药; 以及用于将炸药保持在电荷箱中的衬垫，其中衬垫由可溶于选定的溶解流体的材料制成（例如，酸，酸性基质，注射液，完井液和/或井筒流体）。一种用于在井中穿孔的方法包括以下步骤：将穿孔枪放置在井中，其中穿孔枪包括具有充电箱的成形装药器，设置在充电箱内的炸药和用于将炸药保持在容器内的衬套充电箱，其中所述衬垫由可溶于所选溶解流体的材料制成; 引爆成形装置，以在形成区域形成穿孔隧道; 以及将包含衬垫的材料暴露于所选择的溶解流体。

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